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Original Articles: Clinical

Clinical relevance of FLT3 gene abnormalities in Brazilian patients with infant leukemia

, , , , , , MD, PhD & show all
Pages 2291-2297 | Received 19 Jun 2008, Accepted 18 Sep 2008, Published online: 01 Jul 2009

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Suellen Valadares Moura, Francianne Andrade, Isis Q. Magalhães, Imaruí Costa, Denise Bousfield Silva, Maria Lydia D’Andrea, Vitória P. Pinheiro, Maria Lucia M. Lee, Fernando Werneck, Mariana Emerenciano & Maria S. Pombo-de-Oliveira. (2015) Clinical and molecular epidemiology of neonatal leukemia in Brazil. Leukemia & Lymphoma 56:4, pages 903-909.
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Thayana Conceição Barbosa, Francianne Gomes Andrade, Bruno Almeida Lopes, Camilla Fernanda Gomes de Andrade, Marcela Braga Mansur, Mariana Emerenciano & Maria S. Pombo-de-Oliveira. (2014) Impact of mutations in FLT3, PTPN11 and RAS genes on the overall survival of pediatric B cell precursor acute lymphoblastic leukemia in Brazil. Leukemia & Lymphoma 55:7, pages 1501-1509.
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Celalettin Ustun, David L DeRemer, Anand P Jillella & Kapil N Bhalla. (2009) Investigational drugs targeting FLT3 for leukemia. Expert Opinion on Investigational Drugs 18:10, pages 1445-1456.
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Articles from other publishers (16)

