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Review Articles

Glyphosate in the general population and in applicators: a critical review of studies on exposures

Pages 21-27 | Received 08 Apr 2016, Accepted 15 Jul 2016, Published online: 28 Sep 2016

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Gary M. Williams, Marilyn Aardema, John Acquavella, Sir Colin Berry, David Brusick, Michele M. Burns, Joao Lauro Viana de Camargo, David Garabrant, Helmut A. Greim, Larry D. Kier, David J. Kirkland, Gary Marsh, Keith R. Solomon, Tom Sorahan, Ashley Roberts & Douglas L. Weed. (2016) A review of the carcinogenic potential of glyphosate by four independent expert panels and comparison to the IARC assessment. Critical Reviews in Toxicology 46:sup1, pages 3-20.
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Francesca Coperchini, Alessia Greco, Laura Croce, Marco Denegri, Flavia Magri, Mario Rotondi & Luca Chiovato. (2023) In vitro study of glyphosate effects on thyroid cells. Environmental Pollution 317, pages 120801.
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Ellen T. Chang, Nnaemeka U. Odo & John F. Acquavella. (2022) Systematic literature review of the epidemiology of glyphosate and neurological outcomes. International Archives of Occupational and Environmental Health 96:1, pages 1-26.
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Juliana dos Santos Mendonça, Líria Queiroz Luz Hirano, André Luiz Quagliatto Santos, Daniela de Melo e Silva, Carolina de Castro Pereira, Matheus Santos Costa, Phâmella Neres de Lima, Amanda Pereira da Costa Araújo, Guilherme Malafaia, Isabela Sayuri Ambrósio, Lais de Moura Bife Castilho, Allyson Leandro Rodrigues dos Santos, Anizio Marcio de Faria, Denis Vieira de Andrade & Lucélia Gonçalves Vieira. (2022) The exposure in ovo of embryos belonging to Amazonian turtle species Podocnemis expansa (Testudines) to commercial glyphosate and fipronil formulations impairs their growth and changes their skeletal development. Science of The Total Environment 842, pages 156709.
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Guangdong Bai, Ruiying Zhou, Xu Jiang, Yingbin Zou & Baoming Shi. (2022) Glyphosate‐based herbicides induces autophagy in IPEC‐J2 cells and the intervention of N‐acetylcysteine . Environmental Toxicology 37:8, pages 1878-1890.
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Ingrid Del Castilo, Arthur S. Neumann, Felipe S. Lemos, Marco A. De Bastiani, Felipe L. Oliveira, Eduardo R. Zimmer, Amanda M. Rêgo, Cristiane C. P. Hardoim, Luis Caetano M. Antunes, Flávio A. Lara, Claudia P. Figueiredo & Julia R. Clarke. (2022) Lifelong Exposure to a Low-Dose of the Glyphosate-Based Herbicide RoundUp® Causes Intestinal Damage, Gut Dysbiosis, and Behavioral Changes in Mice. International Journal of Molecular Sciences 23:10, pages 5583.
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Carmen Costas-Ferreira, Rafael Durán & Lilian R. F. Faro. (2022) Toxic Effects of Glyphosate on the Nervous System: A Systematic Review. International Journal of Molecular Sciences 23:9, pages 4605.
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Shengnan Qiu, Yang Liu, Yanan Gao, Huiyang Fu & Baoming Shi. (2021) Response of the nuclear xenobiotic receptors to alleviate glyphosate-based herbicide-induced nephrotoxicity in weaned piglets. Environmental Science and Pollution Research 29:2, pages 2707-2717.
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Dennis D. Weisenburger. (2021) A Review and Update with Perspective of Evidence that the Herbicide Glyphosate (Roundup) is a Cause of Non-Hodgkin Lymphoma. Clinical Lymphoma Myeloma and Leukemia 21:9, pages 621-630.
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Changwon Yang, Whasun Lim & Gwonhwa Song. (2021) Mechanisms of deleterious effects of some pesticide exposure on pigs. Pesticide Biochemistry and Physiology 175, pages 104850.
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Károly Nagy, Roba Argaw Tessema, István Szász, Tamara Smeirat, Alaa Al Rajo & Balázs Ádám. (2021) Micronucleus Formation Induced by Glyphosate and Glyphosate-Based Herbicides in Human Peripheral White Blood Cells. Frontiers in Public Health 9.
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Huiyang Fu, Feng Gao, Xiaoxu Wang, Peng Tan, Shengnan Qiu, Baoming Shi & Anshan Shan. (2021) Effects of glyphosate-based herbicide-contaminated diets on reproductive organ toxicity and hypothalamic-pituitary-ovarian axis hormones in weaned piglets. Environmental Pollution 272, pages 115596.
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Jingwen Zhang, Chengtian Zhao, Feifei Shi, Shaozhi Zhang, Sijie Wang & Xizeng Feng. (2021) Melatonin alleviates the deterioration of oocytes and hormonal disorders from mice subjected to glyphosate. Molecular and Cellular Endocrinology 520, pages 111073.
