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Research Article

Differential Effects of Histone Deacetylase Inhibitors in Tumor and Normal Cells—What Is the Toxicological Relevance?

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Pages 363-378 | Published online: 10 Oct 2008

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Mathieu Vinken, Peggy Papeleu, Sarah Snykers, Evelien De Rop, Tom Henkens, James Kevin Chipman, Vera Rogiers & Tamara Vanhaecke. (2006) Involvement of Cell Junctions in Hepatocyte Culture Functionality. Critical Reviews in Toxicology 36:4, pages 299-318.
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M. Lemper, S. Snykers, T. Vanhaecke, K. De Paepe & V. Rogiers. (2014) Current Status of Healthy Human Skin Models: Can Histone Deacetylase Inhibitors Potentially Improve the Present Replacement Models?. Skin Pharmacology and Physiology 27:1, pages 36-46.
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Y.-L. Chung, M.-Y. Lee & N. N.M. Pui. (2009) Epigenetic therapy using the histone deacetylase inhibitor for increasing therapeutic gain in oral cancer: prevention of radiation-induced oral mucositis and inhibition of chemical-induced oral carcinogenesis. Carcinogenesis 30:8, pages 1387-1397.
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Tom Henkens, Mathieu Vinken, Aneta Lukaszuk, Dirk Tourwé, Tamara Vanhaecke & Vera Rogiers. (2008) Differential effects of hydroxamate histone deacetylase inhibitors on cellular functionality and gap junctions in primary cultures of mitogen-stimulated hepatocytes. Toxicology Letters 178:1, pages 37-43.
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Won-Jun Lee. (2007) Effects of Histone Deacetylase Inhibitor, Trichostatin A, on the Differentiation of C2C12 Myoblasts and the Expression of Cell Cycle Regulators. Journal of Life Science 17:7, pages 976-982.
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L. David Wise, Katie J. Turner & Janet S. Kerr. (2007) Assessment of developmental toxicity of vorinostat, a histone deacetylase inhibitor, in Sprague‐Dawley rats and Dutch Belted rabbits. Birth Defects Research Part B: Developmental and Reproductive Toxicology 80:1, pages 57-68.
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Nichole Boyer Arnold, Nohea Arkus, Jason Gunn & Murray Korc. (2007) The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Growth Inhibition and Enhances Gemcitabine-Induced Cell Death in Pancreatic Cancer. Clinical Cancer Research 13:1, pages 18-26.
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. (2005) Modulacon of Cell Cycle Control by Histone Deacetylase Inhibitor Trichostatin A in A549 Human Non-small Cell Lung Cancer Cells. Journal of Life Science 15:5, pages 726-733.
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