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Leukemia & Lymphoma Volume 48, 2007 - Issue 3
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Original

Acute promyelocytic leukemia: A novel PML/RARα fusion that generates a frameshift in the RARα transcript and ATRA resistance

Adham Zayed Department of Pathology and Laboratory Medicine
,
Stephen Couban Department of Medicine, Capital District Health Authority and Dalhousie University, Halifax, NS, Canada
,
Ormille Hayne Department of Medicine, Capital District Health Authority and Dalhousie University, Halifax, NS, Canada
,
Nebojsa Sparavalo Department of Medicine, Capital District Health Authority and Dalhousie University, Halifax, NS, Canada
,
Allam Shawwa Department of Pathology and Laboratory Medicine
,
Irene Sadek Department of Pathology and Laboratory Medicine
&
Dr. Wenda Greer Department of Pathology and Laboratory MedicineCorrespondence[email protected]
 show all
Pages 489-496 | Received 09 Sep 2006, Accepted 22 Nov 2006, Published online: 01 Jul 2009

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Joanna Opalinska, Li Zhou & Amit Verma. (2007) A new PML-RARs fusion transcript hints at the important role of PML dysregulation in the pathogenesis of APL. Leukemia & Lymphoma 48:3, pages 443-444.
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Articles from other publishers (12)

Faramarz Ghasemian Sorbeni, Soheila Montazersaheb, Atefeh Ansarin, Ali Esfahani, Azim Rezamand & Ebrahim Sakhinia. (2017) Molecular analysis of more than 140 gene fusion variants and aberrant activation of EVI1 and TLX1 in hematological malignancies. Annals of Hematology 96:10, pages 1605-1623.
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X Wang, Q Lin, F Lv, N Liu, Y Xu, M Liu, Y Chen & Z Yi. (2016) LG-362B targets PML-RARα and blocks ATRA resistance of acute promyelocytic leukemia. Leukemia 30:7, pages 1465-1474.
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Wenzhe Yan & Guangsen Zhang. (2016) Molecular Characteristics and Clinical Significance of 12 Fusion Genes in Acute Promyelocytic Leukemia: A Systematic Review. Acta Haematologica 136:1, pages 1-15.
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S M Yun, K Yoon, S Lee, E Kim, S-H Kong, J Choe, J M Kang, T-S Han, P Kim, Y Choi, S Jho, H Yoo, J Bhak, H-K Yang & S-J Kim. (2013) PPP1R1B-STARD3 chimeric fusion transcript in human gastric cancer promotes tumorigenesis through activation of PI3K/AKT signaling. Oncogene 33:46, pages 5341-5347.
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Caroline Palmeira-dos-Santos, Gustavo J. S. Pereira, Christiano M. V. Barbosa, Aron Jurkiewicz, Soraya S. Smaili & Claudia Bincoletto. (2014) Comparative study of autophagy inhibition by 3MA and CQ on Cytarabine-induced death of leukaemia cells. Journal of Cancer Research and Clinical Oncology 140:6, pages 909-920.
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Yanfeng Liu, Pengcheng He, Feng Liu, Naicen Zhou, Xiaoyan Cheng, Lili Shi, Huachao Zhu, Jing Zhao, Yuan Wang & Mei Zhang. (2014) Tetra-arsenic tetra-sulfide (As4S4) promotes apoptosis in retinoid acid -resistant human acute promyelocytic leukemic NB4-R1 cells through downregulation of SET protein. Tumor Biology 35:4, pages 3421-3430.
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Yuwang Tian, Yanfeng Liu, Pengcheng He, Feng Liu, Naicen Zhou, Xiaoyan Cheng, Lili Shi, Huachao Zhu, Jing Zhao, Yuan Wang & Mei Zhang. (2014) Arsenic Sulfide Promotes Apoptosis in Retinoid Acid Resistant Human Acute Promyelocytic Leukemic NB4-R1 Cells through Downregulation of SET Protein. PLoS ONE 9:1, pages e83184.
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Yanhong Tan, Sicheng Bian, Zhifang Xu, Xiuhua Chen, Xiling Qi, Fanggang Ren, Li Li, Haixiu Guo, Aining Xu, Linlin Zhang & Hongwei Wang. (2013) The short isoform of the long‐type PML ‐ RARA fusion gene in acute promyelocytic leukaemia lacks sensitivity to all‐trans‐retinoic acid . British Journal of Haematology 162:1, pages 93-97.
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Bin-Tao Huang, Qing-Chun Zeng, Arati Gurung, Wei-Hong Zhao, Zhen Xiao & Bing-Sheng Li. (2011) The early addition of arsenic trioxide versus high-dose arabinoside is more effective and safe as consolidation chemotherapy for risk-tailored patients with acute promyelocytic leukemia: multicenter experience. Medical Oncology 29:3, pages 2088-2094.
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Tae Sung Park, Jin Seok Kim, Jaewoo Song, Kyung-A. Lee, Seoyoung Yoon, Borum Suh, Jong-Han Lee, Hyeon-Ji Lee, Jong-Kee Kim & Jong Rak Choi. (2009) Acute promyelocytic leukemia with insertion of PML exon 7a and partial deletion of exon 3 of RARA: a novel variant transcript related to aggressive course and not detected with real-time polymerase chain reaction analysis. Cancer Genetics and Cytogenetics 188:2, pages 103-107.
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Tae Sung Park, Seung Tae Lee, Jin Seok Kim, Jaewoo Song, Kyung-A. Lee, Sue Jung Kim, Yoon-Mi Seok, Hyeon-Ji Lee, Jeong-Hyun Han, Jong-Kee Kim, Eun Yup Lee & Jong Rak Choi. (2009) Acute promyelocytic leukemia in early pregnancy with translocation t(15;17) and variant PML/RARA fusion transcripts. Cancer Genetics and Cytogenetics 188:1, pages 48-51.
Crossref
K L Rice, I Hormaeche & J D Licht. (2007) Epigenetic regulation of normal and malignant hematopoiesis. Oncogene 26:47, pages 6697-6714.
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