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María Florencia Kronberg, Ariana Rossen & Eliana Rosa Munarriz. 2021. Toxicology. Toxicology 79 90 .
Jose Luis Rodríguez-Gil, Ryan S. Prosser, Stephen O. Duke & Keith. R. Solomon. 2021. Reviews of Environmental Contamination and Toxicology Volume 255. Reviews of Environmental Contamination and Toxicology Volume 255 129 205 .
Andrey Korchevskiy. (2020) Using benchmark dose modeling for the quantitative risk assessment: Carbon nanotubes, asbestos, glyphosate. Journal of Applied Toxicology 41:1, pages 148-160.
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Pasquale Avino, Ivan Notardonato & Mario Vincenzo Russo. 2020. Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production. Pests, Weeds and Diseases in Agricultural Crop and Animal Husbandry Production.
Romina Coullery, Alejandra M. Pacchioni & Silvana B. Rosso. (2020) Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway. Reproductive Toxicology 96, pages 390-398.
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Keith R Solomon. (2019) Estimated exposure to glyphosate in humans via environmental, occupational, and dietary pathways: an updated review of the scientific literature. Pest Management Science 76:9, pages 2878-2885.
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Jéssica Samara Herek, Luana Vargas, Suélen Andressa Rinas Trindade, Camila Fatima Rutkoski, Natani Macagnan, Paulo Afonso Hartmann & Marilia Teresinha Hartmann. (2020) Can environmental concentrations of glyphosate affect survival and cause malformation in amphibians? Effects from a glyphosate-based herbicide on Physalaemus cuvieri and P. gracilis (Anura: Leptodactylidae). Environmental Science and Pollution Research 27:18, pages 22619-22630.
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Carlo Caiati, Paolo Pollice, Stefano Favale & Mario Erminio Lepera. (2020) The Herbicide Glyphosate and Its Apparently Controversial Effect on Human Health: An Updated Clinical Perspective. Endocrine, Metabolic & Immune Disorders - Drug Targets 20:4, pages 489-505.
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Simranjeet Singh, Vijay Kumar, Shivika Datta, Abdul Basit Wani, Daljeet Singh Dhanjal, Romina Romero & Joginder Singh. (2020) Glyphosate uptake, translocation, resistance emergence in crops, analytical monitoring, toxicity and degradation: a review. Environmental Chemistry Letters 18:3, pages 663-702.
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Yassine Ait-Bali, Saadia Ba-M’hamed, Giovanna Gambarotta, Marco Sassoè-Pognetto, Maurizio Giustetto & Mohamed Bennis. (2020) Pre- and postnatal exposure to glyphosate-based herbicide causes behavioral and cognitive impairments in adult mice: evidence of cortical ad hippocampal dysfunction. Archives of Toxicology 94:5, pages 1703-1723.
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Cristina Eugenia Gallegos, Mariana Bartos, Fernanda Gumilar, Rita Raisman-Vozari, Alejandra Minetti & Carlos Javier Baier. (2020) Intranasal glyphosate-based herbicide administration alters the redox balance and the cholinergic system in the mouse brain. NeuroToxicology 77, pages 205-215.
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Shengnan Qiu, Huiyang Fu, Ruiying Zhou, Zheng Yang, Guangdong Bai & Baoming Shi. (2020) Toxic effects of glyphosate on intestinal morphology, antioxidant capacity and barrier function in weaned piglets. Ecotoxicology and Environmental Safety 187, pages 109846.
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Allan S. Felsot. 2020. Information Resources in Toxicology. Information Resources in Toxicology 203 220 .
John L Vicini, William R Reeves, John T Swarthout & Katherine A Karberg. (2019) Glyphosate in livestock: feed residues and animal health1. Journal of Animal Science 97:11, pages 4509-4518.
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Mark A. Martens, Marian S. Bleeke, Vincent A. Leopold & Donna R. Farmer. (2019) Toxicology and human health risk assessment of polyethoxylated tallow amine surfactant used in glyphosate formulations. Regulatory Toxicology and Pharmacology 107, pages 104347.
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Thu Ha Pham, Lohann Derian, Christine Kervarrec, Pierre-Yves Kernanec, Bernard Jégou, Fatima Smagulova & Aurore Gely-Pernot. (2019) Perinatal Exposure to Glyphosate and a Glyphosate-Based Herbicide Affect Spermatogenesis in Mice. Toxicological Sciences 169:1, pages 260-271.
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Yassine Ait Bali, Nour-eddine Kaikai, Saadia Ba-M’hamed & Mohamed Bennis. (2019) Learning and memory impairments associated to acetylcholinesterase inhibition and oxidative stress following glyphosate based-herbicide exposure in mice. Toxicology 415, pages 18-25.
