708
Views
39
CrossRef citations to date
0
Altmetric
Original Articles: Clinical

Clinicopathologic investigation of methotrexate-induced lymphoproliferative disorders, with a focus on regression

, , , , , , , , , , , , & show all
Pages 1143-1152 | Received 17 Feb 2017, Accepted 12 Aug 2017, Published online: 07 Sep 2017

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Chaninan Kositkuljorn, Suthinee Rutnin, Teerapong Rattananukrom, Teeraya Puavilai, Burana Khiankaew, Paisarn Boonsakan & Wimolsiri Iamsumang. (2023) Cutaneous Methotrexate-Related Epstein–Barr Virus-Positive Diffuse Large B-Cell Lymphoma in a Patient with Granulomatous Cutaneous T-Cell Lymphoma: A Case Report and Literature Review. Clinical, Cosmetic and Investigational Dermatology 16, pages 2229-2235.
Read now
Koshiro Sonomoto & Yoshiya Tanaka. (2023) Malignancies and rheumatoid arthritis, csDMARDs, biological DMARDs, and JAK inhibitors: challenge and outlook. Expert Review of Clinical Immunology 19:11, pages 1325-1342.
Read now
Kazuhisa Nakano, Kazuyoshi Saito, Aya Nawata, Kentaro Hanami, Satoshi Kubo, Ippei Miyagawa, Yoshihisa Fujino, Shingo Nakayamada & Yoshiya Tanaka. (2021) Clinical aspects in patients with rheumatoid arthritis complicated with lymphoproliferative disorders without regression after methotrexate withdrawal and treatment for arthritis after regression of lymphoproliferative disorders. Modern Rheumatology 31:1, pages 94-100.
Read now
Masahiro Kondo, Yohko Murakawa, Mayuko Moriyama, Manabu Honda, Tomoko Sugiura, Keiichi Onoda, Yohei Watanabe & Hiroyuki Kakimaru. (2021) Distinct decrease in peripheral lymphocytes in EBER-positive cases of MTX-LPD. Modern Rheumatology 31:1, pages 88-93.
Read now
Chika Yamada, Eri Oguro, Soichiro Tsuji, Eriko Kudo-Tanaka, Satoru Teshigawara, Shiro Ohshima, Jun Hashimoto, Yukihiko Saeki, Tetsuya Horiuchi, Norishige Iizuka, Yasuhiko Tomita & Yoshihiko Hoshida. (2020) Pathological assessment of the lymph node biopsies for lymphadenopathy in rheumatoid arthritis. Modern Rheumatology 30:5, pages 835-842.
Read now
Michihide Tokuhira, Shuntaro Saito, Katsuya Suzuki, Morihiro Higashi, Shuju Momose, Takayuki Shimizu, Takehiko Mori, Yuta Kimura, Koichi Amano, Shinichiro Okamoto, Tsutomu Takeuchi, Jun-Ichi Tamaru & Masahiro Kizaki. (2019) Clinicopathological features of clinical methotrexate-related lymphoproliferative disorders. Leukemia & Lymphoma 60:10, pages 2508-2515.
Read now
Anja Mottok & Andreas Rosenwald. (2018) Methotrexate-induced lymphoproliferative disorders: regression matters. Leukemia & Lymphoma 59:5, pages 1027-1029.
Read now
Yayoi Hashiba, Toshihiko Hidaka, Kunihiko Umekita, Eiko Nishi, Yasufumi Kai, Kazuyoshi Kubo & Akihiko Okayama. (2018) Remission of chronic type ATL in a patient with rheumatoid arthritis after withdrawing methotrexate and infliximab combination therapy: a case report. Modern Rheumatology Case Reports 2:1, pages 9-13.
Read now

Articles from other publishers (31)

Hiroki Hosoi, Ken Tanaka, Ayaka Sakaki, Hideki Kosako, Ryuta Iwamoto, Ai Matsumoto, Fumiko Arakawa, Toshikazu Yamoto, Shogo Murata, Toshiki Mushino, Shin-Ichi Murata, Naoyuki Nakao, Koichi Ohshima & Takashi Sonoki. (2023) Rituximab Monotherapy for Grade 2-3 Lymphomatoid Granulomatosis with Central Nervous System Involvement in a Patient Receiving Methotrexate for Rheumatoid Arthritis. Internal Medicine 62:13, pages 1977-1982.
