825
Views
76
CrossRef citations to date
0
Altmetric
Review Article

A comparison of rat chronic progressive nephropathy with human renal disease—implications for human risk assessment

, &
Pages 332-346 | Received 02 May 2008, Accepted 25 Jul 2008, Published online: 01 Apr 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (10)

Samuel M. Cohen, Christopher Bevan, Bhaskar Gollapudi & James E. Klaunig. (2023) Evaluation of the carcinogenicity of carbon tetrachloride. Journal of Toxicology and Environmental Health, Part B 26:6, pages 342-370.
Read now
Lisa M. Sweeney, Janet E. Kester, Christopher R. Kirman, P. Robinan Gentry, Marcy I. Banton, James S. Bus & Michael L. Gargas. (2015) Risk assessments for chronic exposure of children and prospective parents to ethylbenzene (CAS No. 100-41-4). Critical Reviews in Toxicology 45:8, pages 662-726.
Read now
James S. Bus, Marcy I. Banton, Willem D. Faber, Christopher R. Kirman, Douglas B. McGregor & Daniel B. Pourreau. (2015) Human health screening level risk assessments of tertiary-butyl acetate (TBAC): Calculated acute and chronic reference concentration (RfC) and Hazard Quotient (HQ) values based on toxicity and exposure scenario evaluations. Critical Reviews in Toxicology 45:2, pages 142-171.
Read now
Andrew Bartholomaeus, Wayne Parrott, Genevieve Bondy & Kate Walker. (2013) The use of whole food animal studies in the safety assessment of genetically modified crops: Limitations and recommendations. Critical Reviews in Toxicology 43:sup2, pages 1-24.
Read now
Yongzhen Liu, Hao Wang, Yumei Cheng, Jingjun Sun, Junwen Qiao, Henglei Lu, Liang Zhu, Likun Gong & Jin Ren. (2013) A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats. Drug and Chemical Toxicology 36:4, pages 443-450.
Read now
Ronald L Melnick, Jerrold M Ward & James Huff. (2013) War on Carcinogens: Industry Disputes Human Relevance of Chemicals Causing Cancer in Laboratory Animals Based on Unproven Hypotheses, Using Kidney Tumors as an Example. International Journal of Occupational and Environmental Health 19:4, pages 255-260.
Read now
Jeff R. Fowles, Marcy I. Banton & Lynn H. Pottenger. (2013) A toxicological review of the propylene glycols. Critical Reviews in Toxicology 43:4, pages 363-390.
Read now
Andrea Trevisan, Annamaria Nicolli & Federica Chiara. (2010) Are rats the appropriate experimental model to understand age-related renal drug metabolism and toxicity?. Expert Opinion on Drug Metabolism & Toxicology 6:12, pages 1451-1459.
Read now
Douglas McGregor. (2010) Tertiary-Butanol: A toxicological review. Critical Reviews in Toxicology 40:8, pages 697-727.
Read now

Articles from other publishers (66)

Marcy I. Banton. 2024. Encyclopedia of Toxicology. Encyclopedia of Toxicology 457 465 .
Lyle D. Burgoon, Christopher J. Borgert, Claudio Fuentes & James E. Klaunig. (2023) Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene. Archives of Toxicology.
Crossref
Alex A. Gutsol, Taben M. Hale, Jean-Francois Thibodeau, Chet E. Holterman, Rania Nasrallah, Jose W. N. Correa, Rhian M. Touyz, Chris R. J. Kennedy, Dylan Burger, Richard L. Hébert & Kevin D. Burns. (2023) Comparative Analysis of Hypertensive Tubulopathy in Animal Models of Hypertension and Its Relevance to Human Pathology. Toxicologic Pathology 51:4, pages 160-175.
