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Critical Reviews in Clinical Laboratory Sciences Volume 44, 2007 - Issue 2
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Research Article

Tumor-Associated Proteolytic Factors uPA and PAI-1: Critical Appraisal of Their Clinical Relevance in Breast Cancer and Their Integration into Decision-Support Algorithms

Nadia Harbeck Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
,
Manfred Schmitt Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
,
Stefan Paepke Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany
,
Heike Allgayer Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Klinikum Mannheim, University of Heidelberg, and DKFZ HeidelbergGermany
&
Ronald E. Kates Department of Obstetrics and Gynecology, Technical University of Munich, Munich, Germany; Department of Experimental Surgery and Molecular Oncology of Solid Tumors, Klinikum Mannheim, University of Heidelberg, and DKFZ HeidelbergGermany
Pages 179-201 | Published online: 10 Oct 2008

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Manfred Schmitt, Nadia Harbeck, Nils Brünner, Fritz Jänicke, Christoph Meisner, Bernd Mühlenweg, Heike Jansen, Julia Dorn, Ulrike Nitz, Eva J Kantelhardt & Christoph Thomssen. (2011) Cancer therapy trials employing level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1. Expert Review of Molecular Diagnostics 11:6, pages 617-634.
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Manfred Schmitt, Karin Mengele, Rudolf Napieralski, Viktor Magdolen, Ute Reuning, Apostolos Gkazepis, Fred Sweep, Nils Brünner, John Foekens & Nadia Harbeck. (2010) Clinical utility of level-of-evidence-1 disease forecast cancer biomarkers uPA and its inhibitor PAI-1. Expert Review of Molecular Diagnostics 10:8, pages 1051-1067.
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Zu-Liang Deng, Ding-Zhong Zhou, Su-Juan Cao, Qing Li, Jian-Fang Zhang & Hui Xie. (2022) Development and Validation of an Inflammatory Response-Related Gene Signature for Predicting the Prognosis of Pancreatic Adenocarcinoma. Inflammation 45:4, pages 1732-1751.
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Hongyan Yuan, Xiaoyi Wang, Chunmei Shi, Lu Jin, Jianxia Hu, Alston Zhang, James Li, Nairuthya Vijayendra, Venkata Doodala, Spencer Weiss, Yong Tang, Louis M. Weiner & Robert I. Glazer. (2018) Plac1 Is a Key Regulator of the Inflammatory Response and Immune Tolerance In Mammary Tumorigenesis. Scientific Reports 8:1.
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Marko Buta, Radan Džodić, Igor Đurišić, Ivan Marković, Tijana Vujasinović, Milan Markićević & Dragica Nikolić-Vukosavljević. (2015) Potential clinical relevance of uPA and PAI-1 levels in node-negative, postmenopausal breast cancer patients bearing histological grade II tumors with ER/PR expression, during an early follow-up. Tumor Biology 36:10, pages 8193-8200.
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MARZENA WYGANOWSKA-ŞWIĄTKOWSKA & JERZY JANKUN. (2015) Plasminogen activation system in oral cancer: Relevance in prognosis and therapy (Review). International Journal of Oncology 47:1, pages 16-24.
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Brygida Berse & Julie A. Lynch. (2015) Molecular Diagnostic Testing in Breast Cancer. Seminars in Oncology Nursing 31:2, pages 108-121.
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László Herszényi. (2014) Impact of proteolytic enzymes in colorectal cancer development and progression. World Journal of Gastroenterology 20:37, pages 13246.
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Ceri E. Stewart & Ian Sayers. (2013) Urokinase Receptor Orchestrates the Plasminogen System in Airway Epithelial Cell Function. Lung 191:2, pages 215-225.
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Debora Fumagalli, Fabrice Andre, Martine J. Piccart-Gebhart, Christos Sotiriou & Christine Desmedt. (2012) Molecular biology in breast cancer: Should molecular classifiers be assessed by conventional tools or by gene expression arrays?. Critical Reviews in Oncology/Hematology 84, pages e58-e69.
