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Critical Reviews in Toxicology Volume 46, 2016 - Issue 10
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Review Articles

Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects

Peter T. TheunissenCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; ;Medicines Evaluation Board, Utrecht, The Netherlands; ;Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences Utrecht (HU), Utrecht, The Netherlands; Correspondence[email protected]
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Sonja BekenFederal Agency for Medicines and Health Products, Brussels, Belgium;
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Bruce K. BeyerSanofi U.S. Inc. Bridgewater, NJ, USA;
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William J. BreslinLilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA;
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Gregg D. CapponPfizer Worldwide Research & Development, Groton, CT, USA;
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Connie L. ChenILSI-Health and Environmental Sciences Institute, Washington, DC, USA;
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Gary ChmielewskiCovance Laboratories Inc, Greenfield, IN, USA;
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Luc De SchaepdrijverJanssen R&D, Preclinical Development & Safety Beerse, Belgium;
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Brian EnrightAbbVie Inc, North Chicago, IL, USA;
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Jennifer E. ForemanExxonMobil Biomedical Sciences, Inc, Annandale, NJ, USA;
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Wafa HarroukU.S. Food & Drug Administration, Silver Spring, MD, USA;
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Kok-Wah HewTakeda Pharmaceutical Company, Deerfield, IL, USA;
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Alan M. HobermanCharles-River Laboratories, Preclinical Services, Horsham, PA, USA;
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Julia Y. HuiCelgene Corporation, Summit, NJ, USA;
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Thomas B. KnudsenU.S. Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, NC, USA;
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Susan B. LaffanSafety Assessment, GlaxoSmithKline, King of Prussia, PA, USA;
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Susan L. MakrisU.S. Environmental Protection Agency, National Center for Environmental Assessment, Washington, DC, USA;
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Matt MartinU.S. Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, NC, USA;
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Mary Ellen McNerneyDrug Safety Evaluation, Bristol-Myers Squibb, New Brunswick, NJ, USA;
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Christine L. SiezenMedicines Evaluation Board, Utrecht, The Netherlands;
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Dinesh J. StanislausSafety Assessment, GlaxoSmithKline, King of Prussia, PA, USA;
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Jane StewartDrug Safety & Metabolism, AstraZeneca, Macclesfield, UK;
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Kary E. ThompsonDrug Safety Evaluation, Bristol-Myers Squibb, New Brunswick, NJ, USA;
,
Belen TornesiAbbVie Inc, North Chicago, IL, USA;
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Jan Willem Van der LaanCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; ;Medicines Evaluation Board, Utrecht, The Netherlands;
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Gerhard F. WeinbauerCovance Preclinical Services GmbH, Muenster, Germany;
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Sandra WoodMerck Research Laboratories, Upper Gwynedd, Pennsylvania, USA;
&
Aldert H. PiersmaCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; ;Institute for Risk Assessment Sciences, Faculty of Veterinary Sciences, Utrecht University, Utrecht, The Netherlands
 show all
Pages 900-910 | Received 09 Feb 2016, Accepted 11 Aug 2016, Published online: 19 Oct 2016

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Peter T. Theunissen, Sonia Beken, Bruce Beyer, William J. Breslin, Gregg D. Cappon, Connie L. Chen, Gary Chmielewski, Luc de Schaepdrijver, Brian Enright, Jennifer E. Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M. Hoberman, Julia Y. Hui, Thomas B. Knudsen, Susan B. Laffan, Susan L. Makris, Matthew Martin, Mary Ellen McNerney, Christine L. Siezen, Dinesh J. Stanislaus, Jane Stewart, Kary E. Thompson, Belen Tornesi, Jan Willem Van der Laan, Gerhard F. Weinbauer, Sandra Wood & Aldert H. Piersma. (2017) Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects. Critical Reviews in Toxicology 47:5, pages 409-421.
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Thomas B. Knudsen, Jocylin D. Pierro & Nancy C. Baker. (2021) Retinoid signaling in skeletal development: Scoping the system for predictive toxicology. Reproductive Toxicology 99, pages 109-130.
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Paul A. Andrews, Mary Ellen McNerney & Joseph J. DeGeorge. (2019) Exposure assessments in reproductive and developmental toxicity testing: An IQ-DruSafe industry survey on current practices and experiences in support of exposure-based high dose selection. Regulatory Toxicology and Pharmacology 107, pages 104413.
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Hedwig M. Braakhuis, Peter T. Theunissen, Wout Slob, Emiel Rorije & Aldert H. Piersma. (2019) Testing developmental toxicity in a second species: are the differences due to species or replication error?. Regulatory Toxicology and Pharmacology 107, pages 104410.
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Evy Verbueken, Chloé Bars, Jonathan S. Ball, Jelena Periz-Stanacev, Waleed F. A. Marei, Anna Tochwin, Isabelle J. Gabriëls, Ellen D. G. Michiels, Evelyn Stinckens, Lucia Vergauwen, Dries Knapen, Chris J. Van Ginneken & Steven J. Van Cruchten. (2018) From mRNA Expression of Drug Disposition Genes to In Vivo Assessment of CYP-Mediated Biotransformation during Zebrafish Embryonic and Larval Development. International Journal of Molecular Sciences 19:12, pages 3976.
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E. Teixidó, E. Krupp, A. Amberg, A. Czich & S. Scholz. (2018) Species-specific developmental toxicity in rats and rabbits: Generation of a reference compound list for development of alternative testing approaches. Reproductive Toxicology 76, pages 93-102.
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Sofia Alves-Pimenta, Bruno Colaço, Paula A. Oliveira & Carlos Venâncio. 2018. Teratogenicity Testing. Teratogenicity Testing 61 93 .
Manon Beekhuijzen. (2017) The era of 3Rs implementation in developmental and reproductive toxicity (DART) testing: Current overview and future perspectives. Reproductive Toxicology 72, pages 86-96.
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Shaunna L. Beedie, Alexandra J. Diamond, Lucas Rosa Fraga, William D. Figg & Neil Vargesson. (2017) Vertebrate embryos as tools for anti-angiogenic drug screening and function. Reproductive Toxicology 70, pages 49-59.
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