Crossref
Ji-Young Lee, Hyo-Jeong Han, Soo Min Ko, Da Som Jeong, Jiyeon Kang, Dong Hyun Lee, Hwa Jun Cha & Woo-Chan Son. (2023) Evaluation of the 52-week chronic toxicity of a novel phthalate-free plasticizer, Eco-DEHCH (bis(2-ethylhexyl) cyclohexane-1,4-dicarboxylate), in Han Wistar rats. Food and Chemical Toxicology, pages 113809.
Crossref
Jeanne M. Davidsen, Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Thomas J. Rosol, Christie L. Harman & Sean V. Taylor. (2023) FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes. Food and Chemical Toxicology 175, pages 113646.
Crossref
Shuyi Gu, Gaosong Wu, Dong Lu, Guofeng Meng, Yu Wang, Liming Tang & Weidong Zhang. (2023) Nephrotoxicity assessment of Esculentoside A using human‐induced pluripotent stem cell‐derived organoids. Phytotherapy Research.
Crossref
Klaudia M. Maksymiuk, Mateusz Szudzik, Marta Gawryś-Kopczyńska, Maksymilian Onyszkiewicz, Emilia Samborowska, Izabella Mogilnicka & Marcin Ufnal. (2022) Trimethylamine, a gut bacteria metabolite and air pollutant, increases blood pressure and markers of kidney damage including proteinuria and KIM-1 in rats. Journal of Translational Medicine 20:1.
Crossref
Dusanka Milenkovic, Adrián Sanz-Moreno, Julia Calzada-Wack, Birgit Rathkolb, Oana Veronica Amarie, Raffaele Gerlini, Antonio Aguilar-Pimentel, Jelena Misic, Marie-Lune Simard, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis & Nils-Göran Larsson. (2022) Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction. PLOS Genetics 18:5, pages e1010190.
Crossref
Melvin E. Andersen. (2022) Assessing modes of action, measures of tissue dose and human relevance of rodent toxicity endpoints with octamethylcyclotetrasiloxane (D4). Toxicology Letters 357, pages 57-72.
Crossref
Gordon C Hard. (2022) Confounders for kidney carcinogenesis in rodent cancer bioassays. Journal of Toxicologic Pathology 35:1, pages 1-6.
Crossref
Peter J.M. Clements, Brad Bolon, Elizabeth McInnes, Sydney Mukaratirwa & Cheryl Scudamore. 2022. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 653 694 .
Patrik Andersson. 2022. Antisense RNA Design, Delivery, and Analysis. Antisense RNA Design, Delivery, and Analysis 355 370 .
Stuart J. Shankland, Yuliang Wang, Andrey S. Shaw, Joshua C. Vaughan, Jeffrey W. Pippin & Oliver Wessely. (2021) Podocyte Aging: Why and How Getting Old Matters. Journal of the American Society of Nephrology 32:11, pages 2697-2713.
Crossref
Pratibha Mistry, Elizabeth F. McInnes, Carol Beevers, Douglas Wolf, Richard A. Currie, Rejin Salimraj & Paul Parsons. (2021) An evaluation of carcinogenicity predictors from short-term and sub chronic repeat-dose studies of agrochemicals in rats: Opportunities to refine and reduce animal use. Toxicology Letters 351, pages 18-27.
Crossref
. (2021) Methoxytridecafluoroheptene isomers (MPHE). Toxicology and Industrial Health 37:8, pages 451-457.
Crossref
Martha A. Delaney, Denise M. Imai & Rochelle Buffenstein. 2021. The Extraordinary Biology of the Naked Mole-Rat. The Extraordinary Biology of the Naked Mole-Rat 353 380 .
Liqiang Li, Cong Wang & Yongquan Gu. (2020) Collagen IV, a promising serum biomarker for evaluating the prognosis of revascularization in a 2-kidney, 1-clip hypertensive rat model. Interactive CardioVascular and Thoracic Surgery 30:3, pages 483-490.
