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Original Articles

Caffeic Acid Phenethyl Ester: A Review of Its Antioxidant Activity, Protective Effects against Ischemia-reperfusion Injury and Drug Adverse Reactions

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Xiaodan Li, Xiangfeng Meng, Tijn C. de Leeuw, Evelien M. te Poele, Tjaard Pijning, Lubbert Dijkhuizen & Weifeng Liu. (2023) Enzymatic glucosylation of polyphenols using glucansucrases and branching sucrases of glycoside hydrolase family 70. Critical Reviews in Food Science and Nutrition 63:21, pages 5247-5267.
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Yordan Yordanov, Denitsa Aluani, Virginia Tzankova, Stanislav Rangelov, Feodor Odzhakov, Alexandar Apostolov & Krassimira Yoncheva. (2020) Safety assessment of a newly synthesized copolymer for micellar delivery of hydrophobic caffeic acid phenethyl ester. Pharmaceutical Development and Technology 25:10, pages 1271-1280.
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Ali Doğukan Anğın, Ismet Gün, Önder Sakin, Muzaffer Seyhan Çıkman, Engin Ersin Şimşek, Resul Karakuş, Kayhan Başak & Asuman Orçun Kaptanağası. (2020) Investigation of the preventive effects of dehydroepiandrosterone (DHEA) and Caffeic acid phenethyl ester (CAPE) on cisplatin-induced ovarian damage in rats. Ultrastructural Pathology 44:1, pages 71-80.
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Wei Li, Cong Yang, Zhongxiu Shi, Qingqing Long, Zhiying Cheng, Shan He, Jiahui Dong, Tao Liu & Chengcheng Wang. (2023) Caffeic Acid Phenethyl Ester Inhibits Ubiquitination and Degradation of p53 and Blocks Cervical Cancer Cell Growth. Current Molecular Medicine 23:9, pages 960-970.
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Manikandan Ramar, Sangeetha Ravi, Parimalanandhini Duraisamy, Mahalakshmi Krishnan, Livya Catherene Martin, Manikandan Kumaresan, Arumugam Munusamy & Beulaja Manikandan. (2023) Gentamicin-induced acute nephrotoxicity counteraction using Boerhaavia diffusa in Swiss albino mice. Comparative Clinical Pathology 32:6, pages 1005-1017.
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Aslı Özkök, Semiramis Karlıdağ, Merve Keskin, Sinan Bayram, Şaban Keskin, Ercan Karabulut, Fevzi Çiçek & İsmet Yılmaz. (2023) Palynological, chemical, antimicrobial, and enzyme inhibition properties of Cannabis sativa L. propolis. European Food Research and Technology 249:8, pages 2175-2187.
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Alexandra Tosheva, Petar Petrov, Georgy Grancharov, Krassimira Yoncheva, Diana Tzankova, Virginia Tzankova & Denitsa Aluani. (2022) In vitro evaluation of antioxidant activity and biocompatibility of caffeic acid phenethyl ester loaded in polymeric micelles. Molecular & Cellular Toxicology 19:1, pages 89-98.
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Mohammed Z. Nasrullah. (2022) Caffeic Acid Phenethyl Ester Loaded PEG–PLGA Nanoparticles Enhance Wound Healing in Diabetic Rats. Antioxidants 12:1, pages 60.
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Sabarisah Hashim, Che Mohd Nasril Che Mohd Nassir, Mohd Haniff Abu Zarim, Khaidatul Akmar Kamaruzaman, Sanihah Abdul Halim, Mahaneem Mohamed & Muzaimi Mustapha. 2022. Post-Stroke Rehabilitation. Post-Stroke Rehabilitation.
Weichao Sun, Wei Xie, Dixi Huang, Yinxing Cui, Jiaji Yue, Qifei He, Luoyong Jiang, Jianyi Xiong, Wei Sun & Qian Yi. (2022) Caffeic acid phenethyl ester attenuates osteoarthritis progression by activating NRF2/HO‑1 and inhibiting the NF‑κB signaling pathway. International Journal of Molecular Medicine 50:5.
