327
Views
48
CrossRef citations to date
0
Altmetric
Research Article

The Tumor Microenvironment: Key to Early Detection

, , &
Pages 393-425 | Published online: 10 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Catherine J. Lee, Edgardo V. Ariztia & David A. Fishman. (2007) Conventional and Proteomic Technologies for the Detection of Early Stage Malignancies: Markers for Ovarian Cancer. Critical Reviews in Clinical Laboratory Sciences 44:1, pages 87-114.
Read now

Articles from other publishers (47)

Rui Tang, Haitao Wang & Mingxi Tang. (2023) Roles of tissue-resident immune cells in immunotherapy of non-small cell lung cancer. Frontiers in Immunology 14.
Crossref
Li Lin & Lihong V. Wang. (2022) The emerging role of photoacoustic imaging in clinical oncology. Nature Reviews Clinical Oncology 19:6, pages 365-384.
Crossref
Aruni Ghose, Sri Vidya Niharika Gullapalli, Naila Chohan, Anita Bolina, Michele Moschetta, Elie Rassy & Stergios Boussios. (2022) Applications of Proteomics in Ovarian Cancer: Dawn of a New Era. Proteomes 10:2, pages 16.
Crossref
. 2022. Eosinophil Ultrastructure. Eosinophil Ultrastructure 475 488 .
Rossana C.N. Melo, Ann M. Dvorak & Peter F. Weller. 2022. Eosinophil Ultrastructure. Eosinophil Ultrastructure 289 394 .
Feridey N. Carr, Elizabeth M. Sosa & Brian I. Carr. 2022. Psychological Aspects of Cancer. Psychological Aspects of Cancer 1 19 .
Wayne Ng & Andrew Morokoff. 2021. Tumor Microenvironment. Tumor Microenvironment 123 144 .
Gadi Cohen, Parwathy Chandran, Rebecca M. Lorsung, Lauren E. Tomlinson, Maggie Sundby, Scott R. Burks & Joseph A. Frank. (2020) The Impact of Focused Ultrasound in Two Tumor Models: Temporal Alterations in the Natural History on Tumor Microenvironment and Immune Cell Response. Cancers 12:2, pages 350.
Crossref
Marriam Yamin, Hadeeqa Gull Raza & Iffat Fatima. 2020. 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine. 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine 3 33 .
Wei Liu, Lei Zhang, Hui-Jing Xu, Yan Li, Chuan-Min Hu, Jing-Yan Yang & Mei-Yan Sun. (2018) The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis. International Journal of Molecular Sciences 19:9, pages 2736.
Crossref
Mohammad H. Kazemi, Sahar Raoofi Mohseni, Mohammad Hojjat-Farsangi, Enayat Anvari, Ghasem Ghalamfarsa, Hamed Mohammadi & Farhad Jadidi-Niaragh. (2018) Adenosine and adenosine receptors in the immunopathogenesis and treatment of cancer. Journal of Cellular Physiology 233:3, pages 2032-2057.
Crossref
Hong Yin, Jie Yang, Qing Zhang, Jie Yang, Haiyu Wang, Jinjing Xu & Junnian Zheng. (2017) iRGD as a tumor-penetrating peptide for cancer therapy. Molecular Medicine Reports 15:5, pages 2925-2930.
Crossref
Khosrow Kashfi & Pascale L. Duvalsaint. 2017. Nitric Oxide Donors. Nitric Oxide Donors 75 119 .
Aron Parekh & Alissa M. Weaver. (2016) Regulation of invadopodia by mechanical signaling. Experimental Cell Research 343:1, pages 89-95.
Crossref
Rachel J. Jerrell & Aron Parekh. (2016) Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2. Biomaterials 84, pages 119-129.
Crossref
Jennifer L. Steel, Feridey N. Carr, Alexandra Savkova, Naadia Ahmed, Andrea DiMartini & Mary A. Dew. 2016. Hepatocellular Carcinoma. Hepatocellular Carcinoma 547 577 .
Françoise Remacle & Raphael D. Levine. (2014) Prédiction de la réponse moléculaire à des perturbations mesurée sur des cellules uniques. médecine/sciences 30:12, pages 1129-1135.
Crossref
Steven Michael Santana, Marc A Antonyak, Richard A Cerione & Brian J Kirby. (2014) Cancerous epithelial cell lines shed extracellular vesicles with a bimodal size distribution that is sensitive to glutamine inhibition. Physical Biology 11:6, pages 065001.
