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Leukemia & Lymphoma Volume 48, 2007 - Issue 6
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Commentary

Bendamustine and cloretazine: Alkylators with sharply contrasting activity in AML

Francis J. Giles MD Division of Hematology and Medical Oncology, UT Health Science Center at San Antonio, San Antonio, TX, USA, and Institute for Drug Development, Cancer Therapy and Research Center, San Antonio, TX, USACorrespondence[email protected]
Pages 1064-1066 | Published online: 01 Jul 2009

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Sara Rockwell, Yanfeng Liu, Helen A. Seow, Kimiko Ishiguro, Raymond P. Baumann, Philip G. Penketh, Krishnamurthy Shyam, Oluwatoyin M. Akintujoye, Peter M. Glazer & Alan C. Sartorelli. (2012) Preclinical evaluation of Laromustine for use in combination with radiation therapy in the treatment of solid tumors. International Journal of Radiation Biology 88:3, pages 277-285.
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Articles from other publishers (4)

Kimiko Ishiguro, Yong-Lian Zhu, Krishnamurthy Shyam, Philip G. Penketh, Raymond P. Baumann & Alan C. Sartorelli. (2010) Quantitative relationship between guanine O6-alkyl lesions produced by Onrigin™ and tumor resistance by O6-alkylguanine-DNA alkyltransferase. Biochemical Pharmacology 80:9, pages 1317-1325.
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Gary J. SchillerSusan M. O'BrienArnaud PigneuxDaniel J. DeAngeloNorbert VeyJonathan KellScott SolomonRobert K. StuartVerena KarstenAnn L. CahillMaher X. AlbitarFrancis J. Giles. (2010) Single-Agent Laromustine, A Novel Alkylating Agent, Has Significant Activity in Older Patients With Previously Untreated Poor-Risk Acute Myeloid Leukemia. Journal of Clinical Oncology 28:5, pages 815-821.
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Francis GilesNorbert VeyDaniel DeAngeloKaren SeiterWendy StockRobert StuartDarinka BoskovicArnaud PigneuxMartin TallmanJoseph BrandweinJonathan KellTadeusz RobakPeter StaibXavier ThomasAnn CahillMaher Albitar & Susan O'Brien. (2009) Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse. Blood 114:19, pages 4027-4033.
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Abbie M. Frederick, Marguerite L. Davis & Kevin P. Rice. (2009) Inhibition of human DNA polymerase β activity by the anticancer prodrug Cloretazine. Biochemical and Biophysical Research Communications 378:3, pages 419-423.
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