O. V. Paina, E. V. Semenova, I. V. Markova, L. S. Zubarovskaya & B. V. Afanasyev. (2019) Modern views on the treatment of acute leukemia in children under 1 year. Russian Journal of Pediatric Hematology and Oncology 6:2, pages 11-19.
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Katherine Tarlock, Todd A. Alonzo, Michael R. Loken, Robert B. Gerbing, Rhonda E. Ries, Richard Aplenc, Lillian Sung, Susana C. Raimondi, Betsy A. Hirsch, Samir B. Kahwash, Amy McKenney, E. Anders Kolb, Alan S. Gamis & Soheil Meshinchi. (2017) Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group. Clinical Cancer Research 23:14, pages 3649-3656.
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Graciele Burnatt, Marley Aparecida Licínio, Pâmela Cristina Gaspar, Arthur Schveitzer Ferreira, Manoela Lira Reis, Ana Carolina Rabello de Moraes, Thaís Cristine Marques Sincero & Maria Cláudia Santos-Silva. (2017) Analysis of the presence of FLT3 gene mutation and association with prognostic factors in adult and pediatric acute leukemia patients. Brazilian Journal of Pharmaceutical Sciences 53:2.
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Jorge Cuervo-Sierra, José Carlos Jaime-Pérez, Ramón A. Martínez-Hernández, Ricardo D. García-Sepúlveda, Mónica Sánchez-Cárdenas, David Gómez-Almaguer, Rocío Ortíz-López, César D. Villarreal-Villarreal, Guillermo J. Ruiz-Arguelles, Guillermo Ruiz-Delgado, Julia Lutz-Presno, Javier Garcés-Eisele, Gregorio Ignacio-Ibarra, Gabriel Muciño-Hernández, Rosa M. Arana-Trejo, Angélica M. Jiménez-Mejia & Gonzalo Vásquez-Palacio. (2016) Prevalence and Clinical Significance of FLT3 Mutation Status in Acute Myeloid Leukemia Patients: A Multicenter Study. Archives of Medical Research 47:3, pages 172-179.
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Elda Pereira Noronha, Francianne Gomes Andrade, Carolina Zampier, Camilla F.C.G. de Andrade, Eug?nia Terra-Granado & Maria S. Pombo-de-Oliveira. (2016) Immunophenotyping with CD135 and CD117 predicts the FLT3, IL-7R and TLX3 gene mutations in childhood T-cell acute leukemia. Blood Cells, Molecules, and Diseases 57, pages 74-80.
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Alejandra Sanjuan-PlaClara BuenoCristina PrietoPamela AchaRonald W. StamRolf Marschalek & Pablo Menéndez. (2015) Revisiting the biology of infant t(4;11)/MLL-AF4+ B-cell acute lymphoblastic leukemia. Blood 126:25, pages 2676-2685.
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Francianne Gomes Andrade, Juliana Montibeller Furtado-Silva, Bruno Alves de Aguiar Gonçalves, Luiz Claudio Santos Thuler, Thayana Conceição Barbosa, Mariana Emerenciano, André Siqueira & Maria S Pombo-de-Oliveira. (2014) RAS mutations in early age leukaemia modulated by NQO1 rs1800566 (C609T) are associated with second-hand smoking exposures. BMC Cancer 14:1.
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Antonio R. Lucena-Araujo, Haesook T. Kim, Rafael H. Jacomo, Raul A. Melo, Rosane Bittencourt, Ricardo Pasquini, Katia Pagnano, Evandro M. Fagundes, Maria de Lourdes Chauffaille, Carlos S. Chiattone, Ana Silvia Lima, Guillermo Ruiz-Argüelles, Maria Soledad Undurraga, Lem Martinez, Hau C. Kwaan, Robert Gallagher, Charlotte M. Niemeyer, Stanley L. Schrier, Martin S. Tallman, David Grimwade, Arnold Ganser, Nancy Berliner, Raul C. Ribeiro, Francesco Lo-Coco, Bob Löwenberg, Miguel A. Sanz & Eduardo M. Rego. (2014) Internal tandem duplication of the FLT3 gene confers poor overall survival in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukemia study. Annals of Hematology 93:12, pages 2001-2010.
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R S Kotecha, N G Gottardo, U R Kees & C H Cole. (2014) The evolution of clinical trials for infant acute lymphoblastic leukemia. Blood Cancer Journal 4:4, pages e200-e200.
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R Montes, V Ayllón, C Prieto, A Bursen, C Prelle, D Romero-Moya, P J Real, O Navarro-Montero, C Chillón, R Marschalek, C Bueno & P Menendez. (2013) Ligand-independent FLT3 activation does not cooperate with MLL-AF4 to immortalize/transform cord blood CD34+ cells. Leukemia 28:3, pages 666-674.
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Clara BuenoVerónica AyllónRosa MontesOscar Navarro-MonteroVerónica Ramos-MejiaPedro J. RealDamià Romero-MoyaMarcos J. Araúzo-BravoPablo Menendez. (2013) FLT3 activation cooperates with MLL-AF4 fusion protein to abrogate the hematopoietic specification of human ESCs. Blood 121:19, pages 3867-3878.
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M C Chillón, M T Gómez-Casares, C E López-Jorge, C Rodriguez-Medina, A Molines, M E Sarasquete, M Alcoceba, J D G-S Miguel, C Bueno, R Montes, F Ramos, J N Rodríguez, P Giraldo, M Ramírez, R García-Delgado, J L Fuster, M González-Díaz & P Menendez. (2012) Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemia. Leukemia 26:11, pages 2360-2366.
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Naveen Pemmaraju, Hagop Kantarjian, Farhad Ravandi & Jorge Cortes. (2011) FLT3 inhibitors in the treatment of acute myeloid leukemia. Cancer 117:15, pages 3293-3304.
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Elvira Deolinda Rodrigues Pereira Velloso, Carlos Henrique Ares Silveira da Motta, Juliana Braga Furtado, Nydia Strachman Bacal, Paulo Augusto Achucarro Silveira, Cynthia Bachir Moyses, Roberta Sitnik & João Renato Rebello Pinho. (2011) Molecular and cytogenetic abnormalities in acute myeloid leukemia: review and case studies. Einstein (São Paulo) 9:2, pages 184-189.
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Marcela Braga Mansur, Mariana Emerenciano, Alessandra Splendore, Lilian Brewer, Rocio Hassan & Maria S. Pombo-de-Oliveira. (2010) T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements. Leukemia Research 34:4, pages 483-486.
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Antonio R. Lucena-Araujo, Danielle L. Souza, Fabio Morato de Oliveira, Mariana Tereza Lira Benicio, Lorena L. Figueiredo-Pontes, Barbara A. Santana-Lemos, Guilherme A. dos Santos, Rafael H. Jacomo, Anemari R. Dinarte-Santos, Mihoko Yamamoto, Wilson A. Silva-Jr, Maria de Lourdes Chauffaille & Eduardo M. Rego. (2009) Results of FLT3 mutation screening and correlations with immunophenotyping in 169 Brazilian patients with acute myeloid leukemia. Annals of Hematology 89:2, pages 225-228.
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