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Original Articles: Research

Beta-aescin: A potent natural inhibitor of proliferation and inducer of apoptosis in human chronic myeloid leukemia K562 cells in vitro

, & , PhD
Pages 1384-1391 | Received 22 Jan 2008, Accepted 31 Mar 2008, Published online: 01 Jul 2009

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Burcu Uner & Ahmet Dogan Ergin. (2023) Enhanced mitochondrial co-localization of β-escin micelle and pancreatic tumor accumulation relation. Journal of Drug Delivery Science and Technology 89, pages 104994.
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Gerard Giménez-Ribes, Jack Yang, Qixin He, Mehdi Habibi & Leonard M.C. Sagis. (2023) Self-similarity and Payne effect of whey protein-escin mixtures at the air-water interface. Food Hydrocolloids 139, pages 108554.
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Sakine AKAR, Hamiyet DONMEZ-ALTUNTAS & Zuhal HAMURCU. (2022) β-Escin reduces cancer progression in aggressive MDA-MB-231 cells by inhibiting glutamine metabolism through downregulation of c-myc oncogene. Molecular Biology Reports 49:8, pages 7409-7415.
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Gerard Giménez-Ribes, Mehdi Habibi & Leonard M.C. Sagis. (2020) Interfacial rheology and relaxation behavior of adsorption layers of the triterpenoid saponin Escin. Journal of Colloid and Interface Science 563, pages 281-290.
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Chen-Li Cheng, Wei-Ting Chao, Yu-Hsuan Li, Yen-Chuan Ou, Shian-Shiang Wang, Kun-Yuan Chiu & Sheau-Yun Yuan. (2018) Escin induces apoptosis in human bladder cancer cells: An in vitro and in vivo study. European Journal of Pharmacology 840, pages 79-88.
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Zhong Wang, Qiang Chen, Bin Li, Jia-ming Xie, Xiao-dong Yang, Kui Zhao, Yong Wu, Zhen-yu Ye, Zheng-rong Chen, Zheng-hong Qin & Chun-gen Xing. (2018) Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway. Acta Pharmacologica Sinica 39:10, pages 1645-1660.
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Dorothy H.J. Cheong, Frank Arfuso, Gautam Sethi, Lingzhi Wang, Kam Man Hui, Alan Prem Kumar & Thai Tran. (2018) Molecular targets and anti-cancer potential of escin. Cancer Letters 422, pages 1-8.
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Jin-Tang Cheng, Shi-Tao Chen, Cong Guo, Meng-Jiao Jiao, Wen-Jin Cui, Shu-Hui Wang, Zhe Deng, Chang Chen, Sha Chen, Jun Zhang & An Liu. (2017) Triterpenoid Saponins from the Seeds of Aesculus chinensis and Their Cytotoxicities. Natural Products and Bioprospecting 8:1, pages 47-56.
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Sheau-Yun YuanChen-Li ChengShian-Shiang WangHao-Chung HoKun-Yuan ChiuChuan-Shu ChenCheng-Che ChenMing-Yuh ShiauYen-Chuan Ou. (2017) Escin induces apoptosis in human renal cancer cells through G2/M arrest and reactive oxygen species-modulated mitochondrial pathways. Oncology Reports.
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Maria Zeniou, Marie Fève, Samir Mameri, Jihu Dong, Christophe Salomé, Wanyin Chen, Elias A. El-Habr, Fanny Bousson, Mohamadou Sy, Julie Obszynski, Alexandre Boh, Pascal Villa, Suzana Assad Kahn, Bruno Didier, Dominique Bagnard, Marie-Pierre Junier, Hervé Chneiweiss, Jacques Haiech, Marcel Hibert & Marie-Claude Kilhoffer. (2015) Chemical Library Screening and Structure-Function Relationship Studies Identify Bisacodyl as a Potent and Selective Cytotoxic Agent Towards Quiescent Human Glioblastoma Tumor Stem-Like Cells. PLOS ONE 10:8, pages e0134793.
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Jun Liu, Yazhou Yao, Huifang Ding & Renan Chen. (2014) Oxymatrine triggers apoptosis by regulating Bcl-2 family proteins and activating caspase-3/caspase-9 pathway in human leukemia HL-60 cells. Tumor Biology 35:6, pages 5409-5415.
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V. Szabadosova, E. Hijova, L. Strojny, R. Salaj, A. Bomba, D. Cokasova, B. Pramukova, J. Zofcakova, I. Bertkova, A. Supukova, A. Soltesova, A. Brandeburova & A. Chmelarova. (2013) Effect of horse chestnut and inulin as single supplements or in combination on chemically induced colon cancer in rats. Veterinární medicína 58:9, pages 491-499.
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G. G?ney, H. M. Kutlu & A. ??can. (2013) The Apoptotic Effects of Escin in The H- Ras Transformed 5RP7 Cell Line . Phytotherapy Research 27:6, pages 900-905.
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Chun Li, Saeed M. Hashimi, Siyu Cao, Albert S. Mellick, Wei Duan, David Good & Ming Q. Wei. (2013) The Mechanisms of Chansu in Inducing Efficient Apoptosis in Colon Cancer Cells. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-11.
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. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy 353 961 .
Muthu K. Shanmugam, An H. Nguyen, Alan P. Kumar, Benny K.H. Tan & Gautam Sethi. (2012) Targeted inhibition of tumor proliferation, survival, and metastasis by pentacyclic triterpenoids: Potential role in prevention and therapy of cancer. Cancer Letters 320:2, pages 158-170.
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Jia-He Wang, Yi-Jun Zhou, Meng Zhang, Liang Kan & Ping He. (2012) Active lipids of Ganoderma lucidum spores-induced apoptosis in human leukemia THP-1 cells via MAPK and PI3K pathways. Journal of Ethnopharmacology 139:2, pages 582-589.
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Hui Chang, Hui Lin, Long Yi, Jundong Zhu, Yong Zhou, Mantian Mi & Qianyong Zhang. (2010) 3,6-Dihydroxyflavone induces apoptosis in leukemia HL-60 cell via reactive oxygen species-mediated p38 MAPK/JNK pathway. European Journal of Pharmacology 648:1-3, pages 31-38.
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Z.J. Ming, Y. Hu, Y.H. Qiu, L. Cao & X.G. Zhang. (2010) Synergistic effects of β-aescin and 5-fluorouracil in human hepatocellular carcinoma SMMC-7721 cells. Phytomedicine 17:8-9, pages 575-580.
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C Bachran, A Weng, D Bachran, SB Riese, N Schellmann, MF Melzig & H Fuchs. (2010) The distribution of saponins in vivo affects their synergy with chimeric toxins against tumours expressing human epidermal growth factor receptors in mice. British Journal of Pharmacology 159:2, pages 345-352.
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