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Radhika Adhikari, Saugat Shiwakoti, Ju-Young Ko, Bikalpa Dhakal, Sin-Hee Park, Ik Jun Choi, Hyun Jung Kim & Min-Ho Oak. (2022) Oxidative Stress in Calcific Aortic Valve Stenosis: Protective Role of Natural Antioxidants. Antioxidants 11:6, pages 1169.
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Bilgesu Onur Sucu, Elif Beyza Koc, Ozgecan Savlug Ipek, Afranur Mirat, Furkan Almas, Melike Aybala Guzel, Berna Dogan, Damla Uludag, Nihal Karakas, Serdar Durdagi & Mustafa Guzel. (2022) Design and synthesis of novel caffeic acid phenethyl ester (CAPE) derivatives and their biological activity studies in glioblastoma multiforme (GBM) cancer cell lines. Journal of Molecular Graphics and Modelling 113, pages 108160.
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Beata Olas. (2022) Bee Products as Interesting Natural Agents for the Prevention and Treatment of Common Cardiovascular Diseases. Nutrients 14:11, pages 2267.
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Khalifa S. Al-Khalifa, Mohammed M. Gad, Faris A. Alshahrani, Firas K. Alqarawi, Faisal R. Hassanein, Zohaib Khurshid & Khalid S. Al-Abidi. (2022) Influence of Propolis Extract (Caffeic Acid Phenethyl Ester) Addition on the Candida albicans Adhesion and Surface Properties of Autopolymerized Acrylic Resin. International Journal of Dentistry 2022, pages 1-7.
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Zuotian Huang, Junliang Pu, Yunhai Luo, Jing Fan, Kaili Li, Dadi Peng, Kezhen Zong, Baoyong Zhou, Xiangdong Guan & Fachun Zhou. (2022) FAM49B, restrained by miR-22, relieved hepatic ischemia/reperfusion injury by inhibiting TRAF6/IKK signaling pathway in a Rac1-dependent manner. Molecular Immunology 143, pages 135-146.
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Yan Zhang, Ying-Fan Hu, Wei Li, Guang-Ya Xu, Kun-Rong Wang, Lin Li, Hao Luo, Liang Zou & Jia-Si Wu. (2022) Updates and advances on pharmacological properties of Taraxacum mongolicum Hand.-Mazz and its potential applications. Food Chemistry 373, pages 131380.
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Büşra Gültekin Subaşı, Tugba Ozdal & Esra Capanoglu. 2022. Bee Products and Their Applications in the Food and Pharmaceutical Industries. Bee Products and Their Applications in the Food and Pharmaceutical Industries 139 158 .
Victor Emanuel Miranda Soares, Thiago Inácio Teixeira do Carmo, Fernanda dos Anjos, Jonatha Wruck, Sarah Franco Vieira de Oliveira Maciel, Margarete Dulce Bagatini & Débora Tavares de Resende e Silva. (2021) Role of inflammation and oxidative stress in tissue damage associated with cystic fibrosis: CAPE as a future therapeutic strategy. Molecular and Cellular Biochemistry 477:1, pages 39-51.
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Paulo Henrique Neves Santos, Hebert Lacerda Silva, Elizabeth Ferreira Martinez, Júlio César Joly, Ana Paula Dias Demasi, Larissa Moreira Spinola de Castro Raucci & Lucas Novaes Teixeira. (2021) Low concentrations of caffeic acid phenethyl ester stimulate osteogenesis in vitro. Tissue and Cell 73, pages 101618.
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Feyza Otan Özden, Müge Lütfioğlu, Esra Demir & Birşen Bilgici. (2021) Antioxidant effect of caffeic acid phenethyl ester in experimentally induced periodontitis. Clinical Oral Investigations 25:8, pages 4959-4966.
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Nermeen Yosri, Aida A. Abd El-Wahed, Reem Ghonaim, Omar M. Khattab, Aya Sabry, Mahmoud A. A. Ibrahim, Mahmoud F. Moustafa, Zhiming Guo, Xiaobo Zou, Ahmed F. M. Algethami, Saad H. D. Masry, Mohamed F. AlAjmi, Hanan S. Afifi, Shaden A. M. Khalifa & Hesham R. El-Seedi. (2021) Anti-Viral and Immunomodulatory Properties of Propolis: Chemical Diversity, Pharmacological Properties, Preclinical and Clinical Applications, and In Silico Potential against SARS-CoV-2. Foods 10:8, pages 1776.