Crossref
Nunzia D'Onofrio, Michele Caraglia, Anna Grimaldi, Raffaele Marfella, Luigi Servillo, Giuseppe Paolisso & Maria Luisa Balestrieri. (2014) Vascular-homing peptides for targeted drug delivery and molecular imaging: Meeting the clinical challenges. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1846:1, pages 1-12.
Crossref
Delphine Tamara Marie-Egyptienne, Ines Lohse & Richard Peter Hill. (2013) Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia. Cancer Letters 341:1, pages 63-72.
Crossref
Feridey N. Carr & Elizabeth M. Sosa. 2013. Psychological Aspects of Cancer. Psychological Aspects of Cancer 13 30 .
P. Anandakumar, S. Kamaraj, S. Jagan, G. Ramakrishnan, S. Asokkumar, C. Naveenkumar, S. Raghunandhakumar & T. Devaki. (2012) Capsaicin inhibits benzo(a)pyrene-induced lung carcinogenesis in an in vivo mouse model. Inflammation Research 61:11, pages 1169-1175.
Crossref
Zhi Jie Li & Chi Hin Cho. (2012) Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery. Journal of Translational Medicine 10:S1.
Crossref
Pnina Fishman, Sara Bar-Yehuda, Bruce T. Liang & Kenneth A. Jacobson. (2012) Pharmacological and therapeutic effects of A3 adenosine receptor agonists. Drug Discovery Today 17:7-8, pages 359-366.
Crossref
Zarana S Patel, Katharine D Grugan, Anil K Rustgi, Francis A Cucinotta & Janice L Huff. (2012) Ionizing Radiation Enhances Esophageal Epithelial Cell Migration and Invasion Through a Paracrine Mechanism Involving Stromal-Derived Hepatocyte Growth Factor. Radiation Research 177:2, pages 200-208.
Crossref
Kathryn A. Bailey, Kathleen Wallace, Lisa Smeester, Sheau-Fung Thai, Douglas C. Wolf, Stephen W. Edwards & Rebecca C. Fry. (2012) Transcriptional Modulation of the ERK1/2 MAPK and NF-kB Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer. Journal of Cancer Research Updates 1:1.
Crossref
Young Shik Shin, F. Remacle, Rong Fan, Kiwook Hwang, Wei Wei, Habib Ahmad, R.D. Levine & James R. Heath. (2011) Protein Signaling Networks from Single Cell Fluctuations and Information Theory Profiling. Biophysical Journal 100:10, pages 2378-2386.
Crossref
Zhi Jie Li, William Ka Kei Wu, Simon Siu Man Ng, Le Yu, Hai Tao Li, Clover Ching Man Wong, Ya Chun Wu, Lin Zhang, Shun Xiang Ren, Xue Gang Sun, Kam Ming Chan & Chi Hin Cho. (2010) A novel peptide specifically targeting the vasculature of orthotopic colorectal cancer for imaging detection and drug delivery. Journal of Controlled Release 148:3, pages 292-302.
Crossref
Allison S. Betof & Mark W. Dewhirst. 2010. Tumor Microenvironment. Tumor Microenvironment 7 33 .
Leroi V. DeSouza, Olga Krakovska, Marlene M. Darfler, David B. Krizman, Alexander D. Romaschin, Terence J. Colgan & K. W. Michael Siu. (2010) mTRAQ‐based quantification of potential endometrial carcinoma biomarkers from archived formalin‐fixed paraffin‐embedded tissues. PROTEOMICS 10:17, pages 3108-3116.
Crossref
Feng-qiang Wang, Edgardo V. Ariztia, Leslie R. Boyd, Faith R. Horton, Yoel Smicun, Jessica A. Hetherington, Phillip J. Smith & David A. Fishman. (2010) Lysophosphatidic acid (LPA) effects on endometrial carcinoma in vitro proliferation, invasion, and matrix metalloproteinase activity. Gynecologic Oncology 117:1, pages 88-95.
Crossref
C. Escudero-Lourdes, M.K. Medeiros, M.C. Cárdenas-González, S.M. Wnek & J.A. Gandolfi. (2010) Low level exposure to monomethyl arsonous acid-induced the over-production of inflammation-related cytokines and the activation of cell signals associated with tumor progression in a urothelial cell model. Toxicology and Applied Pharmacology 244:2, pages 162-173.
Crossref
Peter Jantscheff, Vittorio Ziroli, Norbert Esser, Ralph Graeser, Jessica Kluth, Alena Sukolinskaya, Lenka A. Taylor, Clemens Unger & Ulrich Massing. (2009) Anti-metastatic effects of liposomal gemcitabine in a human orthotopic LNCaP prostate cancer xenograft model. Clinical & Experimental Metastasis 26:8, pages 981-992.
