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Research Article

Mode of Action: Developmental Thyroid Hormone Insufficiency—Neurological Abnormalities Resulting From Exposure to Propylthiouracil

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Pages 771-781 | Published online: 10 Oct 2008

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M. Sue Marty, Ursula G. Sauer, Alex Charlton, Rashin Ghaffari, Davy Guignard, Nina Hallmark, Bethany R. Hannas, Sylvia Jacobi, Heike-Antje Marxfeld, Stephanie Melching-Kollmuss, Larry P. Sheets, Daniel Urbisch, Philip A. Botham & Bennard van Ravenzwaay. (2022) Towards a science-based testing strategy to identify maternal thyroid hormone imbalance and neurodevelopmental effects in the progeny—part III: how is substance-mediated thyroid hormone imbalance in pregnant/lactating rats or their progeny related to neurodevelopmental effects?. Critical Reviews in Toxicology 52:7, pages 546-617.
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Larry P. Sheets & William SlikkerJr.Jr.. 2018. Handbook of Developmental Neurotoxicology. Handbook of Developmental Neurotoxicology 527 538 .
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
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Crossref
R.G. Ahmed & S. Incerpi. (2012) Gestational doxorubicin alters fetal thyroid–brain axis. International Journal of Developmental Neuroscience 31:2, pages 96-104.
Crossref
Hong‐Mei Zhang, Ning Lin, Yan Dong, Qing Su & Min Luo. (2012) Protein kinase cα is involved in impaired perinatal hypothyroid rat brain development. Journal of Neuroscience Research 91:2, pages 211-219.
Crossref
Alexandre Pastoris MüLlerAline LongoniMarcelo Farina, Clarice K B Da SilveiraDiogo Onofre SouzaMarcos Luiz Santos PerryAdriano Martimbianco De Assis. (2013) Propylthiouracil-induced hypothyroidism during lactation alters leucine and mannose metabolism in rat cerebellar slices. Experimental Biology and Medicine 238:1, pages 31-36.
Crossref
Shravani Bhanja & Srikanta Jena. (2012) Modulation of Antioxidant Enzyme Expression by PTU-Induced Hypothyroidism in Cerebral Cortex of Postnatal Rat Brain. Neurochemical Research 38:1, pages 42-49.
Crossref
Kevin M. Crofton, William R. Mundy & Timothy J. Shafer. (2012) Developmental neurotoxicity testing: A path forward. Congenital Anomalies 52:3, pages 140-146.
Crossref
T.Ø. Bechshøft, C. Sonne, R. Dietz, E.W. Born, D.C.G. Muir, R.J. Letcher, M.A. Novak, E. Henchey, J.S. Meyer, B.M. Jenssen & G.D. Villanger. (2012) Associations between complex OHC mixtures and thyroid and cortisol hormone levels in East Greenland polar bears. Environmental Research 116, pages 26-35.
Crossref
Fred Parham, Amber Wise, Daniel A. Axelrad, Kathryn Z. Guyton, Christopher Portier, Lauren Zeise, R. Thomas Zoeller & Tracey J. Woodruff. (2012) Adverse effects in risk assessment: Modeling polychlorinated biphenyls and thyroid hormone disruption outcomes in animals and humans. Environmental Research 116, pages 74-84.
Crossref
Gennaro Giordano & Lucio G. Costa. (2012) Developmental Neurotoxicity: Some Old and New Issues. ISRN Toxicology 2012, pages 1-12.
Crossref
Goutam Chakraborty, Alejandra Magagna-Poveda, Carolyn Parratt, Jason G. Umans, Neil J. MacLusky & Helen E. Scharfman. (2012) Reduced Hippocampal Brain-Derived Neurotrophic Factor (BDNF) in Neonatal Rats after Prenatal Exposure to Propylthiouracil (PTU). Endocrinology 153:3, pages 1311-1316.
Crossref
In Youb Chang, Takbum Ohn, Gil Seok Ko, Young Yoon, Jung Woo Kim & Sang Pil Yoon. (2012) Immunolocalization of steroidogenic acute regulatory protein-related lipid transfer (START) domain-containing proteins in the developing cerebellum of normal and hypothyroid rats. Journal of Chemical Neuroanatomy 43:1, pages 28-33.
Crossref
Edison S.M. Carvalho, Juan Fuentes & Deborah M. Power. (2011) Integument structure and function in juvenile Xenopus laevis with disrupted thyroid balance. General and Comparative Endocrinology 174:3, pages 301-308.
Crossref
Tracey J. Woodruff. (2011) Bridging epidemiology and model organisms to increase understanding of endocrine disrupting chemicals and human health effects. The Journal of Steroid Biochemistry and Molecular Biology 127:1-2, pages 108-117.
Crossref
Milou M.L. Dingemans, Martin van den Berg & Remco H.S. Westerink. (2011) Neurotoxicity of Brominated Flame Retardants: (In)direct Effects of Parent and Hydroxylated Polybrominated Diphenyl Ethers on the (Developing) Nervous System. Environmental Health Perspectives 119:7, pages 900-907.
Crossref
