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Critical Reviews in Toxicology Volume 52, 2022 - Issue 3

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Critical review and analysis of literature on low dose exposure to chemical mixtures in mammalian in vivo systems

Chris S. Elcombea Institute of Biodiversity Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK;b School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UKCorrespondence[email protected]

https://orcid.org/0000-0002-7869-0123 View further author information

Neil P. Evansa Institute of Biodiversity Animal Health and Comparative Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

https://orcid.org/0000-0001-7395-3222 View further author information

Michelle Bellinghamb School of Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK

https://orcid.org/0000-0002-3646-8989 View further author information

Pages 221-238 | Received 11 Jan 2022, Accepted 11 Jun 2022, Published online: 27 Jul 2022

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https://doi.org/10.1080/10408444.2022.2091423
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Mohammad Ghasemzadeh‐Hasankolaei, Chris S. Elcombe, Samantha Powls, Richard G. Lea, Kevin D. Sinclair, Vasantha Padmanabhan, Neil P. Evans & Michelle Bellingham. (2023) Preconceptional and in utero exposure of sheep to a real‐life environmental chemical mixture disrupts key markers of energy metabolism in male offspring. Journal of Neuroendocrinology 36:1.
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Olwenn V. Martin. (2023) Synergistic effects of chemical mixtures: How frequent is rare?. Current Opinion in Toxicology 36, pages 100424.
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Vatsal Mehta, Mahmoud Shobair & Catherine Mahony. (2023) Evaluation of mixture toxicity literature and chemical space: a data centric approach. Environmental Science: Processes & Impacts 25:11, pages 1752-1758.
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S.V. Thangaraj, L. Zeng, S. Pennathur, R. Lea, K.D. Sinclair, M. Bellingham, N.P. Evans, R. Auchus & V. Padmanabhan. (2023) Developmental programming: Impact of preconceptional and gestational exposure to a real-life environmental chemical mixture on maternal steroid, cytokine and oxidative stress milieus in sheep. Science of The Total Environment 900, pages 165674.
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Denise Bloch, Patrick Diel, Bernd Epe, Michael Hellwig, Alfonso Lampen, Angela Mally, Doris Marko, María A. Villar Fernández, Sabine Guth, Angelika Roth, Rosemarie Marchan, Ahmed Ghallab, Cristina Cadenas, Patrick Nell, Nachiket Vartak, Christoph van Thriel, Andreas Luch, Sebastian Schmeisser, Matthias Herzler, Robert Landsiedel, Marcel Leist, Philip Marx-Stoelting, Tewes Tralau & Jan G. Hengstler. (2023) Basic concepts of mixture toxicity and relevance for risk evaluation and regulation. Archives of Toxicology 97:11, pages 3005-3017.
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Neil P. Evans, Michelle Bellingham, Christopher S. Elcombe, Mohammad Ghasemzadeh-Hasankolaei, Richard G. Lea, Kevin D. Sinclair & Vasantha Padmanabhan. (2023) Sexually dimorphic impact of preconceptional and gestational exposure to a real-life environmental chemical mixture (biosolids) on offspring growth dynamics and puberty in sheep. Environmental Toxicology and Pharmacology 102, pages 104257.
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Chris S. Elcombe, Ana Monteiro, Mohammad Ghasemzadeh-Hasankolaei, Vasantha Padmanabhan, Richard Lea, Kevin D. Sinclair, Neil P. Evans & Michelle Bellingham. (2023) Developmental exposure to a real-life environmental chemical mixture alters testicular transcription factor expression in neonatal and pre-pubertal rams, with morphological changes persisting into adulthood. Environmental Toxicology and Pharmacology 100, pages 104152.
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Viorica Dinca, Anca Oana Docea, Andrei Ioan Drocas, Taxiarchis Konstantinos Nikolouzakis, Polychronis D. Stivaktakis, Dragana Nikitovic, Kirill S. Golokhvast, Antonio F. Hernandez, Daniela Calina & Aristidis Tsatsakis. (2023) A mixture of 13 pesticides, contaminants, and food additives below individual NOAELs produces histopathological and organ weight changes in rats. Archives of Toxicology 97:5, pages 1285-1298.
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S.V. Thangaraj, M. Kachman, K.M. Halloran, K.D. Sinclair, R. Lea, M. Bellingham, N.P. Evans & V. Padmanabhan. (2023) Developmental programming: Preconceptional and gestational exposure of sheep to a real-life environmental chemical mixture alters maternal metabolome in a fetal sex-specific manner. Science of The Total Environment 864, pages 161054.
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Critical review and analysis of literature on low dose exposure to chemical mixtures in mammalian in vivo systems

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Critical review and analysis of literature on low dose exposure to chemical mixtures in mammalian in vivo systems

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