Crossref
Francesco Meani, Sergio Pecorelli, Lance Liotta & Emanuel F. Petricoin. (2012) Clinical Application of Proteomics in Ovarian Cancer Prevention and Treatment. Molecular Diagnosis & Therapy 13:5, pages 297-311.
Crossref
James D. BortnerJr.Jr., Arunangshu Das, Todd M. Umstead, Williard M. Freeman, Richard Somiari, Cesar Aliaga, David S. Phelps & Karam El-Bayoumy. (2009) Down-Regulation of 14-3-3 Isoforms and Annexin A5 Proteins in Lung Adenocarcinoma Induced by the Tobacco-Specific Nitrosamine NNK in the A/J Mouse Revealed by Proteomic Analysis. Journal of Proteome Research 8:8, pages 4050-4061.
Crossref
Zhen Xiao, Josip Blonder, Ming Zhou & Timothy D. Veenstra. (2009) Proteomic analysis of extracellular matrix and vesicles. Journal of Proteomics 72:1, pages 34-45.
Crossref
Ranju Ralhan, Leroi V. DeSouza, Ajay Matta, Satyendra Chandra Tripathi, Shaun Ghanny, Siddhartha DattaGupta, Alok Thakar, Shyam S. Chauhan & K. W. Michael Siu. (2008) iTRAQ-Multidimensional Liquid Chromatography and Tandem Mass Spectrometry-Based Identification of Potential Biomarkers of Oral Epithelial Dysplasia and Novel Networks between Inflammation and Premalignancy. Journal of Proteome Research 8:1, pages 300-309.
Crossref
Ariel Fernández, Alejandro Crespo & Abhinav Tiwari. (2009) Is there a case for selectively promiscuous anticancer drugs?. Drug Discovery Today 14:1-2, pages 1-5.
Crossref
Khosrow Kashfi. 2009. Contemporary Aspects of Biomedical Research - Drug Discovery. Contemporary Aspects of Biomedical Research - Drug Discovery 31 89 .
Peter Vaupel. 2009. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies. The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies 51 92 .
Radhika Gogoi, Marek Kudla, Orlando Gil & David Fishman. (2008) The Activity of Medroxyprogesterone Acetate, an Androgenic Ligand, in Ovarian Cancer Cell Invasion. Reproductive Sciences 15:8, pages 846-852.
Crossref
Isabella Imhof, Warren J. Gasper & Rik Derynck. (2008) Association of tetraspanin CD9 with transmembrane TGFα confers alterations in cell-surface presentation of TGFα and cytoskeletal organization. Journal of Cell Science 121:13, pages 2265-2274.
Crossref
Ranju Ralhan, Leroi V. DeSouza, Ajay Matta, Satyendra Chandra Tripathi, Shaun Ghanny, Siddartha Datta Gupta, Sudhir Bahadur & K. W. Michael Siu. (2008) Discovery and Verification of Head-and-neck Cancer Biomarkers by Differential Protein Expression Analysis Using iTRAQ Labeling, Multidimensional Liquid Chromatography, and Tandem Mass Spectrometry. Molecular & Cellular Proteomics 7:6, pages 1162-1173.
Crossref
Orlando D. Gil, Catherine Lee, Edgardo V. Ariztia, Feng-Qiang Wang, Phillip J. Smith, Joanie Mayer Hope & David A. Fishman. (2008) Lysophosphatidic acid (LPA) promotes E-cadherin ectodomain shedding and OVCA429 cell invasion in an uPA-dependent manner. Gynecologic Oncology 108:2, pages 361-369.
Crossref
Gianfranco Baronzio & Isabel Freitas. 2008. Atlas Effectors of Anti-Tumor Immunity. Atlas Effectors of Anti-Tumor Immunity 25 43 .
Valerie DubéJörg GrigullLeroi V. DeSouzaShaun GhannyTerence J. ColganAlexander D. RomaschinK. W. Michael Siu. (2007) Verification of Endometrial Tissue Biomarkers Previously Discovered Using Mass Spectrometry-Based Proteomics by Means of Immunohistochemistry in a Tissue Microarray Format. Journal of Proteome Research 6:7, pages 2648-2655.
Crossref
Hongyan Li, Leroi V. DeSouza, Shaun Ghanny, Wei Li, Alexander D. Romaschin, Terence J. Colgan & K. W. Michael Siu. (2007) Identification of Candidate Biomarker Proteins Released by Human Endometrial and Cervical Cancer Cells Using Two-Dimensional Liquid Chromatography/Tandem Mass Spectrometry. Journal of Proteome Research 6:7, pages 2615-2622.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.