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Leukemia & Lymphoma Volume 50, 2009 - Issue 9
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Original Articles: Clinical

Optimizing the CD34 + cell dose for reduced-intensity allogeneic hematopoietic stem cell transplantation

Jayesh Mehta The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USACorrespondence[email protected]
,
Jayesh Mehta The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USACorrespondence[email protected]
,
Olga Frankfurt The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Jessica Altman The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Andrew Evens The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Martin Tallman The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Leo Gordon The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Stephanie Williams The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Jane Winter The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Jairam Krishnamurthy The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Sara Duffey The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Veerpal Singh The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Richard Meagher The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
David Grinblatt The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
,
Lynne Kaminer The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
&
Seema Singhal The Feinberg School of Medicine, The Robert H Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA
 show all
Pages 1434-1441 | Received 11 Apr 2009, Accepted 01 Jun 2009, Published online: 15 Sep 2009

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Matthew Li, Brent Morse & Sadik Kassim. (2022) Development and Clinical Translation Considerations for the Next Wave of Gene Modified Hematopoietic Stem and Progenitor Cells Therapies. Expert Opinion on Biological Therapy 22:9, pages 1177-1191.
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Avichai Shimoni & Arnon Nagler. (2009) Stem-cell dose for allogeneic hematopoietic stem cell transplantation in hematological malignancies: is more better?. Leukemia & Lymphoma 50:9, pages 1395-1396.
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Articles from other publishers (23)

