Search in:

Critical Reviews in Biochemistry and Molecular Biology Volume 55, 2020 - Issue 6

Submit an article Journal homepage

Open access

8,723

Views

CrossRef citations to date

Altmetric

Review Articles

Mammalian mitochondrial DNA replication and mechanisms of deletion formation

Maria FalkenbergDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, SwedenCorrespondence[email protected]

https://orcid.org/0000-0001-8713-173X View further author information

Claes M. GustafssonDepartment of Medical Biochemistry and Cell Biology, University of Gothenburg, Gothenburg, SwedenView further author information

Pages 509-524 | Received 07 Feb 2020, Accepted 31 Aug 2020, Published online: 24 Sep 2020

Cite this article
https://doi.org/10.1080/10409238.2020.1818684
CrossMark

Full Article
Figures & data
References
Citations
Metrics
Licensing
Reprints & Permissions
View PDF PDF View EPUB EPUB

Citations (31)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Articles from other publishers (31)

Rahul Gupta, Masahiro Kanai, Timothy J. Durham, Kristin Tsuo, Jason G. McCoy, Anna V. Kotrys, Wei Zhou, Patrick F. Chinnery, Konrad J. Karczewski, Sarah E. Calvo, Benjamin M. Neale & Vamsi K. Mootha. (2023) Nuclear genetic control of mtDNA copy number and heteroplasmy in humans. Nature 620:7975, pages 839-848.
Crossref

Laura E. NewmanGerald S. Shadel. (2023) Mitochondrial DNA Release in Innate Immune Signaling. Annual Review of Biochemistry 92:1, pages 299-332.
Crossref

Juan Pablo Muñoz, Paula Sànchez-Fernàndez-de-Landa, Elena María Goretti Diarte-Añazco, Antonio Zorzano, Francisco Blanco-Vaca & Josep Julve. (2023) FTY720-P, a Biased S1PR Ligand, Increases Mitochondrial Function through STAT3 Activation in Cardiac Cells. International Journal of Molecular Sciences 24:8, pages 7374.
Crossref

Ismael Plaza-G.A.Kateryna M Lemishko, Rodrigo Crespo, Thinh Q Truong, Laurie S Kaguni, Francisco J Cao-García, Grzegorz L Ciesielski & Borja Ibarra. (2023) Mechanism of strand displacement DNA synthesis by the coordinated activities of human mitochondrial DNA polymerase and SSB. Nucleic Acids Research 51:4, pages 1750-1765.
Crossref

Anna Klucnika, Peiqiang Mu, Jan Jezek, Matthew McCormack, Ying Di, Charles R. Bradshaw & Hansong Ma. (2023) REC drives recombination to repair double-strand breaks in animal mtDNA. Journal of Cell Biology 222:1.
Crossref

Laura C. Johnson, Anupam Singh & Smita S. Patel. (2023) The N-terminal domain of human mitochondrial helicase Twinkle has DNA-binding activity crucial for supporting processive DNA synthesis by polymerase γ. Journal of Biological Chemistry 299:1, pages 102797.
Crossref

Zhenyu Zhu, Meihua Gong, Weipeng Gong, Bishi Wang, Changhao Li, Qingsheng Hou, Hongliang Guo, Jie Chai, Jie Guan & Yanhan Jia. (2022) SHF confers radioresistance in colorectal cancer by the regulation of mitochondrial DNA copy number. Clinical and Experimental Medicine.
Crossref

Ana P.C. Rodrigues, Audrey C. Novaes, Grzegorz L. Ciesielski & Marcos T. Oliveira. (2022) Mitochondrial DNA maintenance in Drosophila melanogaster . Bioscience Reports 42:11.
Crossref

Margalida Puigròs, Anna Calderon, Alexandra Pérez-Soriano, Cristina de Dios, Manel Fernández, Anna Colell, Maria-José Martí, Eduardo Tolosa & Ramon Trullas. (2022) Cell-free mitochondrial DNA deletions in idiopathic, but not LRRK2, Parkinson's disease. Neurobiology of Disease 174, pages 105885.
Crossref

