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Original Article: Clinical

A phase 2 study of pracinostat combined with ruxolitinib in patients with myelofibrosis

ORCID Icon, , , , , , , , , , , , , , , , & ORCID Icon show all
Pages 1767-1774 | Received 21 Aug 2018, Accepted 29 Oct 2018, Published online: 11 Jan 2019

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Read on this site (5)

Erika Morsia & Naseema Gangat. (2021) Myelofibrosis: challenges for preclinical models and emerging therapeutic targets. Expert Opinion on Therapeutic Targets 25:3, pages 211-222.
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Giacomo Coltro & Alessandro M. Vannucchi. (2021) The safety of JAK kinase inhibitors for the treatment of myelofibrosis. Expert Opinion on Drug Safety 20:2, pages 139-154.
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Helen T. Chifotides, Prithviraj Bose & Srdan Verstovsek. (2020) Givinostat: an emerging treatment for polycythemia vera. Expert Opinion on Investigational Drugs 29:6, pages 525-536.
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Aniket Bankar & Vikas Gupta. (2020) Investigational non-JAK inhibitors for chronic phase myelofibrosis. Expert Opinion on Investigational Drugs 29:5, pages 461-474.
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Prithviraj Bose. (2019) Advances in potential treatment options for myeloproliferative neoplasm associated myelofibrosis. Expert Opinion on Orphan Drugs 7:10, pages 415-425.
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Articles from other publishers (14)

Weiwei Dong, He Zhang, Qingyan Li, Na Guan, Chao Yun, Huixia Zhao, Fengyun Zhang, Zhiyan Zeng, Yanyan Hu, Qiuwen Li, Jingwen Yang, Zihuan Ma, Meiling Chen & Wenhua Xiao. (2023) A novel prognostic signature contributes to precision treatment in colon adenocarcinoma with KRAS mutation. European Journal of Cancer Prevention.
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Ailin Zhao, Hui Zhou, Jinrong Yang, Meng Li & Ting Niu. (2023) Epigenetic regulation in hematopoiesis and its implications in the targeted therapy of hematologic malignancies. Signal Transduction and Targeted Therapy 8:1.
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Al-Hassan M. Mustafa & Oliver H. Krämer. (2023) Pharmacological Modulation of the Crosstalk between Aberrant Janus Kinase Signaling and Epigenetic Modifiers of the Histone Deacetylase Family to Treat Cancer. Pharmacological Reviews 75:1, pages 35-61.
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Charlotte EJ. Downes, Barbara J. McClure, Daniel P. McDougal, Susan L. Heatley, John B. Bruning, Daniel Thomas, David T. Yeung & Deborah L. White. (2022) JAK2 Alterations in Acute Lymphoblastic Leukemia: Molecular Insights for Superior Precision Medicine Strategies. Frontiers in Cell and Developmental Biology 10.
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Fuping Wang, Tian Qiu, Haitao Wang & Qiong Yang. (2022) State-of-the-Art Review on Myelofibrosis Therapies. Clinical Lymphoma Myeloma and Leukemia 22:5, pages e350-e362.
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Giuseppe G. Loscocco & Alessandro M. Vannucchi. (2022) Role of JAK inhibitors in myeloproliferative neoplasms: current point of view and perspectives. International Journal of Hematology 115:5, pages 626-644.
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Andrew Dunbar, Young Park & Ross Levine. (2021) Epigenetic Dysregulation of Myeloproliferative Neoplasms. Hematology/Oncology Clinics of North America 35:2, pages 237-251.
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Wenhua Liu, Yuchen Liang & Xiaoyong Si. (2020) Hydroxamic acid hybrids as the potential anticancer agents: An Overview. European Journal of Medicinal Chemistry 205, pages 112679.
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Andrew T. Kuykendall, Nathan P. Horvat, Garima Pandey, Rami Komrokji & Gary W. Reuther. (2020) Finding a Jill for JAK: Assessing Past, Present, and Future JAK Inhibitor Combination Approaches in Myelofibrosis. Cancers 12:8, pages 2278.
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Prithviraj Bose & Srdan Verstovsek. (2020) JAK Inhibition for the Treatment of Myelofibrosis: Limitations and Future Perspectives. HemaSphere 4:4, pages e424.
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Xing Hao, Wen Xing, Jiajia Yuan, Yingshao Wang, Jiaojiao Bai, Jie Bai & Yuan Zhou. (2019) Cotargeting the JAK/STAT signaling pathway and histone deacetylase by ruxolitinib and vorinostat elicits synergistic effects against myeloproliferative neoplasms. Investigational New Drugs 38:3, pages 610-620.
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Yujin Li, Shirong Zhu, Weiyi Liu, Jing Ming, Xueying Wang & Xiaomei Hu. (2020) Ruxolitinib-based combinations in the treatment of myelofibrosis: worth looking forward to. Annals of Hematology 99:6, pages 1161-1176.
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Giorgio Milazzo, Daniele Mercatelli, Giulia Di Muzio, Luca Triboli, Piergiuseppe De Rosa, Giovanni Perini & Federico M. Giorgi. (2020) Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability. Genes 11:5, pages 556.
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J. Mascarenhas, B.K. Marcellino, M. Lu, M. Kremyanskaya, F. Fabris, L. Sandy, M. Mehrotra, J. Houldsworth, V. Najfeld, S. El Jamal, B. Petersen, E. Moshier & R. Hoffman. (2020) A phase I study of panobinostat and ruxolitinib in patients with primary myelofibrosis (PMF) and post-­polycythemia vera/essential thrombocythemia myelofibrosis (post-­PV/ET MF). Leukemia Research 88, pages 106272.
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