Crossref
Chio Okuyama, Tatsuya Higashi, Koichi Ishizu & Tsuneo Saga. (2022) FDG–PET findings associated with various medical procedures and treatments. Japanese Journal of Radiology 41:5, pages 459-476.
Crossref
Hiroyuki Murakami, Masanori Makita, Tatsunori Ishikawa, Takanori Yoshioka, Keina Nagakita, Yoko Shinno, Tadashi Yoshino, Yoshinobu Maeda & Kazutaka Sunami. (2022) Angioimmunoblastic T-cell Lymphoma Presenting as a Methotrexate-associated Lymphoproliferative Disorder with Extreme Peripheral Blood Plasmacytosis. Internal Medicine 61:17, pages 2655-2660.
Crossref
Sawako Shiraiwa, Yara Yukie Kikuti, Joaquim Carreras, Yusuke Kondo, Ken Ohmachi, Yoshiaki Ogawa, Hiroshi Kawada, Shinji Sato, Yuka Gion, Yasuharu Sato, Naoya Nakamura & Kiyoshi Ando. (2022) 9p24.1 Genetic Alteration and PD-L1 Expression Are Characteristic of De Novo and Methotrexate-associated Epstein-Barr Virus–positive Hodgkin Lymphoma, But Not Methotrexate-associated Hodgkin-like Lesions. American Journal of Surgical Pathology 46:8, pages 1017-1024.
Crossref
Kazuki Doi, Mototsugu Muramaki, Tetsuro Yamamoto, Daiki Katsura, Hiroyuki Fukunaga, Kosuke Takahashi, Minori Matsumoto & Yuji Yamada. (2022) Epstein‐Barr virus‐related diffuse large B‐cell lymphoma type methotrexate‐associated lymphoproliferative disorders presenting in the adrenal gland. IJU Case Reports 5:3, pages 172-174.
Crossref
Carolina Afonso, Adriana Roque, Cátia Almeida, Maria Beatriz Pimentão, Maria José Julião, Rodolfo Silva, Catarina Geraldes & Marília Gomes. (2022) Methotrexate-Associated Lymphoproliferative Disorder in a Patient with Psoriasis: A Case Report and Review of the Literature. Case Reports in Hematology 2022, pages 1-6.
Crossref
Takahiro Fujinaga, Yukiko Ohyama, Koki Nagano, Ikumi Imajo, Tomohiro Yamada, Tamotsu Kiyoshima & Yoshihide Mori. (2022) Methotrexate-associated lymphoproliferative disorder affecting the gingiva and intestinal mucosa with intestinal perforation: A case report. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology 34:2, pages 169-173.
Crossref
Motoharu Shibusawa, Keisuke Kidoguchi & Tetsuya Tanimoto. 2022. Lymphoma. Lymphoma 59 70 .
Daisuke Kaji, Manabu Kusakabe, Mamiko Sakata‐Yanagimoto, Kenichi Makishima, Yasuhito Suehara, Keiichiro Hattori, Yasunori Ota, Takashi Mitsuki, Mitsuhiro Yuasa, Kosei Kageyama, Yuki Taya, Aya Nishida, Kazuya Ishiwata, Shinsuke Takagi, Hisashi Yamamoto, Yuki Asano‐Mori, Yoshifumi Ubara, Koji Izutsu, Naoyuki Uchida, Atsushi Wake, Shuichi Taniguchi, Go Yamamoto & Shigeru Chiba. (2021) Retrospective analyses of other iatrogenic immunodeficiency‐associated lymphoproliferative disorders in patients with rheumatic diseases. British Journal of Haematology 195:4, pages 585-594.
Crossref
Toshihito Nakai, Mitsuharu Tsuura, Hiroki Enomoto, Hirotaka Yamanaka, Nobuyuki Miyatake & Hideki Takemoto. (2021) Central Nervous System Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis : Two Case Reports関節リウマチに合併した中枢神経発生メトトレキサート関連リンパ増殖性疾患の2例. Japanese Journal of Neurosurgery 30:7, pages 530-537.
