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Critical Reviews in Toxicology Volume 47, 2017 - Issue 5
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Review Articles

Comparing rat and rabbit embryo-fetal developmental toxicity data for 379 pharmaceuticals: on systemic dose and developmental effects

Peter T. TheunissenCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; ;Medicines Evaluation Board, Utrecht, The Netherlands; ;Innovative Testing in Life Sciences and Chemistry, University of Applied Sciences Utrecht (HU), Utrecht, The Netherlands; Correspondence[email protected]
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Sonia BekenFederal Agency for Medicines and Health Products, Brussels, Belgium;
,
Bruce BeyerSanofi U.S. Inc, Bridgewater, NJ, USA;
,
William J. BreslinLilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, USA;
,
Gregg D. CapponPfizer Worldwide Research & Development, Groton, CT, USA;
,
Connie L. ChenILSI-Health and Environmental Sciences Institute, Washington, DC, USA;
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Gary ChmielewskiCovance Laboratories Inc, Greenfield, IN, USA;
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Luc de SchaepdrijverPreclinical Development & Safety, Beerse, Belgium;
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Brian EnrightAbbVie Inc, North Chicago, IL, USA;
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Jennifer E. ForemanExxonMobil Biomedical Sciences, Inc, Annandale, NJ, USA;
,
Wafa HarroukUS Food & Drug Administration, Silver Spring, MD, USA;
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Kok-Wah HewTakeda Pharmaceutical Company, Deerfield, IL, USA;
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Alan M. HobermanPreclinical Services, Charles-River Laboratories, Horsham, PA, USA;
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Julia Y. HuiCelgene Corporation, Summit, NJ, USA;
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Thomas B. KnudsenUS Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, NC, USA;
,
Susan B. LaffanSafety Assessment, GlaxoSmithKline, King of Prussia, PA, USA;
,
Susan L. MakrisNational Center for Environmental Assessment, US Environmental Protection Agency, Washington, DC, USA;
,
Matthew MartinUS Environmental Protection Agency, National Center for Computational Toxicology, Research Triangle Park, NC, USA;
,
Mary Ellen McNerneyDrug Safety Evaluation, Bristol-Myers Squibb, New Brunswick, NJ, USA;
,
Christine L. SiezenMedicines Evaluation Board, Utrecht, The Netherlands;
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Dinesh J. StanislausSafety Assessment, GlaxoSmithKline, King of Prussia, PA, USA;
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Jane StewartDrug Safety & Metabolism, AstraZeneca, Macclesfield, UK;
,
Kary E. ThompsonDrug Safety Evaluation, Bristol-Myers Squibb, New Brunswick, NJ, USA;
,
Belen TornesiAbbVie Inc, North Chicago, IL, USA;
,
Jan Willem Van der LaanCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; ;Medicines Evaluation Board, Utrecht, The Netherlands;
,
Gerhard F. WeinbauerCovance Preclinical Services GmbH, Muenster, Germany;
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Sandra WoodMerck Research Laboratories, Upper Gwynedd, PA, USA;
&
Aldert H. PiersmaCentre for Health Protection, National Institute for Public Health and the Environment (RIVM), Bilthoven, The Netherlands; ;Faculty of Veterinary Sciences, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
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Pages 409-421 | Received 09 Feb 2016, Accepted 11 Aug 2016, Published online: 21 Oct 2016

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Peter T. Theunissen, Sonja Beken, Bruce K. Beyer, William J. Breslin, Gregg D. Cappon, Connie L. Chen, Gary Chmielewski, Luc De Schaepdrijver, Brian Enright, Jennifer E. Foreman, Wafa Harrouk, Kok-Wah Hew, Alan M. Hoberman, Julia Y. Hui, Thomas B. Knudsen, Susan B. Laffan, Susan L. Makris, Matt Martin, Mary Ellen McNerney, Christine L. Siezen, Dinesh J. Stanislaus, Jane Stewart, Kary E. Thompson, Belen Tornesi, Jan Willem Van der Laan, Gerhard F. Weinbauer, Sandra Wood & Aldert H. Piersma. (2016) Comparison of rat and rabbit embryo–fetal developmental toxicity data for 379 pharmaceuticals: on the nature and severity of developmental effects. Critical Reviews in Toxicology 46:10, pages 900-910.
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Hedwig M. Braakhuis, Peter T. Theunissen, Wout Slob, Emiel Rorije & Aldert H. Piersma. (2019) Testing developmental toxicity in a second species: are the differences due to species or replication error?. Regulatory Toxicology and Pharmacology 107, pages 104410.
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S.L. Makris. 2018. Comprehensive Toxicology. Comprehensive Toxicology 10 20 .
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