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Original Articles

The Bioactivity and Toxicological Actions of Carvacrol

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Zuhal Emire & Erdal Yabalak. (2023) Can Origanum be a hope for cancer treatment? A review on the potential of Origanum species in preventing and treating cancers. International Journal of Environmental Health Research 33:9, pages 894-910.
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Neda Tariverdizadeh, Mehdi Mohebodini, Asghar Ebadi & Hamid Reza Heydari. (2023) Response of Satureja hortensis L. to gamma radiation and its impact on secondary metabolite content and biochemical characteristics. International Journal of Radiation Biology 99:9, pages 1424-1432.
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José Fernando Rinaldi de Alvarenga, Brunna Genaro, Bruna Lamesa Costa, Eduardo Purgatto, Claudine Manach & Jarlei Fiamoncini. (2023) Monoterpenes: current knowledge on food source, metabolism, and health effects. Critical Reviews in Food Science and Nutrition 63:10, pages 1352-1389.
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Ariana Azevedo Vasconcelos, Idia Nara de Sousa Veras, Mayron Alves de Vasconcelos, Alexandre Lopes Andrade, Hélcio Silva dos Santos, Paulo Nogueira Bandeira, Elnatan Bezerra de Souza, Maria Rose Jane Ribeiro Albuquerque & Edson Holanda Teixeira. (2023) Chemical composition determination and evaluation of the antibacterial activity of essential oils from Ruellia asperula (Mart. Ex Ness) Lindau and Ruellia paniculata L. against oral streptococci. Natural Product Research 37:2, pages 333-337.
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Tuncer Kutlu & Mehmet Güvenç. (2023) Effects of carvacrol on experimental nephrolithiasis in female rats. Biotechnic & Histochemistry 98:1, pages 69-76.
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Isaac Filipe Moreira Konig, Aline Chaves Reis, Mariana Aparecida Braga, Dirceu De Sousa Melo, Erika Aparecida Oliveira, Elaine Maria Seles Dorneles, Sérgio Scherrer Thomasi, Rafael Neodini Remedio & Silvana Marcussi. (2022) Comparative toxicological evaluation of carvacrol, acetylcarvacrol anda fipronil-based pesticide in human blood cells. Drug and Chemical Toxicology 0:0, pages 1-10.
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Tülay Ceren Ölmeztürk Karakurt, İzzet Emir, Zehra Bedir, Kezban Tuna Ozkaloglu Erdem, Halis Süleyman, Cengiz Sarıgül & Ali Sefa Mendil. (2022) Effects of carvacrol on ketamine-induced cardiac injury in rats: an experimental study. Drug and Chemical Toxicology 0:0, pages 1-6.
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Vijay Kumar Arruri, Chayanika Gundu, Anil Kumar Kalvala, Bhoomika Sherkhane, Dharmendra Kumar Khatri & Shashi Bala Singh. (2022) Carvacrol abates NLRP3 inflammasome activation by augmenting Keap1/Nrf-2/p62 directed autophagy and mitochondrial quality control in neuropathic pain. Nutritional Neuroscience 25:8, pages 1731-1746.
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Bruno Dutra da Silva, Denes Kaic Alves do Rosario & Carlos Adam Conte-Junior. (2022) Can droplet size influence antibacterial activity in ultrasound-prepared essential oil nanoemulsions?. Critical Reviews in Food Science and Nutrition 0:0, pages 1-11.
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Victoria Vilaça Martins Alencar Souza, Jaqueline Milagres Almeida, Lidiane Nunes Barbosa & Nathália Cristina Cirone Silva. (2022) Citral, carvacrol, eugenol and thymol: antimicrobial activity and its application in food. Journal of Essential Oil Research 34:3, pages 181-194.
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Cristina Fuentes, Ana Fuentes, José Manuel Barat & María José Ruiz. (2021) Relevant essential oil components: a minireview on increasing applications and potential toxicity. Toxicology Mechanisms and Methods 31:8, pages 559-565.
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Vahideh Ghorani, Azam Alavinezhad, Omid Rajabi, Amir Hooshang Mohammadpour & Mohammad Hossein Boskabady. (2021) Safety and tolerability of carvacrol in healthy subjects: a phase I clinical study. Drug and Chemical Toxicology 44:2, pages 177-189.
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Karina Kachur & Zacharias Suntres. (2020) The antibacterial properties of phenolic isomers, carvacrol and thymol. Critical Reviews in Food Science and Nutrition 60:18, pages 3042-3053.
