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Acrylamide in human diet, its metabolism, toxicity, inactivation and the associated European Union legal regulations in food industry

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F. İnci Özdemir, Burcu Karaaslan, Ahmet Tülek & Deniz Yildirim. (2023) Covalent immobilization of recombinant L-asparaginase from Geobacillus kaustophilus on ReliZyme supports for mitigation of acrylamide. Biocatalysis and Biotransformation 0:0, pages 1-14.
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Francesco Pesce, Valentina Ponzo, Davide Mazzitelli, Paolo Varetto, Simona Bo & I. Sam Saguy. (2023) Strategies to Reduce Acrylamide Formation During Food Processing Focusing on Cereals, Children and Toddler Consumption: A Review. Food Reviews International 0:0, pages 1-27.
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Alica Navrátilová, Marek Kovár, Jana Kopčeková, Jana Mrázová, Anna Trakovická & Miroslava Požgajová. (2023) Protective effect of Aronia melanocarpa juice against acrylamide-induced cellular toxicity. Journal of Environmental Science and Health, Part B 58:2, pages 139-149.
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Yahdiana Harahap, Afaf Amma Lahilla, Anastasia Sharon Jautan, Amiral Hafidz & Sunarsih Sunarsih. (2022) Analysis of Acrylamide and Glycidamide in Dried Blood Spot of Smokers Using Ultra-High-Performance Liquid Chromatography–Tandem Mass Spectrometry. Drug Design, Development and Therapy 16, pages 521-531.
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Amir Hossein Abedini, Naiema Vakili Saatloo, Mahla Salimi, Parisa Sadighara, Mahmood Alizadeh Sani, Paula Garcia-Oliviera, Miguel A. Prieto, Mohammad Saeed Kharazmi & Seid Mahdi Jafari. (2022) The role of additives on acrylamide formation in food products: a systematic review. Critical Reviews in Food Science and Nutrition 0:0, pages 1-21.
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Mónica Quesada-Valverde, Graciela Artavia, Fabio Granados-Chinchilla & Carolina Cortés-Herrera. (2022) Acrylamide in foods: from regulation and registered levels to chromatographic analysis, nutritional relevance, exposure, mitigation approaches, and health effects. Toxin Reviews 41:4, pages 1343-1373.
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Articles from other publishers (73)

Baoxin Cheng, Xiuhua Xia, Zhiqiang Han, Hang Yu, Yufei Xie, Yahui Guo, Weirong Yao, He Qian & Yuliang Cheng. (2024) A ratiometric fluorescent “off-on” sensor for acrylamide detection in toast based on red-emitting copper nanoclusters stabilized by bovine serum albumin. Food Chemistry 437, pages 137878.
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Chloé Marques, Pauline Frenoy, Alexis Elbaz, Nasser Laouali, Sanam Shah, Gianluca Severi & Francesca Romana Mancini. (2024) Association between dietary intake of acrylamide and increased risk of mortality in women: Evidence from the E3N prospective cohort. Science of The Total Environment 906, pages 167514.
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Tolgahan Kocadağlı & Vural Gökmen. 2024. Acrylamide in Food. Acrylamide in Food 111 129 .
Y Gao, D Zhang, P Wang, X Qu, J Xu, Y Yu & X Zhou. (2023) Acrylamide-induced meiotic arrest of spermatocytes in adolescent mice by triggering excessive DNA strand breaks: Potential therapeutic effects of resveratrol. Human & Experimental Toxicology 42.
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Javiera Miranda, Nicolás Lefin, Jorge F. Beltran, Lisandra Herrera Belén, Argyro Tsipa, Jorge G. Farias & Mauricio Zamorano. (2023) Enzyme Engineering Strategies for the Bioenhancement of l-Asparaginase Used as a Biopharmaceutical. BioDrugs 37:6, pages 793-811.
