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Research Article

Toxicity Review of Ethylene Glycol Monomethyl Ether and its Acetate Ester

Pages 307-345 | Published online: 29 Sep 2008

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Isaac A. Adedara, Premendu P. Mathur & Ebenezer O. Farombi. (2013) Kolaviron prevents ethylene glycol monoethyl ether-induced testicular apoptosis via down-regulation of stress proteins, Fas/Fas-L and caspases expressions in rats. Toxicology Mechanisms and Methods 23:9, pages 689-696.
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Glenn Ritchie, Kenneth Still, John Rossi III, Marni Bekkedal, Andrew Bobb & Darryl Arfsten. (2003) Biological And Health Effects Of Exposure To Kerosene-Based Jet Fuels And Performance Additives. Journal of Toxicology and Environmental Health, Part B 6:4, pages 357-451.
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RandaA. El-Zein, SherifZ. Abdel-Rahman, DebraL. Morris & MarvinS. Legator. (2002) Exposure to Ethylene Glycol Monomethyl Ether: Clinical and Cytogenetic Findings. Archives of Environmental Health: An International Journal 57:4, pages 371-376.
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Oluwatobi T. Somade, Babatunji E. Oyinloye, Basiru O. Ajiboye & Olukemi A. Osukoya. (2023) Syringic acid demonstrates an anti-inflammatory effect via modulation of the NF-κB-iNOS-COX-2 and JAK-STAT signaling pathways in methyl cellosolve-induced hepato-testicular inflammation in rats. Biochemistry and Biophysics Reports 34, pages 101484.
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Maria Celeiro, Laura Rubio, Carmen Garcia-Jares & Marta Lores. (2021) Miniaturized Sample Preparation Methods to Simultaneously Determine the Levels of Glycols, Glycol Ethers and Their Acetates in Cosmetics. Cosmetics 8:4, pages 102.
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Xiaoyan Shi, Yilong Miao, Kemei Zhang, Shuai Gong & Bo Xiong. (2021) Ethylene glycol butyl ether deteriorates oocyte quality via impairing mitochondrial function. The FASEB Journal 35:4.
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Oluwatobi T. Somade, Babajide O. Ajayi, Olubisi E. Adeyi, Anuoluwapo A. Adeshina, Mary O. Adekoya & Ridwan O. Abdulhameed. (2021) Oxidative stress-mediated induction of pulmonary oncogenes, inflammatory, and apoptotic markers following time-course exposure to ethylene glycol monomethyl ether in rats. Metabolism Open 9, pages 100075.
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Oluwatobi T. Somade, Babajide O. Ajayi, Oyinkansola E. Olunaike & Latifah A. Jimoh. (2020) Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats. Biochemistry and Biophysics Reports 24, pages 100806.
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Oluwatobi T. Somade, Babajide O. Ajayi, Olubisi E. Adeyi, Anuoluwapo A. Adeshina, Adewale S. James & Peter F. Ayodele. (2020) Ethylene glycol monomethyl ether-induced testicular oxidative stress and time-dependent up-regulation of apoptotic, pro-inflammatory, and oncogenic markers in rats. Metabolism Open 7, pages 100051.
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Oluwatobi T. Somade, Babajide O. Ajayi, Mariana O. Olushola & Esther O. Omoseebi. (2020) Methyl cellosolve-induced renal oxidative stress and time-dependent up-regulation of pro-inflammatory cytokines, apoptotic, and oncogenic markers in rats. Toxicology Reports 7, pages 779-787.
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Yoshikazu TaketaHiroshi MineshimaEtsuko OhtaKyoko Nakano-Ito. (2017) The effects of ethylene glycol monomethyl ether on female reproductive system in juvenile rats. The Journal of Toxicological Sciences 42:6, pages 707-713.
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Ken Sakurai, Kei Mikamoto, Makoto Shirai, Takuma Iguchi, Kazumi Ito, Wataru Takasaki & Kazuhiko Mori. (2016) MicroRNA profiles in a monkey testicular injury model induced by testicular hyperthermia. Journal of Applied Toxicology 36:12, pages 1614-1621.
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Yoshikazu Taketa, Kaoru Inoue, Miwa Takahashi, Yohei Sakamoto, Gen Watanabe, Kazuyoshi Taya & Midori Yoshida. (2016) Effects of sulpiride and ethylene glycol monomethyl ether on endometrial carcinogenicity in Donryu rats. Journal of Applied Toxicology 36:6, pages 769-776.
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Arturo Bejarano & Juan C. de la Fuente. (2015) Isobaric (vapor+liquid) equilibria for the binary systems (1-methoxy-2-propanol+2-methoxyethanol), (2-butanone+2-methoxyethanol) and (water+2-methoxyethanol) at pressures of (74.5, 101.3, and 134.0)kPa. The Journal of Chemical Thermodynamics 87, pages 88-95.
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Beata Starek-Świechowicz, Wiesław Szymczak, Bogusława Budziszewska & Andrzej Starek. (2015) Testicular effect of a mixture of 2-methoxyethanol and 2-ethoxyethanol in rats. Pharmacological Reports 67:2, pages 289-293.
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M. Sethu Raman, M. Kesavan, K. Senthilkumar & V. Ponnuswamy. (2015) Ultrasonic, DFT and FT-IR studies on hydrogen bonding interactions in aqueous solutions of diethylene glycol. Journal of Molecular Liquids 202, pages 115-124.
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Ken SakuraiKei MikamotoMakoto ShiraiTakuma IguchiKazumi ItoWataru TakasakiKazuhiko Mori. (2015) MicroRNA profling in ethylene glycol monomethyl ether-induced monkey testicular toxicity model. The Journal of Toxicological Sciences 40:3, pages 375-382.
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Takashi Yamada, Yushiro Tanaka, Ryuichi Hasegawa, Yuki Sakuratani, Yasushi Yamazoe, Atsushi Ono, Akihiko Hirose & Makoto Hayashi. (2014) Development of a category approach to predict the testicular toxicity of chemical substances structurally related to ethylene glycol methyl ether. Regulatory Toxicology and Pharmacology 70:3, pages 711-719.
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N.H. Al-Hardan, Azman Jalar, M.A. Abdul Hamid, Lim Kar Keng, R. Shamsudin & B.Y. Majlis. (2014) The room-temperature sensing performance of ZnO nanorods for 2-methoxyethanol solvent. Sensors and Actuators B: Chemical 203, pages 223-228.
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Bartosz Pomierny, Weronika Krzyżanowska, Irena Smaga, Lucyna Pomierny-Chamioło, Piotr Stankowicz & Bogusława Budziszewska. (2014) Ethylene Glycol Ethers Induce Oxidative Stress in the Rat Brain. Neurotoxicity Research 26:4, pages 422-429.
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Caroline Dayan & Barbara F. Hales. (2014) Effects of Ethylene Glycol Monomethyl Ether and Its Metabolite, 2‐Methoxyacetic Acid, on Organogenesis Stage Mouse Limbs In Vitro. Birth Defects Research Part B: Developmental and Reproductive Toxicology 101:3, pages 254-261.
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Afidah A. Rahim, Bahruddin Saad, Hasnah Osman, NoorHasani Hashim, Solhan Yahya & Khairuddin Md Talib. (2011) Simultaneous determination of diethylene glycol, diethylene glycol monoethyl ether, coumarin and caffeine in food items by gas chromatography. Food Chemistry 126:3, pages 1412-1416.
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