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Amani Hizem, Selim M’rad, Myriam Oudni-M’rad, Habib Mezhoud, Hichem Ben Jannet, Guido Flamini, Kamel Ghedira & Hamouda Babba. (2020) In vitro scolicidal activity of Thymus capitatus Hoff. et Link. essential oil on Echinococcus granulosus protoscoleces. Journal of Essential Oil Research 32:2, pages 178-185.
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Mehmet Güvenç, Mustafa Cellat, İshak Gökçek, İlker Yavaş & Şule Yurdagül Özsoy. (2019) Effects of thymol and carvacrol on sperm quality and oxidant/antioxidant balance in rats. Archives of Physiology and Biochemistry 125:5, pages 396-403.
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Djamel Djenane, Malek Aboudaou, Mohamed Amine Ferhat, Akli Ouelhadj & Agustín Ariño. (2019) Effect of the aromatisation with summer savory (Satureja hortensis L.) essential oil on the oxidative and microbial stabilities of liquid whole eggs during storage. Journal of Essential Oil Research 31:5, pages 444-455.
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Dalia A. Alraey, Samia A. Haroun, Mohammed N. Omar, Ahmed M. Abd-ElGawad, Ahmed M. El-Shobaky & Amr M. Mowafy. (2019) Fluctuation of Essential Oil Constituents in Origanum syriacum subsp. sinaicum in Response to Plant Growth Promoting Bacteria. Journal of Essential Oil Bearing Plants 22:4, pages 1022-1033.
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Kaibo Wang, Shanshan Jiang, Yunhai Yang, Liming Fan, Fawu Su & Min Ye. (2019) Synthesis and antifungal activity of carvacrol and thymol esters with heteroaromatic carboxylic acids. Natural Product Research 33:13, pages 1924-1930.
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Lícia T. S. Pina, Jamylle N. S. Ferro, Thallita K. Rabelo, Marlange A. Oliveira, Luciana Scotti, Marcus Tullius Scotti, Cristiani Isabel Bandero Walker, Emiliano O. Barreto, Lucindo J. Quintans Júnior & Adriana G. Guimarães. (2019) Alcoholic monoterpenes found in essential oil of aromatic spices reduce allergic inflammation by the modulation of inflammatory cytokines. Natural Product Research 33:12, pages 1773-1777.
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Kaibo Wang, Shanshan Jiang, Te Pu, Liming Fan, Fawu Su & Min Ye. (2019) Antifungal activity of phenolic monoterpenes and structure-related compounds against plant pathogenic fungi. Natural Product Research 33:10, pages 1423-1430.
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M. Nikolova, I. Aneva, P. Zhelev & S. Berkov. (2023) Analysis of exudate compounds of Thymus species . Plant Biosystems - An International Journal Dealing with all Aspects of Plant Biology, pages 1-9.
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Tülay Akan, Yasemin Aydın, Orhan Tansel Korkmaz, Emel Ulupınar & Faruk Saydam. (2023) The Effects of Carvacrol on Transient Receptor Potential (TRP) Channels in an Animal Model of Parkinson’s Disease. Neurotoxicity Research 41:6, pages 660-669.
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Tenzile Alagöz, Fatma Güneş Çalişkan, Hayriye Genç Bilgiçli, Mustafa Zengin, Morteza Sadeghi, Parham Taslimi & İlhami Gulçin. (2023) Synthesis, characterization, biochemical, and molecular modeling studies of carvacrol‐based new thiosemicarbazide and 1,3,4‐thiadiazole derivatives. Archiv der Pharmazie 356:12.
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Hasan ASİL & Muaz KÖROĞLU. (2023) Analysis of Essential Oil and Volatile Components of Different Organs of Isgin (Rheum ribes L.) Plant by Ultrasound-Assisted Extraction Method. International Journal of Chemistry and Technology, pages 154-162.
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Elham Abbasloo, Mohammad Khaksari, Mojgan Sanjari, Firas Kobeissy & Theresa Currier Thomas. (2023) Carvacrol decreases blood–brain barrier permeability post-diffuse traumatic brain injury in rats. Scientific Reports 13:1.