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Divya Gupta, Shubham Singh, Richa Soni, Shamli S. Gupte, Arti Rathour, Sadhana Shrivastava & Sangeeta Shukla. (2023) Possible metabolic effect of acrylamide on biological system. Food Safety and Health 1:2, pages 126-138.
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Mohamed Mohamed Soliman, Samy M. Sayed, Gehan Basiony Ahmed Youssef, Saed Athobaiti & Ahmed M. El-Shehawi. (2023) Taify Pomegranate Juice Extract Abrogates Testicular Dysfunction Induced by Acrylamide: Role of Inflammatory, Antioxidants, and Oxidative Stress Biomarkers. Andrologia 2023, pages 1-10.
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Ningyi Xu, Xinyue Ma, Yue Cao, Huan Wang, Han Wu, Hongru Zheng, Chuanyu Yang, Ruiqi Zou, Jiayi Liu, Chunyan Sun & Yuan Yuan. (2023) A novel fluorescent structure-switching aptasensor for the sensitive detection of acrylamide based on AuNPs-assisted separation of ssDNA. Advanced Agrochem 2:3, pages 276-283.
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Pengcheng Pang, Xing Zhang, Jingping Yuan, Hong Yan & Dandan Yan. (2023) Acrylamide interferes with autophagy and induces apoptosis in Neuro-2a cells by interfering with TFEB-regulated lysosomal function. Food and Chemical Toxicology 177, pages 113818.
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Min Fan, Xiaoying Xu, Wenjun Lang, Wenjing Wang, Xinyu Wang, Angjun Xin, Fangmei Zhou, Zhishan Ding, Xiaoqing Ye & Bingqi Zhu. (2023) Toxicity, formation, contamination, determination and mitigation of acrylamide in thermally processed plant-based foods and herbal medicines: A review. Ecotoxicology and Environmental Safety 260, pages 115059.
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Jiamin Chen, Liuying Li, Liying Ye, Xiao Lin, Songyuan Huang, Wenqi Yue & Xuli Wu. (2023) Aggravation of food allergy symptoms by treatment with acrylamide in a mouse model. Food and Chemical Toxicology 176, pages 113808.
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Yufei Pang, Jingxin Chen, Jianjun Yang, Yanzhong Xue, Hua Gao & Qinghan Gao. (2023) Protective effect and mechanism of Lycium ruthenicum polyphenols against acrylamide-induced neurotoxicity . Food & Function 14:10, pages 4552-4568.
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Feng-chao Zhao, Xiang Li, Yu-xin Wang, Sheng-jie Zhou & Yang Lu. (2023) Relationship between acrylamide and glycidamide hemoglobin adduct levels and osteoarthritis: a NHANES analysis. Environmental Science and Pollution Research 30:30, pages 75262-75272.
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Yucel Buyukdere & Asli Akyol. (2023) From a toxin to an obesogen: a review of potential obesogenic roles of acrylamide with a mechanistic approach. Nutrition Reviews.
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Cuicui Li, Long Chen, David Julian McClements, Wenmeng Liu, Jie Long, Chao Qiu, Yi Wang, Zhongyu Yang, Zhenlin Xu, Man Meng & Zhengyu Jin. (2023) Utilization of plant extracts to control the safety and quality of fried foods—A review. Comprehensive Reviews in Food Science and Food Safety 22:3, pages 2310-2345.
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Si-Le Wu, Jia-Qian Ju, Yi-Ming Ji, Hao-Lin Zhang, Yuan-Jing Zou & Shao-Chen Sun. (2023) Exposure to acrylamide induces zygotic genome activation defects of mouse embryos. Food and Chemical Toxicology 175, pages 113753.
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Lujia ZhangLiuqing YangYinghua LuoLi DongFang Chen. (2023) Acrylamide-Induced Hepatotoxicity Through Oxidative Stress: Mechanisms and Interventions. Antioxidants & Redox Signaling.
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Hui Wang, Zizheng Tang, Shasha Liu, Kangqi Xie & Hua Zhang. (2023) Acrylamide induces human chondrocyte cell death by initiating autophagy‑dependent ferroptosis. Experimental and Therapeutic Medicine 25:6.
