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Coenzyme Q10: From bench to clinic in aging diseases, a translational review

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Kailin Xing, Xinyu Bian, Dongmin Shi, Shuangshuang Dong, Hongxin Zhou, Shuxiu Xiao, Jinjin Bai & Weizhong Wu. (2023) miR-612 Enhances RSL3-Induced Ferroptosis of Hepatocellular Carcinoma Cells via Mevalonate Pathway. Journal of Hepatocellular Carcinoma 10, pages 2173-2185.
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Linjin Yu, Chuyan Chao, Qinglan Li, Songling Ye, Jiasen Lin, Shuling Zhong, Qiancheng Xuan, Kailin Xu & Suqing Zhao. (2023) A Co-Encapsulation of Coenzyme Q10 and Curcumin in Liposomes Coated with Chitosan (Q10-Cur-Lip-Chi) with Enhanced Solubility and Stability for Good Release Performance and Antioxidative Activity. Current Drug Delivery 20:9, pages 1391-1403.
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Xv-shen Ding, Li Gao, Zheng Han, Simona Eleuteri, Wei Shi, Yun Shen, Zi-yao Song, Mingming Su, Qian Yang, Yan Qu, David K. Simon, Xue-lian Wang & Bao Wang. (2023) Ferroptosis in Parkinson's disease: Molecular mechanisms and therapeutic potential. Ageing Research Reviews 91, pages 102077.
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Davoud Ahmadimoghaddam, Seyed Saman Talebi, Ayesheh Rahmani, Maryam Zamanirafe, Erfan Parvaneh, Akram Ranjbar, Jalal Poorolajal & Maryam Mehrpooya. (2023) Prevention of contrast induced-acute kidney injury using coenzyme Q10 in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. European Journal of Clinical Pharmacology 79:10, pages 1341-1356.
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Ludovica Cogorno, Elena Formisano, Andrea Vignati, Amalia Prigione, Antonio Tramacere, Consuelo Borgarelli, Samir Giuseppe Sukkar & Livia Pisciotta. (2023) Non-alcoholic fatty liver disease: Dietary and nutraceutical approaches. Liver Research.
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Michael D. Guile, Akash Jain, Kyle A. Anderson & Catherine F. Clarke. (2023) New Insights on the Uptake and Trafficking of Coenzyme Q. Antioxidants 12:7, pages 1391.
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Xiaoying Jiang, Kaiyu Wu, Xiang‐Yang Ye, Tian Xie, Pengfei Zhang, Benjamin E. Blass & Renren Bai. (2023) Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis. Medicinal Research Reviews 43:4, pages 872-896.
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Shanchuan Cao, Honglin Yan, Wenjie Tang, Hongfu Zhang & Jingbo Liu. (2023) Effects of dietary coenzyme Q10 supplementation during gestation on the embryonic survival and reproductive performance of high-parity sows. Journal of Animal Science and Biotechnology 14:1.
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Guilherme Renke, Marcela Batista Pereira & Aline Renke. (2023) Coenzyme Q10 for Diabetes and Cardiovascular Disease: Useful or Useless?. Current Diabetes Reviews 19:4.
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Junyuan Sun, Fei Yang, Lianlei Wang, Haichao Yu, Zhijie Yang, Jingjing Wei, Krasimir Vasilev, Xuesong Zhang, Xinyu Liu & Yunpeng Zhao. (2023) Delivery of coenzyme Q10 loaded micelle targets mitochondrial ROS and enhances efficiency of mesenchymal stem cell therapy in intervertebral disc degeneration. Bioactive Materials 23, pages 247-260.
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Trine Baur Opstad, Jan Alexander, Jan Aaseth, Anders Larsson, Ingebjørg Seljeflot & Urban Alehagen. (2023) Increased SIRT1 Concentration Following Four Years of Selenium and Q10 Intervention Associated with Reduced Cardiovascular Mortality at 10-Year Follow-Up—Sub-Study of a Previous Prospective Double-Blind Placebo-Controlled Randomized Clinical Trial. Antioxidants 12:3, pages 759.
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Kuan-Hao Tsui & Chia-Jung Li. (2023) Mitoquinone shifts energy metabolism to reduce ROS-induced oxeiptosis in female granulosa cells and mouse oocytes. Aging 15:1, pages 246-260.
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Arastu Sharma, Sophie Chabloz, Rebecca A. Lapides, Elisabeth Roider & Collin Y. Ewald. (2023) Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan. Nutrients 15:2, pages 445.
