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Original Articles: Clinical

Toxicity of a second autologous peripheral blood stem cell transplant in patients with relapsed or recurrent multiple myeloma

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Pages 1442-1447 | Received 05 Mar 2009, Accepted 01 Jun 2009, Published online: 15 Sep 2009

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Joanna Drozd-Sokołowska, Anna Waszczuk-Gajda, Przemysław Biecek, Katarzyna Kobylińska, Joanna Mańko, Iwona Hus, Anna Szmigielska-Kapłon, Mateusz Nowicki, Joanna Romejko-Jarosińska, Magdalena Kozioł, Mariola Sędzimirska, Wojciech Sachs, Krzysztof Mądry, Piotr Boguradzki, Małgorzata Król, Marek Hus, Grzegorz Basak & Jadwiga Dwilewicz-Trojaczek. (2021) Salvage autologous hematopoietic stem cell transplantation for multiple myeloma performed with stem cells procured after previous high dose therapy – a multicenter report by the Polish Myeloma Study Group. Leukemia & Lymphoma 62:13, pages 3226-3234.
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Dimitrios C. Ziogas, Evangelos Terpos & Meletios A. Dimopoulos. (2017) When to recommend a second autograft in patients with relapsed myeloma?. Leukemia & Lymphoma 58:4, pages 781-787.
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Morie A. Gertz. (2011) Stem cell transplant: an effective salvage therapy for multiple myeloma. Leukemia & Lymphoma 52:8, pages 1413-1414.
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Roland Fenk, Vanessa Liese, Florian Neubauer, Ingmar Bruns, Mustafa Kondakci, Sebastian Balleisen, Christian Saure, Thomas Schröder, Rainer Haas & Guido Kobbe. (2011) Predictive factors for successful salvage high-dose therapy in patients with multiple myeloma relapsing after autologous blood stem cell transplantation. Leukemia & Lymphoma 52:8, pages 1455-1462.
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Articles from other publishers (33)

Abdullah M. Khan, Michael Ozga, Harshil Bhatt, Muhammad S. Faisal, Sadia Ansari, Qiuhong Zhao, Naresh Bumma, Francesca Cottini, Srinivas Devarakonda, Ashley Rosko, Nidhi Sharma, Elvira Umyarova & Don Benson. (2023) Outcomes After Salvage Autologous Hematopoietic Cell Transplant for Patients With Relapsed/Refractory Multiple Myeloma: A Single-Institution Experience. Clinical Lymphoma Myeloma and Leukemia 23:3, pages e182-e189.
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Joanna Drozd-Sokołowska, Luuk Gras, Nienke Zinger, John A. Snowden, Mutlu Arat, Grzegorz Basak, Anastasia Pouli, Charles Crawley, Keith M. O. Wilson, Herve Tilly, Jennifer Byrne, Claude Eric Bulabois, Jakob Passweg, Zubeyde Nur Ozkurt, Wilfried Schroyens, Bruno Lioure, Mercedes Colorado Araujo, Xavier Poiré, Gwendolyn Van Gorkom, Gunhan Gurman, Liesbeth C. de Wreede, Patrick J. Hayden, Meral Beksac, Stefan O. Schönland & Ibrahim Yakoub-Agha. (2022) Autologous hematopoietic cell transplantation for relapsed multiple myeloma performed with cells procured after previous transplantation–study on behalf of CMWP of the EBMT. Bone Marrow Transplantation 57:4, pages 633-640.
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Shaji K. KumarNatalie S. CallanderKehinde AdekolaLarry AndersonMuhamed BaljevicErica CampagnaroJorge J. CastilloJason C. ChandlerCaitlin CostelloYvonne EfeberaMatthew FaimanAlfred GarfallKelly GodbyJens HillengassLeona HolmbergMyo HtutCarol Ann HuffYubin KangMalin HultcrantzSarah LarsonMichaela LiedtkeThomas MartinJames OmelKenneth ShainDouglas SborovKeith Stockerl-GoldsteinDonna Weber, Jennifer Keller & Rashmi Kumar. (2020) Multiple Myeloma, Version 3.2021, NCCN Clinical Practice Guidelines in Oncology. Journal of the National Comprehensive Cancer Network 18:12, pages 1685-1717.
