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Phosphorus, Sulfur, and Silicon and the Related Elements Volume 178, 2003 - Issue 5
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Original Articles

Recent Trends in the Chemistry of Thienopyridines

Etify Abdel-Ghafar Bakhite Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt
Pages 929-992 | Published online: 27 Oct 2010

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LeandroF. Pedrosa, WilliamP. de Macedo, AntoniaC. R. Furtado, GuilhermeP. Guedes, LuizC. S. Pinheiro, JacksonA. L. C. Resende, MariaG. F. Vaz, AliceM. R. Bernardino & MarcosC. de Souza. (2013) Synthesis, Crystal Structures, and in Silico Toxicity Prediction of Thienopyridine Phosphoramidates. Synthetic Communications 43:24, pages 3373-3386.
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Articles from other publishers (38)

Suzan Abuelhassan, Etify A. Bakhite, Abdu E. Abdel‐Rahman, Ahmed F. M. El‐Mahdy, Abdelreheem A. Saddik, Islam S. Marae, Shams H. Abdel‐Hafez & Mahmoud Tolba. (2022) Synthesis, photophysical properties, and biological activities of some new thienylpyridines, thienylthieno[2.3‐ b ]pyridines and related fused heterocyclic compounds . Journal of Heterocyclic Chemistry 60:3, pages 458-470.
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Victor V. Dotsenko, Alexander V. Aksenov, Anna E. Sinotsko, Ekaterina A. Varzieva, Alena A. Russkikh, Arina G. Levchenko, Nicolai A. Aksenov & Inna V. Aksenova. (2022) The Reactions of N,N′-Diphenyldithiomalondiamide with Arylmethylidene Meldrum’s Acids. International Journal of Molecular Sciences 23:24, pages 15997.
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Shaaban K. Mohamed, Etify A. Bakhite, Sevim Türktekin Çelikesir, Hajjaj H. M. Abdu-Allah, Mehmet Akkurt, Omaima F. Ibrahim, Joel T. Mague & Safiyyah A. H. Al-Waleedy. (2022) Crystal structure and Hirshfeld surface analysis of 5-acetyl-3-amino-6-methyl- N -phenyl-4-[( E )-2-phenylethenyl]thieno[2,3- b ]pyridine-2-carboxamide . Acta Crystallographica Section E Crystallographic Communications 78:2, pages 225-230.
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Suzan Abuelhassan, Etify A.‐G. Bakhite, Abdu E. Abdel‐Rahman & Ahmed F. M. El‐Mahdy. (2021) Synthesis, characterization, and biological activities of some novel thienylpyrido[3′,2′:4,5]thieno[3,2‐ d ]pyrimidines and related heterocycles . Journal of Heterocyclic Chemistry 58:9, pages 1784-1801.
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O. F. Ibrahim, E. A. Bakhite, S. A. M. Metwally, Y. A. El-Ossaily, H. H. M. Abdu-Allah, E. A. Al-Taifi & M. Kandel. (2021) Synthesis, Characterization, and Antifungal Activity of Some New Thieno[2,3-b]pyridines Incorporating Quinazoline or Benzimidazole Moiety. Russian Journal of Bioorganic Chemistry 47:4, pages 918-928.
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L. Yu. Ukhin, L. G. Kuz’mina, D. V. Alexeenko, L. V. Belousova, T. N. Gribanova, A. S. Morkovnik, E. N. Shepelenko, G. S. Borodkin, O. I. Dmitrieva & V. A. Podshibyakin. (2021) Synthesis, structure, and properties of 2-[(4,6-di-tert-butyl-2,3-dihydroxyphenyl)thio]acetic acid amides. Russian Chemical Bulletin 70:7, pages 1368-1376.