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Mbese Zintle, Peteni Siwaphiwe, Fotsing Marthe Carine, Fonkui Thierry Youmbi, Ndinteh Derek Tantoh, Ray Suprakas Sinha & Aderibigbe Blessing Atim. (2023) Antibacterial study of carbopol-mastic gum/silver nanoparticle-based topical gels with carvacrol/neem bark extract in vitro. Journal of Wound Care 32:Sup9a, pages clxxxi-clxxxix.
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Huawei Wei, Dong Wu, Mingying Zheng, Wanjin Wang & Dapeng Wang. (2023) Elucidating the role of two types of essential oils in regulating antibiotic resistance in soil. Journal of Hazardous Materials 454, pages 131443.
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Seyedeh Sahar Mirmoeini, Seyede Hanieh Hosseini, Anita Lotfi Javid, Mahmoud Esmaeili Koutamehr, Houshmand Sharafi, Rahim Molaei & Mehran Moradi. (2023) Essential oil-loaded starch/cellulose aerogel: Preparation, characterization and application in cheese packaging. International Journal of Biological Macromolecules 244, pages 125356.
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Alberto Gonçalves Evangelista, Lucas dos Santos Janotto, Eduardo Henrique Custódio Matté, Carolina Cini Perry, Francine Lemes Ribeiro & Fernando Bittencourt Luciano. (2023) In vitro interaction between essential oil compounds and halquinol against zoonotic pathogenic bacteria. Biocatalysis and Agricultural Biotechnology 50, pages 102672.
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Spogmay Anwar, Arif-ullah Khan & Nadeem Irshad. (2023) Pharmacological evaluation of carvacrol anti-migraine potential. Naunyn-Schmiedeberg's Archives of Pharmacology 396:6, pages 1309-1324.
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Samuel Malburet, Hugo Bertrand, Cécile Richard, Colette Lacabanne, Eric Dantras & Alain Graillot. (2023) Biobased epoxy reactive diluents prepared from monophenol derivatives: effect on viscosity and glass transition temperature of epoxy resins. RSC Advances 13:22, pages 15099-15106.
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Meilin Li, Shenrui Feng, Siyi Huang, Jacques Guillot & Fang Fang. (2023) In Vitro Efficacy of Terpenes from Essential Oils against Sarcoptes scabiei. Molecules 28:8, pages 3361.
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Ling Zhang, Xiong Ye, Yuntao Liu, Zhongde Zhang, Xueshan Xia & Shuwei Dong. (2023) Research progress on the effect of traditional Chinese medicine on the activation of PRRs-mediated NF-κB signaling pathway to inhibit influenza pneumonia. Frontiers in Pharmacology 14.
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Eleftherios A. Petrakis, Eleni V. Mikropoulou, Sofia Mitakou, Maria Halabalaki & Eleftherios Kalpoutzakis. (2023) A GC–MS and LC–HRMS perspective on the chemotaxonomic investigation of the natural hybrid Origanum × lirium and its parents, O. vulgare subsp. hirtum and O. scabrum . Phytochemical Analysis 34:3, pages 289-300.
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Elham Abbasloo, Sedigheh Amiresmaili, Sara Shirazpour, Mohammad Khaksari, Firas Kobeissy & Theresa Currier Thomas. (2023) Satureja khuzistanica Jamzad essential oil and pure carvacrol attenuate TBI-induced inflammation and apoptosis via NF-κB and caspase-3 regulation in the male rat brain. Scientific Reports 13:1.
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Kemal Dinc, Ramazan Ozyurt, Taha Abdulkadir Coban, Gulce Naz Yazici, Zeynep Suleyman, Bulent Yavuzer & Halis Suleyman. (2023) The effect of carvacrol on the proinflammatory cytokines, histology, and fertility outcome of cisplatin-related ovarian change in a rat model. Taiwanese Journal of Obstetrics and Gynecology 62:2, pages 256-263.
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Lunaike Zhao, Junjie Wang, Huaiyu Zhang, Peng Wang, Cong Wang, Yueli Zhou, Huanhuan Li, Shukun Yu & Rina Wu. (2023) Inhibitory effect of carvacrol against Alternaria alternata causing goji fruit rot by disrupting the integrity and composition of cell wall. Frontiers in Microbiology 14.
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Minnja S. Foote, Ke Du, Soraya Mousavi, Stefan Bereswill & Markus M. Heimesaat. (2023) Therapeutic Oral Application of Carvacrol Alleviates Acute Campylobacteriosis in Mice Harboring a Human Gut Microbiota. Biomolecules 13:2, pages 320.