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Michaela Gabašová, Lucia Zeleňáková, Zuzana Ciesarová, Lucia Benešová, Kristína Kukurová & Viera Jelemenská. (2023) The variability of acrylamide content in potato French fries depending on the oil used and deep-frying conditions. Potravinarstvo Slovak Journal of Food Sciences 17, pages 170-184.
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Ranabir Chakraborty, Arkadeb Mukhopadhyay, Subhadip Paul, Subhasis Sarkar & Raj Mukhopadhyay. (2023) Nanocomposite-based smart fertilizers: A boon to agricultural and environmental sustainability. Science of The Total Environment 863, pages 160859.
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Tong Zhang, Chunmei Zhang, Yuyou Luo, Shuping Liu, Siyuan Li, Lixia Li, Yuxin Ma & Jing Liu. (2023) Protective effect of rutin on spinal motor neuron in rats exposed to acrylamide and the underlying mechanism. NeuroToxicology 95, pages 127-135.
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Julen Sanz-Serrano, Roncesvalles Garayoa, Ana Isabel Vitas, Adela López de Cerain & Amaya Azqueta. (2023) In vitro genotoxicity assessment of French fries from mass catering companies: a preliminary study . Mutagenesis 38:1, pages 51-57.
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L. González-Mulero, M. Mesías, F.J. Morales, B. Navajas-Porras, J.A. Rufián-Henares & C. Delgado-Andrade. (2023) Acrylamide bioaccessibility in potato and veggie chips. Impact of in vitro colonic fermentation on the non-bioaccessible fraction. Food Research International 164, pages 112409.
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Selahattin Gazi, Neslihan Göncüoğlu Taş, Ahmet Görgülü & Vural Gökmen. (2023) Effectiveness of asparaginase on reducing acrylamide formation in bakery products according to their dough type and properties. Food Chemistry 402, pages 134224.
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John Hulme. (2023) Staphylococcus Infection: Relapsing Atopic Dermatitis and Microbial Restoration. Antibiotics 12:2, pages 222.
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R. Wang, X. Deng, Q. Ma & F. Ma. (2023) Association between acrylamide exposure and sex hormones among premenopausal and postmenopausal women: NHANES, 2013–2016. Journal of Endocrinological Investigation 46:8, pages 1533-1547.
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Chaoyi Xue, Yong Li, Wei Quan, Peng Deng, Zhiyong He, Fang Qin, Zhaojun Wang, Jie Chen & Maomao Zeng. (2023) Simultaneous alleviation of acrylamide and methylimidazole accumulation in cookies by Rhizoma kaempferiae and kaempferol and potential mechanism revealed by density functional theory. LWT 173, pages 114302.
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Naief Dahran, Yasmina M. Abd-Elhakim, Amany Abdel-Rahman Mohamed, Marwa M. Abd-Elsalam, Enas N. Said, Mohamed M.M. Metwally, Ahmed E. Abdelhamid, Bayan A. Hassan, Mohammed Alsieni, Manal E. Alosaimi, Maram H. abduljabbar & Eman S. El-Shetry. (2023) Palliative effect of Moringa olifera-mediated zinc oxide nanoparticles against acrylamide-induced neurotoxicity in rats. Food and Chemical Toxicology 171, pages 113537.
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Dan Su, Aitong Lei, Chunchao Nie & Yi Chen. (2022) The protective effect of Ganoderma atrum polysaccharide on intestinal barrier function damage induced by acrylamide in mice through TLR4/MyD88/NF-κB based on the iTRAQ analysis. Food and Chemical Toxicology, pages 113548.
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Velliyath Ligina, Ranjana Martin, Moolamkottil Venugopalan Aiswarya, Kajahussain Reeha Mashirin & Kumari Chidambaran Chitra. (2022) Acute and sublethal effects of acrylamide on the freshwater fish Anabas testudineus (Bloch, 1792). Environmental Science and Pollution Research 29:60, pages 90835-90851.
