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Review Article

Sleeping Beauty transposition: from biology to applications

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Pages 18-44 | Received 27 Jul 2016, Accepted 14 Sep 2016, Published online: 04 Oct 2016

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Rafaqat A. Gill, Federico Scossa, Graham J. King, Agnieszka A. Golicz, Chaobo Tong, Rod J. Snowdon, Alisdair R. Fernie & Shengyi Liu. (2021) On the Role of Transposable Elements in the Regulation of Gene Expression and Subgenomic Interactions in Crop Genomes. Critical Reviews in Plant Sciences 40:2, pages 157-189.
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Suleiman Yusuf Alhaji, Siew Ching Ngai & Syahril Abdullah. (2019) Silencing of transgene expression in mammalian cells by DNA methylation and histone modifications in gene therapy perspective. Biotechnology and Genetic Engineering Reviews 35:1, pages 1-25.
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Michael Hudecek, Zsuzsanna Izsvák, Sandra Johnen, Matthias Renner, Gabriele Thumann & Zoltán Ivics. (2017) Going non-viral: the Sleeping Beauty transposon system breaks on through to the clinical side. Critical Reviews in Biochemistry and Molecular Biology 52:4, pages 355-380.
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Articles from other publishers (33)

Reihaneh Alsadat Mahmoudian, Fardin Fathi, Moein Farshchian & Mohammad Reza Abbaszadegan. (2022) Construction and Quantitative Evaluation of a Tissue-Specific Sleeping Beauty by EDL2-Specific Transposase Expression in Esophageal Squamous Carcinoma Cell Line KYSE-30. Molecular Biotechnology 65:3, pages 350-360.
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Samantha Baldassarri, Daniela Benati, Federica D’Alessio, Clarissa Patrizi, Eleonora Cattin, Michela Gentile, Angelo Raggioli & Alessandra Recchia. (2022) Engineered Sleeping Beauty Transposon as Efficient System to Optimize Chimp Adenoviral Production. International Journal of Molecular Sciences 23:14, pages 7538.
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Alex Moretti, Marianna Ponzo, Charles A. Nicolette, Irina Y. Tcherepanova, Andrea Biondi & Chiara F. Magnani. (2022) The Past, Present, and Future of Non-Viral CAR T Cells. Frontiers in Immunology 13.
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Yun Haeng Lee, Ji Yun Park, Eun Seon Song, Haneur Lee, Myeong Uk Kuk, Junghyun Joo, Hyungmin Roh & Joon Tae Park. (2022) Improvement of Sleeping Beauty Transposon System Enabling Efficient and Stable Protein Production. Biotechnology and Bioprocess Engineering 27:3, pages 353-360.
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Myeong Uk Kuk, Ji Yun Park, Eun Seon Song, Haneur Lee, Yun Haeng Lee, Junghyun Joo, Hyung Wook Kwon & Joon Tae Park. (2022) Bacterial Artificial Chromosome-based Protein Expression Platform Using the Tol2 Transposon System. Biotechnology and Bioprocess Engineering 27:3, pages 344-352.
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Csaba Miskey, Lisa Kesselring, Irma Querques, György Abrusán, Orsolya Barabas & Zoltán Ivics. (2022) Engineered Sleeping Beauty transposase redirects transposon integration away from genes . Nucleic Acids Research 50:5, pages 2807-2825.
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Su Young Hwang, Yun Haeng Lee, Myeong Uk Kuk, Jae Won Kim, Sekyung Oh & Joon Tae Park. (2021) Improvement of Tol2 Transposon System Enabling Efficient Protein Production in CHO Cells. Biotechnology and Bioprocess Engineering 26:5, pages 767-775.
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Nicolás Sandoval-Villegas, Wasifa Nurieva, Maximilian Amberger & Zoltán Ivics. (2021) Contemporary Transposon Tools: A Review and Guide through Mechanisms and Applications of Sleeping Beauty, piggyBac and Tol2 for Genome Engineering. International Journal of Molecular Sciences 22:10, pages 5084.
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Hirokazu Suzuki, Tatsunari Taketani, Misaki Tanabiki, Misaki Ohara, Jyumpei Kobayashi & Takashi Ohshiro. (2021) Frequent Transposition of Multiple Insertion Sequences in Geobacillus kaustophilus HTA426. Frontiers in Microbiology 12.
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Thirumala R. Talluri, Dharmendra Kumar & Wilfried A. Kues. 2022. Induced Pluripotent Stem (iPS) Cells. Induced Pluripotent Stem (iPS) Cells 791 809 .
Mathilde Dupeyron, Tobias Baril, Chris Bass & Alexander Hayward. (2020) Phylogenetic analysis of the Tc1/mariner superfamily reveals the unexplored diversity of pogo-like elements. Mobile DNA 11:1.
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Maximilian Amberger & Zoltán Ivics. (2020) Latest Advances for the Sleeping Beauty Transposon System: 23 Years of Insomnia but Prettier than Ever . BioEssays 42:11, pages 2000136.
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Shufeng Ma, Xinlong Wang, Yongfei Hu, Jie Lv, Chengfang Liu, Kaitong Liao, Xiaohua Guo, Dong Wang, Ying Lin & Zhili Rong. (2020) Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain. Nucleic Acids Research 48:18, pages 10590-10601.
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Natalie Tschorn, Karen Berg & Jörn Stitz. (2020) Transposon vector-mediated stable gene transfer for the accelerated establishment of recombinant mammalian cell pools allowing for high-yield production of biologics. Biotechnology Letters 42:7, pages 1103-1112.
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Masahiro Sato, Emi Inada, Issei Saitoh, Satoshi Watanabe & Shingo Nakamura. (2020) piggyBac-Based Non-Viral In Vivo Gene Delivery Useful for Production of Genetically Modified Animals and Organs. Pharmaceutics 12:3, pages 277.