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R. Matthew Klein, Daniel Bernstein, Steven P. Higgins, Craig E. Higgins & Paul J. Higgins. (2012) SERPINE1 expression discriminates site-specific metastasis in human melanoma. Experimental Dermatology 21:7, pages 551-554.
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Ferda Ari, Rudolf Napieralski, Engin Ulukaya, Egemen Dere, Christoph Colling, Katja Honert, Achim Krüger, Marion Kiechle & Manfred Schmitt. (2011) Modulation of protein expression levels and DNA methylation status of breast cancer metastasis genes by anthracycline-based chemotherapy and the demethylating agent decitabine. Cell Biochemistry and Function 29:8, pages 651-659.
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M Sudol. (2011) From Rous sarcoma virus to plasminogen activator, src oncogene and cancer management. Oncogene 30:27, pages 3003-3010.
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Sanda Jelisavac-Cosic, Maja Sirotkovic-Skerlev, Ana Kulic, Jasminka Jakic-Razumovic, Zdenko Kovac & Damir Vrbanec. (2018) Prognostic significance of urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor (PAI-1) in patients with primary invasive ductal breast carcinoma – a 7.5-year follow-up study. Tumori Journal 97:4, pages 532-539.
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Julia Annabel Kandenwein, Tjoung-Won Park-Simon, Johannes Schramm & Matthias Simon. (2010) uPA/PAI-1 expression and uPA promoter methylation in meningiomas. Journal of Neuro-Oncology 103:3, pages 533-539.
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Tone Hoel LendeEmiel A.M. JanssenEinar GudlaugssonFeja VoorhorstRune SmaalandPaul van DiestHåvard SøilandJan P.A. Baak. (2011) In Patients Younger Than Age 55 Years With Lymph Node–Negative Breast Cancer, Proliferation by Mitotic Activity Index Is Prognostically Superior to Adjuvant!. Journal of Clinical Oncology 29:7, pages 852-858.
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Daniel M Appledorn, Kim-Hien T Dao, Sandra O'Reilly, Veronica M Maher & J Justin McCormick. (2010) Rac1 and Cdc42 are regulators of HRasV12-transformation and angiogenic factors in human fibroblasts. BMC Cancer 10:1.
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Enke Baldini, Salvatore Ulisse & Massimino D’Armiento. 2010. Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy, and Prognosis 445 458 .
Helene Rundqvist & Randall S. Johnson. 2010. Diverse Effects of Hypoxia on Tumor Progression. Diverse Effects of Hypoxia on Tumor Progression 121 139 .
Jennifer Freytag, Cynthia E. Wilkins-Port, Craig E. Higgins, J. Andrew Carlson, Agnes Noel, Jean-Michel Foidart, Stephen P. Higgins, Rohan Samarakoon & Paul J. Higgins. (2009) PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma. Journal of Oncology 2009, pages 1-12.
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László Herszényi, Fabio Farinati, Romilda Cardin, Gábor István, László D Molnár, István Hritz, Massimo De Paoli, Mario Plebani & Zsolt Tulassay. (2008) Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer. BMC Cancer 8:1.
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László Herszényi, Gábor István, Romilda Cardin, Massimo De Paoli, Mario Plebani, Zsolt Tulassay & Fabio Farinati. (2008) Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers. European Journal of Cancer Prevention 17:5, pages 438-445.
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Christos Markopoulos. (2008) Safely promoting breast-conserving surgery and preventing early relapses with an aromatase inhibitor. Surgical Oncology 17:2, pages 113-128.
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V Gouyer, D Fontaine, P Dumont, O de Wever, H Fontayne-Devaud, E Leteurtre, S Truant, D Delacour, H Drobecq, J-P Kerckaert, Y de Launoit, M Bracke, C Gespach, J-L Desseyn & G Huet. (2008) Autocrine induction of invasion and metastasis by tumor-associated trypsin inhibitor in human colon cancer cells. Oncogene 27:29, pages 4024-4033.
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Steven Walczak. 2008. Intelligent Decision Making: An AI-Based Approach. Intelligent Decision Making: An AI-Based Approach 259 287 .

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