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Yawen Rong, Md Mehedi Hassan, Qin Ouyang, Yunlian Zhang, Li Wang & Quansheng Chen. (2022) An upconversion biosensor based on DNA hybridization and DNA-templated silver nanoclusters for the determination of acrylamide. Biosensors and Bioelectronics 215, pages 114581.
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Swetha Senthil Kumar, Abhinaya Swaminathan, Mohamed M. Abdel-Daim & Sahabudeen Sheik Mohideen. (2022) A systematic review on the effects of acrylamide and bisphenol A on the development of Drosophila melanogaster. Molecular Biology Reports 49:11, pages 10703-10713.
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Jesús Rodríguez-Miranda, Erasmo Herman-Lara, Julio César Serrano-Niño, Bruno Alberto Sánchez-Ruiz & Cecilia Eugenia Martínez-Sánchez. (2022) Effects of sucrose and sodium chloride pretreatments on cassava and plantain chips fried in CLA-enriched soybean oil: an analysis of acrylamide content, microstructure, and other physical properties. International Journal of Food Engineering 18:8-9, pages 571-581.
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Wenbo Gu, Jiacheng Zhang, Chunling Ren, Yang Gao, Tongfang Zhang, Yujia Long, Wei Wei, Shaoying Hou, Changhao Sun, Changhong Wang, Wenbo Jiang & Junfei Zhao. (2022) The association between biomarkers of acrylamide and cancer mortality in U.S. adult population: Evidence from NHANES 2003-2014. Frontiers in Oncology 12.
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Muhammad Hammad Rasool, Maqsood Ahmad, Muhammad Ayoub, Asif Zamir & Muhammad Adeem Abbas. (2022) A review of the usage of deep eutectic solvents as shale inhibitors in drilling mud. Journal of Molecular Liquids 361, pages 119673.
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Emanuela Lo Faro, Tommaso Salerno, Giuseppe Montevecchi & Patrizia Fava. (2022) Mitigation of Acrylamide Content in Biscuits through Combined Physical and Chemical Strategies. Foods 11:15, pages 2343.
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Huanyu Wu, Xinyi Sun, Hongyan Jiang, Cong Hu, Jiaxu Xu, Changhao Sun, Wei Wei, Tianshu Han & Wenbo Jiang. (2022) The Association Between Exposure to Acrylamide and Mortalities of Cardiovascular Disease and All-Cause Among People With Hyperglycemia. Frontiers in Cardiovascular Medicine 9.
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Isaac Duah Boateng. (2022) A critical review of current technologies used to reduce ginkgotoxin, ginkgotoxin-5′-glucoside, ginkgolic acid, allergic glycoprotein, and cyanide in Ginkgo biloba L. seed. Food Chemistry 382, pages 132408.
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Sandra J Henao Toro, Faver Gómez-Narváez, José Contreras-Calderón & Adriana P Arisseto. (2022) Acrylamide in sugar products. Current Opinion in Food Science 45, pages 100841.
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Bastien Maurice, Anne Saint-Eve, Aurélia Pernin, Pascal Leroy & Isabelle Souchon. (2022) How Different Are Industrial, Artisanal and Homemade Soft Breads?. Foods 11:10, pages 1484.
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Klaus Abraham, Iris Trefflich, Fabian Gauch & Cornelia Weikert. (2022) Nutritional Intake and Biomarker Status in Strict Raw Food Eaters. Nutrients 14:9, pages 1725.
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Mengyao Zhao, Boya Zhang & Linlin Deng. (2022) The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives. Frontiers in Nutrition 9.
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Ahmed M. El-Shehawi, Samy Sayed, Mohamed M. Hassan, Saad Al-Otaibi, Fayez Althobaiti, Mona M. Elseehy & Mohamed Soliman. (2022) Taify Pomegranate Juice (TPJ) Abrogates Acrylamide-Induced Oxidative Stress Through the Regulation of Antioxidant Activity, Inflammation, and Apoptosis-Associated Genes. Frontiers in Veterinary Science 9.
