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Original Article

Bryostatin Induces Protein Kinase C Modulation, Mcl-1 Up-Regulation and Phosphorylation of Bcl-2 Resulting in Cellular Differentiation and Resistance to Drug-induced Apoptosis in B-cell Chronic Lymphocytic Leukemia Cells

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Pages 997-1008 | Received 16 Oct 2003, Published online: 03 Aug 2009

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Read on this site (4)

Cecile Liffraud, Anne Quillet-Mary, Jean-Jacques Fournié, Guy Laurent & Loic Ysebaert. (2012) Protein phosphatase-2A activation is a critical step for enzastaurin activity in chronic lymphoid leukemia cells. Leukemia & Lymphoma 53:5, pages 966-972.
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Kumudha Balakrishnan & Varsha Gandhi. (2012) Protein kinases: emerging therapeutic targets in chronic lymphocytic leukemia. Expert Opinion on Investigational Drugs 21:4, pages 409-423.
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Amanda J. Redig & Leonidas C. Platanias. (2008) Protein kinase C signalling in leukemia. Leukemia & Lymphoma 49:7, pages 1255-1262.
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Thomas J. Manning, Emily Rhodes, Michael Land, Render Parkman, Brandy Sumner, TuKiet T. Lam, Alan G. Marshall & Dennis Phillips. (2006) Impact of environmental conditions on the marine natural product bryostatin 1. Natural Product Research 20:6, pages 611-628.
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Yin Lu, Yitao Pan, Nan Sheng, Allan Z. Zhao & Jiayin Dai. (2016) Perfluorooctanoic acid exposure alters polyunsaturated fatty acid composition, induces oxidative stress and activates the AKT/AMPK pathway in mouse epididymis. Chemosphere 158, pages 143-153.
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Hussein Ghamlouch, Walaa Darwiche, Ahmed Hodroge, Hakim Ouled-Haddou, Sébastien Dupont, Amrathlal Rabbind Singh, Caroline Guignant, Stéphanie Trudel, Bruno Royer, Brigitte Gubler & Jean-Pierre Marolleau. (2015) Factors involved in CLL pathogenesis and cell survival are disrupted by differentiation of CLL B-cells into antibody-secreting cells. Oncotarget 6:21, pages 18484-18503.
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Marie-Laure Bonnefond, Bernard Lambert, Florence Giffard, Edwige Abeilard, Emilie Brotin, Marie-Hélène Louis, Mor Sény Gueye, Pascal Gauduchon, Laurent Poulain & Monique N’Diaye. (2015) Calcium signals inhibition sensitizes ovarian carcinoma cells to anti-Bcl-xL strategies through Mcl-1 down-regulation. Apoptosis 20:4, pages 535-550.
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Anuradha TarafdarAlison M. Michie. (2014) Protein kinase C in cellular transformation: a valid target for therapy?. Biochemical Society Transactions 42:6, pages 1556-1562.
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Uri Rozovski, Inbal Hazan-Halevy, Michael J. Keating & Zeev Estrov. (2014) Personalized medicine in CLL: Current status and future perspectives. Cancer Letters 352:1, pages 4-14.
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C Rutherford, S Childs, J Ohotski, L McGlynn, M Riddick, S MacFarlane, D Tasker, S Pyne, N J Pyne, J Edwards & T M Palmer. (2013) Regulation of cell survival by sphingosine-1-phosphate receptor S1P1 via reciprocal ERK-dependent suppression of Bim and PI-3-kinase/protein kinase C-mediated upregulation of Mcl-1. Cell Death & Disease 4:11, pages e927-e927.
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John C. Allen, Fatima Talab, Mirko Zuzel, Ke Lin & Joseph R. Slupsky. (2011) c-Abl regulates Mcl-1 gene expression in chronic lymphocytic leukemia cells. Blood 117:8, pages 2414-2422.
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Erin Hertlein & John C. Byrd. (2010) Signalling to drug resistance in CLL. Best Practice & Research Clinical Haematology 23:1, pages 121-131.
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Anthony M. McElligott, Elaina N. Maginn, Lisa M. Greene, Siobhan McGuckin, Amjad Hayat, Paul V. Browne, Stefania Butini, Giuseppe Campiani, Mark A. Catherwood, Elisabeth Vandenberghe, D. Clive Williams, Daniela M. Zisterer & Mark Lawler. (2009) The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia. Cancer Research 69:21, pages 8366-8375.
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C Pepper, R Ward, T T Lin, P Brennan, J Starczynski, M Musson, C Rowntree, P Bentley, K Mills, G Pratt & C Fegan. (2007) Highly purified CD38+ and CD38− sub-clones derived from the same chronic lymphocytic leukemia patient have distinct gene expression signatures despite their monoclonal origin. Leukemia 21:4, pages 687-696.
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Felix Braun & Matthias Behrend. 2007. 424 479 .
Alison M Michie & Rinako Nakagawa. (2006) Elucidating the role of protein kinase C in chronic lymphocytic leukaemia. Hematological Oncology 24:3, pages 134-138.
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Richard W. Beswick, Helen E. Ambrose & Simon D. Wagner. (2006) Nocodazole, a microtubule depolymerising agent, induces apoptosis of chronic lymphocytic leukaemia cells associated with changes in Bcl-2 phosphorylation and expression. Leukemia Research 30:4, pages 427-436.
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Rinako Nakagawa, Jae Won Soh & Alison M. Michie. (2006) Subversion of Protein Kinase Cα Signaling in Hematopoietic Progenitor Cells Results in the Generation of a B-Cell Chronic Lymphocytic Leukemia–Like Population In vivo . Cancer Research 66:1, pages 527-534.
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Sofie Lust, Barbara Vanhoecke, Ann Janssens, Jan Philippe, Marc Bracke & Fritz Offner. (2005) Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism. Molecular Nutrition & Food Research 49:9, pages 844-850.
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L Wang, L Chen, J Benincosa, J Fortney & L F Gibson. (2005) VEGF-induced phosphorylation of Bcl-2 influences B lineage leukemic cell response to apoptotic stimuli. Leukemia 19:3, pages 344-353.
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