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Ramiro Alarcón, Paola I. Ingaramo, Oscar E. Rivera, Gisela H. Dioguardi, María R. Repetti, Luisina D. Demonte, Mercedes M. Milesi, Jorgelina Varayoud, Mónica Muñoz-de-Toro & Enrique H. Luque. (2019) Neonatal exposure to a glyphosate-based herbicide alters the histofunctional differentiation of the ovaries and uterus in lambs. Molecular and Cellular Endocrinology 482, pages 45-56.
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Francisco José Roma Paumgartten. (2019) To be or not to be a carcinogen; delving into the glyphosate classification controversy. Brazilian Journal of Pharmaceutical Sciences 55.
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Martha E. Richmond. (2018) Glyphosate: A review of its global use, environmental impact, and potential health effects on humans and other species. Journal of Environmental Studies and Sciences 8:4, pages 416-434.
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Marlise Guerrero Schimpf, María M Milesi, Enrique H Luque & Jorgelina Varayoud. (2018) Glyphosate-based herbicide enhances the uterine sensitivity to estradiol in rats. Journal of Endocrinology 239:2, pages 197-213.
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Cristina Eugenia Gallegos, Carlos Javier Baier, Mariana Bartos, Cristina Bras, Sergio Domínguez, Nina Mónaco, Fernanda Gumilar, María Sofía Giménez & Alejandra Minetti. (2018) Perinatal Glyphosate-Based Herbicide Exposure in Rats Alters Brain Antioxidant Status, Glutamate and Acetylcholine Metabolism and Affects Recognition Memory. Neurotoxicity Research 34:3, pages 363-374.
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Paolo Gigante, Melissa Berni, Simona Bussolati, Francesca Grasselli, Stefano Grolli, Roberto Ramoni & Giuseppina Basini. (2018) Glyphosate affects swine ovarian and adipose stromal cell functions. Animal Reproduction Science 195, pages 185-196.
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András Székács & Béla Darvas. (2018) Re-registration Challenges of Glyphosate in the European Union. Frontiers in Environmental Science 6.
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Ning Yu, Yun Tong, Danni Zhang, Shanshan Zhao, Xinli Fan, Lihui Wu & Hua Ji. (2018) Circular RNA expression profiles in hippocampus from mice with perinatal glyphosate exposure. Biochemical and Biophysical Research Communications 501:4, pages 838-845.
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Peter F. Infante, Ronald Melnick, Harri Vainio & James Huff. (2018) Commentary: IARC Monographs Program and public health under siege by corporate interests. American Journal of Industrial Medicine 61:4, pages 277-281.
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Vincenzo Torretta, Ioannis Katsoyiannis, Paolo Viotti & Elena Rada. (2018) Critical Review of the Effects of Glyphosate Exposure to the Environment and Humans through the Food Supply Chain. Sustainability 10:4, pages 950.
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A.H.C. Van Bruggen, M.M. He, K. Shin, V. Mai, K.C. Jeong, M.R. Finckh & J.G. MorrisJr.Jr.. (2018) Environmental and health effects of the herbicide glyphosate. Science of The Total Environment 616-617, pages 255-268.
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Roger O. McClellan. 2018. Veterinary Toxicology. Veterinary Toxicology 3 36 .
George Anifandis, George Amiridis, Konstantinos Dafopoulos, Alexandros Daponte, Eleni Dovolou, Eleftherios Gavriil, Vyron Gorgogietas, Elli Kachpani, Zissis Mamuris, Christina Messini, Katerina Vassiou & Anna-Maria Psarra. (2017) The In Vitro Impact of the Herbicide Roundup on Human Sperm Motility and Sperm Mitochondria. Toxics 6:1, pages 2.
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Maria Chiara Perego, Francesca Caloni, Cristina Cortinovis, Luis F. Schutz, Marco Albonico, Denise Tsuzukibashi & Leon J. Spicer. (2017) Influence of a Roundup formulation on glyphosate effects on steroidogenesis and proliferation of bovine granulosa cells in vitro. Chemosphere 188, pages 274-279.
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Carlos Javier Baier, Cristina Eugenia Gallegos, Rita Raisman-Vozari & Alejandra Minetti. (2017) Behavioral impairments following repeated intranasal glyphosate-based herbicide administration in mice. Neurotoxicology and Teratology 64, pages 63-72.
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A. L. Van Eenennaam & A. E. Young. (2017) Detection of dietary DNA, protein, and glyphosate in meat, milk, and eggs1. Journal of Animal Science 95:7, pages 3247-3269.
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James S. Bus. (2017) IARC use of oxidative stress as key mode of action characteristic for facilitating cancer classification: Glyphosate case example illustrating a lack of robustness in interpretative implementation. Regulatory Toxicology and Pharmacology 86, pages 157-166.
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Davidson Robert M. (2016) Environmental Toxicants and Infant Mortality in the USA. Open Journal of Biological Sciences, pages 036-061.
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