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L. V. Dyadyuchenko, V. V. Dotsenko, V. S. Muraviev, I. G. Dmitrieva, N. A. Aksenov & I. V. Aksenova. (2021) Unusual regioselective reaction of 2,6-dichloro-4-methylnicotinonitrile with malononitrile dimer. Russian Chemical Bulletin 70:7, pages 1363-1367.
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Tatyana A. Stroganova, Vladimir K. Vasilin, Victor V. Dotsenko, Nicolai A. Aksenov, Pavel G. Morozov, Pavel M. Vassiliev, Vitaly A. Volynkin & Gennady D. Krapivin. (2021) Unusual Oxidative Dimerization in the 3-Aminothieno[2,3- b ]pyridine-2-carboxamide Series . ACS Omega 6:22, pages 14030-14048.
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V. V. Dotsenko, D. S. Buryi, D. Yu. Lukina & S. G. Krivokolysko. (2020) Recent advances in the chemistry of thieno[2,3-b]pyridines 1. Methods of synthesis of thieno[2,3-b]pyridines. Russian Chemical Bulletin 69:10, pages 1829-1858.
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A. V. KovtunS. V. TokarievaS. A. VarenichenkoO. K. FaratA. V. MazepaV. V. DotsenkoV. I. Markov. (2020) Spirocyclic thienopyrimidines: synthesis, new rearrangements under Vilsmeier conditions and in silico prediction of anticancer activity. Biopolymers and Cell 36:4, pages 279-293.
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Salwa E. M. El-Meligie, Nadia A. Khalil, Hala B. El-Nassan & Ahmed A. M. Ibraheem. (2020) New synthetic approaches to thieno[3,2-d]pyrimidine and thieno[3,4-b]pyridine derivatives. Chemical Papers 74:8, pages 2501-2514.
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Safiyyah A. H. Al‐Waleedy, Etify A. Bakhite, Mohamed S. Abbady & Hajjaj H. M. Abdu‐Allah. (2020) Synthesis and characterization of some new pyridines, thieno[2,3‐ b ] pyridines and pyrido[3′,2′:4,5]thieno[3,2‐ d ]pyrimidine‐4(3 H )‐ones bearing styryl moiety . Journal of Heterocyclic Chemistry 57:6, pages 2379-2388.
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Victor V. Dotsenko, Dmitrii S. Buryi, Darya Yu. Lukina, Angelica N. Stolyarova, Nicolai A. Aksenov, Inna V. Aksenova, Vladimir D. Strelkov & Lyudmila V. Dyadyuchenko. (2019) Substituted N-(thieno[2,3-b]pyridine-3-yl)acetamides: synthesis, reactions, and biological activity. Monatshefte für Chemie - Chemical Monthly 150:11, pages 1973-1985.
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E. A. Chigorina, A. V. Bespalov & V. V. Dotsenko. (2019) Synthesis and Cyclizations of N-(Thieno[2,3-b]pyridin-3-yl)cyanoacetamides. Russian Journal of General Chemistry 89:10, pages 2018-2026.
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D. S. Buryi, V. V. Dotsenko, N. A. Aksenov, I. V. Aksenova, S. G. Krivokolysko & L. V. Dyadyuchenko. (2019) Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines. Russian Journal of General Chemistry 89:8, pages 1575-1585.
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D. S. Buryi, V. V. Dotsenko, A. S. Levashov, D. Yu. Lukina, V. D. Strelkov, N. A. Aksenov, I. V. Aksenova & E. E. Netreba. (2019) Synthesis of 4,6-Disubstituted 2-Thioxo-1,2-dihydropyridine-3-carbonitriles by the Reaction of Acetylenic Ketones with Cyanothioacetamide. Russian Journal of General Chemistry 89:5, pages 886-895.
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Tatyana A. Stroganova, Vladimir K. Vasilin, Victor V. Dotsenko, Nikolai A. Aksenov & Gennady D. Krapivin. (2019) Reaction of thieno[2,3-b]pyridines with sodium hypochlorite: An unusual and stereoselective one-pot approach to dimeric pyrrolo[2′,3′:4,5]thieno[2,3-b]pyridines. Tetrahedron Letters 60:14, pages 997-1000.