Leonard C. Alsfeld & Chitra Hosing. 2024. Manual of Hematopoietic Cell Transplantation and Cellular Therapies. Manual of Hematopoietic Cell Transplantation and Cellular Therapies 29 37 .
Mariam T. Nawas, Annie Im & Brian Shaffer. (2023) Higher graft cell dose does not influence development of acute or chronic GVHD in haploidentical transplantation using PTCy. Blood Advances 7:16, pages 4475-4478.
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Alexandra Pedraza, María Queralt Salas, Luis Gerardo Rodríguez-Lobato, Paola Charry, María Suárez-Lledo, Nuria Martínez-Cibrian, Ariadna Doménech, Maria Teresa Solano, Jordi Arcarons, Noemí de Llobet, Laura Rosiñol, Gonzalo Gutiérrez-García, Francesc Fernández Avilés, Álvaro Urbano-Ispízua, Montserrat Rovira & Carmen Martínez. (2023) Effect of CD34+ Cell Dose on the Outcomes of Allogeneic Stem Cell Transplantation with Post-Transplantation Cyclophosphamide. Transplantation and Cellular Therapy 29:3, pages 181.e1-181.e10.
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Di Yao, Bohan Li, Xinran Chu, Jian Pan, Lijun Meng, Yixin Hu, Li Gao, Jie Li, Yuanyuan Tian & Shaoyan Hu. (2022) Association between CD34+ and CD3+ T-cells in allogeneic grafts and acute graft-versus-host disease in children undergoing allogeneic hematopoietic stem cell transplantation: A single-center study. Transplant Immunology, pages 101779.
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Hany Elmariah. (2022) Commentary: Target CD34 Cell Dose for Allogeneic Hematopoietic Cell Transplantation: Can We Finally Agree?. Transplantation and Cellular Therapy 28:2, pages 59-60.
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Sunu Cyriac, Shruti Prem, Maria Queralt Salas, Shiyi Chen, Zeyad Al‐Shaibani, Wilson Lam, Arjun Law, Vikas Gupta, Fotios V. Michelis, Dennis (Dong Hwan) Kim, Jeffrey Lipton, Rajat Kumar, Jonas Mattsson & Auro Viswabandya. (2021) Effect of pre‐transplant JAK1/2 inhibitors and CD34 dose on transplant outcomes in myelofibrosis. European Journal of Haematology 107:5, pages 517-528.
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Hany Elmariah, Syeda Mahrukh Hussnain Naqvi, Jongphil Kim, Taiga Nishihori, Asmita Mishra, Lia Perez, Rawan Faramand, Aleksandr Lazaryan, Hien D. Liu, Farhad Khimani, Michael Nieder, Claudio Anasetti, Joseph Pidala & Nelli Bejanyan. (2021) Impact of infused CD34+ stem cell dosing for allogeneic peripheral blood stem cell transplantation with post-transplant cyclophosphamide. Bone Marrow Transplantation 56:7, pages 1683-1690.
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Jiali Li, Sanbin Wang, Yicheng Zhang, Shifeng Lou, Yao Liu, Peiyan Kong, Cheng Zhang, Lei Gao, Xiangui Peng, Ping Wang, Xiaojuan Deng, Li Gao & Xi Zhang. (2020) Is It Better to Mobilize Hematopoietic Stem Cells With Pegfilgrastim in Healthy Donors During Allogeneic Hematopoietic Stem Cell Transplantation?. Frontiers in Oncology 10.
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Yasuhisa Yokoyama, Koichiro Maie, Takahiro Fukuda, Naoyuki Uchida, Junichi Mukae, Masashi Sawa, Kohmei Kubo, Mineo Kurokawa, Hirohisa Nakamae, Tatsuo Ichinohe, Yoshiko Atsuta & Shigeru Chiba. (2020) A high CD34+ cell dose is associated with better disease-free survival in patients with low-risk diseases undergoing peripheral blood stem cell transplantation from HLA-matched related donors. Bone Marrow Transplantation 55:9, pages 1726-1735.
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Enrico Maffini, Myriam Labopin, Didier Blaise, Fabio Ciceri, Zafer Gülbas, Eric Deconinck, Veronique Leblond, Patrick Chevallier, Gerard Sociè, Mercedes C. Araujo, Yener Koc, Bipin N. Savani, Norbert C. Gorin, Francesco Lanza, Arnon Nagler & Mohamad Mohty. (2020) CD34 + cell dose effects on clinical outcomes after T‐cell replete haploidentical allogeneic hematopoietic stem cell transplantation for acute myeloid leukemia using peripheral blood stem cells. A study from the acute leukemia working Party of the European Society for blood and marrow transplantation ( EBMT ) . American Journal of Hematology 95:8, pages 892-899.
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Michael Burns, Anurag K Singh, Carrie C Hoefer, Yali Zhang, Paul K Wallace, George L Chen, Alexis Platek, Timothy B Winslow, Austin J Iovoli, Christopher Choi, Maureen Ross, Philip L McCarthy & Theresa Hahn. (2019) Impact of conditioning regimen on peripheral blood hematopoietic cell transplant. World Journal of Clinical Oncology 10:2, pages 86-97.
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Xia Li, Ruoyu Ma, Qi Gu, Lingmin Liang, Lei Wang, Ying Zhang, Xianning Wang, Xin Liu, Zhongwen Li, Jinhui Fang, Jun Wu, Yukai Wang, Wei Li, Baoyang Hu, Liu Wang, Qi Zhou & Jie Hao. (2018) A fully defined static suspension culture system for large-scale human embryonic stem cell production. Cell Death & Disease 9:9.
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W. Fingrut, K. Rikhraj & D. Allan. (2018) Targeted recruitment of male donors for allogeneic haematopoietic cell transplantation: A review of the evidence. Vox Sanguinis 113:4, pages 307-316.
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Chihiro Yamamoto, Hiroyasu Ogawa, Takahiro Fukuda, Aiko Igarashi, Hirokazu Okumura, Naoyuki Uchida, Michihiro Hidaka, Hirohisa Nakamae, Ken-Ichi Matsuoka, Tetsuya Eto, Tatsuo Ichinohe, Yoshiko Atsuta & Yoshinobu Kanda. (2018) Impact of a Low CD34+ Cell Dose on Allogeneic Peripheral Blood Stem Cell Transplantation. Biology of Blood and Marrow Transplantation 24:4, pages 708-716.
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Riddhi Sharma. (2016) iPS Cells—The Triumphs and Tribulations. Dentistry Journal 4:2, pages 19.
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Casey Brewer, Elizabeth Chu, Mike Chin & Rong Lu. (2016) Transplantation Dose Alters the Differentiation Program of Hematopoietic Stem Cells. Cell Reports 15:8, pages 1848-1857.
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William A. Fabricius & Muthalagu Ramanathan. (2016) Review on Haploidentical Hematopoietic Cell Transplantation in Patients with Hematologic Malignancies. Advances in Hematology 2016, pages 1-8.
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Annelies Billen, J. Alejandro Madrigal, Richard M. Szydlo & Bronwen E. Shaw. (2014) Female donors and donors who are lighter than their recipient are less likely to meet the CD34+ cell dose requested for peripheral blood stem cell transplantation. Transfusion 54:11, pages 2953-2960.
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Hien K. Duong, Bipin N. Savani, Ed Copelan, Steven Devine, Luciano J. Costa, John R. Wingard, Paul Shaughnessy, Navneet Majhail, Miguel-Angel Perales, Corey S. Cutler, William Bensinger, Mark R. Litzow, Mohamad Mohty, Richard E. Champlin, Helen Leather, Sergio Giralt & Paul A. Carpenter. (2014) Peripheral Blood Progenitor Cell Mobilization for Autologous and Allogeneic Hematopoietic Cell Transplantation: Guidelines from the American Society for Blood and Marrow Transplantation. Biology of Blood and Marrow Transplantation 20:9, pages 1262-1273.
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Ying Wang, Linzhao Cheng & Sharon Gerecht. (2013) Efficient and Scalable Expansion of Human Pluripotent Stem Cells Under Clinically Compliant Settings: A View in 2013. Annals of Biomedical Engineering 42:7, pages 1357-1372.
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Ying Wang, Bin-Kuan Chou, Sarah Dowey, Chaoxia He, Sharon Gerecht & Linzhao Cheng. (2013) Scalable expansion of human induced pluripotent stem cells in the defined xeno-free E8 medium under adherent and suspension culture conditions. Stem Cell Research 11:3, pages 1103-1116.
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R Martino, A Kerguelen, D Valcárcel, A Sureda, L Fachini, J L Piñana, J Briones, J Delgado, S Brunet & J Sierra. (2010) Reduction of infection-related mortality after allogeneic PBSCT from HLA-identical siblings: longitudinal analysis from 1994 to 2008 at a single institution. Bone Marrow Transplantation 46:5, pages 690-701.
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Zoran Ivanovic. (2010) Hematopoietic stem cells in research and clinical applications: The “CD34 issue”. World Journal of Stem Cells 2:2, pages 18.
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