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Original Article: Research

Mesenchymal stem cell abnormalities in patients with multiple myeloma

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Pages 2032-2041 | Received 09 Jun 2007, Accepted 19 Jul 2007, Published online: 01 Jul 2009

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Dandan Chen, Ping Tang, Linxiang Liu, Fang Wang, Haizhou Xing, Ling Sun & Zhongxing Jiang. (2018) Bone marrow-derived mesenchymal stem cells promote cell proliferation of multiple myeloma through inhibiting T cell immune responses via PD-1/PD-L1 pathway. Cell Cycle 17:7, pages 858-867.
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Articles from other publishers (67)

Lei Wang, Weijun Yi, Li Ma, Emily Lecea, Lori A. Hazlehurst, Donald A. Adjeroh & Gangqing Hu. (2023) Inflammatory Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma: Transcriptional Signature and In Vitro Modeling. Cancers 15:21, pages 5148.
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Natalya Plakhova, Vasilios Panagopoulos, Kate Vandyke, Andrew C. W. Zannettino & Krzysztof M. Mrozik. (2023) Mesenchymal stromal cell senescence in haematological malignancies. Cancer and Metastasis Reviews 42:1, pages 277-296.
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Luca Heinemann, Klara Maria Möllers, Helal Mohammed Mohammed Ahmed, Lanying Wei, Kaiyan Sun, Subbaiah Chary Nimmagadda, Daria Frank, Anja Baumann, Alexandra M. Poos, Martin Dugas, Julian Varghese, Marc-Steffen Raab & Cyrus Khandanpour. (2022) Inhibiting PI3K–AKT–mTOR Signaling in Multiple Myeloma-Associated Mesenchymal Stem Cells Impedes the Proliferation of Multiple Myeloma Cells. Frontiers in Oncology 12.
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Mingyang Deng, Huan Yuan, Hongling Peng, Sufang Liu, Xiang Xiao, Zhihua Wang, Guangsen Zhang & Han Xiao. (2022) Mesenchymal Stem Cells Inhibit the Effects of Dexamethasone in Multiple Myeloma Cells. Stem Cells International 2022, pages 1-12.
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Natella I. Enukashvily, Natalia Semenova, Anna V. Chubar, Dmitry I. Ostromyshenskii, Ekaterina A. Gushcha, Sergei Gritsaev, Stanislav S. Bessmeltsev, Viktor I. Rugal, Egor M. Prikhodko, Ivan Kostroma, Anastasia Zherniakova, Anastasia V. Kotova, Liubov A. Belik, Alexander Shumeev, Irina I. Maslennikova & Dmitry I. Ivolgin. (2022) Pericentromeric Non-Coding DNA Transcription Is Associated with Niche Impairment in Patients with Ineffective or Partially Effective Multiple Myeloma Treatment. International Journal of Molecular Sciences 23:6, pages 3359.
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Ladan Kobari, Martine Auclair, Olivier Piau, Nathalie Ferrand, Maurice Zaoui, François Delhommeau, Bruno Fève, Michèle Sabbah & Laurent Garderet. (2021) Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells. Leukemia 36:2, pages 540-548.
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Chiara Valsecchi, Stefania Croce, Alice Maltese, Lorenza Montagna, Elisa Lenta, Alice Nevone, Maria Girelli, Paolo Milani, Tiziana Bosoni, Margherita Massa, Carlotta Abbà, Rita Campanelli, Jessica Ripepi, Annalisa De Silvestri, Adriana Carolei, Giovanni Palladini, Marco Zecca, Mario Nuvolone & Maria Antonietta Avanzini. (2021) Bone Marrow Microenvironment in Light-Chain Amyloidosis: In Vitro Expansion and Characterization of Mesenchymal Stromal Cells. Biomedicines 9:11, pages 1523.
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Natalia-Del Pilar Vanegas, Paola Fernanda Ruiz-Aparicio, Gloria Inés Uribe, Adriana Linares-Ballesteros & Jean-Paul Vernot. (2021) Leukemia-Induced Cellular Senescence and Stemness Alterations in Mesenchymal Stem Cells Are Reversible upon Withdrawal of B-Cell Acute Lymphoblastic Leukemia Cells. International Journal of Molecular Sciences 22:15, pages 8166.
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Liu Zhaoyun & Fu Rong. (2021) Predictive Role of Immune Profiling for Survival of Multiple Myeloma Patients. Frontiers in Immunology 12.
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Z Liu, F Mi, M Han, M Tian, L Deng, N Meng, J Luo & R Fu. (2021) Bone marrow-derived mesenchymal stem cells inhibit CD8+ T cell immune responses via PD-1/PD-L1 pathway in multiple myeloma. Clinical and Experimental Immunology 205:1, pages 53-62.
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Patricia Maiso, Pedro Mogollón, Enrique M. Ocio & Mercedes Garayoa. (2021) Bone Marrow Mesenchymal Stromal Cells in Multiple Myeloma: Their Role as Active Contributors to Myeloma Progression. Cancers 13:11, pages 2542.
