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Leukemia & Lymphoma Volume 59, 2018 - Issue 8
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Original Article: Research

Ibrutinib and idelalisib block immunophenotypic changes associated with the adhesion and activation of CLL cells in the tumor microenvironment

Yandong ShenSchool of Life and Environmental Sciences, University of Sydney, Sydney, Australia;
,
O. Giles BestNorthern Blood Research Centre, Kolling Institute of Medical Research, St Leonards, AustraliaCorrespondence[email protected]
,
Stephen P. MulliganNorthern Blood Research Centre, Kolling Institute of Medical Research, St Leonards, Australia
&
Richard I. ChristophersonSchool of Life and Environmental Sciences, University of Sydney, Sydney, Australia;
Pages 1927-1937 | Received 09 Jul 2017, Accepted 07 Nov 2017, Published online: 22 Nov 2017

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Yandong Shen, Kyle Crassini, Suneet Sandhu, Narjis Fatima, Richard I. Christopherson, Stephen P. Mulligan & O. Giles Best. (2019) Dual inhibition of MEK1/2 and AKT by binimetinib and MK2206 induces apoptosis of chronic lymphocytic leukemia cells under conditions that mimic the tumor microenvironment. Leukemia & Lymphoma 60:7, pages 1632-1643.
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