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Wilson I. Gonsalves, Francis K. Buadi, Sikander Ailawadhi, P. Leif Bergsagel, Asher A. Chanan Khan, David Dingli, Angela Dispenzieri, Rafael Fonseca, Susan R. Hayman, Prashant Kapoor, Taxiarchis V. Kourelis, Martha Q. Lacy, Jeremy T. Larsen, Eli Muchtar, Craig B. Reeder, Taimur Sher, A. Keith Stewart, Rahma Warsame, Ronald S. Go, Robert A. Kyle, Nelson Leung, Yi Lin, John A. Lust, Stephen J. Russell, Stephen R. Zeldenrust, Amie L. Fonder, Yi L. Hwa, Miriam A. Hobbs, Angela A. Mayo, William J. Hogan, S. Vincent Rajkumar, Shaji K. Kumar, Morie A. Gertz & Vivek Roy. (2018) Utilization of hematopoietic stem cell transplantation for the treatment of multiple myeloma: a Mayo Stratification of Myeloma and Risk-Adapted Therapy (mSMART) consensus statement. Bone Marrow Transplantation 54:3, pages 353-367.
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Patrick Alan Hagen & Patrick Stiff. (2019) The Role of Salvage Second Autologous Hematopoietic Cell Transplantation in Relapsed Multiple Myeloma. Biology of Blood and Marrow Transplantation 25:3, pages e98-e107.
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Laurent Garderet, Simona Iacobelli, Linda Koster, Hartmut Goldschmidt, Jan-Erik Johansson, Jean Henri Bourhis, Marta Krejci, Xavier Leleu, Michael Potter, Didier Blaise, Christian Koenecke, Christian Peschel, Jakub Radocha, Bernd Metzner, Pascal Lenain, Kerstin Schäfer-Eckart, David Pohlreich, Mariella Grasso, Denis Caillot, Herman Einsele, Marco Ladetto, Stefan Schönland & Nicolaus Kröger. (2018) Outcome of a Salvage Third Autologous Stem Cell Transplantation in Multiple Myeloma. Biology of Blood and Marrow Transplantation 24:7, pages 1372-1378.
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Ursina Gössi, Barbara Jeker, Behrouz Mansouri Taleghani, Ulrike Bacher, Urban Novak, Daniel Betticher, Thomas Egger, Thilo Zander & Thomas Pabst. (2018) Prolonged survival after second autologous transplantation and lenalidomide maintenance for salvage treatment of myeloma patients at first relapse after prior autograft. Hematological Oncology 36:2, pages 436-444.
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Tsuyoshi Muta, Toshihiro Miyamoto, Tomohiko Kamimura, Yoshinobu Kanda, Masaharu Nohgawa, Yasunori Ueda, Koji Iwato, Osamu Sasaki, Takehiko Mori, Naoyuki Uchida, Shinsuke Iida, Takahiro Fukuda, Yoshiko Atsuta & Kazutaka Sunami. (2018) Significance of Salvage Autologous Stem Cell Transplantation for Relapsed Multiple Myeloma: A Nationwide Retrospective Study in Japan. Acta Haematologica 139:1, pages 35-44.
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Beatrice Anna Zannetti, Paola Tacchetti, Lucia Pantani, Barbara Gamberi, Patrizia Tosi, Serena Rocchi, Claudia Cellini, Sonia Ronconi, Annalisa Pezzi, Katia Mancuso, Ilaria Rizzello, Isola Caratozzolo, Marina Martello, Luca Dozza, Michele Cavo & Elena Zamagni. (2017) Novel agent-based salvage autologous stem cell transplantation for relapsed multiple myeloma. Annals of Hematology 96:12, pages 2071-2078.
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Tsuyoshi Muta, Toshihiro Miyamoto, Tomoaki Fujisaki, Koichi Osaki, Ryosuke Ogawa, Koji Kato, Kenichi Aoki, Takashi Haro, Tomohiko Kamimura, Kenjiro Kamezaki, Goichi Yoshimoto, Satoshi Yamasaki, Katsuto Takenaka, Yuju Ohno, Hiromi Iwasaki, Testuya Eto, Koji Nagafuji, Koichi Akashi & Fukuoka Blood and Marrow Transplant Group (FBMTG). (2017) Significance of salvage autologous stem cell transplantation (ASCT) for patients with multiple myeloma relapsing after up-front ASCT. Journal of Hematopoietic Cell Transplantation 6:2, pages 98-107.