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Fulvio Massaro, Florent Corrillon, Basile Stamatopoulos, Nathalie Meuleman, Laurence Lagneaux & Dominique Bron. (2020) Aging of Bone Marrow Mesenchymal Stromal Cells: Hematopoiesis Disturbances and Potential Role in the Development of Hematologic Cancers. Cancers 13:1, pages 68.
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Michiko Ichii & Naoki Hosen. (2020) Current Understanding of Myelomatous Mesenchymal Stromal Cells Extended through Advances in Experimental Methods. Cancers 13:1, pages 25.
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Daniel Alameda, Borja Saez, David Lara-Astiaso, Sarai Sarvide, Marta Lasa, Diego Alignani, Idoia Rodriguez, Sonia Garate, Amaia Vilas, Bruno Paiva, Matias Alfonso-Olmos, Jose Maria Lamo De Espinosa, Felipe Prosper, Jesus F. San Miguel & Patricia Maiso. (2020) Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironment. Haematologica 105:9, pages e470-473.
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Hayoung Choi, Yonggoo Kim, Dain Kang, Ahlm Kwon, Jiyeon Kim, Jung Min Kim, Sung‐Soo Park, Yoo‐Jin Kim, Chang‐Ki Min & Myungshin Kim. (2020) Common and different alterations of bone marrow mesenchymal stromal cells in myelodysplastic syndrome and multiple myeloma. Cell Proliferation 53:5.
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Renza Spelat, Federico Ferro, Paolo Contessotto, Nicholas J. Warren, Grazia Marsico, Steven P. Armes & Abhay Pandit. (2020) A worm gel-based 3D model to elucidate the paracrine interaction between multiple myeloma and mesenchymal stem cells. Materials Today Bio 5, pages 100040.
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Alessandro Allegra, Vanessa Innao, Andrea Gaetano Allegra, Marta Pugliese, Eleonora Di Salvo, Elvira Ventura-Spagnolo, Caterina Musolino & Sebastiano Gangemi. (2019) Lymphocyte Subsets and Inflammatory Cytokines of Monoclonal Gammopathy of Undetermined Significance and Multiple Myeloma. International Journal of Molecular Sciences 20:11, pages 2822.
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Véronique Béréziat, Christelle Mazurier, Martine Auclair, Nathalie Ferrand, Séverine Jolly, Tiffany Marie, Ladan Kobari, Indira Toillon, François Delhommeau, Bruno Fève, Annette K. Larsen, Michèle Sabbah & Laurent Garderet. (2019) Systemic Dysfunction of Osteoblast Differentiation in Adipose-Derived Stem Cells from Patients with Multiple Myeloma. Cells 8:5, pages 441.
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Ximena Bonilla, Natalia-Del Pilar Vanegas & Jean Paul Vernot. (2019) Acute Leukemia Induces Senescence and Impaired Osteogenic Differentiation in Mesenchymal Stem Cells Endowing Leukemic Cells with Functional Advantages. Stem Cells International 2019, pages 1-16.
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Olga Blau, Rimma Berenstein, Marlies Wächter, Axel Nogai, Aline Künel, Mirgul Bayanova & Igor Wolfgang Blau. 2019. Stromal Cells - Structure, Function, and Therapeutic Implications. Stromal Cells - Structure, Function, and Therapeutic Implications.
Eoin P. McNeill, Robert W. Reese, Abishek Tondon, Bret H. Clough, Simin Pan, Jeremiah Froese, Daniel Palmer, Ulf Krause, David M. Loeb, Roland Kaunas & Carl A. Gregory. (2018) Three-dimensional in vitro modeling of malignant bone disease recapitulates experimentally accessible mechanisms of osteoinhibition. Cell Death & Disease 9:12.
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Juraj Adamik, Deborah L Galson & G David Roodman. (2018) Osteoblast suppression in multiple myeloma bone disease. Journal of Bone Oncology 13, pages 62-70.
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Shokichi Tsukamoto, Marianne B. Løvendorf, Jihye Park, Karma Z. Salem, Michaela R. Reagan, Salomon Manier, Oksana Zavidij, Mahshid Rahmat, Daisy Huynh, Satoshi Takagi, Yawara Kawano, Katsutoshi Kokubun, Charlotte Albæk Thrue, Kenichi Nagano, Andreas Petri, Aldo M. Roccaro, Marzia Capelletti, Roland Baron, Sakari Kauppinen & Irene M. Ghobrial. (2018) Inhibition of microRNA-138 enhances bone formation in multiple myeloma bone marrow niche. Leukemia 32:8, pages 1739-1750.
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Song Xu, Kim De Veirman, Ann De Becker, Karin Vanderkerken & Ivan Van Riet. (2018) Mesenchymal stem cells in multiple myeloma: a therapeutical tool or target?. Leukemia 32:7, pages 1500-1514.
