Advanced search
Publication Cover
Leukemia & Lymphoma Volume 61, 2020 - Issue 3
Submit an article Journal homepage
689
Views
25
CrossRef citations to date
0
Altmetric
Original Articles

Efficacy and toxicity of reduced vs. standard dose pegylated asparaginase in adults with Philadelphia chromosome-negative acute lymphoblastic leukemia

Benjamin A. DermanSection of Hematology/Oncology, University of Chicago, Chicago, IL, USA; Correspondence[email protected]
ORCID Iconhttp://orcid.org/0000-0002-4070-1819View further author information
ORCID Icon,
Mitchell StreckSimon Cancer Center, Indiana University Health, Indianapolis, IN, USA; View further author information
,
Joseph WynneSection of Hematology/Oncology, University of Chicago, Chicago, IL, USA; View further author information
,
Trevor N. ChristDepartment of Pharmacy, University of Chicago, Chicago, IL, USA; ;Rush University Medical Center, Chicago, IL, USAView further author information
,
Emily CurranSection of Hematology/Oncology, University of Chicago, Chicago, IL, USA; View further author information
,
Wendy StockSection of Hematology/Oncology, University of Chicago, Chicago, IL, USA; View further author information
&
Randall W. KnoebelDepartment of Pharmacy, University of Chicago, Chicago, IL, USA; View further author information
 show all
Pages 614-622 | Received 15 Jun 2019, Accepted 10 Oct 2019, Published online: 04 Nov 2019

Citations (25)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Melissa Sandley & Jonathan Angus. (2023) Asparaginase therapy in patients with acute lymphoblastic leukemia: expert opinion on use and toxicity management. Leukemia & Lymphoma 64:4, pages 776-787.
Read now
Ryan J. Daley, Sridevi Rajeeve, Charlene C. Kabel, Jeremy J. Pappacena, Sarah E. Stump, Jessica A. Lavery, Martin S. Tallman, Mark B. Geyer & Jae H. Park. (2021) Tolerability and toxicity of pegaspargase in adults 40 years and older with acute lymphoblastic leukemia. Leukemia & Lymphoma 62:1, pages 176-184.
Read now

Articles from other publishers (23)

