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Original Articles: Research

Inhibition of p38α MAPK disrupts the pathological loop of proinflammatory factor production in the myelodysplastic syndrome bone marrow microenvironment

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Pages 1963-1975 | Received 26 May 2008, Accepted 05 Jul 2008, Published online: 01 Jul 2009

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Di Zhan & Christopher Y. Park. (2021) Stem Cells in the Myelodysplastic Syndromes. Frontiers in Aging 2.
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Andrew J. Menssen & Matthew J. Walter. (2020) Genetics of progression from MDS to secondary leukemia. Blood 136:1, pages 50-60.
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Shuang Hou, Jie Hao, Yan‐Yu Wang, Bing‐Bing Zhao, Gong‐Wei Xiao, Yan‐Qing Li, Xi Liu, Zhi‐Lan Zou, Ye Yao & Hong Xiong. (2018) Retracted : EBF1 gene promotes the proliferation and inhibits the apoptosis of bone marrow CD34+ cells in patients with myelodysplastic syndrome through negative regulation of mitogen‐activated protein kinase axis . Journal of Cellular Biochemistry 120:2, pages 1407-1419.
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Kathryn S. Ivy & P. Brent FerrellJrJr. (2018) Disordered Immune Regulation and its Therapeutic Targeting in Myelodysplastic Syndromes. Current Hematologic Malignancy Reports 13:4, pages 244-255.
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Cong Wang, Yan Yang, Sujun Gao, Jingcheng Chen, Jinyuan Yu, Han Zhang, Mingxi Li, Xingying Zhan & Wei Li. (2018) Immune dysregulation in myelodysplastic syndrome: Clinical features, pathogenesis and therapeutic strategies. Critical Reviews in Oncology/Hematology 122, pages 123-132.
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Alyssa H Cull & Michael J Rauh. (2017) Success in bone marrow failure? Novel therapeutic directions based on the immune environment of myelodysplastic syndromes. Journal of Leukocyte Biology 102:2, pages 209-219.
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Aditi Shastri, Britta Will, Ulrich Steidl & Amit Verma. (2017) Stem and progenitor cell alterations in myelodysplastic syndromes. Blood 129:12, pages 1586-1594.
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Cornelia S. Schmidt, Pamela Aranda Lopez, Jörn F. Dopheide, Frank Schmidt, Matthias Theobald, Hansjörg Schild, Evi Lauinger-Lörsch, Florian Nolte & Markus P. Radsak. (2016) Phenotypic and functional characterization of neutrophils and monocytes from patients with myelodysplastic syndrome by flow cytometry. Cellular Immunology 308, pages 19-26.
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I Gañán-Gómez, Y Wei, D T Starczynowski, S Colla, H Yang, M Cabrero-Calvo, Z S Bohannan, A Verma, U Steidl & G Garcia-Manero. (2015) Deregulation of innate immune and inflammatory signaling in myelodysplastic syndromes. Leukemia 29:7, pages 1458-1469.
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Irene Gañán‐GómezZachary S. BohannanGuillermo Garcia‐Manero. (2015) p38 MAPK in MDS. Aging 7:6, pages 346-347.
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Lili Yang, Yaqin Qian, Erika Eksioglu, Pearlie K. Epling-Burnette & Sheng Wei. (2015) The inflammatory microenvironment in MDS. Cellular and Molecular Life Sciences 72:10, pages 1959-1966.
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Zhimin He, Jin He, Zhiqiang Liu, Jingda Xu, Sofia F. Yi, Huan Liu & Jing Yang. (2014) MAPK11 in breast cancer cells enhances osteoclastogenesis and bone resorption. Biochimie 106, pages 24-32.
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Xianghong Chen, Erika A. Eksioglu, Junmin Zhou, Ling Zhang, Julie Djeu, Nicole Fortenbery, Pearlie Epling-Burnette, Sandra Van Bijnen, Harry Dolstra, John Cannon, Je-in Youn, Sarah S. Donatelli, Dahui Qin, Theo De Witte, Jianguo Tao, Huaquan Wang, Pingyan Cheng, Dmitry I. Gabrilovich, Alan List & Sheng Wei. (2013) Induction of myelodysplasia by myeloid-derived suppressor cells. Journal of Clinical Investigation 123:11, pages 4595-4611.
