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Critical Reviews in Toxicology Volume 49, 2019 - Issue 6
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Review Article

Current insights in the complexities underlying drug-induced cholestasis

Neel DefermDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Leuven, Belgium; ORCID Iconhttp://orcid.org/0000-0002-5014-1691
ORCID Icon,
Tom De VochtDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Leuven, Belgium; ORCID Iconhttp://orcid.org/0000-0003-0425-8474
ORCID Icon,
Bing QiDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Leuven, Belgium; ORCID Iconhttp://orcid.org/0000-0001-8025-493X
ORCID Icon,
Pieter Van BrantegemDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Leuven, Belgium; ORCID Iconhttp://orcid.org/0000-0002-0365-5841
ORCID Icon,
Eva GijbelsEntity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium; ORCID Iconhttp://orcid.org/0000-0002-7366-0769
ORCID Icon,
Mathieu VinkenEntity of In Vitro Toxicology and Dermato-Cosmetology, Department of Pharmaceutical and Pharmacological Sciences, Vrije Universiteit Brussel, Brussels, Belgium; ORCID Iconhttp://orcid.org/0000-0001-5115-8893
ORCID Icon,
Peter de WitteLaboratory for Molecular Biodiscovery, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, BelgiumORCID Iconhttp://orcid.org/0000-0002-9989-9567
ORCID Icon,
Thomas BouillonDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Leuven, Belgium; ORCID Iconhttp://orcid.org/0000-0001-7218-1267
ORCID Icon &
Pieter AnnaertDepartment of Pharmaceutical and Pharmacological Sciences, Drug Delivery and Disposition, KU Leuven, Leuven, Belgium; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0003-3525-7351
ORCID Icon show all
Pages 520-548 | Received 13 Nov 2018, Accepted 18 Jun 2019, Published online: 07 Oct 2019

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Irene Hernández Lozano & Oliver Langer. (2020) Use of imaging to assess the activity of hepatic transporters. Expert Opinion on Drug Metabolism & Toxicology 16:2, pages 149-164.
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Yihang Dai, Zhixin Jia, Cong Fang, Meixia Zhu, Xiaoning Yan, Yinhuan Zhang, Hao Wu, Menghan Feng, Lirong Liu, Beibei Huang, Yueting Li, Jie Liu & Hongbin Xiao. (2023) Polygoni Multiflori Radix interferes with bile acid metabolism homeostasis by inhibiting Fxr transcription, leading to cholestasis. Frontiers in Pharmacology 14.
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Toshihisa KogaKenji TakeuchiKen Umehara. (2023) Establishment of an <i>in vitro</i> cholestasis risk assessment system using two-dimensional cultured HepaRG cells and 12 bile acids. The Journal of Toxicological Sciences 48:1, pages 47-56.
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Yilin Sun, Shengbao Cai, Yuanyue Zhang, Nan Ma, Junjie Yi, Xiaosong Hu & Tao Wang. (2022) Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation. Nutrients 14:19, pages 4090.
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Véronique M.P. de Bruijn, Zhenguo Wang, Wouter Bakker, Weijia Zheng, Bart Spee & Hans Bouwmeester. (2022) Hepatic bile acid synthesis and secretion: Comparison of in vitro methods. Toxicology Letters 365, pages 46-60.
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Adrian Po Zhu Li & Dulmini Kariyawasam. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 225 243 .
Yunzhou Li & Huiping Zhou. 2022. Comprehensive Pharmacology. Comprehensive Pharmacology 239 270 .
Tom De Vocht, Christophe Buyck, Neel Deferm, Bing Qi, Pieter Van Brantegem, Herman van Vlijmen, Jan Snoeys, Eef Hoeben, An Vermeulen & Pieter Annaert. (2021) Identification of novel inhibitors of rat Mrp3. European Journal of Pharmaceutical Sciences 162, pages 105813.
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Y Yang, L Liu, M Xu, X Zhang, L Wang, Q He, M Xu & X Jiang. (2020) Tanshinone ⅡA may alleviate rifampin-induced cholestasis by regulating the expression and function of NTCP. Human & Experimental Toxicology 40:6, pages 1003-1011.
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Andrés Tabernilla, Bruna dos Santos Rodrigues, Alanah Pieters, Anne Caufriez, Kaat Leroy, Raf Van Campenhout, Axelle Cooreman, Ana Rita Gomes, Emma Arnesdotter, Eva Gijbels & Mathieu Vinken. (2021) In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach. International Journal of Molecular Sciences 22:9, pages 5038.
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LanLan Gui, QingLiang Wu, YiTing Hu, WuShuang Zeng, XianWen Tan, PingPing Zhu, XueJing Li, Lian Yang, Wei Jia, ChangXiao Liu & Ke Lan. (2021) Compensatory Transition of Bile Acid Metabolism from Fecal Disposition of Secondary Bile Acids to Urinary Excretion of Primary Bile Acids Underlies Rifampicin-Induced Cholestasis in Beagle Dogs. ACS Pharmacology & Translational Science 4:2, pages 1001-1013.
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Alison Jee, Samantha Christine Sernoskie & Jack Uetrecht. (2021) Idiosyncratic Drug-Induced Liver Injury: Mechanistic and Clinical Challenges. International Journal of Molecular Sciences 22:6, pages 2954.
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James W. Firman, Cynthia B. Pestana, James F. Rathman, Mathieu Vinken, Chihae Yang & Mark T. D. Cronin. (2020) A Robust, Mechanistically Based In Silico Structural Profiler for Hepatic Cholestasis . Chemical Research in Toxicology 34:2, pages 641-655.
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Michael J. Hafey, Robert Houle, Keith Q. Tanis, Ian Knemeyer, Jackie Shang, Qing Chen, Andreas Baudy, James Monroe, Frank D. Sistare & Raymond Evers. (2020) A Two-Tiered In Vitro Approach to De-Risk Drug Candidates for Potential Bile Salt Export Pump Inhibition Liabilities in Drug Discovery. Drug Metabolism and Disposition 48:11, pages 1147-1160.
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Axelle Cooreman, Raf Van Campenhout, Sara Crespo Yanguas, Eva Gijbels, Kaat Leroy, Alanah Pieters, Andrés Tabernilla, Pieter Van Brantegem, Pieter Annaert, Bruno Cogliati & Mathieu Vinken. (2020) Cholestasis Differentially Affects Liver Connexins. International Journal of Molecular Sciences 21:18, pages 6534.
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Petr Potmešil & Radka Szotkowská. (2020) Drug-induced liver injury after switching from tamoxifen to anastrozole in a patient with a history of breast cancer being treated for hypertension and diabetes. Therapeutic Advances in Chronic Disease 11, pages 204062232096415.
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Pieter Van Brantegem, Sagnik Chatterjee, Tom De Bruyn, Pieter Annaert & Neel Deferm. (2020) Drug-induced cholestasis assay in primary hepatocytes. MethodsX 7, pages 101080.
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