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Felisa Rey, Eliana Alves, Luís Gaspar, Marcos Conceição & M. Rosário Domingues. 2023. Bioactive Lipids. Bioactive Lipids 231 268 .
Shankun Zhao, Weizhou Wu, Jian Liao, Xinsheng Zhang, Maolei Shen, Xin Li, Qi Lin & Chaoliang Cao. (2022) Molecular mechanisms underlying the renal protective effects of coenzyme Q10 in acute kidney injury. Cellular & Molecular Biology Letters 27:1.
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Mohammed F. El Basuini, Shimaa A. Shahin, Medhat E. Eldenary, Shimaa M. Elshora, Mahmoud A.O. Dawood & Mona M. Mourad. (2022) Growth variables, feed efficacy, survival rate, and antioxidant capacity of European seabass (Dicentrarchus labrax L.) larvae treated with Coenzyme Q10 or lipoic acid. Aquaculture Reports 27, pages 101373.
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Parisha Srivastava, Avnish Kumar Verma, Jitendra Kumar Arya & Syed Ibrahim Rizvi. (2022) Modulatory effect of exogenous Coenzyme Q10 on redox and inflammatory biomarkers during aging in rats. Biologia Futura 73:4, pages 473-481.
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Zena S. Hamed, Labeeb H. Al-Alsadoon, Khalid A. Shaban & Ghada A. Taqa. (2022) INFLUENCE OF COENZYME Q10 ON HYPERLIPIDEMIA INDUCED IN MICE. Military Medical Science Letters 91:3, pages 208-215.
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Mona M. Mourad, Shimaa A. Shahin, Ibrahim T. El-Ratel & Mohammed F. El Basuini. (2022) Effect of Treating Eggs with Coenzyme Q10 (CoQ10) on Growth Variables, Histomorphometry, and Antioxidant Capacity in Red Tilapia (Oreochromis aureus × Oreochromis mossambicus) Larvae. Animals 12:17, pages 2219.
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Suming Dai, Zezhong Tian, Dan Zhao, Ying Liang, Meitong Liu, Zhihao Liu, Shanshan Hou & Yan Yang. (2022) Effects of Coenzyme Q10 Supplementation on Biomarkers of Oxidative Stress in Adults: A GRADE-Assessed Systematic Review and Updated Meta-Analysis of Randomized Controlled Trials. Antioxidants 11:7, pages 1360.
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Nilsel Okudan, Muaz Belviranlı & Tuğba Sezer. (2022) Potential Protective Effect of Coenzyme Q10 on Doxorubicin-Induced Neurotoxicity and Behavioral Disturbances in Rats. Neurochemical Research 47:5, pages 1280-1289.
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Lucyna Kozłowska, Tiina Santonen, Radu Corneliu Duca, Lode Godderis, Karolina Jagiello, Beata Janasik, An Van Nieuwenhuyse, Katrien Poels, Tomasz Puzyn, Paul T. J. Scheepers, Monika Sijko, Maria João Silva, Anita Sosnowska, Susana Viegas, Jelle Verdonck & Wojciech Wąsowicz. (2022) HBM4EU Chromates Study: Urinary Metabolomics Study of Workers Exposed to Hexavalent Chromium. Metabolites 12:4, pages 362.
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Urban Alehagen, Jan Aaseth, Anders Larsson & Jan Alexander. (2022) Decreased Concentration of Fibroblast Growth Factor 23 (FGF-23) as a Result of Supplementation with Selenium and Coenzyme Q10 in an Elderly Swedish Population: A Sub-Analysis. Cells 11:3, pages 509.
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Monika Kadian, Garima Sharma, Shivani Pandita, Kritika Sharma, Kanishka Shrivasatava, Neetu Saini & Anil Kumar. (2022) The Impact of Coenzyme Q10 on Neurodegeneration: a Comprehensive Review. Current Pharmacology Reports 8:1, pages 1-19.
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Amira Yasmine Benmelouka, Muhammad Ajmal Shah, Uzma Saleem, Alaa Ahmed Elshanbary, Mostafa Meshref, Ghulam Mujtaba Shah, Ifat Alsharif, Norah A. Althobaiti & Reem Hasaballah Alhasani. 2022. The Role of Phytonutrients in Metabolic Disorders. The Role of Phytonutrients in Metabolic Disorders 127 161 .