Crossref
Hiroshi Kobe, Akihiro Ito, Hiroki Hayata, Keisuke Nishimura, Yasunori Ueda & Tadashi Ishida. (2021) Mycophenolate Mofetil-induced Diffuse Large B-cell Lymphoma in Which a Solitary Lung Nodule Remitted Spontaneously. Internal Medicine 60:1, pages 131-136.
Crossref
Katsuya Fujimoto, Kanako C. Hatanaka, Yutaka Hatanaka, Ikumi Kasahara, Satoshi Yamamoto, Takahiro Tsuji, Masanobu Nakata, Yasunari Takakuwa, Yoshihito Haseyama, Yumiko Oyamada, Masakatsu Yonezumi, Hiroaki Suzuki, Hajime Sakai, Hiroko Noguchi, Akio Mori, Hiroshi Nishihara, Takanori Teshima & Yoshihiro Matsuno. (2020) Association of Epstein–Barr virus with regression after withdrawal of immunosuppressive drugs and subsequent progression of iatrogenic immunodeficiency‐associated lymphoproliferative disorders in patients with autoimmune diseases. Hematological Oncology 38:5, pages 799-807.
Crossref
Iulia Ivan, Fina Climent & Santiago Mercadal. (2020) Linfoma difuso de células grandes B asociado a metotrexato en un paciente afecto de una leucemia linfoblástica aguda. Medicina Clínica 155:10, pages 465-466.
Crossref
Iulia Ivan, Fina Climent & Santiago Mercadal. (2020) Diffuse large B cell lymphoma associated with methotrexate in a patient with acute lymphoblastic leukemia. Medicina Clínica (English Edition) 155:10, pages 465-466.
Crossref
Satoshi Ichikawa, Noriko Fukuhara, Kei Saito, Koichi Onodera, Tsuyoshi Shirai, Yasushi Onishi, Hisayuki Yokoyama, Hiroshi Fujii, Ryo Ichinohasama & Hideo Harigae. (2020) Successful treatment of methotrexate-associated classical Hodgkin lymphoma with brentuximab vedotin-combined chemotherapy: a case series. International Journal of Hematology 111:5, pages 667-672.
Crossref
Keisuke Tanaka, Mai Kuboki, Satoshi Koi & Shigeo Toyota. (2020) Nivolumab for Methotrexate-associated Classic Hodgkin's Lymphoma in a Rheumatoid Arthritis Patient. Internal Medicine 59:6, pages 829-833.
Crossref
Eri Iwami, Fumimaro Ito, Kotaro Sasahara, Aoi Kuroda, Tatsu Matsuzaki, Takahiro Nakajima, Daichi Abe, Kimihiro Matsumoto, Aya Sasaki, Keisuke Eguchi & Takeshi Terashima. (2020) Pulmonary Intravascular Large B-cell Lymphoma in a Patient Administered Methotrexate for Rheumatoid Arthritis. Internal Medicine 59:3, pages 429-433.
Crossref
Michihide TokuhiraYuka TanakaYasuyuki TakahashiYuta KimuraTatsuki TomikawaTomoe AnanJunichi WatanabeMorihiko SagawaMorihiro HigashiShuju MomoseKoichi Amano, Takayuki TabayashiReiko NakasekoJun-ichi TamaruMasahiro Kizaki. (2020) The clinical impact of absolute lymphocyte count in peripheral blood among patients with methotrexate - associated lymphoproliferative disorders. Journal of Clinical and Experimental Hematopathology 60:2, pages 41-50.
Crossref
Keiichi MoriyaYara Yukie KikutiJoaquim CarrerasYusuke KondoSawako Shiraiwa & Naoya Nakamura. (2020) Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer. Journal of Clinical and Experimental Hematopathology 60:1, pages 11-16.