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Guoqiang Li, Qingqing Zhou, Shuxun Liu, Cheng Qian, Jiarun Han, Tao Zhou, Ping Li & Qing Gu. (2023) Effect of Tribute citrus essential oil nanoemulsion-loaded gelatin on the gel behavior and gelation surface morphologies. Food Bioscience 51, pages 102322.
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Xián Farto-Vaamonde, Luis Diaz-Gomez, Ana Parga, Ana Otero, Angel Concheiro & Carmen Alvarez-Lorenzo. (2022) Perimeter and carvacrol-loading regulate angiogenesis and biofilm growth in 3D printed PLA scaffolds. Journal of Controlled Release 352, pages 776-792.
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Zhuang Li, He Wang, Fengxiao Wang, Haiyan Li, Fei Cao, Duqiang Luo, Qiang Zhang & Fengli Chen. (2022) Isolation of essential oil from Mosla chinensis Maxim by surfactant-enzyme pretreatment in high-solid system and evaluation of its biological activity. Industrial Crops and Products 189, pages 115871.
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Erika F. Costa, Wagner V. Magalhães & Luiz C. Di Stasi. (2022) Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications. Molecules 27:21, pages 7518.
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Junwei Wang, Ting Qin, Kai Chen, Liangkun Pan, Jun Xie & Bingwen Xi. (2022) Antimicrobial and Antivirulence Activities of Carvacrol against Pathogenic Aeromonas hydrophila. Microorganisms 10:11, pages 2170.
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Chetan Ram, Shobhit Gairola, Abu Mohammad Syed, Shobhit Verma, Madhav Nilakanth Mugale & Bidya Dhar Sahu. (2022) Carvacrol preserves antioxidant status and attenuates kidney fibrosis via modulation of TGF-β1/Smad signaling and inflammation . Food & Function 13:20, pages 10587-10600.
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Yujing Wang, Liaoxi Tan, Kejun Jiao, Chu Xue, Qinglian Tang, Shan Jiang, Younan Ren, Hao Chen, Tarek Mohamed Abd El‐Aziz, Khalid N. M. Abdelazeem, Ye Yu, Fang Zhao, Michael X. Zhu & Zhengyu Cao. (2022) Scutellarein attenuates atopic dermatitis by selectively inhibiting transient receptor potential vanilloid 3 channels. British Journal of Pharmacology 179:20, pages 4792-4808.
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Mohamad Khalil, Nadia Serale, Farah Diab, Francesca Baldini, Piero Portincasa, Giulio Lupidi & Laura Vergani. (2022) Beneficial Effects of Carvacrol on In Vitro Models of Metabolically-Associated Liver Steatosis and Endothelial Dysfunction: A Role for Fatty Acids in Interfering with Carvacrol Binding to Serum Albumin. Current Medicinal Chemistry 29:30, pages 5113-5129.
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Ricardo Marques de Andrade, Heloísa Pagnussatt, Lucas Eduardo Talian, Alícia Dal Santo, Alana Birck Ribeiro, Felipe Leite, Gilso Mis, Gabriel Hoinoski, Edemar Aniecevski, Leonardo Miguel Fabiani, Giovana Camillo, Gabriela M. Galli, Aleksandro Schafer da Silva, Tiago Goulart Petrolli & Fernando de Castro Tavernari. (2022) Interaction between live vaccines for coccidiosis and phytogenic compounds in the diet of broilers. Parasitology International 89, pages 102584.
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Niluni M. Wijesundara, Song F. Lee & H.P. Vasantha Rupasinghe. (2022) Carvacrol inhibits Streptococcus pyogenes biofilms by suppressing the expression of genes associated with quorum-sensing and reducing cell surface hydrophobicity. Microbial Pathogenesis 169, pages 105684.
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Christian Eric Schumacher, Marvin Rausch, Tobias Greven, Jörg‐Martin Neudörfl, Tanja Schneider & Hans‐Günther Schmalz. (2022) Total Synthesis and Antibiotic Properties of Amino‐Functionalized Aromatic Terpenoids Related to Erogorgiaene and the Pseudopterosins. European Journal of Organic Chemistry 2022:26.
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Samah Mechmechani, Adem Gharsallaoui, Alexandre Fadel, Khaled El Omari, Simon Khelissa, Monzer Hamze & Nour-Eddine Chihib. (2022) Microencapsulation of carvacrol as an efficient tool to fight Pseudomonas aeruginosa and Enterococcus faecalis biofilms. PLOS ONE 17:7, pages e0270200.