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Amer M. Zeidan, Yuliya Linhares & Steven D. Gore. (2013) Current therapy of myelodysplastic syndromes. Blood Reviews 27:5, pages 243-259.
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Rafael BejarRamon V. TiuMikkael A. SekeresRami S. Komrokji. (2013) Myelodysplastic Syndromes: Recent Advancements in Risk Stratification and Unmet Therapeutic Challenges. American Society of Clinical Oncology Educational Book:33, pages e256-e270.
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Deguan Li, Yueying Wang, Hongying Wu, Lu Lu, Xiaochun Wang, Junling Zhang, Heng Zhang, Saijun Fan, Feiyue Fan, Daohong Zhou & Aimin Meng. (2013) The Effects of p38 MAPK Inhibition Combined with G-CSF Administration on the Hematoimmune System in Mice with Irradiation Injury. PLoS ONE 8:4, pages e62921.
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Jin He, Zhiqiang Liu, Yuhuan Zheng, Jianfei Qian, Haiyan Li, Yong Lu, Jingda Xu, Bangxing Hong, Mingjun Zhang, Pei Lin, Zhen Cai, Robert Z. Orlowski, Larry W. Kwak, Qing Yi & Jing Yang. (2012) p38 MAPK in Myeloma Cells Regulates Osteoclast and Osteoblast Activity and Induces Bone Destruction. Cancer Research 72:24, pages 6393-6402.
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Sara Galimberti, Francesca Guerrini, Flavia Salvi, Iacopo Petrini, Daniela Gioia, Emanuela Messa, Giuseppe A Palumbo, Daniela Cilloni, Mario Petrini & Alessandro Levis. (2012) Arsenic trioxide and ascorbic acid interfere with the BCL2 family genes in patients with myelodysplastic syndromes: an ex-vivo study. Journal of Hematology & Oncology 5:1.
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J Yang, J He, J Wang, Y Cao, J Ling, J Qian, Y Lu, H Li, Y Zheng, Y Lan, S Hong, J Matthews, M W Starbuck, N M Navone, R Z Orlowski, P Lin, L W Kwak & Q Yi. (2012) Constitutive activation of p38 MAPK in tumor cells contributes to osteolytic bone lesions in multiple myeloma. Leukemia 26:9, pages 2114-2123.
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Marc H. G. P. Raaijmakers. (2012) Myelodysplastic syndromes: revisiting the role of the bone marrow microenvironment in disease pathogenesis. International Journal of Hematology 95:1, pages 17-25.
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Grant E. Nybakken & Adam Bagg. 2012. Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics. Hematologic Cancers: From Molecular Pathobiology to Targeted Therapeutics 203 240 .
Carolina B. Belli, Yesica Bestach, Yamila Sieza, Marta Gelemur, Mario Giunta, María G. Flores, Nora Watman, Raquel Bengió & Irene Larripa. (2011) The presence of -308A TNFα is associated with anemia and thrombocytopenia in patients with myelodysplastic syndromes. Blood Cells, Molecules, and Diseases 47:4, pages 255-258.
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Bhumika Sharma, Jessica K. Altman, Dennis J. Goussetis, Amit K. Verma & Leonidas C. Platanias. (2011) Protein Kinase R as Mediator of the Effects of Interferon (IFN) γ and Tumor Necrosis Factor (TNF) α on Normal and Dysplastic Hematopoiesis. Journal of Biological Chemistry 286:31, pages 27506-27514.
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Andrew J. Olaharski, Hans Bitter, Nina Gonzaludo, Rama Kondru, David M. Goldstein, Tanja S. Zabka, Henry Lin, Thomas Singer & Kyle Kolaja. (2010) Modeling Bone Marrow Toxicity Using Kinase Structural Motifs and the Inhibition Profiles of Small Molecular Kinase Inhibitors. Toxicological Sciences 118:1, pages 266-275.
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Simone V. da Costa, Rosimeire A. Roela, Mara Souza Junqueira, Camila Arantes & M. Mitzi Brentani. (2010) The role of p38 mitogen-activated protein kinase in serum-induced leukemia inhibitory factor secretion by bone marrow stromal cells from pediatric myelodysplastic syndromes. Leukemia Research 34:4, pages 507-512.
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