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Critical Reviews in Food Science and Nutrition Volume 63, 2023 - Issue 24
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Review Articles

Ellagic acid and intestinal microflora metabolite urolithin A: A review on its sources, metabolic distribution, health benefits, and biotransformation

Mengwei Zhanga State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R ChinaView further author information
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Shumao Cuia State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R ChinaView further author information
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Bingyong Maoa State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R ChinaView further author information
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Qiuxiang Zhanga State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R ChinaView further author information
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Jianxin Zhaoa State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R ChinaView further author information
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Hao Zhanga State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;c National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, P. R China;d Wuxi Translational Medicine Research Center, Jiangsu Translational Medicine Research Institute Wuxi Branch, Wuxi, Jiangsu, P. R ChinaView further author information
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Xin Tanga State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-6391-3075View further author information
ORCID Icon &
Wei Chena State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;b School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China;c National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, P. R ChinaView further author information
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Pages 6900-6922 | Published online: 10 Feb 2022

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Yantao Yin, Remigio Martínez, Wangang Zhang & Mario Estévez. (2023) Crosstalk between dietary pomegranate and gut microbiota: evidence of health benefits. Critical Reviews in Food Science and Nutrition 0:0, pages 1-27.
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Articles from other publishers (16)

Junjie Tan, Qingyu Ma, Jiao Li, Qiuming Liu & Yongliang Zhuang. (2023) Bioavailability and Antioxidant Activity of Rambutan ( Nephelium lappaceum ) Peel Polyphenols during in Vitro Simulated Gastrointestinal Digestion, Caco-2 Monolayer Cell Model Application, and Colonic Fermentation . Journal of Agricultural and Food Chemistry 71:42, pages 15829-15841.
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Haotian Zhao, Ge Song, Hongkang Zhu, He Qian, Xinliang Pan, Xiaoneng Song, Yijie Xie & Chang Liu. (2023) Pharmacological Effects of Urolithin A and Its Role in Muscle Health and Performance: Current Knowledge and Prospects. Nutrients 15:20, pages 4441.
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Lei An, Qiu Lu, Ke Wang & Yousheng Wang. (2023) Urolithins: A Prospective Alternative against Brain Aging. Nutrients 15:18, pages 3884.
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Qitong Liu, Ziyan Hua, Meng Chen, Shu Liu, Sibtain Ahmed, Xiaoyue Hou, Guang Yang & Yaowei Fang. (2023) Changes in Polyphenols and Antioxidant Properties of Pomegranate Peels Fermented by Urolithin A-Producing Streptococcus thermophilus FUA329 . ACS Food Science & Technology 3:8, pages 1383-1392.
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Wenyan Xian, Yu Deng, Yuzhe Yang, Zhaolun Tan, Chunlian Chen, Wu Li & Ruili Yang. (2023) Ameliorative Effect of Ellagic Acid on Aging in Rats with the Potential Mechanism Relying on the Gut Microbiota and Urolithin A-Producing Ability. Journal of Agricultural and Food Chemistry 71:19, pages 7396-7407.
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Mengwei Zhang, Shumao Cui, Bingyong Mao, Qiuxiang Zhang, Jianxin Zhao, Xin Tang & Wei Chen. (2023) Urolithin A Produced by Novel Microbial Fermentation Possesses Anti-aging Effects by Improving Mitophagy and Reducing Reactive Oxygen Species in Caenorhabditis elegans . Journal of Agricultural and Food Chemistry 71:16, pages 6348-6357.
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Huiren Zhuang, Zhenghuan Yang, Tianhao Chen, Nan Jing, Yalin Zhou, Guoqiang Jiang, Yi Wang, Zhao Wang & Zheng Liu. (2023) Boosting HSA Vaccination with Jujube Powder Modulating Gut Microbiota Favorable for Arginine Metabolism. Nutrients 15:8, pages 1955.
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Mingyue Tan, Yunfei Yin, Xiao Ma, Jun Zhang, Wanqian Pan, Minghao Tan, Yongjian Zhao, Tianke Yang, Tingbo Jiang & Hongxia Li. (2023) Glutathione system enhancement for cardiac protection: pharmacological options against oxidative stress and ferroptosis. Cell Death & Disease 14:2.
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Long Jin, Hongyang Dang, Jinyong Wu, Lixia Yuan, Xiangsong Chen & Jianming Yao. (2023) Supplementation of Weizmannia coagulans BC2000 and Ellagic Acid Inhibits High-Fat-Induced Hypercholesterolemia by Promoting Liver Primary Bile Acid Biosynthesis and Intestinal Cholesterol Excretion in Mice. Microorganisms 11:2, pages 264.
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Xiaomeng Zhang, Yaowei Fang, Guang Yang, Xiaoyue Hou, Yang Hai, Mengjie Xia, Fuxiang He, Yaling Zhao & Shu Liu. (2022) Isolation and characterization of a novel human intestinal Enterococcus faecium FUA027 capable of producing urolithin A from ellagic acid. Frontiers in Nutrition 9.
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Jessica Rebeaud, Benjamin Peter & Caroline Pot. (2022) How Microbiota-Derived Metabolites Link the Gut to the Brain during Neuroinflammation. International Journal of Molecular Sciences 23:17, pages 10128.
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Meng-Ying Chen, Jin-Ye Lang, Chen-Chen Bai, Shi-Song Yu, Xiang-Jin Kong, Lin-Yi Dong & Xian-Hua Wang. (2022) Construction of PEGylated boronate-affinity-oriented imprinting magnetic nanoparticles for ultrasensitive detection of ellagic acid from beverages. Analytical and Bioanalytical Chemistry 414:22, pages 6557-6570.
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Haoyu Mi, Shu Liu, Yang Hai, Guang Yang, Jing Lu, Fuxiang He, Yaling Zhao, Mengjie Xia, Xiaoyue Hou & Yaowei Fang. (2022) Lactococcus garvieae FUA009, a Novel Intestinal Bacterium Capable of Producing the Bioactive Metabolite Urolithin A from Ellagic Acid. Foods 11:17, pages 2621.
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Wai-Kit Tow, Pui-Ying Chee, Usha Sundralingam & Uma Devi Palanisamy. (2022) The Therapeutic Relevance of Urolithins, Intestinal Metabolites of Ellagitannin-Rich Food: A Systematic Review of In Vivo Studies. Nutrients 14:17, pages 3494.
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Chunhua LuXintong LiZeyuan GaoYuliang SongYuemao Shen. (2022) Urolithins and intestinal health. Drug Discoveries & Therapeutics 16:3, pages 105-111.
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Kailin Li, Yao Xiao, Ji Bian, Lin Han, Caian He, Emad El-Omar, Lan Gong & Min Wang. (2022) Ameliorative Effects of Gut Microbial Metabolite Urolithin A on Pancreatic Diseases. Nutrients 14:12, pages 2549.
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