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Leukemia & Lymphoma Volume 44, 2003 - Issue 3
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Research Article

High Affinity Molecules Disrupting GRB2 Protein Complexes as a Therapeutic Strategy for Chronic Myelogenous Leukaemia

Stephan M. Feller Cell Signalling Group, Molecular Oncology Laboratory, Cancer Research UK, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
,
Gabriele Tuchscherer Ecole polytechnique fédérale de Lausanne, Institut de chimie moléculaire et biologique (ICMB), EPFL-BCH, Lausanne, Switzerland
&
Jan Voss Department of Neurology, University of Saarland, Homburg/Saar, Germany
Pages 411-427 | Published online: 01 Jul 2009

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Alessio Giubellino, Terrence R Burke & Donald P Bottaro. (2008) Grb2 signaling in cell motility and cancer. Expert Opinion on Therapeutic Targets 12:8, pages 1021-1033.
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Articles from other publishers (20)

Samrein B. M. Ahmed & Sally A. Prigent. (2017) Insights into the Shc Family of Adaptor Proteins. Journal of Molecular Signaling 12.
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Nico J. de Mol, John A.W. Kruijtzer, Ed E. Moret, Isabelle Broutin & Rob M.J. Liskamp. (2013) Unusual binding of Grb2 protein to a bivalent polyproline-ligand immobilized on a SPR sensor: Intermolecular bivalent binding. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1834:2, pages 524-535.
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James Luccarelli, Sam Thompson & Andrew D. Hamilton. 2013. Protein-Protein Interactions in Drug Discovery. Protein-Protein Interactions in Drug Discovery 101 128 .
Alessio Giubellino. 2012. Cell Signaling & Molecular Targets in Cancer. Cell Signaling & Molecular Targets in Cancer 1 22 .
H Modi, L Li, S Chu, J Rossi, J-K Yee & R Bhatia. (2010) Inhibition of Grb2 expression demonstrates an important role in BCR–ABL-mediated MAPK activation and transformation of primary human hematopoietic cells. Leukemia 25:2, pages 305-312.
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Lin-Quan LAI, Yun-Sheng YUAN, Jin GAO, Run-Zhi ZHU & Yan YU. (2011) Differential expression of MAPK-pathway genes during liver regeneration of mouse. Hereditas (Beijing) 32:10, pages 1043-1050.
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Stéphane Pierre, Anne-Sophie Bats, Aline Chevallier, Linh-Chi Bui, Ariane Ambolet-Camoit, Michèle Garlatti, Martine Aggerbeck, Robert Barouki & Xavier Coumoul. (2011) Induction of the Ras activator Son of Sevenless 1 by environmental pollutants mediates their effects on cellular proliferation. Biochemical Pharmacology 81:2, pages 304-313.
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Alessio Giubellino & Praveen R. Arany. 2010. Signal Transduction in Cancer Metastasis. Signal Transduction in Cancer Metastasis 77 102 .
Maria Harkiolaki, Theodora Tsirka, Marc Lewitzky, Philip C. Simister, Dhira Joshi, Louise E. Bird, E. Yvonne Jones, Nicola O'Reilly & Stephan M. Feller. (2009) Distinct Binding Modes of Two Epitopes in Gab2 that Interact with the SH3C Domain of Grb2. Structure 17:6, pages 809-822.
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Sarasija Hoare, Kishalay Hoare, Mary K. Reinhard, Young J. Lee, S. Paul Oh & W. Stratford MayJr.Jr.. (2008) Tnk1/Kos1 Knockout Mice Develop Spontaneous Tumors. Cancer Research 68:21, pages 8723-8732.
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Yun-Bin Ye, Jian-Yin Lin, Qiang Chen, Fang Liu, Hui-Jing Chen, Jie-Yu Li, Wang-Qing Liu, Christiane Garbay & Michel Vidal. (2008) The cytotoxicity of a Grb2-SH3 inhibitor in Bcr-Abl positive K562 cells. Biochemical Pharmacology 75:11, pages 2080-2091.
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Adriaan W. Tuin, Gregg Siegal, Gijsbert A. van der Marel, Herman S. Overkleeft & Dmitri V. Filippov. (2006) Facile synthesis and application of uniformly 13C, 15N-labeled phosphotyrosine for ligand binding studies. Bioorganic & Medicinal Chemistry Letters 16:14, pages 3806-3808.
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Pamela H. Correll, Robert F. Paulson & Xin Wei. (2006) Molecular regulation of receptor tyrosine kinases in hematopoietic malignancies. Gene 374, pages 26-38.
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Zhen-Dan Shi, Hongpeng Liu, Manchao Zhang, Karen M. Worthy, Lakshman Bindu, Dajun Yang, Robert J. Fisher & Terrence R. BurkeJr.Jr.. (2005) Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity. Bioorganic & Medicinal Chemistry 13:13, pages 4200-4208.
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Sang-Uk Kang, Zhen-Dan Shi, Karen M. Worthy, Lakshman K. Bindu, Pathirage G. Dharmawardana, Sarah J. Choyke, Donald P. Bottaro, Robert J. Fisher & Terrence R. Burke. (2005) Examination of Phosphoryl-Mimicking Functionalities within a Macrocyclic Grb2 SH2 Domain-Binding Platform. Journal of Medicinal Chemistry 48:12, pages 3945-3948.
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Zhen-Dan Shi, Rajeshri G. Karki, Shinya Oishi, Karen M. Worthy, Lakshman K. Bindu, Pathirage G. Dharmawardana, Marc C. Nicklaus, Donald P. Bottaro, Robert J. Fisher & Terrence R. BurkeJr.Jr.. (2005) Utilization of a nitrobenzoxadiazole (NBD) fluorophore in the design of a Grb2 SH2 domain-binding peptide mimetic. Bioorganic & Medicinal Chemistry Letters 15:5, pages 1385-1388.
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Robert L IlariaJrJr. (2004) Animal models of chronic myelogenous leukemia. Hematology/Oncology Clinics of North America 18:3, pages 525-543.
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Yan-Li Song, Peter P. Roller & Ya-Qiu Long. (2004) Development of l-3-aminotyrosine suitably protected for the synthesis of a novel nonphosphorylated hexapeptide with low-nanomolar Grb2-SH2 domain-binding affinity. Bioorganic & Medicinal Chemistry Letters 14:12, pages 3205-3208.
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Zhen-Dan Shi, Kyeong Lee, Hongpeng Liu, Manchao Zhang, Lindsey R Roberts, Karen M Worthy, Matthew J Fivash, Robert J Fisher, Dajun Yang & Terrence R BurkeJr.Jr.. (2003) A novel macrocyclic tetrapeptide mimetic that exhibits low-picomolar Grb2 SH2 domain-binding affinity. Biochemical and Biophysical Research Communications 310:2, pages 378-383.
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. (2003) Current Awareness in Hematological Oncology. Hematological Oncology 21:2, pages 91-98.
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