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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 170, 2001 - Issue 1
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Original Articles

SYNTHESIS, REACTIONS AND CONFORMATIONAL ANALYSIS OF 5-ARYLIDENE-2-THIOHYDANTOINS AS POTENTIAL ANTIVIRAL AGENTS

A. I. Khodair Chemistry Department, Faculty of Education, Tanta University, Kafr El-Sheikh Branch, Kafr El-Sheikh, Egypt
,
A. A. El-barbary Chemistry Department, Faculty of science, Tanta University, Tanta, Egypt
,
Y. A. Abbas Chemistry Department, Faculty of Education, Tanta University, Kafr El-Sheikh Branch, Kafr El-Sheikh, Egypt
&
D. R. Imam Chemistry Department, Faculty of Education, Tanta University, Kafr El-Sheikh Branch, Kafr El-Sheikh, Egypt
Pages 261-278 | Received 01 Sep 2000, Accepted 29 Nov 2000, Published online: 27 Oct 2006

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Ravi Kumar, Shashi Pandey, Shahnawaz Khan & Prem M. S. Chauhan. (2011) SnCl2·2H2O: An Efficient Reagent for Selective and Direct Oxidative Desulfurization of Phenylmethylene-2-thiohydantoins to Corresponding Hydantoins. Phosphorus, Sulfur, and Silicon and the Related Elements 186:7, pages 1404-1410.
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A.A. El-Barbary, A.Z. Abou El-Ezz, A.M. Sharaf & C. Nielsen. (2007) Studies on 2,4-Dithioxo and 2-Thioxoimidazolidene Derivatives. Phosphorus, Sulfur, and Silicon and the Related Elements 182:7, pages 1621-1632.
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YoussefL. Aly, AhmedA. El-Barbary & AshrafA. El-Shehawy. (2004) ALKYLATION OF THIOHYDANTOINS INCLUDING SYNTHESIS, CONFORMATIONAL AND CONFIGURATIONAL STUDIES OF SOME ACETYLATED S-PYRANOSIDES. Phosphorus, Sulfur, and Silicon and the Related Elements 179:1, pages 185-202.
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Articles from other publishers (14)

Ahmed I. Khodair, Safyah B. Bakare, Mohamed K. Awad, Siham A. Al‐Issa & Mohamed S. Nafie. (2022) Design, synthesis, and computational explorations of novel 2‐thiohydantoin nucleosides with cytotoxic activities. Journal of Heterocyclic Chemistry 59:4, pages 664-685.
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Mostafa M. Elbadawi, Ahmed I. Khodair, Mohamed K. Awad, Shaymaa E. Kassab, Mohammed T. Elsaady & Khaled R.A. Abdellatif. (2022) Design, synthesis and biological evaluation of novel thiohydantoin derivatives as antiproliferative agents: A combined experimental and theoretical assessments. Journal of Molecular Structure 1249, pages 131574.
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Mohamed S. Nafie, Ahmed I. Khodair, Hebat Allah Y. Hassan, Noha M. Abd El-Fadeal, Hanin A. Bogari, Sameh S. Elhady & Safwat A. Ahmed. (2021) Evaluation of 2-Thioxoimadazolidin-4-one Derivatives as Potent Anti-Cancer Agents through Apoptosis Induction and Antioxidant Activation: In Vitro and In Vivo Approaches. Molecules 27:1, pages 83.
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Ahmed I. Khodair, Safyah B. Bakare, Mohamed K. Awad & Mohamed S. Nafie. (2021) Design, synthesis, DFT, molecular modelling studies and biological evaluation of novel 3-substituted (E)-5-(arylidene)-1-methyl-2-thioxoimidazolidin-4-ones with potent cytotoxic activities against breast MCF-7, liver HepG2, and lung A549. Journal of Molecular Structure 1229, pages 129805.
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Ahmed I. Khodair, Ahmed A. El-Barbary, Dalia R. Imam, Nabila A. Kheder, Faisal Elmalki & Taibi Ben Hadda. (2021) Synthesis, antiviral, DFT and molecular docking studies of some novel 1,2,4-triazine nucleosides as potential bioactive compounds. Carbohydrate Research 500, pages 108246.
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Rei Saito, Naohiro Uemura, Hiroki Ishikawa, Akina Magara, Yasushi Yoshida, Takashi Mino, Yoshio Kasashima & Masami Sakamoto. (2018) Umpolung cyclization reaction of N -cinnamoylthioureas in the presence of DBU . Organic & Biomolecular Chemistry 16:42, pages 7910-7919.
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Hamid Aziz, Aamer Saeed & Jim Simpson. (2018) 5,5-Diphenyl-2-thioxoimidazolidin-4-one dimethyl sulfoxide monosolvate. IUCrData 3:7.
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Duygu Erşen, Mahmut Ülger, Sven Mangelinckx, Müge Gemili, Ertan Şahin & Yahya Nural. (2017) Synthesis and anti(myco)bacterial activity of novel 5,5-diphenylpyrrolidine N-aroylthiourea derivatives and a functionalized hexahydro-1H-pyrrolo[1,2-c]imidazole. Medicinal Chemistry Research 26:9, pages 2152-2160.
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Yun Soo Bae, Sun Choi, Jung Jae Park, Jung Hee Joo, Minghua Cui, Hyunsung Cho, Won Jae Lee & Sang Hyup Lee. (2016) Synthesis and biological evaluation of 3-substituted 5-benzylidene-1-methyl-2-thiohydantoins as potent NADPH oxidase (NOX) inhibitors. Bioorganic & Medicinal Chemistry 24:18, pages 4144-4151.
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Elena K. Beloglazkina, Alexander G. Majouga, Andrei V. Mironov, Anna V. Yudina, Olga Yu. Kuznetsova & Nikolai V. Zyk. (2014) Conversion of 2-thiohydantoins and their derivatives to the corresponding hydantoins in the processes of complexation reactions with copper(II) chloride dihydrate. Polyhedron 76, pages 45-50.
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Yahya Nural, H. Ali Döndaş, Hayati Sarı, Hasan Atabey, Samet Belveren & Müge Gemili. (2014) Determination of Acid Dissociation Constants ( ) of Bicyclic Thiohydantoin-Pyrrolidine Compounds in 20% Ethanol-Water Hydroorganic Solvent . International Journal of Analytical Chemistry 2014, pages 1-6.
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Mudit Mudit & Khalid A. El Sayed. (2011) Optimization of (Phenylmethylidene)‐hydantoins as Prostate Cancer Migration Inhibitors: SAR‐Directed Design, Synthesis, and Pharmacophore Modeling. Chemistry & Biodiversity 8:8, pages 1470-1485.
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H. Ali Döndaş, Yahya Nural, Ronald Grigg & Ertan Şahin. (2011) Polysubstituted Fused Ring Bicyclic Thiohydantoins from Aminocarbo-N-thioylpyrrolidines Derived from Azomethine Ylide 1,3-Dipolar Cycloadditions. HETEROCYCLES 83:9, pages 2091.
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Brian T. Gregg, Kathryn C. Golden, John F. Quinn, Dmytro O. Tymoshenko, William G. Earley, Dacia A. Maynard, Dana A. Razzano, W. Martin Rennells & Jennifer Butcher. (2007) Expedient Lewis Acid Catalyzed Synthesis of a 3-Substituted 5-Arylidene-1-methyl-2-thiohydantoin Library. Journal of Combinatorial Chemistry 9:6, pages 1036-1040.
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