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Research Article

Formaldehyde as a Potential Human Leukemogen: An Assessment of Biological Plausibility

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Pages 135-153 | Published online: 10 Oct 2008

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Read on this site (4)

Laura H. Allen, Claire Hamaji, Hannah L. Allen, Gwendolyn H. Parker, Jzyk S. Ennis & Marisa L. Kreider. (2022) Assessment of formaldehyde exposures under contemporary embalming conditions in U.S. funeral homes. Journal of Occupational and Environmental Hygiene 19:7, pages 425-436.
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Sumira Malik, Shilpa Prasad, Shristi Kishore, Abhishek Kumar & Vineet Upadhyay. (2021) A perspective review on impact and molecular mechanism of environmental carcinogens on human health. Biotechnology and Genetic Engineering Reviews 37:2, pages 178-207.
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Lorenz R. Rhomberg, Lisa A. Bailey, Julie E. Goodman, Ali K. Hamade & David Mayfield. (2011) Is exposure to formaldehyde in air causally associated with leukemia?—A hypothesis-based weight-of-evidence analysis. Critical Reviews in Toxicology 41:7, pages 555-621.
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Articles from other publishers (34)

Huijuan Ma, Kaiyan Lou, Qi Shu, Xiaodong Song & Huan Xu. (2023) Aldehyde dehydrogenase 2 deficiency reinforces formaldehyde‐potentiated pro‐inflammatory responses and glycolysis in macrophages. Journal of Biochemical and Molecular Toxicology.
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Hongfei Zhang, Fengpeng Zhu, Xiangyu Li, Yanbo Luo, Xingyi Jiang, Yongqiang Pang, Hongwei Hou, Qingyuan Hu, Chao Chen & Wenliang Zhang. (2022) Acid-Catalyzed Isomerization of Carbonyls-2,4- dinitrophenylhydrazone in Mainstream Smoke of Heat-Not-Burn Tobacco Product for HPLC Analysis. LCGC North America, pages 34-40.
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Doo Seok Kang, Hyun Soo Kim, Jong-Hyeon Jung, Cheol Min Lee, Yeon-Soon Ahn & Young Rok Seo. (2021) Formaldehyde exposure and leukemia risk: a comprehensive review and network-based toxicogenomic approach. Genes and Environment 43:1.
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Dragan Adamović, Zoran Čepić, Savka Adamović, Milena Stošić, Boris Obrovski, Slobodan Morača & Mirjana Vojinović Miloradov. (2021) Occupational Exposure to Formaldehyde and Cancer Risk Assessment in an Anatomy Laboratory. International Journal of Environmental Research and Public Health 18:21, pages 11198.
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George D. Leikauf. 2020. Environmental Toxicants. Environmental Toxicants 555 626 .
Kenneth A. Mundt, P. Robinan Gentry, Linda D. Dell, Joseph V. Rodricks & Paolo Boffetta. (2018) Six years after the NRC review of EPA's Draft IRIS Toxicological Review of Formaldehyde : Regulatory implications of new science in evaluating formaldehyde leukemogenicity. Regulatory Toxicology and Pharmacology 92, pages 472-490.
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Nathan H. Chen, Karrera Y. Djoko, Frédéric J. Veyrier & Alastair G. McEwan. (2016) Formaldehyde Stress Responses in Bacterial Pathogens. Frontiers in Microbiology 7.
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. 2016. Meyler's Side Effects of Drugs. Meyler's Side Effects of Drugs 437 443 .
Yali She, Yi Li, Yongqi Liu, Guli Asai, Shaobo Sun, Jianxin He, Zheng Pan & Yan Cui. (2013) Formaldehyde induces toxic effects and regulates the expression of damage response genes in BM-MSCs. Acta Biochimica et Biophysica Sinica 45:12, pages 1011-1020.
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Shigehisa Uchiyama, Takuya Tomizawa, Yohei Inaba & Naoki Kunugita. (2013) Simultaneous determination of volatile organic compounds and carbonyls in mainstream cigarette smoke using a sorbent cartridge followed by two-step elution. Journal of Chromatography A 1314, pages 31-37.
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Ibrahim Al-Adham, Randa Haddadin & Phillip Collier. 2013. Russell, Hugo & Ayliffe's. Russell, Hugo & Ayliffe's 5 70 .
Ioannis Polychronakis, George Dounias, Vasilios Makropoulos, Elena Riza & Athena Linos. (2013) Work-related leukemia: a systematic review. Journal of Occupational Medicine and Toxicology 8:1, pages 14.
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Lisa A. Bailey, Robyn L. Prueitt & Lorenz R. Rhomberg. (2012) Hypothesis-Based Weight-of-Evidence evaluation of methanol as a human carcinogen. Regulatory Toxicology and Pharmacology 62:2, pages 278-291.
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Bernard D Goldstein. (2010) Hematological and toxicological evaluation of formaldehyde as a potential cause of human leukemia. Human & Experimental Toxicology 30:7, pages 725-735.