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Aditya Manivannan Iyer, Vedika Dadlani & Harshal Ashok Pawar. (2022) Review on Acrylamide: A Hidden Hazard in Fried Carbohydrate-rich Food. Current Nutrition & Food Science 18:3, pages 274-286.
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Burhan BAŞARAN. (2022) The Effect of Different Orders of Vegetables in Frying on Acrylamide LevelsThe Effect of Different Orders of Vegetables in Frying on Acrylamide Levels. Türkiye Tarımsal Araştırmalar Dergisi 9:1, pages 49-59.
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Marta Kopańska, Anna Łagowska, Barbara Kuduk & Agnieszka Banaś-Ząbczyk. (2022) Acrylamide Neurotoxicity as a Possible Factor Responsible for Inflammation in the Cholinergic Nervous System. International Journal of Molecular Sciences 23:4, pages 2030.
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Ilze Laukalēja, Zanda Krūma & Ingmars Cinkmanis. (2022) Impact of The Roast Level on Chemical Composition of Coffee from Colombia. Proceedings of the Latvian Academy of Sciences. Section B. Natural, Exact, and Applied Sciences. 76:1, pages 145-151.
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R. Paranthaman, J.A. Moses & C. Anandharamakrishnan. (2022) Novel powder-XRD method for detection of acrylamide in processed foods. Food Research International 152, pages 110893.
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Katarzyna Petka, Paweł Sroka, Tomasz Tarko & Aleksandra Duda-Chodak. (2022) The Acrylamide Degradation by Probiotic Strain Lactobacillus acidophilus LA-5. Foods 11:3, pages 365.
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M. S. Nadeem, J. A. Khan, M. A. Al-Ghamdi, M. I. Khan & M. A. Zeyadi. (2022) Studies on the recombinant production and anticancer activity of thermostable L- asparaginase I from Pyrococcus abyssi. Brazilian Journal of Biology 82.
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Lujia Zhang, Li Dong, Liuqing Yang, Yinghua Luo & Fang Chen. (2022) MiR-27a-5p regulates acrylamide-induced mitochondrial dysfunction and intrinsic apoptosis via targeting Btf3 in rats. Food Chemistry 368, pages 130816.
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Yu-Syuan Luo, Su-Yin Chiang, Tai-Ying Long, Tung-Hu Tsai & Kuen-Yuh Wu. (2022) Simultaneous toxicokinetics characterization of acrylamide and its primary metabolites using a novel microdialysis isotope-dilution liquid chromatography mass spectrometry method. Environment International 158, pages 106954.
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Yiju Zhang, Qiao Wang, Yaoran Li, Jun Cheng, Xinyu Chen & Yu Zhang. (2022) Comprehensive profile of DNA adducts as both tissue and urinary biomarkers of exposure to acrylamide and chemo-preventive effect of catechins in rats. Chemosphere 286, pages 131852.
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Zhen Lin, Ping Luo, Dongmin Huang, Yulian Wu, Fangping Li & Huazhong Liu. (2021) Multi-omics based strategy for toxicity analysis of acrylamide in Saccharomyces cerevisiae model. Chemico-Biological Interactions 349, pages 109682.
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Anli Wang, Xinyu Chen, Shanyun Wu, Wei Jia, Jingjing Jiao & Yu Zhang. (2021) Unraveling the Serum Metabolomic Profile of Acrylamide-Induced Cardiovascular Toxicity. Journal of Agricultural and Food Chemistry 69:40, pages 12012-12020.
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Alireza Emadi, Bahman Yousefi, Majid Eslami & Anna Abdolshahi. (2021) Reduction of acrylamide formation in bread and fried potato products using probiotic microorganisms: a systematic review and dose–response meta-analysis. Journal of Food Measurement and Characterization 15:5, pages 4277-4287.