Ryan D. Cassaday. (2023) Asparaginase dosing for obese patients with acute lymphoblastic leukemia and factors that contribute to outcomes. Best Practice & Research Clinical Haematology 36:4, pages 101519.
Crossref
Shai Shimony & Marlise R. Luskin. (2023) Approach to Older Adults with Philadelphia-Chromosome Negative Acute Lymphoblastic Leukemia. Clinical Lymphoma Myeloma and Leukemia.
Crossref
Renato Bassan, Sabina Chiaretti, Irene Della Starza, Orietta Spinelli, Alessandra Santoro, Francesca Paoloni, Monica Messina, Loredana Elia, Maria Stefania De Propris, Anna Maria Scattolin, Ernesta Audisio, Laura Marbello, Erika Borlenghi, Patrizia Zappasodi, Elisa Mauro, Giovanni Martinelli, Daniele Mattei, Nicola Fracchiolla, Monica Bocchia, Paolo De Fabritiis, Massimiliano Bonifacio, Anna Candoni, Vincenzo Cassibba, Paolo Di Bartolomeo, Giancarlo Latte, Silvia Trappolini, Anna Guarini, Antonella Vitale, Paola Fazi, Alfonso Piciocchi, Alessandro Rambaldi & Robin Foà. (2023) Pegaspargase-modified risk-oriented program for adult acute lymphoblastic leukemia: results of the GIMEMA LAL1913 trial. Blood Advances 7:16, pages 4448-4461.
Crossref
Jack T. Seki, Reem Alsibai, Eshetu G. Atenafu, Ruiqi Chen & Hassan Sibai. (2023) Is native E coli- or Peg-ASP more thrombogenic in adult ALL? A systematic review and meta-analysis. Thrombosis Update 12, pages 100143.
Crossref
Taylor D. Coe-Eisenberg, Anthony J. Perissinotti, Bernard L. Marini, Kristen M. Pettit, Dale L. Bixby, Patrick W. Burke & Lydia Benitez. (2023) Evaluating the efficacy and toxicity of dose adjusted pegylated L-asparaginase in combination with therapeutic drug monitoring. Annals of Hematology.
Crossref
RuiQi Chen, Eshetu G. Atenafu, Jack Seki, Xing Liu, Steven Chan, Vikas Gupta, Dawn Maze, Andre C. Shuh, Mark D. Minden, Karen Yee, Aaron D. Schimmer & Hassan Sibai. (2023) Venous thromboembolism incidence associated with pegylated asparaginase (ASP) compared to the native L‐ASP: A retrospective analysis with an ASP‐based protocol in adult patients with acute lymphoblastic leukaemia . British Journal of Haematology 201:4, pages 645-652.
Crossref
Ibrahim Aldoss, Jun Yin, Anna Wall, Krzysztof Mrózek, Michaela Liedtke, David F. Claxton, Matthew C. Foster, Frederick R. Appelbaum, Harry P. Erba, Mark R. Litzow, Martin S. Tallman, Richard M. Stone, Richard A. Larson, Anjali S. Advani, Wendy Stock & Selina M. Luger. (2023) The impact of early PEG-asparaginase discontinuation in young adults with ALL: a post hoc analysis of the CALGB 10403 study. Blood Advances 7:2, pages 196-204.
Crossref
Yang Wan, Honghong Zhang, Li Zhang, Jiaoyang Cai, Jie Yu, Shaoyan Hu, Yongjun Fang, Ju Gao, Hua Jiang, Minghua Yang, Changda Liang, Runming Jin, Xin Tian, Xiuli Ju, Qun Hu, Hui Jiang, Hui Li, Ningling Wang, Lirong Sun, Alex W. K. Leung, Xuedong Wu, Junxia Wang, Chi‐kong Li, Jun Yang, Jingyan Tang, Shuhong Shen, Xiaowen Zhai, Ching‐Hon Pui & Xiaofan Zhu. (2022) Extended vincristine and dexamethasone pulse therapy may not be necessary for children with TCF3‐PBX1 positive acute lymphoblastic leukaemia . British Journal of Haematology 199:4, pages 587-596.
Crossref
Ibrahim Aldoss, Hoda Pourhassan & Dan Douer. (2022) SOHO State of the Art Updates and Next Questions | Asparaginase—Understanding and Overcoming Toxicities in Adults with ALL. Clinical Lymphoma Myeloma and Leukemia 22:11, pages 787-794.
Crossref
Antonio Parrella, Arcangelo Iannuzzi, Mario Annunziata, Giuseppe Covetti, Raimondo Cavallaro, Emilio Aliberti, Elena Tortori & Gabriella Iannuzzo. (2022) Haematological Drugs Affecting Lipid Metabolism and Vascular Health. Biomedicines 10:8, pages 1935.
Crossref