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Shigehisa Uchiyama, Yohei Inaba & Naoki Kunugita. (2011) Derivatization of carbonyl compounds with 2,4-dinitrophenylhydrazine and their subsequent determination by high-performance liquid chromatography. Journal of Chromatography B 879:17-18, pages 1282-1289.
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Shigehisa Uchiyama, Yohei Inaba & Naoki Kunugita. (2011) A diffusive sampling device for simultaneous determination of ozone and carbonyls. Analytica Chimica Acta 691:1-2, pages 119-124.
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Kazushi OHTA, Shigehisa UCHIYAMA, Yohei INABA, Hideki NAKAGOME & Naoki KUNUGITA. (2011) Determination of Carbonyl Compounds Generated from the Electronic Cigarette Using Coupled Silica Cartridges Impregnated with Hydroquinone and 2,4-Dinitrophenylhydrazineハイドロキノンと2,4-ジニトロフェニルヒドラジンを含浸させた二連シリカカートリッジを用いる電子タバコから発生するカルボニル化合物の分析. BUNSEKI KAGAKU 60:10, pages 791-797.
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Harold I Zeliger. 2011. Human Toxicology of Chemical Mixtures. Human Toxicology of Chemical Mixtures 143 158 .
Gunnar Damgård Nielsen & Peder Wolkoff. (2010) Cancer effects of formaldehyde: a proposal for an indoor air guideline value. Archives of Toxicology 84:6, pages 423-446.
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Luoping Zhang, Xiaojiang Tang, Nathaniel Rothman, Roel Vermeulen, Zhiying Ji, Min Shen, Chuangyi Qiu, Weihong Guo, Songwang Liu, Boris Reiss, Laura Beane Freeman, Yichen Ge, Alan E. Hubbard, Ming Hua, Aaron Blair, Noe Galvan, Xiaolin Ruan, Blanche P. Alter, Kerry X. Xin, Senhua Li, Lee E. Moore, Sungkyoon Kim, Yuxuan Xie, Richard B. Hayes, Mariko Azuma, Michael Hauptmann, Jun Xiong, Patricia Stewart, Laiyu Li, Stephen M. Rappaport, Hanlin Huang, Joseph F. FraumeniJr.Jr., Martyn T. Smith & Qing Lan. (2010) Occupational Exposure to Formaldehyde, Hematotoxicity, and Leukemia-Specific Chromosome Changes in Cultured Myeloid Progenitor Cells. Cancer Epidemiology, Biomarkers & Prevention 19:1, pages 80-88.
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. 2010. Meyler's Side Effects of Antimicrobial Drugs. Meyler's Side Effects of Antimicrobial Drugs 1085 1134 .
Susan C. Lester. 2010. Manual of Surgical Pathology. Manual of Surgical Pathology 9 27 .
Günter Speit, Jasmin Zeller, Oliver Schmid, Azeddine Elhajouji, Lan Ma-Hock & Simone Neuss. (2009) Inhalation of formaldehyde does not induce systemic genotoxic effects in rats. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 677:1-2, pages 76-85.
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Luoping Zhang, Craig Steinmaus, David A. Eastmond, Xianjun K. Xin & Martyn T. Smith. (2009) Formaldehyde exposure and leukemia: A new meta-analysis and potential mechanisms. Mutation Research/Reviews in Mutation Research 681:2-3, pages 150-168.
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P. Magee. 2009. 409 412 .
Takayuki Shibamoto. 2008. Process‐Induced Food Toxicants. Process‐Induced Food Toxicants 51 73 .
Solange Costa, Patrícia Coelho, Carla Costa, Susana Silva, Olga Mayan, Luís Silva Santos, Jorge Gaspar & João Paulo Teixeira. (2008) Genotoxic damage in pathology anatomy laboratory workers exposed to formaldehyde. Toxicology 252:1-3, pages 40-48.
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Inesa Levovich, Abraham Nudelman, Gili Berkovitch, Lonnie P. Swift, Suzanne M. Cutts, Don R. Phillips & Ada Rephaeli. (2007) Formaldehyde-releasing prodrugs specifically affect cancer cells by depletion of intracellular glutathione and augmentation of reactive oxygen species. Cancer Chemotherapy and Pharmacology 62:3, pages 471-482.
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David Pyatt, Ethan Natelson & Robert Golden. (2008) Is inhalation exposure to formaldehyde a biologically plausible cause of lymphohematopoietic malignancies?. Regulatory Toxicology and Pharmacology 51:1, pages 119-133.
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S. Neuss & G. Speit. (2008) Further characterization of the genotoxicity of formaldehyde in vitro by the sister chromatid exchange test and co-cultivation experiments. Mutagenesis 23:5, pages 355-357.
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Harold I. Zeliger. 2008. Human Toxicology of Chemical Mixtures. Human Toxicology of Chemical Mixtures 175 195 .
Petter Kristensen, Bjørn Hilt, Kristin Svendsen & Tom K. Grimsrud. (2007) Incidence of lymphohaematopoietic cancer at a university laboratory: a cluster investigation. European Journal of Epidemiology 23:1, pages 11-15.
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Jerrold M. Ward. (2007) The Two-Year Rodent Carcinogenesis Bioassay - Will It Survive?. Journal of Toxicologic Pathology 20:1, pages 13-19.
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Günter Speit. (2006) The Implausibility of Systemic Genotoxic Effects Measured by the Comet Assay in Rats Exposed to Formaldehyde. Journal of Proteome Research 5:10, pages 2523-2524.
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