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Review Article

Etiology of bacterial vaginosis and polymicrobial biofilm formation

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Pages 651-667 | Received 10 Jun 2016, Accepted 02 Feb 2017, Published online: 30 Mar 2017

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Jordi Antoni Vives, María Jesús Cancelo, Miguel Ángel Losada & Alejandro Doménech. (2022) Dequalinium chloride use in adult Spanish women with bacterial vaginosis: an observational study. Journal of Obstetrics and Gynaecology 42:1, pages 103-109.
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Suzanne Reiter & Susan Kellogg Spadt. (2019) Bacterial vaginosis: a primer for clinicians. Postgraduate Medicine 131:1, pages 8-18.
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Crossref
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Crossref
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Crossref
E.V. Starikova, S.I. Koshechkin & V.V. Demkin. (2020) Prophage sequences in genomes of vaginal lactobacteria. Molecular Genetics Microbiology and Virology (Russian version) 38:2, pages 82.
Crossref
Aliona S Rosca, Joana Castro, Lúcia G V Sousa & Nuno Cerca. (2020) Gardnerella and vaginal health: the truth is out there . FEMS Microbiology Reviews 44:1, pages 73-105.
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Shengjun Wu, Xuexiang Lin, Kwok Min Hui, Su Yang, Xuanlan Wu, Yichen Tan, Meimei Li, Ai-Qing Qin, Qingxi Wang, Qi Zhao, Pengfei Ding, Kaisheng Shi & X. James Li. (2019) A Biochemiluminescent Sialidase Assay for Diagnosis of Bacterial Vaginosis. Scientific Reports 9:1.
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Jun Zou, Xiaoying Yang, Lingbing Zeng, Xingxing Wang, Yanling Liu, Dandan Wei, Xuefei Hu & Niya Hu. (2019) Identification and Antimicrobial Susceptibility of Clinically Isolated Anaerobic Bacteria: A Retrospectively Study in a Jiangxi Tertiary-Care Hospital. Jundishapur Journal of Microbiology In Press:In Press.
Crossref
Marina Pekmezovic, Selene Mogavero, Julian R. Naglik & Bernhard Hube. (2019) Host–Pathogen Interactions during Female Genital Tract Infections. Trends in Microbiology 27:12, pages 982-996.
Crossref
Fernando Vazquez, Ana Fernández-Blázquez & Beatriz García. (2019) Vaginosis. Vaginal microbiota. Enfermedades infecciosas y microbiologia clinica (English ed.) 37:9, pages 592-601.
Crossref
Fernando Vazquez, Ana Fernández-Blázquez & Beatriz García. (2019) Vaginosis. Microbiota vaginal. Enfermedades Infecciosas y Microbiología Clínica 37:9, pages 592-601.
Crossref
E. R. Dovletkhanova & P. R. Abakarova. (2019) Modern opportunities for the diagnosis and treatment of vulvovaginal candidiasis (in aid of a practitioner). Medical Council:13, pages 42-48.
Crossref
Adriana Peric, Jürgen Weiss, Nicolas Vulliemoz, David Baud & Milos Stojanov. (2019) Bacterial Colonization of the Female Upper Genital Tract. International Journal of Molecular Sciences 20:14, pages 3405.
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Gerardo Leyva-Gómez, María L. Del Prado-Audelo, Silvestre Ortega-Peña, Néstor Mendoza-Muñoz, Zaida Urbán-Morlán, Maykel González-Torres, Manuel González-Del Carmen, Gabriela Figueroa-González, Octavio D. Reyes-Hernández & Hernán Cortés. (2019) Modifications in Vaginal Microbiota and Their Influence on Drug Release: Challenges and Opportunities. Pharmaceutics 11:5, pages 217.
Crossref
Joana Castro, Daniela Machado & Nuno Cerca. (2019) Unveiling the role of Gardnerella vaginalis in polymicrobial Bacterial Vaginosis biofilms: the impact of other vaginal pathogens living as neighbors. The ISME Journal 13:5, pages 1306-1317.
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Nuno Cerca. (2019) Could targeting neighboring bacterial populations help combat bacterial vaginosis?. Future Microbiology 14:5, pages 365-368.
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Karol Gliniewicz, G. Maria Schneider, Benjamin J. Ridenhour, Christopher J. Williams, Yuli Song, Miranda A. Farage, Kenneth Miller & Larry J. Forney. (2019) Comparison of the Vaginal Microbiomes of Premenopausal and Postmenopausal Women. Frontiers in Microbiology 10.
Crossref
Elvira Marín, Annelies Haesaert, Laura Padilla, Jaume Adán, María L. Hernáez, Lucía Monteoliva & Concha Gil. (2018) Unraveling Gardnerella vaginalis Surface Proteins Using Cell Shaving Proteomics. Frontiers in Microbiology 9.
Crossref
Gregor Reid. (2018) Has knowledge of the vaginal microbiome altered approaches to health and disease?. F1000Research 7, pages 460.
Crossref
Leighann Sherry, Ryan Kean, Emily McKloud, Lindsay E. O'Donnell, Rebecca Metcalfe, Brian L. Jones & Gordon Ramage. (2017) Biofilms Formed by Isolates from Recurrent Vulvovaginal Candidiasis Patients Are Heterogeneous and Insensitive to Fluconazole. Antimicrobial Agents and Chemotherapy 61:9.
Crossref

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