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Yibiao Li, Xianglin Luo, Yan Shao & Lu Chen. (2018) 2-Acetylthienopyridine Synthesis via Thiolation and Copper-Catalyzed Cyclization of o -Propynol Fluoropyridine Using Xanthate as a Thiol Surrogate . The Journal of Organic Chemistry 83:15, pages 8768-8774.
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V. V. Dotsenko, S. G. Krivokolysko, B. S. Krivokolysko & K. A. Frolov. (2018) A New Approach to the Synthesis of Functional Derivatives of 3-(4-Pyridinyl)-1H-indole and 4-(1H-Indol-3-yl)thieno[2,3-b]pyridine. Russian Journal of General Chemistry 88:4, pages 682-688.
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Shaaban K. Mohamed, Joel T. Mague, Mehmet Akkurt, Etify A. Bakhite & Elham A. Al-Taifi. (2017) 5-Acetyl-3-amino-4-(4-methoxyphenyl)-6-methylthieno[2,3- b ]pyridine-2-carbonitrile . IUCrData 2:12.
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H. Abdel-Ghany, A. M. El-Sayed, A. A. Amer & A. M. Ahmed. (2016) Synthesis of Novel Fused Heterocycles Based on 6-Amino-4-phenyl-2-thioxo-1,2-dihydropyridine-3,5-dicarbonitrile. Journal of Heterocyclic Chemistry 53:6, pages 2013-2019.
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Victor V. Dotsenko, Arif I. Ismiev, Anastasiya N. Khrustaleva, Konstantin A. Frolov, Sergey G. Krivokolysko, Elena A. Chigorina, Aleksey P. Snizhko, Vladimir M. Gromenko, Ivan S. Bushmarinov, Rizvan K. Askerov, Tatyana M. Pekhtereva, Sergey Yu. Suykov, Elena S. Papayanina, Aleksandr V. Mazepa & Abel M. Magerramov. (2016) Synthesis, structure, and reactions of (4-aryl-3-cyano-6-oxopiperidin-2-ylidene)malononitriles. Chemistry of Heterocyclic Compounds 52:7, pages 473-483.
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Elham A. Al-Taifi, Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt & Etify A. Bakhite. (2016) Ethyl 13-(4-chlorophenyl)-11-methyl-6-oxo-5-phenyl-8-thia-3,4,5,10-tetraazatricyclo[7.4.0.0 2,7 ]trideca-1(9),2(7),3,10,12-pentaene-12-carboxylate . IUCrData 1:5.
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Etify A. Bakhite, Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt & Elham A. Al-Taifi. (2016) Ethyl 3-amino-4-(4-chlorophenyl)-2-[(4-methoxyphenyl)carbamoyl]-6-phenylthieno[2,3- b ]pyridine-5-carboxylate . IUCrData 1:4.
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Joel T. Mague, Mehmet Akkurt, Shaaban K. Mohamed, Etify A. Bakhite & Mustafa R. Albayati. (2016) Crystal structure of ethyl 3-amino-6-methyl-2-[(4-methylphenyl)carbamoyl]-4-[( E )-2-phenylethenyl]thieno[2,3- b ]pyridine-5-carboxylate monohydrate . Acta Crystallographica Section E Crystallographic Communications 72:3, pages 297-299.
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Joel T. Mague, Shaaban K. Mohamed, Mehmet Akkurt, Etify A. Bakhite & Mustafa R. Albayati. (2016) Diethyl 3-amino-6-methyl-4-[( E )-2-phenylethenyl]thieno[2,3- b ]pyridine-2,5-dicarboxylate . IUCrData 1:2.
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Jelena Vasiljeva, Ilona Domracheva & Pavel Arsenyan. (2016) Selenium analogues of ( S )-clopidogrel: preparation method and properties. Tetrahedron Letters 57:2, pages 196-198.