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Yiming Wang, Wei Xu, Hao Wu, Wenli Zhang, Cuie Guang & Wanmeng Mu. (2021) Microbial production, molecular modification, and practical application of l-Asparaginase: A review. International Journal of Biological Macromolecules 186, pages 975-983.
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Marta Mesias, Cristina Delgado-Andrade, Francisca Holgado, Lucía González-Mulero & Francisco J. Morales. (2021) Effect of consumer's decisions on acrylamide exposure during the preparation of French fries. Part 2: Color analysis. Food and Chemical Toxicology 154, pages 112321.
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Liuqing Yang, Li Dong, Lujia Zhang, Jie Bai, Fang Chen & Yinghua Luo. (2021) Acrylamide Induces Abnormal mtDNA Expression by Causing Mitochondrial ROS Accumulation, Biogenesis, and Dynamics Disorders. Journal of Agricultural and Food Chemistry 69:27, pages 7765-7776.
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Anita Mielech, Anna Puścion-Jakubik & Katarzyna Socha. (2021) Assessment of the Risk of Contamination of Food for Infants and Toddlers. Nutrients 13:7, pages 2358.
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Agnieszka Lipowczan & Andrzej W. Trochimczuk. (2021) Phosphates-Containing Interpenetrating Polymer Networks (IPNs) Acting as Slow Release Fertilizer Hydrogels (SRFHs) Suitable for Agricultural Applications. Materials 14:11, pages 2893.
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Cristina Sarion, Georgiana Gabriela Codină & Adriana Dabija. (2021) Acrylamide in Bakery Products: A Review on Health Risks, Legal Regulations and Strategies to Reduce Its Formation. International Journal of Environmental Research and Public Health 18:8, pages 4332.
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Zhonghui Han, Jianxin Gao, Shunyang Zhang, Yan Zhang & Shuo Wang. (2021) Simultaneously Mitigation of Acrylamide, 5-Hydroxymethylfurfural, and Oil Content in Fried Dough Twist via Different Ingredients Combination and Infrared-Assisted Deep-Frying. Foods 10:3, pages 604.
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Gabriella Giovanelli & Carola Cappa. (2021) 5-Hydroxymethylfurfural Formation in Bread as a Function of Heat Treatment Intensity: Correlations with Browning Indices. Foods 10:2, pages 417.
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Astrid Nehlig & Rodrigo Cunha. (2020) The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation. Nutrients 12:10, pages 3141.
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Ewa Tomaszewska, Piotr Dobrowolski, Iwona Puzio, Janine Donaldson & Siemowit Muszyński. (2020) Acrylamide-Induced Prenatal Programming of Bone Structure in Mammal Model. Annals of Animal Science 20:4, pages 1257-1287.
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Arezoo Habibagahi, Nicholas Alderman & Cariton Kubwabo. (2020) A review of the analysis of biomarkers of exposure to tobacco and vaping products. Analytical Methods 12:35, pages 4276-4302.
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Juanying Ou, Jie Zheng, Junqing Huang, Chi-Tang Ho & Shiyi Ou. (2020) Interaction of Acrylamide, Acrolein, and 5-Hydroxymethylfurfural with Amino Acids and DNA. Journal of Agricultural and Food Chemistry 68:18, pages 5039-5048.
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Mingfei Pan, Kaixin Liu, Jingying Yang, Liping Hong, Xiaoqian Xie & Shuo Wang. (2020) Review of Research into the Determination of Acrylamide in Foods. Foods 9:4, pages 524.
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Adriana Nowak, Małgorzata Zakłos-Szyda, Dorota Żyżelewicz, Agnieszka Koszucka & Ilona Motyl. (2020) Acrylamide Decreases Cell Viability, and Provides Oxidative Stress, DNA Damage, and Apoptosis in Human Colon Adenocarcinoma Cell Line Caco-2. Molecules 25:2, pages 368.
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