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Sarah M. Ridge, Dibyangana Bhattacharyya, Eoin Dervan, Serika D. Naicker, Amy J. Burke, J.M. Murphy, Karen O'leary, John Greene, Aideen E. Ryan, Francis J. Sullivan & Sharon A. Glynn. (2018) Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro‐tumourigenic ‘activated’ state that enhances prostate cancer cell migration. International Journal of Cancer 142:10, pages 2056-2067.
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Jerome T. Higgs, Joo Hyoung Lee, Hong Wang, Vishnu C. Ramani, Diptiman Chanda, Cherlene Y. Hardy, Ralph D. Sanderson & Selvarangan Ponnazhagan. (2017) Mesenchymal stem cells expressing osteoprotegerin variants inhibit osteolysis in a murine model of multiple myeloma. Blood Advances 1:25, pages 2375-2385.
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Juraj Adamik, Shunqian Jin, Quanhong Sun, Peng Zhang, Kurt R. Weiss, Judith L. Anderson, Rebecca Silbermann, G. David Roodman & Deborah L. Galson. (2017) EZH2 or HDAC1 Inhibition Reverses Multiple Myeloma–Induced Epigenetic Suppression of Osteoblast Differentiation. Molecular Cancer Research 15:4, pages 405-417.
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G McNee, K L Eales, W Wei, D S Williams, A Barkhuizen, D B Bartlett, S Essex, S Anandram, A Filer, P A H Moss, G Pratt, S Basu, C C Davies & D A Tennant. (2016) Citrullination of histone H3 drives IL-6 production by bone marrow mesenchymal stem cells in MGUS and multiple myeloma. Leukemia 31:2, pages 373-381.
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M. Qayed, I. Copland & J. Galipeau. 2017. Mesenchymal Stromal Cells. Mesenchymal Stromal Cells 97 120 .
Cesarina Giallongo, Daniele Tibullo, Nunziatina L. Parrinello, Piera La Cava, Michelino Di Rosa, Vincenzo Bramanti, Cosimo Di Raimondo, Concetta Conticello, Annalisa Chiarenza, Giuseppe A. Palumbo, Roberto Avola, Alessandra Romano & Francesco Di Raimondo. (2016) Granulocyte-like myeloid derived suppressor cells (G-MDSC) are increased in multiple myeloma and are driven by dysfunctional mesenchymal stem cells (MSC). Oncotarget 7:52, pages 85764-85775.
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Alessandro Poggi & Massimo Giuliani. (2016) Mesenchymal Stromal Cells Can Regulate the Immune Response in the Tumor Microenvironment. Vaccines 4:4, pages 41.
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Shirin Ferdowsi, Shirin Azizidoost, Nasim Ghafari & Najmaldin Saki. (2016) Cytogenetic changes of mesenchymal stem cells in the neoplastic bone marrow niche in leukemia. Frontiers in Biology 11:4, pages 305-310.
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G. Shay, L. Hazlehurst & C. C. Lynch. (2015) Dissecting the multiple myeloma-bone microenvironment reveals new therapeutic opportunities. Journal of Molecular Medicine 94:1, pages 21-35.
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Rimma Berenstein, Olga Blau, Axel Nogai, Marlies Waechter, Ekaterina Slonova, Martin Schmidt-Hieber, Annegret Kunitz, Antonio Pezzutto, Bernd Doerken & Igor Wolfgang Blau. (2015) Multiple myeloma cells alter the senescence phenotype of bone marrow mesenchymal stromal cells under participation of the DLK1-DIO3 genomic region. BMC Cancer 15:1.
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Ana Entrena, Alberto Varas, Miriam Vázquez, Gustavo J. Melen, Lidia M. Fernández-Sevilla, Javier García-Castro, Manuel Ramírez, Agustín G. Zapata & Ángeles Vicente. (2015) Mesenchymal stem cells derived from low risk acute lymphoblastic leukemia patients promote NK cell antitumor activity. Cancer Letters 363:2, pages 156-165.
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Wenzhuo Zhuang, Xueping Ge, Sijun Yang, Moli Huang, Wenyue Zhuang, Ping Chen, Xiaohui Zhang, Jinxiang Fu, Jing Qu & Bingzong Li. (2015) Upregulation of lncRNA MEG3 Promotes Osteogenic Differentiation of Mesenchymal Stem Cells From Multiple Myeloma Patients By Targeting BMP4 Transcription. Stem Cells 33:6, pages 1985-1997.
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Dong Soon Choi, Daniel J. Stark, Robert M. Raphael, Jianguo Wen, Jing Su, Xiaobo Zhou, Chung-Che Chang & Youli Zu. (2015) SDF-1α stiffens myeloma bone marrow mesenchymal stromal cells through the activation of RhoA-ROCK-Myosin II. International Journal of Cancer 136:5, pages E219-E229.
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