Crossref
Despina Komninou, Virginia L. Malloy, Jay A. Zimmerman, Raghu Sinha & John P. RichieJrJr. (2019) Methionine restriction delays aging-related urogenital diseases in male Fischer 344 rats. GeroScience 42:1, pages 287-297.
Crossref
Maria Bastaki, Anne Marie Api, Michel Aubanel, Mark Bauter, Thierry Cachet, Jan C.R. Demyttenaere, Maodo Malick Diop, Christie L. Harman, Shim-mo Hayashi, Gerhard Krammer, Vivian Lu, Palma Ann Marone, Odete Mendes, Kevin J. Renskers, Jürgen Schnabel, Sai Yee Tsang & Sean V. Taylor. (2020) Dietary administration of β-caryophyllene and its epoxide to Sprague-Dawley rats for 90 days. Food and Chemical Toxicology 135, pages 110876.
Crossref
Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Maria Bastaki, Jeanne M. Davidsen, Christie L. Harman, Margaret M. McGowen & Sean V. Taylor. (2020) FEMA GRAS assessment of natural flavor complexes: Mint, buchu, dill and caraway derived flavoring ingredients. Food and Chemical Toxicology 135, pages 110870.
Crossref
Wolfgang Dekant. (2019) Tetrahydrofuran-induced tumors in rodents are not relevant to humans: Quantitative weight of evidence analysis of mode of action information does not support classification of tetrahydrofuran as a possible human carcinogen. Regulatory Toxicology and Pharmacology 109, pages 104499.
Crossref
Leslie A. Obert & Kendall S. Frazier. (2019) Intrarenal Renin–Angiotensin System Involvement in the Pathogenesis of Chronic Progressive Nephropathy—Bridging the Informational Gap Between Disciplines. Toxicologic Pathology 47:7, pages 799-816.
Crossref
Mu-Jin Lee, Ho-Kyung Jung, Ki-Ho Lee, Ji-Hun Jang, Mi-Ok Sim, Tea-Gyeong Seong, Byung-Kwan Ahn, Jin-Han Shon, Seong-Ho Ham, Hyun-Woo Cho, Yong-Min Kim, Sung-Jin Park, Ji-Young Yoon, Je-Won Ko & Jong-Choon Kim. (2019) A 90-Day Repeated Oral Dose Toxicity Study of Alismatis Rhizoma Aqueous Extract in Rats . Toxicological Research 35:2, pages 191-200.
Crossref
Gordon C. Hard, Samuel M. Cohen, Jihyun Ma, Fang Yu, Lora L. Arnold & Marcy I. Banton. (2019) Histopathology re-examination of the NTP toxicity/carcinogenicity studies of tert-butyl alcohol to identify renal tumor and toxicity modes of action. Regulatory Toxicology and Pharmacology 102, pages 65-73.
Crossref
Samuel M. Cohen, Gerhard Eisenbrand, Shoji Fukushima, Nigel J. Gooderham, F. Peter Guengerich, Stephen S. Hecht, Ivonne M.C.M. Rietjens, Maria Bastaki, Jeanne M. Davidsen, Christie L. Harman, Margaret McGowen & Sean V. Taylor. (2019) FEMA GRAS assessment of natural flavor complexes: Citrus-derived flavoring ingredients. Food and Chemical Toxicology 124, pages 192-218.
Crossref
Gordon C. Hard. (2018) Mechanisms of Rodent Renal Carcinogenesis Revisited. Toxicologic Pathology 46:8, pages 956-969.
Crossref
Maria Bastaki, Michel Aubanel, Mark Bauter, Thierry Cachet, Jan Demyttenaere, Maodo Malick Diop, Christie L. Harman, Shim-mo Hayashi, Gerhard Krammer, Xiaodong Li, Craig Llewellyn, Odete Mendes, Kevin J. Renskers, Jürgen Schnabel, Benjamin P.C. Smith & Sean V. Taylor. (2018) Absence of renal adverse effects from β-myrcene dietary administration in OECD guideline-compliant subchronic toxicity study. Food and Chemical Toxicology 120, pages 222-229.