Carlos Constantino Arias-Romualdo & Edmundo Vázquez-Cornejo. (2022) Pancreatitis aguda asociada a errores de dosificación de L-asparaginasa en pacientes pediátricos con leucemia linfoblástica aguda en terapia de inducción: estudio exploratorio. Revista Colombiana de Ciencias Químico-Farmacéuticas 51:1.
Crossref
Dan Douer, Nicola Gökbuget, Wendy Stock & Nicolas Boissel. (2022) Optimizing use of L-asparaginase–based treatment of adults with acute lymphoblastic leukemia. Blood Reviews 53, pages 100908.
Crossref
Line Stensig Lynggaard, Cecilie Utke Rank, Stefan Nygaard HansenSofie Gottschalk Højfeldt, Louise Tram Henriksen, Kirsten Brunsvig Jarvis, Susanna Ranta, Riitta Niinimäki, Arja Harila-SaariBenjamin O Wolthers, Thomas L. Frandsen, Mats Heyman, Kjeld Schmiegelow & Birgitte Klug Albertsen. (2022) Asparaginase enzyme activity levels and toxicity in childhood acute lymphoblastic leukemia: a NOPHO ALL2008 study. Blood Advances 6:1, pages 138-147.
Crossref
Marlise R. Luskin. (2021) Acute lymphoblastic leukemia in older adults: curtain call for conventional chemotherapy?. Hematology 2021:1, pages 7-14.
Crossref
Kjeld Schmiegelow, Cecilie Utke Rank, Wendy Stock, Emily Dworkin & Inge van der Sluis. (2021) SOHO State of the Art Updates and Next Questions: Management of Asparaginase Toxicity in Adolescents and Young Adults with Acute Lymphoblastic Leukemia. Clinical Lymphoma Myeloma and Leukemia 21:11, pages 725-733.
Crossref
Rachael Schulte, Ashley Hinson, Van Huynh, Erin H. Breese, Joanna Pierro, Seth Rotz, Benjamin A. Mixon, Jennifer L. McNeer, Michael J. Burke & Etan Orgel. (2021) Levocarnitine for pegaspargase‐induced hepatotoxicity in older children and young adults with acute lymphoblastic leukemia. Cancer Medicine 10:21, pages 7551-7560.
Crossref
Anand Ashwin Patel, Joseph Heng, Emily Dworkin, Sarah Monick, Benjamin A. Derman, Adam S. DuVall, Sandeep Gurbuxani, Satyajit Kosuri, Hongtao Liu, Michael Thirman, Lucy A. Godley, Olatoyosi Odenike, Richard A. Larson & Wendy Stock. (2021) Efficacy and tolerability of a modified pediatric‐inspired intensive regimen for acute lymphoblastic leukemia in older adults. eJHaem 2:3, pages 413-420.
Crossref
Anjali S. Advani, Eric LarsenKristina LaumannSelina M. LugerMichaela Liedtke, Meenakshi Devidas, Zhiguo ChenJun Yin, Matthew C. FosterDavid Claxton, Kristin CoffanMartin S. TallmanFrederick R. AppelbaumHarry Erba, Richard M. StoneStephen P. Hunger, Jennifer L. McNeerMignon L. LohElizabeth RaetzNaomi Winick, William CarrollRichard A. Larson & Wendy Stock. (2021) Comparison of CALGB 10403 (Alliance) and COG AALL0232 toxicity results in young adults with acute lymphoblastic leukemia. Blood Advances 5:2, pages 504-512.
Crossref
Flavia Castellano & Valérie Molinier-Frenkel. (2020) Control of T-Cell Activation and Signaling by Amino-Acid Catabolizing Enzymes. Frontiers in Cell and Developmental Biology 8.
Crossref
Federico Lussana, Paola Minetto, Felicetto Ferrara, Sabina Chiaretti, Giorgina Specchia & Renato Bassan. (2020) National Italian Delphi panel consensus: which measures are indicated to minimize pegylated-asparaginase associated toxicity during treatment of adult acute lymphoblastic leukemia?. BMC Cancer 20:1.
Crossref
Kevin Prescott, Michael Jacobs, Wendy Stock & Joseph Wynne. (2020) New Approaches to Treating Challenging Subtypes of ALL in AYA Patients. Current Hematologic Malignancy Reports 15:6, pages 424-435.
Crossref
Cecilie Utke Rank & Kjeld Schmiegelow. (2020) Optimal approach to the treatment of young adults with acute lymphoblastic leukemia in 2020. Seminars in Hematology 57:3, pages 102-114.
Crossref
Anand A. Patel, Joseph Thomas, Alexandra E. Rojek & Wendy Stock. (2020) Biology and Treatment Paradigms in T Cell Acute Lymphoblastic Leukemia in Older Adolescents and Adults. Current Treatment Options in Oncology 21:7.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.