Elena Korchivaya, Yulia Silaeva, Ilya Mazunin & Ilya Volodyaev. (2022) The mitochondrial challenge: Disorders and prevention strategies. Biosystems, pages 104819.
Crossref

Majda Mehmedović, Martial Martucci, Henrik Spåhr, Layal Ishak, Anup Mishra, Maria Eugenia Sanchez-Sandoval, Carlos Pardo-Hernández, Bradley Peter, Siet M. van den Wildenberg, Maria Falkenberg & Geraldine Farge. (2022) Disease causing mutation (P178L) in mitochondrial transcription factor A results in impaired mitochondrial transcription initiation. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1868:10, pages 166467.
Crossref

Jelena Misic, Dusanka Milenkovic, Ali Al-Behadili, Xie Xie, Min Jiang, Shan Jiang, Roberta Filograna, Camilla Koolmeister, Stefan J Siira, Louise Jenninger, Aleksandra Filipovska, Anders R Clausen, Leonardo Caporali, Maria Lucia Valentino, Chiara La Morgia, Valerio Carelli, Thomas J Nicholls, Anna Wredenberg, Maria Falkenberg & Nils-Göran Larsson. (2022) Mammalian RNase H1 directs RNA primer formation for mtDNA replication initiation and is also necessary for mtDNA replication completion. Nucleic Acids Research 50:15, pages 8749-8766.
Crossref

Md. Mostafijur Rahman, Carolyn K.J. Young, Steffi Goffart, Jaakko L.O. Pohjoismäki & Matthew J. Young. (2022) Heterozygous p.Y955C mutation in DNA polymerase γ leads to alterations in bioenergetics, complex I subunit expression, and mtDNA replication. Journal of Biological Chemistry 298:8, pages 102196.
Crossref

Maria Miranda, Nina A. Bonekamp & Inge Kühl. (2022) Starting the engine of the powerhouse: mitochondrial transcription and beyond. Biological Chemistry 403:8-9, pages 779-805.
Crossref

Vibhuti Rambani, Dominika Hromnikova, Daniela Gasperikova & Martina Skopkova. (2022) Mitochondria and mitochondrial disorders: an overview update. Endocrine Regulations 56:3, pages 232-248.
Crossref

Shanjiang Zhao, Nuo Heng, Huan Wang, Haoyu Wang, Haobo Zhang, Jianfei Gong, Zhihui Hu & Huabin Zhu. (2022) Mitofusins: from mitochondria to fertility. Cellular and Molecular Life Sciences 79:7.
Crossref

Yves Pommier, André Nussenzweig, Shunichi Takeda & Caroline Austin. (2022) Human topoisomerases and their roles in genome stability and organization. Nature Reviews Molecular Cell Biology 23:6, pages 407-427.
Crossref

David F. Wilson & Franz M. Matschinsky. (2022) Integration of Eukaryotic Energy Metabolism: The Intramitochondrial and Cytosolic Energy States ([ATP]f/[ADP]f[Pi]). International Journal of Molecular Sciences 23:10, pages 5550.
Crossref

Heike Katrin Schreier, Rahel Stefanie Wiehe, Miria Ricchetti & Lisa Wiesmüller. (2022) Polymerase ζ Is Involved in Mitochondrial DNA Maintenance Processes in Concert with APE1 Activity. Genes 13:5, pages 879.
Crossref

Dusanka Milenkovic, Adrián Sanz-Moreno, Julia Calzada-Wack, Birgit Rathkolb, Oana Veronica Amarie, Raffaele Gerlini, Antonio Aguilar-Pimentel, Jelena Misic, Marie-Lune Simard, Eckhard Wolf, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis & Nils-Göran Larsson. (2022) Mice lacking the mitochondrial exonuclease MGME1 develop inflammatory kidney disease with glomerular dysfunction. PLOS Genetics 18:5, pages e1010190.
Crossref

