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Leukemia & Lymphoma Volume 61, 2020 - Issue 2
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Original Articles

Phase 1 study of the Aurora kinase A inhibitor alisertib (MLN8237) combined with the histone deacetylase inhibitor vorinostat in lymphoid malignancies

Tanya SiddiqiDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0001-5292-8298View further author information
ORCID Icon,
Paul FrankelDepartment of Information Sciences, City of Hope National Medical Center, Duarte, CA, USA; View further author information
,
Jan H. BeumerCancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; ;Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA; ;Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; View further author information
,
Brian F. KieselCancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; ;Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA; View further author information
,
Susan ChristnerCancer Therapeutics Program, UPMC Hillman Cancer Center, Pittsburgh, PA, USA; View further author information
,
Chris RuelDepartment of Information Sciences, City of Hope National Medical Center, Duarte, CA, USA; View further author information
,
Joo Y. SongDepartment of Pathology, City of Hope National Medical Center, Duarte, CA, USA; ORCID Iconhttp://orcid.org/0000-0003-3497-2513View further author information
ORCID Icon,
Robert ChenDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; View further author information
,
Kevin R. KellyDivision of Hematology, University of Southern California, Los Angeles, CA, USA; View further author information
,
Sikander AilawadhiDepartment of Hematology, Mayo Clinic, Jacksonville, FL, USA; View further author information
,
Paul KaesbergDepartment of Internal Medicine, Division of Hematology and Oncology, University of California-Davis Medical Center, Sacramento, CA, USA; View further author information
,
Leslie PopplewellDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; View further author information
,
Sandrine PuverelDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; ORCID Iconhttp://orcid.org/0000-0002-8667-5193View further author information
ORCID Icon,
Richard PiekarzCancer Therapy Evaluation Program, National Institutes of Health, National Cancer Institute, Bethesda, MD, USA; View further author information
,
Stephen J. FormanDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA, USA; View further author information
&
Edward M. NewmanDepartment of Medical Oncology, Division of Molecular Pharmacology, City of Hope, Duarte, CA, USAORCID Iconhttp://orcid.org/0000-0001-6988-5909View further author information
ORCID Icon show all
Pages 309-317 | Received 31 Jan 2019, Accepted 19 Sep 2019, Published online: 16 Oct 2019

Citations (21)

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Thuy Ho, Cara Coleman, Palak Shah & Victor Yazbeck. (2023) Advances in Hodgkin’s lymphoma pharmacotherapy: a focus on histone deacetylase inhibitors. Expert Opinion on Pharmacotherapy 24:13, pages 1427-1438.
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Xavier Thomas. (2023) T-cell acute lymphoblastic leukemia: promising experimental drugs in clinical development. Expert Opinion on Investigational Drugs 32:1, pages 37-52.
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Articles from other publishers (19)