Crossref
Nathália P. Souza, Gordon C. Hard, Lora L. Arnold, Kirk W. Foster, Karen L. Pennington & Samuel M. Cohen. (2018) Epithelium Lining Rat Renal Papilla: Nomenclature and Association with Chronic Progressive Nephropathy (CPN). Toxicologic Pathology 46:3, pages 266-272.
Crossref
Zhiyong Qian, JoAnna Bultman, Sabitha Papineni, Ning He, Lisa Lanigan, Rod A. Herman & Gordon C. Hard. (2018) Safety evaluation of DAS-44406-6 soybeans in Wistar rats. Regulatory Toxicology and Pharmacology 92, pages 152-164.
Crossref
Brendan T. Bowman & Emaad M. Abdel-Rahman. 2018. Conn's Handbook of Models for Human Aging. Conn's Handbook of Models for Human Aging 863 871 .
Wolfgang Dekant, Anthony R. Scialli, Kathy Plotzke & James E. Klaunig. (2017) Biological relevance of effects following chronic administration of octamethylcyclotetrasiloxane (D4) in Fischer 344 rats. Toxicology Letters 279, pages 42-53.
Crossref
Roland Schmitt & Anette Melk. (2017) Molecular mechanisms of renal aging. Kidney International 92:3, pages 569-579.
Crossref
Susan J. Borghoff, Caroline Ring, Marcy I. Banton & Teresa L. Leavens. (2017) Physiologically based pharmacokinetic model for ethyl tertiary -butyl ether and tertiary -butyl alcohol in rats: Contribution of binding to α2u-globulin in male rats and high-exposure nonlinear kinetics to toxicity and cancer outcomes . Journal of Applied Toxicology 37:5, pages 621-640.
Crossref
Catherine A. Picut. 2017. Immunopathology in Toxicology and Drug Development. Immunopathology in Toxicology and Drug Development 221 327 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 18 .
Prashant R. Nambiar, Daniel Morton, Leland Wayne Dochterman, Christopher Houle, Peter J. Thomford, Gwendolyn Fate, Steven A. Bailey & Gregory L. Finch. (2014) Two-year Carcinogenicity Study in Rats with a Nonnucleoside Reverse Transcriptase Inhibitor. Toxicologic Pathology 43:3, pages 354-365.
Crossref
Keith D. Salazar. 2015. Hamilton & Hardy's Industrial Toxicology. Hamilton & Hardy's Industrial Toxicology 651 656 .
Scott S. Auerbach & B. Alex Merrick. 2015. Mammalian Toxicology. Mammalian Toxicology 49 73 .
Mariano Gastón Portillo, Fiorella Carla Tesán, Marcela Beatriz Zubillaga & María Jimena Salgueiro. (2015) Modificación cualicuantitativa de estudios dinámicos renales por interacción con medios de contraste iodado. Imagen Diagnóstica 6:1, pages 18-23.
Crossref
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 16 .
Richard H. McKee, David Steup, Ceinwen Schreiner, Paula Podhasky, Linda A. Malley & Linda Roberts. (2013) Toxicological Assessment of Heavy Straight Run Naphtha in a Repeated Dose/Reproductive Toxicity Screening Test. International Journal of Toxicology 33:1_suppl, pages 52S-67S.
Crossref
M. Banton. 2014. Encyclopedia of Toxicology. Encyclopedia of Toxicology 516 518 .
Rick Perry, Carol A. Thompson, J. Nicole Earnhardt, David J. Wright, Steven Bailey, Barry Komm & Mark A. Cukierski. (2013) Renal Tumors in Male Rats Following Long-term Administration of Bazedoxifene, a Tissue-selective Estrogen Receptor Modulator. Toxicologic Pathology 41:7, pages 1001-1010.