G.D. Villanger, C. Lydersen, K.M. Kovacs, E. Lie, J.U. Skaare & B.M. Jenssen. (2011) Disruptive effects of persistent organohalogen contaminants on thyroid function in white whales (Delphinapterus leucas) from Svalbard. Science of The Total Environment 409:13, pages 2511-2524.
Crossref
Gro D. Villanger, Bjørn M. Jenssen, Rita R. Fjeldberg, Robert J. Letcher, Derek C.G. Muir, Maja Kirkegaard, Christian Sonne & Rune Dietz. (2011) Exposure to mixtures of organohalogen contaminants and associative interactions with thyroid hormones in East Greenland polar bears (Ursus maritimus). Environment International 37:4, pages 694-708.
Crossref
Marta Axelstad, Julie Boberg, Karin Sørig Hougaard, Sofie Christiansen, Pernille Rosenskjold Jacobsen, Karen Riiber Mandrup, Christine Nellemann, Søren Peter Lund & Ulla Hass. (2011) Effects of pre- and postnatal exposure to the UV-filter Octyl Methoxycinnamate (OMC) on the reproductive, auditory and neurological development of rat offspring. Toxicology and Applied Pharmacology 250:3, pages 278-290.
Crossref
Robert F. Berman, Claire M. Koenig, Michael R. Hunsaker, Isaac N. Pessah & Janine M. Lasalle. 2011. Developmental Neurotoxicology Research. Developmental Neurotoxicology Research 439 476 .
Lucio G. Costa & Gennaro Giordano. (2011) Is decabromodiphenyl ether (BDE-209) a developmental neurotoxicant?. NeuroToxicology 32:1, pages 9-24.
Crossref
M. Fernández, M. Paradisi, G. D’Intino, G. Del Vecchio, S. Sivilia, L. Giardino & L. Calzà. (2010) A single prenatal exposure to the endocrine disruptor 2,3,7,8-tetrachlorodibenzo-p-dioxin alters developmental myelination and remyelination potential in the rat brain. Journal of Neurochemistry 115:4, pages 897-909.
Crossref
A.M. El‐bakry, A.W. El‐Gareib & R.G. Ahmed. (2010) Comparative study of the effects of experimentally induced hypothyroidism and hyperthyroidism in some brain regions in albino rats. International Journal of Developmental Neuroscience 28:5, pages 371-389.
Crossref
S. Bhanja & G.B.N. Chainy. (2010) PTU‐induced hypothyroidism modulates antioxidant defence status in the developing cerebellum. International Journal of Developmental Neuroscience 28:3, pages 251-262.
Crossref
Timm Schreiber, Kathrin Gassmann, Christine Götz, Ulrike Hübenthal, Michaela Moors, Guido Krause, Hans F. Merk, Ngoc-Ha Nguyen, Thomas S. Scanlan, Josef Abel, Christine R. Rose & Ellen Fritsche. (2010) Polybrominated Diphenyl Ethers Induce Developmental Neurotoxicity in a Human in Vitro Model: Evidence for Endocrine Disruption . Environmental Health Perspectives 118:4, pages 572-578.
Crossref
Mark D. Miller, Kevin M. Crofton, Deborah C. Rice & R. Thomas Zoeller. (2009) Thyroid-Disrupting Chemicals: Interpreting Upstream Biomarkers of Adverse Outcomes. Environmental Health Perspectives 117:7, pages 1033-1041.
Crossref
N. Van Wijk, E. Rijntjes & B. J. M. Van De Heijning. (2008) Perinatal and chronic hypothyroidism impair behavioural development in male and female rats. Experimental Physiology 93:11, pages 1199-1209.
Crossref
Andrew K. Hotchkiss, Cynthia V. Rider, Chad R. Blystone, Vickie S. Wilson, Phillip C. Hartig, Gerald T. Ankley, Paul M. Foster, Clark L. Gray & L. Earl Gray. (2008) Fifteen Years after “Wingspread”—Environmental Endocrine Disrupters and Human and Wildlife Health: Where We are Today and Where We Need to Go. Toxicological Sciences 105:2, pages 235-259.
Crossref
Marta Axelstad, Pernille Reimar Hansen, Julie Boberg, Mia Bonnichsen, Christine Nellemann, Søren Peter Lund, Karin Sørig Hougaard & Ulla Hass. (2008) Developmental neurotoxicity of Propylthiouracil (PTU) in rats: Relationship between transient hypothyroxinemia during development and long-lasting behavioural and functional changes. Toxicology and Applied Pharmacology 232:1, pages 1-13.
Crossref
David S. Sharlin, Daniel Tighe, Mary E. Gilbert & R. Thomas Zoeller. (2008) The Balance between Oligodendrocyte and Astrocyte Production in Major White Matter Tracts Is Linearly Related to Serum Total Thyroxine. Endocrinology 149:5, pages 2527-2536.
Crossref
Kevin M. Crofton. (2008) Thyroid disrupting chemicals: mechanisms and mixtures. International Journal of Andrology 31:2, pages 209-223.
Crossref
Ariane Zamoner, Carine Royer, Kátia Padilha Barreto, Regina Pessoa-Pureur & Fátima Regina Mena Barreto Silva. (2007) Ionic involvement and kinase activity on the mechanism of nongenomic action of thyroid hormones on 45Ca2+ uptake in cerebral cortex from young rats. Neuroscience Research 57:1, pages 98-103.
Crossref
Ulla Hass. (2006) The need for developmental neurotoxicity studies in risk assessment for developmental toxicity. Reproductive Toxicology 22:2, pages 148-156.
Crossref

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