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Lisa Kesselring, Csaba Miskey, Cecilia Zuliani, Irma Querques, Vladimir Kapitonov, Andrea Laukó, Anita Fehér, Antonio Palazzo, Tanja Diem, Janna Lustig, Attila Sebe, Yongming Wang, András Dinnyés, Zsuzsanna Izsvák, Orsolya Barabas & Zoltán Ivics. (2020) A single amino acid switch converts the Sleeping Beauty transposase into an efficient unidirectional excisionase with utility in stem cell reprogramming. Nucleic Acids Research 48:1, pages 316-331.
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Natalia Egri, Iñaki Ortiz de Landazuri, Clara San Bartolomé, J. Ramón Ortega, Marta Español-Rego & Manel Juan. (2020) CART manufacturing process and reasons for academy-pharma collaboration. Immunology Letters 217, pages 39-48.
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Maria Hernandez, Sergio Recalde, Laura Garcia-Garcia, Jaione Bezunartea, Csaba Miskey, Sandra Johnen, Sabine Diarra, Attila Sebe, Juan Roberto Rodriguez-Madoz, Severine Pouillot, Corinne Marie, Zsuzsanna Izsvák, Daniel Scherman, Martina Kropp, Felipe Prosper, Gabriele Thumann, Zoltán Ivics, Alfredo Garcia-Layana & Patricia Fernandez-Robredo. (2019) Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization. Molecular Therapy - Methods & Clinical Development 15, pages 403-417.
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Amy Guimaraes-Young, Charlotte R. Feddersen & Adam J. Dupuy. (2019) Sleeping Beauty Mouse Models of Cancer: Microenvironmental Influences on Cancer Genetics. Frontiers in Oncology 9.
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Irina R Arkhipova & Irina A Yushenova. (2019) Giant Transposons in Eukaryotes: Is Bigger Better?. Genome Biology and Evolution 11:3, pages 906-918.
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Robin Loesch, Christèle Desbois-Mouthon & Sabine Colnot. (2019) Potentials of CRISPR in liver research and therapy. Clinics and Research in Hepatology and Gastroenterology 43:1, pages 5-11.
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Orsolya Kolacsek & Tamás I. Orbán. (2018) Transcription activity of transposon sequence limits Sleeping Beauty transposition. Gene 676, pages 184-188.
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Michael Hudecek & Zoltán Ivics. (2018) Non-viral therapeutic cell engineering with the Sleeping Beauty transposon system. Current Opinion in Genetics & Development 52, pages 100-108.
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Yi Zhao, Guili Song, Jing Ren, Qing Li, Shan Zhong & Zongbin Cui. (2018) Sleeping beauty transposon-mediated poly(A)-trapping and insertion mutagenesis in mouse embryonic stem cells . Environmental and Molecular Mutagenesis 59:8, pages 687-697.
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Antonia W. Godehardt, Stoyan Petkov, Barbara Gulich, Nicole Fischer, Heiner Niemann & Ralf R. Tönjes. (2018) Comparative gene expression profiling of pig-derived iPSC-like cells: Effects of induced pluripotency on expression of porcine endogenous retrovirus (PERV). Xenotransplantation 25:4, pages e12429.
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Marie Pastor, Sandra Johnen, Nina Harmening, Mickäel Quiviger, Julie Pailloux, Martina Kropp, Peter Walter, Zoltán Ivics, Zsuzsanna Izsvák, Gabriele Thumann, Daniel Scherman & Corinne Marie. (2018) The Antibiotic-free pFAR4 Vector Paired with the Sleeping Beauty Transposon System Mediates Efficient Transgene Delivery in Human Cells. Molecular Therapy - Nucleic Acids 11, pages 57-67.
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Jaitip Tipanee, Yoke Chin Chai, Thierry VandenDriessche & Marinee K. Chuah. (2017) Preclinical and clinical advances in transposon-based gene therapy. Bioscience Reports 37:6.
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Guoqing Wei, Lijuan Ding, Jiasheng Wang, Yongxian Hu & He Huang. (2017) Advances of CD19-directed chimeric antigen receptor-modified T cells in refractory/relapsed acute lymphoblastic leukemia. Experimental Hematology & Oncology 6:1.
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Jaitip TipaneeThierry VandenDriesscheMarinee K. Chuah. (2017) Transposons: Moving Forward from Preclinical Studies to Clinical Trials. Human Gene Therapy 28:11, pages 1087-1104.
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Russ HodgeSuneel A. NarayanavariZsuzsanna IzsvákZoltán Ivics. (2017) Wide Awake and Ready to Move: 20 Years of Non-Viral Therapeutic Genome Engineering with the Sleeping Beauty Transposon System . Human Gene Therapy 28:10, pages 842-855.
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Tatiana A. Konnova, Christopher M. Singer & Irina V. Nesmelova. (2017) NMR solution structure of the RED subdomain of the Sleeping Beauty transposase . Protein Science 26:6, pages 1171-1181.
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Sebastien VerhenneNele VandeputteInge PareynZsuzsanna IzsvákHanspeter RottensteinerHans DeckmynSimon F. De MeyerKaren Vanhoorelbeke. (2017) Long-Term Prevention of Congenital Thrombotic Thrombocytopenic Purpura in ADAMTS13 Knockout Mice by Sleeping Beauty Transposon-Mediated Gene Therapy. Arteriosclerosis, Thrombosis, and Vascular Biology 37:5, pages 836-844.
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Tania Sultana, Alessia Zamborlini, Gael Cristofari & Pascale Lesage. (2017) Integration site selection by retroviruses and transposable elements in eukaryotes. Nature Reviews Genetics 18:5, pages 292-308.
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