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Review

JAK2 V617F in myeloid disorders: What do we know now, and where are we headed?

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Pages 177-194 | Received 08 Aug 2005, Published online: 01 Jul 2009

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Jana Marková, Jana Marková, Zuzana Trnková, Petra Michková, Jacqueline Maaloufová, Jan Starý, Petr Cetkovský & Jiří Schwarz. (2009) Monitoring of minimal residual disease in patients with core binding factor acute myeloid leukemia and the impact of C-KIT, FLT3, and JAK2 mutations on clinical outcome. Leukemia & Lymphoma 50:9, pages 1448-1460.
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Eugenio Lucia, Bruno Martino, Corrado Mammi, Ernesto Vigna, Carla Mazzone, Massimo Gentile, Gabriele Qualtieri, Maria Grazia Bisconte, Maria Naccarato, Carlo Gentile, Carmelo Laganà, Francesco Romeo, Antonino Neri, Francesco Nobile & Fortunato Morabito. (2008) The incidence of JAK2 V617F mutation in bcr/abl-negative chronic myeloproliferative disorders: assessment by two different detection methods. Leukemia & Lymphoma 49:10, pages 1907-1915.
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Aaron Polliack, Koen van Besien & John F. Seymour. (2008) 2007: The year in review for Leukemia and Lymphoma. Leukemia & Lymphoma 49:1, pages 1-3.
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Joanne Bareng, Iman Jilani, Mercedes Gorre, Hagop Kantarjian, Francis J. Giles, Alison Hannah & Maher Albitar. (2007) A potential role for HSP90 inhibitors in the treatment of JAK2 mutant-positive diseases as demonstrated using quantitative flow cytometry. Leukemia & Lymphoma 48:11, pages 2189-2195.
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Jana Marková, Dana Průková, Zuzana Volková & Jiří Schwarz. (2007) A new allelic discrimination assay using locked nucleic acid-modified nucleotides (LNA) probes for detection of JAK2 V617F mutation. Leukemia & Lymphoma 48:3, pages 636-639.
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Ekaterina Belotserkovskaya, Vasily Golotin, Burhan Uyanik & Oleg N. Demidov. (2023) Clonal haematopoiesis - a novel entity that modifies pathological processes in elderly. Cell Death Discovery 9:1.
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Rachel B. Salit. (2022) The role of JAK inhibitors in hematopoietic cell transplantation. Bone Marrow Transplantation 57:6, pages 857-865.
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Sanam Loghavi & Robert P. Hasserjian. 2018. Diagnosis of Blood and Bone Marrow Disorders. Diagnosis of Blood and Bone Marrow Disorders 17 79 .
Jun Xia, Mi-ze Lu, Yuan-qiang Jiang, Guo-hua Yang, Yun Zhuang, Hong-li Sun & Yun-feng Shen. (2012) JAK2 V617F, MPL W515L and JAK2 exon 12 mutations in Chinese patients with primary myelofibrosis. Chinese Journal of Cancer Research 24:1, pages 72-76.
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Joëlle Rubert, Zhiyan Qian, Rita Andraos, Daniel A Guthy & Thomas Radimerski. (2011) Bim and Mcl-1 exert key roles in regulating JAK2V617Fcell survival. BMC Cancer 11:1.
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Cornelis J.J. Huijsmans, Jeroen Poodt, Paul H.M. Savelkoul & Mirjam H.A. Hermans. (2011) Sensitive Detection and Quantification of the JAK2V617F Allele by Real-Time PCR. The Journal of Molecular Diagnostics 13:5, pages 558-564.
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Tao Wang, Stephanos Ioannidis, Lynsie Almeida, Michael H. Block, Audrey M. Davies, Michelle L. Lamb, David A. Scott, Mei Su, Hai-Jun Zhang, Marat Alimzhanov, Geraldine Bebernitz, Kirsten Bell & Michael Zinda. (2011) In vitro and in vivo evaluation of 6-aminopyrazolyl-pyridine-3-carbonitriles as JAK2 kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 21:10, pages 2958-2961.
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David R. Head & Katherine S. Hamilton. 2011. Hematopathology. Hematopathology 656 671 .
Wing C. (John) Chan, Timothy C. Greiner & Adam Bagg. 2011. Hematopathology. Hematopathology 56 80 .
Wanlong Ma, Hagop Kantarjian, Xi Zhang, Xiuqiang Wang, Zhong Zhang, Chen-Hsiung Yeh, Susan O'Brien, Francis Giles, Jean Marie Bruey & Maher Albitar. (2010) JAK2 Exon 14 Deletion in Patients with Chronic Myeloproliferative Neoplasms. PLoS ONE 5:8, pages e12165.
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Meredith A. Lakey, Animesh Pardanani, James D. Hoyer, Phuong L. Nguyen, Terra L. Lasho, Ayalew Tefferi & Curtis A. Hanson. (2010) Bone Marrow Morphologic Features in Polycythemia Vera With JAK2 Exon 12 Mutations . American Journal of Clinical Pathology 133:6, pages 942-948.
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W. MA, H. KANTARJIAN, X. ZHANG, C.‐H. YEH, Z. J. ZHANG, S. VERSTOVSEK, S. O’BRIEN, F. GILES & M. ALBITAR. (2010) Plasma levels of JAK2 mRNA in patients with chronic myeloproliferative diseases with and without V617F mutation: implications for prognosis and disease biology . International Journal of Laboratory Hematology 32:1p2, pages 95-102.
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Jason D. Merker, Carol D. Jones, Stephen T. Oh, Iris Schrijver, Jason Gotlib & James L. Zehnder. (2010) Design and Evaluation of a Real-Time PCR Assay for Quantification of JAK2 V617F and Wild-Type JAK2 Transcript Levels in the Clinical Laboratory. The Journal of Molecular Diagnostics 12:1, pages 58-64.