Lucía Fernández-del-Río, Sandra Rodríguez-López, Elena Gutiérrez-Casado, José Antonio González-Reyes, Catherine F. Clarke, María Isabel Burón & José Manuel Villalba. (2021) Regulation of hepatic coenzyme Q biosynthesis by dietary omega-3 polyunsaturated fatty acids. Redox Biology 46, pages 102061.
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Anthony Moschetti, Ruben K. Dagda & Robert O. Ryan. (2021) Coenzyme Q nanodisks counteract the effect of statins on C2C12 myotubes. Nanomedicine: Nanotechnology, Biology and Medicine 37, pages 102439.
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Farnaz Farsi, Nasser Ebrahimi-Daryani, Fereshteh Golab, Abolfazl Akbari, Leila Janani, Mohammad Yahya Karimi, Pardis Irandoost, Naimeh Mesri Alamdari, Shahram Agah & Mohammadreza Vafa. (2021) RETRACTED ARTICLE: A randomized controlled trial on the coloprotective effect of coenzyme Q10 on immune-inflammatory cytokines, oxidative status, antimicrobial peptides, and microRNA-146a expression in patients with mild-to-moderate ulcerative colitis. European Journal of Nutrition 60:6, pages 3397-3410.
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Jan Aaseth, Jan Alexander & Urban Alehagen. (2021) Coenzyme Q10 supplementation – In ageing and disease. Mechanisms of Ageing and Development 197, pages 111521.
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Lucía Fernández-del-Río & Catherine F. Clarke. (2021) Coenzyme Q Biosynthesis: An Update on the Origins of the Benzenoid Ring and Discovery of New Ring Precursors. Metabolites 11:6, pages 385.
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Nicola Rizzardi, Irene Liparulo, Giorgia Antonelli, Francesca Orsini, Antonella Riva, Christian Bergamini & Romana Fato. (2021) Coenzyme Q10 Phytosome Formulation Improves CoQ10 Bioavailability and Mitochondrial Functionality in Cultured Cells. Antioxidants 10:6, pages 927.
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Francisco M. Gutierrez-Mariscal, Silvia de la Cruz-Ares, Jose D. Torres-Peña, Juan F. Alcalá-Diaz, Elena M. Yubero-Serrano & José López-Miranda. (2021) Coenzyme Q10 and Cardiovascular Diseases. Antioxidants 10:6, pages 906.
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Lara Testai, Alma Martelli, Lorenzo Flori, Arrigo Cicero & Alessandro Colletti. (2021) Coenzyme Q10: Clinical Applications beyond Cardiovascular Diseases. Nutrients 13:5, pages 1697.
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Urban Alehagen, Jan Aaseth, Tomas L. Lindahl, Anders Larsson & Jan Alexander. (2021) Dietary Supplementation with Selenium and Coenzyme Q10 Prevents Increase in Plasma D-Dimer While Lowering Cardiovascular Mortality in an Elderly Swedish Population. Nutrients 13:4, pages 1344.
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Tareq Al Saadi, Yazan Assaf, Medhat Farwati, Khaled Turkmani, Ahmad Al-Mouakeh, Baraa Shebli, Mohammed Khoja, Adib Essali & Mohammed E Madmani. (2021) Coenzyme Q10 for heart failure. Cochrane Database of Systematic Reviews 2021:2.
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Alper Sonmez, Cemal Nuri Ercin, Mustafa Cesur & Teoman Dogru. 2021. Nutraceuticals and Cardiovascular Disease. Nutraceuticals and Cardiovascular Disease 141 165 .
Yaning Shi, Fan Ye, Yimei Chen, Qianru Hui & Ming Miao. (2020) Dendrimer-like glucan nanoparticulate system improves the solubility and cellular antioxidant activity of coenzyme Q10. Food Chemistry 333, pages 127510.
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Francisco Miguel Gutierrez-Mariscal, Antonio Pablo Arenas-de Larriva, Laura Limia-Perez, Juan Luis Romero-Cabrera, Elena Maria Yubero-Serrano & Jose López-Miranda. (2020) Coenzyme Q10 Supplementation for the Reduction of Oxidative Stress: Clinical Implications in the Treatment of Chronic Diseases. International Journal of Molecular Sciences 21:21, pages 7870.
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Giovanni Pagano, Federico V. Pallardó, Alex Lyakhovich, Luca Tiano, Maria Rosa Fittipaldi, Maria Toscanesi & Marco Trifuoggi. (2020) Aging-Related Disorders and Mitochondrial Dysfunction: A Critical Review for Prospect Mitoprotective Strategies Based on Mitochondrial Nutrient Mixtures. International Journal of Molecular Sciences 21:19, pages 7060.
