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Original

Application of BIOMED-2 clonality assays to formalin-fixed paraffin embedded follicular lymphoma specimens: Superior performance of the IGK assays compared to IGH for suboptimal specimens

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Pages 1338-1343 | Received 30 Oct 2006, Accepted 28 Mar 2007, Published online: 01 Jul 2009

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Anton W Langerak, Patricia JTA Groenen, J Han JM van Krieken & Jacques JM van Dongen. (2007) Immunoglobulin/T-cell receptor clonality diagnostics. Expert Opinion on Medical Diagnostics 1:4, pages 451-461.
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Articles from other publishers (32)

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Yuma Sakamoto, Ayako Masaki, Satsuki Aoyama, Shusen Han, Kosuke Saida, Kana Fujii, Hisashi Takino, Takayuki Murase, Shinsuke Iida & Hiroshi Inagaki. (2017) Improved clonality detection in B-cell lymphoma using a semi-nested modification of the BIOMED-2 PCR assay for IGH rearrangement: A paraffin-embedded tissue study . Pathology International 67:9, pages 453-460.
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Andres M. Acosta, Snehal Sonawane, Asma Sharif & Michael R. Pins. (2017) Metastatic intestinal adenocarcinoma to a lymph node involved by follicular lymphoma: The importance of looking beyond the apparent. Pathology - Research and Practice 213:6, pages 713-716.
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S. Ghorbian, I. Jahanzad, G. R. Javadi & E. Sakhinia. (2014) Evaluation diagnostic usefulness of immunoglobulin light chains (Igκ, Igλ) and incomplete IGH D-J clonal gene rearrangements in patients with B-cell non-Hodgkin lymphomas using BIOMED-2 protocol. Clinical and Translational Oncology 16:11, pages 1006-1011.
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Anna Gazzola, Claudia Mannu, Maura Rossi, Maria Antonella Laginestra, Maria Rosaria Sapienza, Fabio Fuligni, Maryam Etebari, Federica Melle, Elena Sabattini, Claudio Agostinelli, Francesco Bacci, Carlo Alberto Sagramoso Sacchetti, Stefano Aldo Pileri & Pier Paolo Piccaluga. (2014) The evolution of clonality testing in the diagnosis and monitoring of hematological malignancies. Therapeutic Advances in Hematology 5:2, pages 35-47.
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Ji Hyun KimJa Young LeeJong Ae SonSae Am SongSeung Hwan OhJeong Hwan ShinHye Ran KimKyung Ran JunJeong Nyeo Lee. (2014) Clinical Significance of Clonal Rearrangement of the Immunoglobulin Gene in the Bone Marrow of Patients with B-cell Non-Hodgkin Lymphoma. Laboratory Medicine Online 4:3, pages 125.
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Sylvia Hartmann, Alexandra Helling, Claudia Döring, Christoph Renné & Martin-Leo Hansmann. (2013) Clonality testing of malignant lymphomas with the BIOMED-2 primers in a large cohort of 1969 primary and consultant biopsies. Pathology - Research and Practice 209:8, pages 495-502.
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Karen P. Mann. (2012) Molecular Pathology of Malignant Lymphoma. Surgical Pathology Clinics 5:4, pages 879-902.
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A W Langerak, P J T A Groenen, M Brüggemann, K Beldjord, C Bellan, L Bonello, E Boone, G I Carter, M Catherwood, F Davi, M-H Delfau-Larue, T Diss, P A S Evans, P Gameiro, R Garcia Sanz, D Gonzalez, D Grand, Å Håkansson, M Hummel, H Liu, L Lombardia, E A Macintyre, B J Milner, S Montes-Moreno, E Schuuring, M Spaargaren, E Hodges & J J M van Dongen. (2012) EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations. Leukemia 26:10, pages 2159-2171.
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Anne M. Sproul & John R. Goodlad. (2012) Clonality testing of cutaneous lymphoid infiltrates: practicalities, pitfalls and potential uses. Journal of Hematopathology 5:1-2, pages 69-82.
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Paul G. Rothberg, Anton W. Langerak, Brenda Verhaaf, Jacques J. M. van Dongen, W. Richard Burack, Mahlon D. Johnson, Donald Slate, Todd S. Laughlin, Karen Payne, Luis Figueiredo, Betty N. Bandoh, Qingguo Yan, Chris M Bacon, Penny Wright, Anthony Bench, Ming-Qing Du & Hongxiang Liu. (2012) Clonal antigen receptor gene PCR products outside the expected size range. Journal of Hematopathology 5:1-2, pages 57-67.