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Nina Shah, Natalie Callander, Siddhartha Ganguly, Zartash Gul, Mehdi Hamadani, Luciano Costa, Salyka Sengsayadeth, Muneer Abidi, Parameswaran Hari, Mohamad Mohty, Yi-Bin Chen, John Koreth, Heather Landau, Hillard Lazarus, Helen Leather, Navneet Majhail, Rajneesh Nath, Keren Osman, Miguel-Angel Perales, Jeffrey Schriber, Paul Shaughnessy, David Vesole, Ravi Vij, John Wingard, Sergio Giralt & Bipin N. Savani. (2015) Hematopoietic Stem Cell Transplantation for Multiple Myeloma: Guidelines from the American Society for Blood and Marrow Transplantation. Biology of Blood and Marrow Transplantation 21:7, pages 1155-1166.
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C Phipps, M Linenberger, L A Holmberg, D Green, P Becker, L Connelly-Smith, Z Klippel, N Burwick, A Gopal, W I Bensinger & E Libby. (2015) Utilization of stored autologous PBSCs to support second autologous transplantation in multiple myeloma patients in the era of novel agent therapy. Bone Marrow Transplantation 50:5, pages 663-667.
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Sarah A. Holstein, Paul G. Richardson, Jacob P. Laubach & Philip L. McCarthy. (2015) Management of Relapsed Multiple Myeloma after Autologous Stem Cell Transplant. Biology of Blood and Marrow Transplantation 21:5, pages 793-798.
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Sarah A. Holstein, Hong Liu & Philip L. McCarthy. (2014) Multiple Myeloma. Hematology/Oncology Clinics of North America 28:6, pages 1113-1129.
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César O. Freytes, Juan J. Toro, Rosa F. Yeh, Edward A. Stadtmauer, Voravit Ratanatharathorn, Görgün Akpek, Entezam Sahovic, Guido J. Tricot, Paul J. Shaughnessy, Darrell J. White, Tulio E. Rodriguez, Scott R. Solomon, Louie H. Yu, Cathy Zhao, Shiva Patil, Elizabeth Armstrong, Angela Smith, Agnes Elekes, Kazunobu Kato & Donna E. Reece. (2014) Safety and Efficacy of Targeted-Dose Busulfan and Bortezomib as a Conditioning Regimen for Patients with Relapsed Multiple Myeloma Undergoing a Second Autologous Blood Progenitor Cell Transplantation. Biology of Blood and Marrow Transplantation 20:12, pages 1949-1957.
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C O Freytes, D H Vesole, J LeRademacher, X Zhong, R P Gale, R A Kyle, D E Reece, J Gibson, H C Schouten, P L McCarthy, S Lonial, A Y Krishnan, A Dispenzieri & P N Hari. (2013) Second transplants for multiple myeloma relapsing after a previous autotransplant—reduced-intensity allogeneic vs autologous transplantation. Bone Marrow Transplantation 49:3, pages 416-421.
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Morie A. Gertz & Craig B. Reeder. 2014. Multiple Myeloma. Multiple Myeloma 101 123 .
Djordje Atanackovic & Georgia Schilling. (2013) Second autologous transplant as salvage therapy in multiple myeloma. British Journal of Haematology 163:5, pages 565-572.
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Leopold Sellner, Christiane Heiss, Axel Benner, Marc S. Raab, Jens Hillengass, Dirk Hose, Nicola Lehners, Gerlinde Egerer, Anthony D. Ho, Hartmut Goldschmidt & Kai Neben. (2013) Autologous retransplantation for patients with recurrent multiple myeloma. Cancer 119:13, pages 2438-2446.
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Saad Z. Usmani. (2013) Melphalan Continues to Rock the Myeloma World. Biology of Blood and Marrow Transplantation 19:5, pages 680-681.
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Laura C. Michaelis, Ayman Saad, Xiaobo Zhong, Jennifer Le-Rademacher, Cesar O. Freytes, David I. Marks, Hillard M. Lazarus, Jennifer M. Bird, Leona Holmberg, Rammurti T. Kamble, Shaji Kumar, Michael Lill, Kenneth R. Meehan, Wael Saber, Jeffrey Schriber, Jason Tay, Dan T. Vogl, Baldeep Wirk, Bipin N. Savani, Robert P. Gale, David H. Vesole, Gary J. Schiller, Muneer Abidi, Kenneth C. Anderson, Taiga Nishihori, Matt E. Kalaycio, Julie M. Vose, Jan S. Moreb, William Drobyski, Reinhold Munker, Vivek Roy, Armin Ghobadi, H. Kent Holland, Rajneesh Nath, L. Bik To, Angelo Maiolino, Adetola A. Kassim, Sergio A. Giralt, Heather Landau, Harry C. Schouten, Richard T. Maziarz, Joseph Mikhael, Tamila Kindwall-Keller, Patrick J. Stiff, John Gibson, Sagar Lonial, Amrita Krishnan, Angela Dispenzieri & Parameswaran Hari. (2013) Salvage Second Hematopoietic Cell Transplantation in Myeloma. Biology of Blood and Marrow Transplantation 19:5, pages 760-766.