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Justina Kamarauskaite, Rasa Baniene, Darius Trumbeckas, Arvydas Strazdauskas & Sonata Trumbeckaite. (2021) Caffeic Acid Phenethyl Ester Protects Kidney Mitochondria against Ischemia/Reperfusion Induced Injury in an In Vivo Rat Model. Antioxidants 10:5, pages 747.
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Zübeyir Huyut, Hamit Hakan Alp, Turan Yaman, Ömer Faruk Keleş, Zabit Yener, Fikret Türkan & Kemal Ayengin. (2020) Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity. Andrologia 53:2.
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Davood Soleimani, Mahsa Miryan, Helda Tutunchi, Jamshid G. Navashenaq, Ehsan Sadeghi, Majid Ghayour‐Mobarhan, Gordon A. Ferns & Alireza Ostadrahimi. (2020) A systematic review of preclinical studies on the efficacy of propolis for the treatment of inflammatory bowel disease. Phytotherapy Research 35:2, pages 701-710.
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Mariya‐Desislava Atanasova, Georgy Grancharov & Petar D. Petrov. (2020) Poly(ethylene oxide)‐ block ‐poly(α‐cinnamyl‐ε‐caprolactone‐ co ‐ε‐caprolactone) diblock copolymer nanocarriers for enhanced solubilization of caffeic acid phenethyl ester . Journal of Polymer Science 59:3, pages 251-260.
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Nada I. Abou-Taleb, Ola A. Elblasy, Esraa A. Elbesoumy, Haidy I. Basuny, Esraa A. Elhamadi, Mohamed S. Nasr eldin, Ahmed A. Emara, Ali A. Ali, Mohamed A. Salem, Fakher M. Ahmed & Mohammed A. Hussein. (2021) Mechanism of Antiangiogenic and Antioxidant Activity of Newly Synthesized CAMBA in Ehrlich Ascites Carcinoma-Bearing Mice. Asian Journal of Chemistry 33:10, pages 2465-2471.
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Meltem Kolgazi, Sumeyye Cilingir, Ozgur Yilmaz, Merve Gemici, Hasan Yazar, Samed Ozer, Merve Acikel-Elmas, Serap Arbak & Guldal Gulec Suyen. (2021) Caffeic acid attenuates gastric mucosal damage induced by ethanol in rats via nitric oxide modulation. Chemico-Biological Interactions 334, pages 109351.
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Edoardo Parrella, Cristina Gussago, Vanessa Porrini, Marina Benarese & Marina Pizzi. (2020) From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke. Nutrients 13:1, pages 85.
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Radostina Kalinova, Yordan Yordanov, Borislav Tzankov, Virginia Tzankova, Krassimira Yoncheva & Ivaylo Dimitrov. (2020) Cinnamyl modified polymer micelles as efficient carriers of caffeic acid phenethyl ester. Reactive and Functional Polymers 157, pages 104763.
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Marwa A. Ali, Esther T. Menze, Marianne G. Tadros & Mai F. Tolba. (2020) Caffeic acid phenethyl ester counteracts doxorubicin-induced chemobrain in Sprague-Dawley rats: Emphasis on the modulation of oxidative stress and neuroinflammation. Neuropharmacology 181, pages 108334.
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Ayman Khalil & Diana Tazeddinova. (2020) The upshot of Polyphenolic compounds on immunity amid COVID-19 pandemic and other emerging communicable diseases: An appraisal. Natural Products and Bioprospecting 10:6, pages 411-429.
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Carine S. F. Marques, Nathalia S. Barreto, Simone S. C. de Oliveira, André L. S. Santos, Marta H. Branquinha, Damião P. de Sousa, Mayara Castro, Luciana N. Andrade, Matheus M. Pereira, Classius F. da Silva, Marco V. Chaud, Sona Jain, Alini T. Fricks, Eliana B. Souto & Patricia Severino. (2020) β-Cyclodextrin/Isopentyl Caffeate Inclusion Complex: Synthesis, Characterization and Antileishmanial Activity. Molecules 25:18, pages 4181.
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Jia Fu, Yan Zhang, Yichen Hu, Gang Zhao, Yong Tang & Liang Zou. (2020) Concise review: Coarse cereals exert multiple beneficial effects on human health. Food Chemistry 325, pages 126761.