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Patricia J. T. A. Groenen, Annemiek van Raaij, Margarethe C. van Altena, Paul M. Rombout & J. M. Han van Krieken. (2012) A practical approach to diagnostic Ig/TCR clonality evaluation in clinical pathology. Journal of Hematopathology 5:1-2, pages 17-25.
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Gustavo Tapia, Carolina Sanz, José L Mate, Ana M Muñoz‐Mármol & Aurelio Ariza. (2012) Improved clonality detection in Hodgkin lymphoma using the BIOMED‐2‐based heavy and kappa chain assay: a paraffin‐embedded tissue study. Histopathology 60:5, pages 768-773.
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Karen Payne, Penny Wright, John W. Grant, Yuanxue Huang, Rifat Hamoudi, Chris M. Bacon, Ming-Qing Du & Hongxiang Liu. (2011) BIOMED-2 PCR assays for IGK gene rearrangements are essential for B-cell clonality analysis in follicular lymphoma. British Journal of Haematology 155:1, pages 84-92.
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Szu-Yin Kuo, Hongxiang Liu, Yung-Liang Liao, Sheng-Tsung Chang, Yen-Chuan Hsieh, Betty Angela Nuako Bandoh, Ming-Qing Du & Shih-Sung Chuang. (2011) A parallel comparison of T-cell clonality assessment between an in-house PCR assay and the BIOMED-2 assay leading to an efficient and cost-effective strategy. Journal of Clinical Pathology 64:6, pages 536-542.
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Ji-Youn SungSo Young KangSun-Hee KimJi Eun KwonYoung-Hyeh Ko. (2011) Analysis of Immunoglobulin Gene Rearrangement: Comparison between BIOMED-2 Multiplex PCR and Conventional Nested PCR. Laboratory Medicine Online 1:4, pages 195.
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Moritz Felcht, Nina Booken, Philipp Stroebel, Sergij Goerdt & Claus-Detlev Klemke. (2011) The value of molecular diagnostics in primary cutaneous B-cell lymphomas in the context of clinical findings, histology, and immunohistochemistry. Journal of the American Academy of Dermatology 64:1, pages 135-143.e4.
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Michele Roullet & Adam Bagg. (2010) The Basis and Rational Use of Molecular Genetic Testing in Mature B-cell Lymphomas. Advances in Anatomic Pathology 17:5, pages 333-358.
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W. Richard Burack, Todd S. Laughlin, Jonathan W. Friedberg, Janice M. Spence & Paul G. Rothberg. (2010) PCR Assays Detect B-Lymphocyte Clonality in Formalin-Fixed, Paraffin-Embedded Specimens of Classical Hodgkin Lymphoma Without Microdissection. American Journal of Clinical Pathology 134:1, pages 104-111.
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W. Richard Burack. 2010. Molecular Pathology of Hematolymphoid Diseases. Molecular Pathology of Hematolymphoid Diseases 249 255 .
Richard J. Jones, Christopher D. Gocke, Richard F. Ambinder & William Matsui. (2009) Response: Hodgkin lymphoma stem cells. Blood 114:18, pages 3971-3972.
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K. M. Hebeda, M. C. Van Altena, P. Rombout, J. H. J. M. Van Krieken & P. J. T. A. Groenen. (2009) PCR clonality detection in Hodgkin lymphoma. Journal of Hematopathology 2:1, pages 34-41.
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Anjali V Morales, Daniel A Arber, Katie Seo, Sabine Kohler, Youn H Kim & Uma N Sundram. (2008) Evaluation of B-Cell Clonality Using the BIOMED-2 PCR Method Effectively Distinguishes Cutaneous B-Cell Lymphoma From Benign Lymphoid Infiltrates. The American Journal of Dermatopathology 30:5, pages 425-430.
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Adam Bagg. (2008) Malleable Immunoglobulin Genes and Hematopathology – The Good, the Bad, and the Ugly. The Journal of Molecular Diagnostics 10:5, pages 396-410.
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Patricia J. T. A. Groenen, Anton W. Langerak, Jacques J. M. van Dongen & Johan H. J. M. van Krieken. (2008) Pitfalls in TCR gene clonality testing: teaching cases. Journal of Hematopathology 1:2.
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Anna Margrét Halldórsdóttir, Margareta Frühwirth, Alexander Deutsch, Ariane Aigelsreiter, Christine Beham-Schmid, Bjarni A. Agnarsson, Peter Neumeister & W. Richard Burack. (2008) Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma. Leukemia Research 32:7, pages 1015-1021.
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