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W I Gonsalves, M A Gertz, M Q Lacy, A Dispenzieri, S R Hayman, F K Buadi, D Dingli, W J Hogan & S K Kumar. (2012) Second auto-SCT for treatment of relapsed multiple myeloma. Bone Marrow Transplantation 48:4, pages 568-573.
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H-Y Yhim, K Kim, J S Kim, H J Kang, J-A Kim, C-K Min, S H Bae, E Park, D-H Yang, C Suh, M K Kim, Y-C Mun, H S Eom, H J Shin, H-J Yoon, J H Kwon, J H Lee, Y S Kim, S-S Yoon & J-Y Kwak. (2012) Matched-pair analysis to compare the outcomes of a second salvage auto-SCT to systemic chemotherapy alone in patients with multiple myeloma who relapsed after front-line auto-SCT. Bone Marrow Transplantation 48:3, pages 425-432.
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Emilie Lemieux, Cyrille Hulin, Denis Caillot, Stéphanie Tardy, Véronique Dorvaux, Jessica Michel, Thomas Gastinne, Cédric Rossi, Caroline Legouge, Cyrille Touzeau, Lucie Planche, Marion Loirat, Ingrid Lafon & Philippe Moreau. (2013) Autologous Stem Cell Transplantation: An Effective Salvage Therapy in Multiple Myeloma. Biology of Blood and Marrow Transplantation 19:3, pages 445-449.
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A. W. S. Chow, C. H. S. Lee, D. K. Hiwase, L. B. To & N. Horvath. (2013) Relapsed multiple myeloma: who benefits from salvage autografts?. Internal Medicine Journal 43:2, pages 156-161.
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Nina Shah, Fraz Ahmed, Qaiser Bashir, Sofia Qureshi, Yvonne Dinh, Gabriela Rondon, Sijin Wen, Peter Thall, Hassan Khan, Sergio Giralt, Richard Champlin & Muzaffar H. Qazilbash. (2011) Durable remission with salvage second autotransplants in patients with multiple myeloma. Cancer 118:14, pages 3549-3555.
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Andrzej Jakubowiak. (2012) Management Strategies for Relapsed/Refractory Multiple Myeloma: Current Clinical Perspectives. Seminars in Hematology 49, pages S16-S32.
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Victor H. Jimenez-Zepeda, Joseph Mikhael, Andrew Winter, Norman Franke, Esther Masih-Khan, Suzanne Trudel, Christine Chen, Vishal Kukreti & Donna E. Reece. (2012) Second Autologous Stem Cell Transplantation as Salvage Therapy for Multiple Myeloma: Impact on Progression-Free and Overall Survival. Biology of Blood and Marrow Transplantation 18:5, pages 773-779.
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Gordon Cook, Effie Liakopoulou, Rachel Pearce, Jim Cavet, Gareth J. Morgan, Keiren Kirkland, Julia Lee, Faith E. Davies, Rachel Hall, Amin Rahemtulla, Nigel Russell & David I. Marks. (2011) Factors Influencing the Outcome of a Second Autologous Stem Cell Transplant (ASCT) in Relapsed Multiple Myeloma: A Study from the British Society of Blood and Marrow Transplantation Registry. Biology of Blood and Marrow Transplantation 17:11, pages 1638-1645.
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Sagar Lonial, Constantine S. Mitsiades & Paul G. Richardson. (2011) Treatment Options for Relapsed and Refractory Multiple Myeloma. Clinical Cancer Research 17:6, pages 1264-1277.
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Nina ShahSagar Lonial. (2010) Evidence-Based Mini-Review: Treatment Options for Patients with Relapsed/Refractory Myeloma Previously Treated with Novel Agents and High-Dose Chemotherapy and Autologous Stem-Cell Transplantation. Hematology 2010:1, pages 310-313.
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Nina ShahSagar Lonial. (2010) Evidence-Based Mini-Review: Treatment Options for Patients with Relapsed/Refractory Myeloma Previously Treated with Novel Agents and High-Dose Chemotherapy and Autologous Stem-Cell Transplantation. Hematology 2010:1, pages 310-313.
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