Crossref
Atsuhito Uneda, Koji Hirashita, Takahiro Kanda, Masatoshi Yunoki, Kimihiro Yoshino, Kazuhiko Kurozumi & Isao Date. (2020) Primary Central Nervous System Methotrexate-associated Lymphoproliferative Disorder in a Patient with Rheumatoid Arthritis: Case Report and Review of Literature. NMC Case Report Journal 7:3, pages 121-127.
Crossref
Mai Kawazoe, Kaichi Kaneko & Toshihiro Nanki. (2020) Methotrexate-associated lymphoproliferative disorders in the central nervous system and stomach. Medicine 99:15, pages e19850.
Crossref
Daisuke Kurita, Hiroaki Miyoshi, Ayako Ichikawa, Koji Kato, Yoshitaka Imaizumi, Ritsuko Seki, Kensaku Sato, Yuya Sasaki, Keisuke Kawamoto, Joji Shimono, Kyohei Yamada, Reiji Muto, Masahiro Kizaki, Koji Nagafuji, Jun-ichi Tamaru, Michihide Tokuhira & Koichi Ohshima. (2019) Methotrexate-associated Lymphoproliferative Disorders in Patients With Rheumatoid Arthritis. American Journal of Surgical Pathology 43:7, pages 869-884.
Crossref
Tatsuyoshi Ikeue, Hiroaki Kawachi, Hiroshi Yoshida, Eiichiro Tanaka, Susumu Noguchi, Akari Fukao, Satoshi Terashita, Tomoko Tajiri, Sadao Horikawa & Takakazu Sugita. (2019) Endobronchial Manifestation of Methotrexate-induced Lymphoproliferative Disorder. Internal Medicine 58:11, pages 1597-1603.
Crossref
Shuntaro Saito & Tsutomu Takeuchi. (2019) Immune response in LPD during methotrexate administration (MTX-LPD) in rheumatoid arthritis patients. Journal of Clinical and Experimental Hematopathology 59:4, pages 145-155.
Crossref
Shuji Momose & Jun-ichi Tamaru. (2019) Iatrogenic immunodeficiency-associated lymphoproliferative disorders of B-cell type that develop in patients receiving immunosuppressive drugs other than in the post-transplant setting. Journal of Clinical and Experimental Hematopathology 59:2, pages 48-55.
Crossref
Michihide Tokuhira, Jun-ichi Tamaru & Masahiro Kizaki. (2019) Clinical management for other iatrogenic immunodeficiency-associated lymphoproliferative disorders. Journal of Clinical and Experimental Hematopathology 59:2, pages 72-92.
Crossref
Akira Satou, Shogo Banno, Ichiro Hanamura, Emiko Takahashi, Taishi Takahara, Hironobu Nobata, Takayuki Katsuno, Akiyoshi Takami, Yasuhiko Ito, Ryuzo Ueda, Shigeo Nakamura & Toyonori Tsuzuki. (2019) EBV-positive mucocutaneous ulcer arising in rheumatoid arthritis patients treated with methotrexate: Single center series of nine cases. Pathology International 69:1, pages 21-28.
Crossref
Masao Hagihara, Toru Mese, Shin Ohara, Jian Hua, Shiro Ide & Morihiro Inoue. (2018) Methotrexate-associated Intravascular Large B-cell Lymphoma in a Patient with Rheumatoid Arthritis: A Very Rare Case. Internal Medicine 57:20, pages 3001-3005.
Crossref
Yudai Uchida, Keiichi Hokkoku, Yuki Hatanaka, Yoshinao Kikuchi, Haruko Tashiro & Masahiro Sonoo. (2018) Primary central nervous system methotrexate associated lymphoproliferative disorders in a patient with rheumatoid arthritis関節リウマチに合併した中枢神経原発のメトトレキサート関連リンパ増殖性疾患の1例. Rinsho Shinkeigaku 58:8, pages 485-491.
Crossref
Alejandro A. Gru & Dennis P. O’Malley. (2018) Autoimmune and medication-induced lymphadenopathies. Seminars in Diagnostic Pathology 35:1, pages 34-43.
Crossref
J. H. van Krieken. (2017) New developments in the pathology of malignant lymphoma. A review of the literature published from September–August 2017. Journal of Hematopathology 10:3-4, pages 117-127.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.