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Leukemia & Lymphoma Volume 45, 2004 - Issue 1
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Original Article

Internal Tandem Duplications of Flt3 Gene (Flt3/ITD) Predicts a Poor Post-Remission Outcome in Adult Patients with Acute Non-Promyelocytic Leukemia

S CIOLLI Department of Hematology, University and Hospital Careggi, 50139 Florence, ItalyCorrespondence[email protected]
,
AM VANNUCCHI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
,
F LEONI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
,
C NOZZOLI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
,
G LONGO Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
,
A SALATI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
,
A PANCRAZZI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
,
L BIANCHI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
,
F GIGLI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
&
A BOSI Department of Hematology, University and Hospital Careggi, 50139 Florence, Italy
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Pages 73-78 | Published online: 03 Aug 2009

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Shannon R. McCurdy & Mark J. Levis. (2018) Emerging molecular predictive and prognostic factors in acute myeloid leukemia. Leukemia & Lymphoma 59:9, pages 2021-2039.
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Articles from other publishers (17)

Harry P Erba, Pau Montesinos, Hee-Je Kim, Elżbieta Patkowska, Radovan Vrhovac, Pavel Žák, Po-Nan Wang, Tsvetomir Mitov, James Hanyok, Yasser Mostafa Kamel, Jaime E Connolly Rohrbach, Li Liu, Aziz Benzohra, Arnaud Lesegretain, Jorge Cortes, Alexander E Perl, Mikkael A Sekeres, Hervé Dombret, Sergio Amadori, Jianxiang Wang, Mark J Levis & Richard F Schlenk. (2023) Quizartinib plus chemotherapy in newly diagnosed patients with FLT3-internal-tandem-duplication-positive acute myeloid leukaemia (QuANTUM-First): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet 401:10388, pages 1571-1583.
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Kyriaki Tzogani, Yang Yu, Didier Meulendijks, Carla Herberts, Paula Hennik, Remy Verheijen, Torunn Wangen, Gro Dahlseng Håkonsen, Torny Kaasboll, Marianne Dalhus, Bjorg Bolstad, Tomas Salmonson, Christian Gisselbrecht & Francesco Pignatti. (2019) European Medicines Agency review of midostaurin (Rydapt) for the treatment of adult patients with acute myeloid leukaemia and systemic mastocytosis. ESMO Open 4:6, pages e000606.
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Kerstin Maria Kampa-Schittenhelm, Michael Charles Heinrich, Figen Akmut, Hartmut Döhner, Konstanze Döhner & Marcus Matthias Schittenhelm. (2013) Quizartinib (AC220) is a potent second generation class III tyrosine kinase inhibitor that displays a distinct inhibition profile against mutant-FLT3, -PDGFRA and -KIT isoforms. Molecular Cancer 12:1, pages 19.
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Rabab Aly, Dina Shahin & Emad Azmy. (2011) Prognostic significance of FLT3 internal tandem duplication in Egyptian acute myeloid leukemia and normal cytogenetics. Comparative Clinical Pathology 21:5, pages 1029-1035.
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Tamás Bubán, Katalin Koczok, Róza Földesi, Gabriella Szabó, Andrea Sümegi, Miklós Tanyi, László Szerafin, Miklós Udvardy, János Kappelmayer & Péter Antal-Szalmás. (2012) Detection of internal tandem duplications in the FLT3 gene by different electrophoretic methods. Clinical Chemistry and Laboratory Medicine (CCLM) 50:2.
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Hady Ghanem, Niki Tank & Imad A. Tabbara. (2011) Prognostic implications of genetic aberrations in acute myelogenous leukemia with normal cytogenetics. American Journal of Hematology 87:1, pages 69-77.
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Naveen Pemmaraju, Hagop Kantarjian, Farhad Ravandi & Jorge Cortes. (2011) FLT3 inhibitors in the treatment of acute myeloid leukemia. Cancer 117:15, pages 3293-3304.
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Tara K Gregory, David Wald, Yichu Chen, Johanna M Vermaat, Yin Xiong & William Tse. (2009) Molecular prognostic markers for adult acute myeloid leukemia with normal cytogenetics. Journal of Hematology & Oncology 2:1.
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Richard M. Stone. (2009) Prognostic factors in AML in relation to (ab)normal karyotype. Best Practice & Research Clinical Haematology 22:4, pages 523-528.
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David Wald, Johanna M. Vermaat, Gil Peleg & William Tse. (2008) Genetic abnormalities in acute myelogenous leukemia with normal cytogenetics. Current Hematologic Malignancy Reports 3:2, pages 83-88.
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D Auclair, D Miller, V Yatsula, W Pickett, C Carter, Y Chang, X Zhang, D Wilkie, A Burd, H Shi, S Rocks, R Gedrich, L Abriola, H Vasavada, M Lynch, J Dumas, P A Trail & S M Wilhelm. (2007) Antitumor activity of sorafenib in FLT3-driven leukemic cells. Leukemia 21:3, pages 439-445.
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Salvatore Palmieri, Felicetto Ferrara, Franco Leoni, Stefania Ciolli, Filiberto Pollio, Maria Rosaria D'Amico, Maria Celentano, Assunta Viola, Laura Vicari, Barbara Izzo & Fabrizio Pane. (2007) Myeloablative chemotherapy followed by autologous stem cell infusion may overcome the adverse prognostic impact of FLT3 (foetal liver tyrosine kinase 3) mutations in patients with acute myeloid leukaemia and normal karyotype. Hematological Oncology 25:1, pages 1-5.
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Sang-Ho KimYeo-Kyeoung KimIl-Kwon LeeDeog-Yeon JoJong-Ho WonJae-Yong KwakChang-Yeol YimMoo-Rim ParkDeok-Hwan YangSang-Hee ChoJe-Jung LeeIk-Joo ChungHyeoung-Joon Kim. (2007) FLT3 Internal Tandem Duplication in Acute Myeloid Leukemia with Normal Karyotype. The Korean Journal of Hematology 42:3, pages 250.
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M M Schittenhelm, K W H Yee, J W Tyner, L McGreevey, A D Haley, A Town, D J Griffith, T Bainbridge, R M Braziel, A-M O'Farrell, J M Cherrington & M C Heinrich. (2006) FLT3 K663Q is a novel AML-associated oncogenic kinase: determination of biochemical properties and sensitivity to Sunitinib (SU11248). Leukemia 20:11, pages 2008-2014.
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V Ponziani, G Gianfaldoni, F Mannelli, F Leoni, S Ciolli, P Guglielmelli, E Antonioli, G Longo, A Bosi & A M Vannucchi. (2006) The size of duplication does not add to the prognostic significance of FLT3 internal tandem duplication in acute myeloid leukemia patients. Leukemia 20:11, pages 2074-2076.
Crossref
M Yanada, K Matsuo, T Suzuki, H Kiyoi & T Naoe. (2005) Prognostic significance of FLT3 internal tandem duplication and tyrosine kinase domain mutations for acute myeloid leukemia: a meta-analysis. Leukemia 19:8, pages 1345-1349.
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C Callens, S Chevret, J-M Cayuela, B Cassinat, E Raffoux, S de Botton, X Thomas, A Guerci, N Fegueux, A Pigneux, A-M Stoppa, T Lamy, F Rigal-Huguet, A Vekhoff, S Meyer-Monard, A Ferrand, M Sanz, C Chomienne, P Fenaux & H Dombret. (2005) Prognostic implication of FLT3 and Ras gene mutations in patients with acute promyelocytic leukemia (APL): a retrospective study from the European APL Group. Leukemia 19:7, pages 1153-1160.
Crossref

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