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Etify A. Bakhite, Abdu E. Abdel-Rahman & Elham A. Al-Taifi. (2014) Fluorine-containing heterocycles: Part III. Synthesis of some new furo[2,3-b]-, pyrazolo[3,4-b]- and thieno[2,3-b]pyridines with anticipated biological activities. Arabian Journal of Chemistry 7:6, pages 936-946.
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Mani Anusha Rani, Veerappan Jeyachandran, Muthumani Muthu, Subbiah Sivakolunthu & Raju Ranjith Kumar. (2014) Microwave-assisted chemoselective synthesis of novel pyrazolo[3,4-b]thieno[3,4-e]pyridines: substitution induced axial chirality. Tetrahedron Letters 55:42, pages 5805-5807.
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V. V. Dotsenko & S. G. Krivokolysko. (2013) Synthesis of pyrido[3',2':4,5]thieno[3,2-d]-[1,3,2]diazaphosphorine derivatives. Chemistry of Heterocyclic Compounds 48:12, pages 1863-1867.
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V. V. Dotsenko, D. V. Sventukh & S. G. Krivokolysko. (2012) Condensed sulfur-containing pyridine systems 3.* Construction of penta- and hexacyclic heterocyclic systems by the cascade reaction of 3-cyanopyridine-2(1H)-thiones and 3-cyano-pyridine-2(1H)-thiolates with 8-chloromethyl-3-methyl-7-(2-oxo-2-phenylethyl)xanthene. Chemistry of Heterocyclic Compounds 48:9, pages 1397-1409.
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V. V. Dotsenko, I. A. Lebedeva, S. G. Krivokolysko, M. V. Povstyanoi, V. M. Povstyanoi & E. O. Kostyrko. (2012) Reaction of ethyl 4-aryl-6-bromomethyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates with N-methylmorpholinium 3-cyano-1,4-dihydro- and 3-cyano-1,4,5,6-tetrahydropyridine-2-thiolates. Chemistry of Heterocyclic Compounds 48:3, pages 462-469.
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Serry A. A. El Bialy & Moustafa A. Gouda. (2011) Cyanoacetamide in heterocyclic chemistry: Synthesis, antitumor and antioxidant activities of some new benzothiophenes. Journal of Heterocyclic Chemistry 48:6, pages 1280-1286.
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Bruno Leal, Ilídio F. Afonso, Carlos R. Rodrigues, Paula A. Abreu, Rafael Garrett, Luiz Carlos S. Pinheiro, Alexandre R. Azevedo, Julio C. Borges, Percilene F. Vegi, Cláudio C.C. Santos, Francisco C.A. da Silveira, Lúcio M. Cabral, Izabel C.P.P. Frugulhetti, Alice M.R. Bernardino, Dilvani O. Santos & Helena C. Castro. (2008) Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure–activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives. Bioorganic & Medicinal Chemistry 16:17, pages 8196-8204.
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A.R. Sherman. 2008. Comprehensive Heterocyclic Chemistry III. Comprehensive Heterocyclic Chemistry III 263 338 .
V. V. Dotsenko, S. G. Krivokolysko & V. P. Litvinov. (2007) The Mannich reaction in the synthesis of N,S-containing heterocycles. 7. Effective one-pot synthesis of derivatives of spiro[3,5,7,11-tetraazatricyclo-[7.3.1.02,7]tridec-2-ene-13,4′-piperidine]. Chemistry of Heterocyclic Compounds 43:11, pages 1455-1459.
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V. V. Dotsenko, S. G. Krivokolysko, A. N. Chernega & V. P. Litvinov. (2007) A new stereoselective synthesis of 2-amino-4,5-dihydrothiophene-3-carbonitrile derivatives. Russian Chemical Bulletin 56:7, pages 1431-1436.
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