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Rizha Anshori Nasution, Andi Asadul Islam, Mochammad Hatta, Prihantono, Agus Turchan, Nasrullah & Muhammad Faruk. (2020) Role of CAPE in reducing oxidative stress in animal models with traumatic brain injury. Annals of Medicine and Surgery 57, pages 118-122.
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Anna Kleczka, Robert Kubina, Radosław Dzik, Krzysztof Jasik, Jerzy Stojko, Krzysztof Cholewa & Agata Kabała-Dzik. (2020) Caffeic Acid Phenethyl Ester (CAPE) Induced Apoptosis in Serous Ovarian Cancer OV7 Cells by Deregulation of BCL2/BAX Genes. Molecules 25:15, pages 3514.
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Ming Liu, Fei Li, Yuming Huang, Tingwen Zhou, Si Chen, Geng Li, Jiawei Shi, Nianguo Dong & Kang Xu. (2020) Caffeic Acid Phenethyl Ester Ameliorates Calcification by Inhibiting Activation of the AKT/NF-κB/NLRP3 Inflammasome Pathway in Human Aortic Valve Interstitial Cells. Frontiers in Pharmacology 11.
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Tripti Khare, Sushesh Srivatsa Palakurthi, Brijesh M. Shah, Srinath Palakurthi & Sharad Khare. (2020) Natural Product-Based Nanomedicine in Treatment of Inflammatory Bowel Disease. International Journal of Molecular Sciences 21:11, pages 3956.
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Anna Choromanska, Jolanta Saczko & Julita Kulbacka. (2020) Caffeic Acid Phenethyl Ester Assisted by Reversible Electroporation—In Vitro Study on Human Melanoma Cells. Pharmaceutics 12:5, pages 478.
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Dingyi Yang, Yong Jiang, Yuqing Wang, Qianqian Lei, Xin Zhao, Ruokun Yi & Xin Zhang. (2020) Improvement of Flavonoids in Lemon Seeds on Oxidative Damage of Human Embryonic Kidney 293T Cells Induced by H 2 O 2 . Oxidative Medicine and Cellular Longevity 2020, pages 1-10.
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Laura María Reyes-Fermín, Omar Emiliano Aparicio-Trejo, Sabino Hazael Avila-Rojas, Tania Gómez-Sierra, Elena Martínez-Klimova & José Pedraza-Chaverri. (2020) Natural antioxidants' effects on endoplasmic reticulum stress-related diseases. Food and Chemical Toxicology 138, pages 111229.
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Bo Shao, Meixia Wang, Anran Chen, Chunzhi Zhang, Li Lin, Zhaoqiang Zhang & Anlan Chen. (2020) Protective effect of caffeic acid phenethyl ester against imidacloprid-induced hepatotoxicity by attenuating oxidative stress, endoplasmic reticulum stress, inflammation and apoptosis. Pesticide Biochemistry and Physiology 164, pages 122-129.
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Yu Mei, Zihao Wang, Yifan Zhang, Ting Wan, Jincheng Xue, Wei He, Yi Luo, Yijun Xu, Xue Bai, Qi Wang & Yujie Huang. (2020) FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Ameliorates DSS-Induced Colitis Against Oxidative Stress by Activating Nrf2/HO-1 Pathway. Frontiers in Immunology 10.
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Ting Wan, Zihao Wang, Yi Luo, Yifan Zhang, Wei He, Yu Mei, Jincheng Xue, Min Li, Huafeng Pan, Weirong Li, Qi Wang & Yujie Huang. (2019) FA-97, a New Synthetic Caffeic Acid Phenethyl Ester Derivative, Protects against Oxidative Stress-Mediated Neuronal Cell Apoptosis and Scopolamine-Induced Cognitive Impairment by Activating Nrf2/HO-1 Signaling. Oxidative Medicine and Cellular Longevity 2019, pages 1-21.
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Miroslava Valchanova, Yordan Yordanov, Virginia Tzankova, Krassimira Yoncheva, Sevdalina Turmanova & Stanislav Rangelov. (2019) Functional amphiphilic block copolyethers as carriers of caffeic acid phenethyl ester. Polymer International 68:11, pages 1881-1890.
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