Naga Rajiv Lakkaniga, Zhengyu Wang, Yao Xiao, Anupreet Kharbanda, Li Lan & Hong‐yu Li. (2023) Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy. Medicinal Research Reviews.
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Matthew Mei, Lu Chen, James Godfrey, Joo Song, Colt Egelston, Sandrine Puverel, L. Elizabeth Budde, Saro Armenian, Liana Nikolaenko, Mary Nwangwu, Weihua Guo, Lei Gao, Peter Lee, Robert Chen, Shari Daniels, Neena Kennedy, Lacolle Peters, Jasmine Zain, Steven Rosen, Stephen Forman, Leslie Popplewell, Larry Kwak & Alex F. Herrera. (2023) Pembrolizumab plus vorinostat induces responses in patients with Hodgkin lymphoma refractory to prior PD-1 blockade. Blood 142:16, pages 1359-1370.
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Guang Lu, Shikai Jin, Suwen Lin, Yuping Gong, Liwen Zhang, Jingwen Yang, Weiwei Mou & Jun Du. (2023) Update on histone deacetylase inhibitors in peripheral T-cell lymphoma (PTCL). Clinical Epigenetics 15:1.
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Bing He, Yao Xiao, Haodong Liang, Qianhui Huang, Yuheng Du, Yijun Li, David Garmire, Duxin Sun & Lana X. Garmire. (2023) ASGARD is A Single-cell Guided Pipeline to Aid Repurposing of Drugs. Nature Communications 14:1.
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Gaelen Shimkus & Taichiro Nonaka. (2023) Molecular classification and therapeutics in diffuse large B-cell lymphoma. Frontiers in Molecular Biosciences 10.
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Gaelen Shimkus & Taichiro Nonaka. (2023) Molekulare Klassifizierung und Therapien des diffusen großzelligen B-Zell-Lymphoms. Kompass Onkologie 10:2, pages 59-76.
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Mariam Markouli, Dimitrios Strepkos & Christina Piperi. (2022) Impact of Histone Modifications and Their Therapeutic Targeting in Hematological Malignancies. International Journal of Molecular Sciences 23:21, pages 13657.
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Lena Hess, Verena Moos, Arnel A. Lauber, Wolfgang Reiter, Michael Schuster, Natascha Hartl, Daniel Lackner, Thorina Boenke, Anna Koren, Paloma M. Guzzardo, Brigitte Gundacker, Anna Riegler, Petra Vician, Claudia Miccolo, Susanna Leiter, Mahesh B. Chandrasekharan, Terezia Vcelkova, Andrea Tanzer, Jun Qi Jun, James Bradner, Gerald Brosch, Markus Hartl, Christoph Bock, Tilmann Bürckstümmer, Stefan Kubicek, Susanna Chiocca, Srividya Bhaskara & Christian Seiser. (2022) A toolbox for class I HDACs reveals isoform specific roles in gene regulation and protein acetylation. PLOS Genetics 18:8, pages e1010376.
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Mingzheng Hu, Yijie Wang & Jun Zhou. (2022) Centrosome Defects in Hematological Malignancies: Molecular Mechanisms and Therapeutic Insights. Blood Science 4:3, pages 143-151.
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Lisa Rusyn, Sebastian Reinartz, Anastasia Nikiforov, Nelly Mikhael, Alexander vom Stein, Viktoria Kohlhas, Johannes Bloehdorn, Stephan Stilgenbauer, Philipp Lohneis, Reinhard Buettner, Sandra Robrecht, Kirsten Fischer, Christian Pallasch, Michael Hallek, Phuong-Hien Nguyen & Tamina Seeger-Nukpezah. (2022) The scaffold protein NEDD9 is necessary for leukemia-cell migration and disease progression in a mouse model of chronic lymphocytic leukemia. Leukemia 36:7, pages 1794-1805.
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Jiaxin Liu, Jia-nan Li, Hongyu Wu & Panpan Liu. (2022) The Status and Prospects of Epigenetics in the Treatment of Lymphoma. Frontiers in Oncology 12.
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Miranda Fernández-Serrano, René Winkler, Juliana C. Santos, Marguerite-Marie Le Pannérer, Marcus Buschbeck & Gaël Roué. (2021) Histone Modifications and Their Targeting in Lymphoid Malignancies. International Journal of Molecular Sciences 23:1, pages 253.
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Ruijuan Du, Chuntian Huang, Kangdong Liu, Xiang Li & Zigang Dong. (2021) Targeting AURKA in Cancer: molecular mechanisms and opportunities for Cancer therapy. Molecular Cancer 20:1.
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Rita Hleihel, Abdou Akkouche, Hala Skayneh, Olivier Hermine, Ali Bazarbachi & Hiba El Hajj. (2021) Adult T-Cell Leukemia: a Comprehensive Overview on Current and Promising Treatment Modalities. Current Oncology Reports 23:12.
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Moloud Aflaki Sooreshjani, Mohini Kamra, Amina Zoubeidi & Kavita Shah. (2021) Reciprocal deregulation of NKX3.1 and AURKA axis in castration-resistant prostate cancer and NEPC models. Journal of Biomedical Science 28:1.
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Melika Motamedi, Maggie Z. X. Xiao, Aishwarya Iyer & Robert Gniadecki. (2021) Patterns of Gene Expression in Cutaneous T-Cell Lymphoma: Systematic Review of Transcriptomic Studies in Mycosis Fungoides. Cells 10:6, pages 1409.
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Annika P. Schnell, Stephan Kohrt & Andrea K. Thoma-Kress. (2021) Latency Reversing Agents: Kick and Kill of HTLV-1?. International Journal of Molecular Sciences 22:11, pages 5545.
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Hiba El Hajj, Kunihiro Tsukasaki, Morgane Cheminant, Ali Bazarbachi, Toshiki Watanabe & Olivier Hermine. (2020) Novel Treatments of Adult T Cell Leukemia Lymphoma. Frontiers in Microbiology 11.
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Paul H. Frankel, Vincent Chung, Joseph Tuscano, Tanya Siddiqi, Sagus Sampath, Jeffrey Longmate, Susan Groshen & Edward M. Newman. (2020) Model of a Queuing Approach for Patient Accrual in Phase 1 Oncology Studies. JAMA Network Open 3:5, pages e204787.
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