Crossref
M. A. DelaneyL. NagyM. J. Kinsel & P. M. Treuting. (2013) Spontaneous Histologic Lesions of the Adult Naked Mole Rat ( Heterocephalus glaber ) . Veterinary Pathology 50:4, pages 607-621.
Crossref
Darol Dodd, Gabrielle Willson, Horace Parkinson & Edilberto Bermudez. (2011) Two‐year drinking water carcinogenicity study of methyl tertiary‐butyl ether (MTBE) in Wistar rats. Journal of Applied Toxicology 33:7, pages 593-606.
Crossref
Seo-Ho Shin, Kyo-Hwan Koo, Jin-Sook Bae, Seung-Bum Cha, In-Soo Kang, Min-Soo Kang, Hak-Soo Kim, Hyun-Suk Heo, Min-Su Park, Gi-Hyun Gil, Joo-Young Lee, Kap-Ho Kim, Yinghua Li, Hyun-Kul Lee, Si-Whan Song, Han-Seok Choi, Boo-Hyon Kang & Jong-Choon Kim. (2013) Single and 90-day repeated oral dose toxicity studies of fermented Rhus verniciflua stem bark extract in Sprague–Dawley rats. Food and Chemical Toxicology 55, pages 617-626.
Crossref
Sherry J. Morgan, Chandikumar S. Elangbam, Shawn Berens, Evan Janovitz, Allison Vitsky, Tanja Zabka & Laura Conour. (2012) Use of Animal Models of Human Disease for Nonclinical Safety Assessment of Novel Pharmaceuticals. Toxicologic Pathology 41:3, pages 508-518.
Crossref
Gordon C. Hard, Marcy I. Banton, Robert S. Bretzlaff, Wolfgang Dekant, Jefferson R. Fowles, Anthony K. Mallett, Douglas B. McGregor, Kathleen M. Roberts, Robert L. SielkenJrJr, Ciriaco Valdez-Flores & Samuel M. Cohen. (2013) Consideration of Rat Chronic Progressive Nephropathy in Regulatory Evaluations for Carcinogenicity. Toxicological Sciences 132:2, pages 268-275.
Crossref
Kanwar Nasir M. Khan, Gordon C. Hard & Carl L. Alden. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 1667 1773 .
Ricardo Ochoa & Robert C. Sills. 2013. Haschek and Rousseaux's Handbook of Toxicologic Pathology. Haschek and Rousseaux's Handbook of Toxicologic Pathology 1009 1025 .
Sandeep Kadekar, Shyamal Peddada, Ilona Silins, John E. French, Johan Högberg & Ulla Stenius. (2012) Gender Differences in Chemical Carcinogenesis in National Toxicology Program 2-Year Bioassays. Toxicologic Pathology 40:8, pages 1160-1168.
Crossref
K. Isobe, K. Adachi, S. Hayashi, T. Ito, A. Miyoshi, A. Kato & M. Suzuki. (2011) Spontaneous Glomerular and Tubulointerstitial Lesions in Common Marmosets ( Callithrix jacchus ) . Veterinary Pathology 49:5, pages 839-845.
Crossref
Edilberto Bermudez, Gabrielle Willson, Horace Parkinson & Darol Dodd. (2012) Toxicity of methyl tertiary-butyl ether (MTBE) following exposure of Wistar Rats for 13 weeks or one year via drinking water. Journal of Applied Toxicology 32:9, pages 687-706.
Crossref
Ronald L. Melnick, Kathleen M Burns, Jerrold M. Ward & James Huff. (2012) Chemically Exacerbated Chronic Progressive Nephropathy Not Associated with Renal Tubular Tumor Induction in Rats: An Evaluation Based on 60 Carcinogenicity Studies by the National Toxicology Program. Toxicological Sciences 128:2, pages 346-356.