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Senem Çengel Kurnaz, Nilüfer Kuruca, Dilek Güvenç, Muhammed Taha Kaya & Tolga Güvenç. (2022) Topical Administration of Carvacrol Improves Healing in Nasal Septal Perforation: An Experimental Animal Study. American Journal of Rhinology & Allergy 36:4, pages 503-509.
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Mahammad R. Khazdair, Vahideh Ghorani & Mohammad H. Boskabady. (2022) Experimental and clinical evidence on the effect of carvacrol on respiratory, allergic, and immunologic disorders: A comprehensive review. BioFactors 48:4, pages 779-794.
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Edilaine S. Xavier, Rafael L. de Souza, Vinícius C. Rodrigues, Camila O. Melo, Daniel B. Roquini, Bruna L. Lemes, Polrat Wilairatana, Elquio E. Oliveira & Josué de Moraes. (2022) Therapeutic Efficacy of Carvacrol-Loaded Nanoemulsion in a Mouse Model of Schistosomiasis. Frontiers in Pharmacology 13.
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Meryem Nur ATABAY DİNGİL & Mehmet Mustafa İŞGÖR. (2022) İn Vitro Hepatik Oksidatif Hasarda Karvakrolün Etkinliğinin AraştırılmasıInvestigation of the Efficacy of Carvacrol in In Vitro Hepatic Oxidative Damage. Iğdır Üniversitesi Fen Bilimleri Enstitüsü Dergisi 12:2, pages 1034-1044.
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Marion Allaoua, Elsa Bonnafé, Pierre Etienne, Virginie Noirot, Jean-François Gabarrou, Adrien Castinel, Géraldine Pascal, Vincent Darbot, Michel Treilhou & Sylvie Combes. (2022) A carvacrol-based product reduces Campylobacter jejuni load and alters microbiota composition in the caeca of chickens. Journal of Applied Microbiology 132:6, pages 4501-4516.
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Alireza Sanei-Dehkordi, Roghayeh Heiran, Mohammad Djaefar Moemenbellah-Fard, Sina Sayah & Mahmoud Osanloo. (2022) Nanoliposomes Containing Carvacrol and Carvacrol-Rich Essential Oils as Effective Mosquitoes Larvicides. BioNanoScience 12:2, pages 359-369.
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Aslı Şahiner, Sevinç Aksoy, Evren Algın Yapar, Gökhan Cengiz, Ece Halat & Mustafa Ateş. (2022) Evaluation of Antimicrobial Activity of Thymbra spicata L. var. spicata Essential Oil as a Potential Source of Herbal Medicine. Current Nutraceuticals 3:2.
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Sayed Vahid Jasemi, Hosna Khazaei, Saeideh Momtaz, Mohammad Hosein Farzaei & Javier Echeverría. (2022) Natural products in the treatment of pulmonary emphysema: Therapeutic effects and mechanisms of action. Phytomedicine 99, pages 153988.
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Larisa Bora, Stefana Avram, Ioana Zinuca Pavel, Delia Muntean, Sergio Liga, Valentina Buda, Daniela Gurgus & Corina Danciu. (2022) An Up-To-Date Review Regarding Cutaneous Benefits of Origanum vulgare L. Essential Oil. Antibiotics 11:5, pages 549.
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Melinda Mariotti, Giulia Lombardini, Silvia Rizzo, Donatella Scarafile, Monica Modesto, Eleonora Truzzi, Stefania Benvenuti, Alberto Elmi, Martina Bertocchi, Laura Fiorentini, Lorenzo Gambi, Maurizio Scozzoli & Paola Mattarelli. (2022) Potential Applications of Essential Oils for Environmental Sanitization and Antimicrobial Treatment of Intensive Livestock Infections. Microorganisms 10:4, pages 822.
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Elizabeth J. Johnson, Jingyue Ellie Duan, Kanokwan Srirattana, Kumar Venkitanarayanan, Edan R. Tulman & Xiuchun Cindy Tian. (2022) Effects of intramuscularly injected plant-derived antimicrobials in the mouse model. Scientific Reports 12:1.
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Renan Braga Paiano & Pietro Sampaio Baruselli. (2022) The use of herbal treatments as alternatives to control uterine diseases in dairy cows. Tropical Animal Health and Production 54:2.
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