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Mike Perez & Chung-Che (Jeff) Chang. 2010. Molecular Pathology of Hematolymphoid Diseases. Molecular Pathology of Hematolymphoid Diseases 395 403 .
Hans Michael Kvasnicka & Juergen Thiele. (2009) Prodromal myeloproliferative neoplasms: The 2008 WHO classification. American Journal of Hematology 85:1, pages 62-69.
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Juergen Thiele. (2009) Philadelphia Chromosome–Negative Chronic Myeloproliferative Disease. American Journal of Clinical Pathology 132:2, pages 261-280.
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Tai-Sung Lee, Wanlong Ma, Xi Zhang, Francis Giles, Hagop Kantarjian & Maher Albitar. (2009) Mechanisms of constitutive activation of Janus kinase 2-V617F revealed at the atomic level through molecular dynamics simulations. Cancer 115:8, pages 1692-1700.
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Hans Michael Kvasnicka & Juergen Thiele. (2009) Diagnosis of chronic myeloproliferative neoplasms with special emphasis on early stages. Diagnostic Histopathology 15:3, pages 125-133.
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Juergen Thiele & Hans Michael Kvasnicka. (2008) The 2008 WHO diagnostic criteria for polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Current Hematologic Malignancy Reports 4:1, pages 33-40.
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Su-jiang ZHANG & Jian-yong LI. (2008) An update of molecular pathogenesis and diagnosis of myeloproliferative disorders in the JAK2 era. Chinese Medical Journal 121:18, pages 1838-1842.
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Hui-Hua Hsiao, Wen-Chi Yang, Yi-Chang Liu, Ching-Ping Lee & Sheng-Fung Lin. (2008) Disappearance of JAK2 V617F mutation in a rapid leukemic transformed essential thrombocythemia patient. Leukemia Research 32:8, pages 1323-1324.
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Cristina A. Smith & Guang Fan. (2008) The saga of JAK2 mutations and translocations in hematologic disorders: pathogenesis, diagnostic and therapeutic prospects, and revised World Health Organization diagnostic criteria for myeloproliferative neoplasms. Human Pathology 39:6, pages 795-810.
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A Wickrema & J D Crispino. (2007) Erythroid and megakaryocytic transformation. Oncogene 26:47, pages 6803-6815.
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Juergen Thiele, Attilio Orazi & Hans Kvasnicka. 2007. Myeloproliferative Disorders. Myeloproliferative Disorders 19 50 .
Anna D. Panani. (2007) Cytogenetic and molecular aspects of Philadelphia negative chronic myeloproliferative disorders: Clinical implications. Cancer Letters 255:1, pages 12-25.
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Natarajan V. Bhanu, Wulin Aerbajinai, Nicole M. Gantt, Edwin K. Jackson, Sung-Ho Goh, Y. Terry Lee & Jeffery L. Miller. (2007) Cl-IB-MECA inhibits human erythropoiesis. British Journal of Haematology 137:3, pages 233-236.
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Kenneth Kaushansky. (2007) The chronic myeloproliferative disorders and mutation of JAK2: Dameshek's 54 year old speculation comes of age. Best Practice & Research Clinical Haematology 20:1, pages 5-12.
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Hajnalka Andrikovics, Anikó Szilvási, Nóra Meggyesi, Viktória Király, Gabriella Halm, Sándor Lueff, Sarolta Nahajevszky, Gábor Mikala, Andrea Sipos, Nóra Lovas, Zoltán Csukly, Zoltán Mátrai, Júlia Tamáska, Attila Tordai & Tamás Masszi. (2007) Role of the activating mutation Val617Phe of Janus kinase 2 gene in myeloproliferative diseases and significance of its detection. Orvosi Hetilap 148:5, pages 203-210.
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S Verstovsek, R T Silver, N C P Cross & A Tefferi. (2006) JAK2V617F mutational frequency in polycythemia vera: 100%, >90%, less?. Leukemia 20:11, pages 2067-2067.
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David P. Steensma. (2006) JAK2 V617F in Myeloid Disorders: Molecular Diagnostic Techniques and Their Clinical Utility. The Journal of Molecular Diagnostics 8:4, pages 397-411.
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Chung-Che(Jeff) Chang. (2006) BCR/ABL -Negative Chronic Myeloproliferative Disorders: JAK2 Mutation and Beyond . Archives of Pathology & Laboratory Medicine 130:8, pages 1123-1125.
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Asim Khwaja. (2006) The role of Janus kinases in haemopoiesis and haematological malignancy. British Journal of Haematology 134:4, pages 366-384.
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Lambros K. Bourantas, Anthoula Chatzikyriakidou, Aggeliki Dasoula, Marika Syrrou, Konstantinos L. Bourantas & Ioannis Georgiou. (2006) Absence of mutations of the EPO-receptor gene in Greek patients with familiar polycythemia. European Journal of Haematology 76:6, pages 537-538.
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D P Steensma, R F McClure, J E Karp, A Tefferi, T L Lasho, H L Powell, G W DeWald & S H Kaufmann. (2006) JAK2 V617F is a rare finding in de novo acute myeloid leukemia, but STAT3 activation is common and remains unexplained. Leukemia 20:6, pages 971-978.
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J. Brière. (2006) Thrombocytémie essentielle. Critères du diagnostic. Stratification pronostique. Ébauche de stratégie thérapeutique. EMC - Hématologie 1:3, pages 1-19.
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