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Iain Hargreaves, Robert A. Heaton & David Mantle. (2020) Disorders of Human Coenzyme Q10 Metabolism: An Overview. International Journal of Molecular Sciences 21:18, pages 6695.
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Hui-Fang Chiu, Kamesh Venkatakrishnan & Chin-Kun Wang. (2020) The role of nutraceuticals as a complementary therapy against various neurodegenerative diseases: A mini-review. Journal of Traditional and Complementary Medicine 10:5, pages 434-439.
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Lucía Fernández-del-Río, Miranda E. Kelly, Jaime Contreras, Michelle C. Bradley, Andrew M. James, Michael P. Murphy, Gregory S. Payne & Catherine F. Clarke. (2020) Genes and lipids that impact uptake and assimilation of exogenous coenzyme Q in Saccharomyces cerevisiae. Free Radical Biology and Medicine 154, pages 105-118.
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Lucía Fernández-del-Río, Eric Soubeyrand, Gilles J. Basset & Catherine F. Clarke. (2020) Metabolism of the Flavonol Kaempferol in Kidney Cells Liberates the B-ring to Enter Coenzyme Q Biosynthesis. Molecules 25:13, pages 2955.
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David Mantle & Alex Dybring. (2020) Bioavailability of Coenzyme Q10: An Overview of the Absorption Process and Subsequent Metabolism. Antioxidants 9:5, pages 386.
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Phiwayinkosi V. Dludla, Patrick Orlando, Sonia Silvestri, Fabio Marcheggiani, Ilenia Cirilli, Tawanda M. Nyambuya, Vuyolwethu Mxinwa, Kabelo Mokgalaboni, Bongani B. Nkambule, Rabia Johnson, Sithandiwe E. Mazibuko-Mbeje, Christo J. F. Muller, Johan Louw & Luca Tiano. (2020) Coenzyme Q10 Supplementation Improves Adipokine Levels and Alleviates Inflammation and Lipid Peroxidation in Conditions of Metabolic Syndrome: A Meta-Analysis of Randomized Controlled Trials. International Journal of Molecular Sciences 21:9, pages 3247.
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Alma Martelli, Lara Testai, Alessandro Colletti & Arrigo F. G. Cicero. (2020) Coenzyme Q10: Clinical Applications in Cardiovascular Diseases. Antioxidants 9:4, pages 341.
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Ran Zhi, Kefan Cao, Guangming Zhang, Jia Zhu & Guang Xian. (2020) Zero excess sludge wastewater treatment with value-added substances recovery using photosynthetic bacteria. Journal of Cleaner Production 250, pages 119581.
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Juan M. Suárez-Rivero, Carmen J. Pastor-Maldonado, Mario de la Mata, Marina Villanueva-Paz, Suleva Povea-Cabello, Mónica Álvarez-Córdoba, Irene Villalón-García, Alejandra Suárez-Carrillo, Marta Talaverón-Rey, Manuel Munuera & José A. Sánchez-Alcázar. (2019) Atherosclerosis and Coenzyme Q10. International Journal of Molecular Sciences 20:20, pages 5195.
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Giovanna Petrangolini, Massimo Ronchi, Elisabetta Frattini, Eric De Combarieu, Pietro Allegrini & Antonella Riva. (2019) A New Food-grade Coenzyme Q10 Formulation Improves Bioavailability: Single and Repeated Pharmacokinetic Studies in Healthy Volunteers. Current Drug Delivery 16:8, pages 759-767.
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Yang Wei, Liang Zhang, Zhongping Yu, Kangsen Lin, Shufang Yang, Lei Dai, Jingfang Liu, Like Mao, Fang Yuan & Yanxiang Gao. (2019) Enhanced stability, structural characterization and simulated gastrointestinal digestion of coenzyme Q10 loaded ternary nanoparticles. Food Hydrocolloids 94, pages 333-344.
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Isabella Peixoto de Barcelos & Richard H. Haas. (2019) CoQ10 and Aging. Biology 8:2, pages 28.
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Iain Hargreaves, David Mantle & David Milford. (2019) Chronic kidney disease and coenzyme Q10 supplementation. Journal of Kidney Care 4:2, pages 82-90.
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Arrigo Cicero, Alessandro Colletti & Stefano Bellentani. (2018) Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence. Nutrients 10:9, pages 1153.
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