Crossref
Elsa Nielsen, Pia Nørhede, Julie Boberg, Louise Krag Isling, Stine Kroghsbo, Niels Hadrup, Lea Bredsdorff, Alicja Mortensen & John Christian Larsen. (2012) Identification of Cumulative Assessment Groups of Pesticides. EFSA Supporting Publications 9:4.
Crossref
Gordon C. Hard, Laura J. Betz & John Curtis Seely. (2012) Association of Advanced Chronic Progressive Nephropathy (CPN) with Renal Tubule Tumors and Precursor Hyperplasia in Control F344 Rats from Two-Year Carcinogenicity Studies. Toxicologic Pathology 40:3, pages 473-481.
Crossref
Yuval Ramot, Moti Rosenstock, Ety Klinger, Dizza Bursztyn, Abraham Nyska & Doron M. Shinar. (2011) Comparative Long-Term Preclinical Safety Evaluation of Two Glatiramoid Compounds (Glatiramer Acetate, Copaxone®, and TV-5010, Protiramer) in Rats and Monkeys. Toxicologic Pathology 40:1, pages 40-54.
Crossref
Peter Greaves. 2012. Histopathology of Preclinical Toxicity Studies. Histopathology of Preclinical Toxicity Studies 537 614 .
T.B. Adams, C. Lucas Gavin, M.M. McGowen, W.J. Waddell, S.M. Cohen, V.J. Feron, L.J. Marnett, I.C. Munro, P.S. Portoghese, I.M.C.M. Rietjens & R.L. Smith. (2011) The FEMA GRAS assessment of aliphatic and aromatic terpene hydrocarbons used as flavor ingredients. Food and Chemical Toxicology 49:10, pages 2471-2494.
Crossref
Gordon C. Hard, Richard H. Bruner, Samuel M. Cohen, John M. Pletcher & Karen S. Regan. (2011) Renal histopathology in toxicity and carcinogenicity studies with tert-butyl alcohol administered in drinking water to F344 rats: A pathology working group review and re-evaluation. Regulatory Toxicology and Pharmacology 59:3, pages 430-436.
Crossref
Greg S. Travlos, Gordon C. Hard, Laura J. Betz & Grace E. Kissling. (2011) Chronic Progressive Nephropathy in Male F344 Rats in 90-Day Toxicity Studies. Toxicologic Pathology 39:2, pages 381-389.
Crossref
Shakil A. Saghir, Fagen Zhang, David L. Rick, Lynn Kan, James S. Bus & Michael J. Bartels. (2010) Authors response to Huff et al., “Clarifying carcinogenicity of ethylbenzene”. Regulatory Toxicology and Pharmacology 58:2, pages 170-172.
Crossref
Richard H. Bruner, Peter Greaves, Gordon C. Hard, Karen S. Regan, Jerrold M. Ward & Raymond M. David. (2010) Histopathologic changes in the kidneys of male F344 rats from a 2-year inhalation carcinogenicity study of tetrahydrofuran: A pathology working group review and re-evaluation. Regulatory Toxicology and Pharmacology 58:1, pages 100-105.
Crossref
Edward A. Lock & Gordon C. Hard. 2010. Cancer Risk Assessment. Cancer Risk Assessment 482 500 .
Edoardo Zanetti, Arianna Chiusolo, Rossella Defazio, Alessandro Casartelli, Eleonora Cappelletti, Nicola Bocchini, Federica Chiara, Patrizia Cristofori & Andrea Trevisan. (2009) Evaluation of aging influence on renal toxicity caused by segment‐specific nephrotoxicants of the proximal tubule in rat†. Journal of Applied Toxicology 30:2, pages 142-150.
Crossref
Alan R. Boobis, Samuel M. Cohen, Nancy G. Doerrer, Sheila M. Galloway, Patrick J. Haley, Gordon C. Hard, Frederick G. Hess, James S. Macdonald, Stéphane Thibault, Douglas C. Wolf & Jayne Wright. (2009) A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards. Toxicologic Pathology 37:6, pages 714-732.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.