Gustavo CarvalhoBruno Marçal Repolês, Isabela Mendes & Paulina H. Wanrooij. (2022) Mitochondrial DNA Instability in Mammalian Cells. Antioxidants & Redox Signaling 36:13-15, pages 885-905.
Crossref

Matthew J. Young, Ravi Sachidanandam, Dale B. Hales, Laurent Brard, Kathy Robinson, Md. Mostafijur Rahman, Pabitra Khadka, Kathleen Groesch & Carolyn K. J. Young. (2022) Identification of Somatic Mitochondrial DNA Mutations, Heteroplasmy, and Increased Levels of Catenanes in Tumor Specimens Obtained from Three Endometrial Cancer Patients. Life 12:4, pages 562.
Crossref

M Boguenet, V Desquiret-Dumas, D Goudenège, C Bris, L Boucret, O Blanchet, V Procaccio, P E Bouet, P Reynier & P May-Panloup. (2022) Mitochondrial DNA content reduction in the most fertile spermatozoa is accompanied by increased mitochondrial DNA rearrangement. Human Reproduction 37:4, pages 669-679.
Crossref

Pedro Silva-Pinheiro & Michal Minczuk. (2021) The potential of mitochondrial genome engineering. Nature Reviews Genetics 23:4, pages 199-214.
Crossref

Cristina A. Nadalutti, Sylvette Ayala-Peña & Janine H. Santos. (2022) Mitochondrial DNA damage as driver of cellular outcomes. American Journal of Physiology-Cell Physiology 322:2, pages C136-C150.
Crossref

Chaohua Mo, Le Xie, Chang Chen, Jie Ma, Yingxin Huang, Yanxing Wu, Yuanyuan Xu, Huizhi Peng, Zengwei Chen & Rongjun Mao. (2021) The Clinical Significance and Potential Molecular Mechanism of Upregulated CDC28 Protein Kinase Regulatory Subunit 1B in Osteosarcoma. Journal of Oncology 2021, pages 1-18.
Crossref

Christian Brüser, Jan Keller-Findeisen & Stefan Jakobs. (2021) The TFAM-to-mtDNA ratio defines inner-cellular nucleoid populations with distinct activity levels. Cell Reports 37:8, pages 110000.
Crossref

Azadeh Sarfallah, Angelica Zamudio‐Ochoa, Michael Anikin & Dmitry Temiakov. (2021) Mechanism of transcription initiation and primer generation at the mitochondrial replication origin OriL. The EMBO Journal 40:19.
Crossref

Sifeng Gu, Zsolt Bodai, Quinn T. Cowan & Alexis C. Komor. (2021) Base editors: Expanding the types of DNA damage products harnessed for genome editing. Gene and Genome Editing 1, pages 100005.
Crossref

Wilson Sebastian, Sandhya Sukumaran & A. Gopalakrishnan. (2021) The signals of selective constraints on the mitochondrial non-coding control region: insights from comparative mitogenomics of Clupeoid fishes. Genetica 149:3, pages 191-201.
Crossref

Yoon-ha Jang, Sae Ryun Ahn, Ji-yeon Shim & Kwang-il Lim. (2021) Engineering Genetic Systems for Treating Mitochondrial Diseases. Pharmaceutics 13:6, pages 810.
Crossref

Share icon
Back to Top

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.

People also read
Recommended articles
Cited by

To cite this article:

Reference style: APA Chicago Harvard

Citation copied to clipboard

Reference styles above use APA (6th edition), Chicago (16th edition) & Harvard (10th edition)

Download citation

Download a citation file in RIS format that can be imported by citation management software including EndNote, ProCite, RefWorks and Reference Manager.

Choose format: RIS BibTex RefWorks Direct Export

Choose options: Citation Citation & abstract Citation & references

Mammalian mitochondrial DNA replication and mechanisms of deletion formation

Articles from other publishers (31)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Mammalian mitochondrial DNA replication and mechanisms of deletion formation

Citations (31)

Articles from other publishers (31)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date