Different sensitivity of CD19-positive bone marrow and lymph node lymphoblasts may cause resistance to blinatumomab in relapsed B-cell acute lymphoblastic leukemia/lymphoma

Vadim IvanovDepartment of Hematology, La Conception, University Hospital of Marseille, Marseille, France; Correspondence[email protected]

Laure FarnaultDepartment of Hematology, La Conception, University Hospital of Marseille, Marseille, France;

Cedric MercierDepartment of Hematology, La Conception, University Hospital of Marseille, Marseille, France;

Cecile ColavolpeDepartment of Nuclear Medicine, La Timone & North University Hospital, Aix-Marseille University, Marseille, France;

Geoffroy VentonDepartment of Hematology, La Conception, University Hospital of Marseille, Marseille, France; ;INSERM, Marseille, France;

Julien ColleDepartment of Hematology, La Conception, University Hospital of Marseille, Marseille, France;

Hubert LepidiDepartment of Pathology, CHU La Conception, AP-HM, Marseille, France;

Isabelle ArnouxDepartment of Hematology, CHU La Timone, AP-HM, Marseille, France;

Corinne Nicolino-BrunetDepartment of Hematology and Vascular Biology, CHU La Conception, AP-HM, Marseille, France;

Yael Berda-HaddadDepartment of Hematology and Vascular Biology, CHU La Conception, AP-HM, Marseille, France;

Raphaelle FanciullinoPharmacy Unit, La Conception, University Hospital of Marseille, APHM, Marseille, France; ;SMARTc Unit, Pharmacokinetics Laboratory, Marseille, France;

Gleb IvanovSurrey and Sussex NHS Trust, Redhill, UK

Regis CostelloDepartment of Hematology, La Conception, University Hospital of Marseille, Marseille, France; ;INSERM, Marseille, France;

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Different sensitivity of CD19-positive bone marrow and lymph node lymphoblasts may cause resistance to blinatumomab in relapsed B-cell acute lymphoblastic leukemia/lymphoma

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Different sensitivity of CD19-positive bone marrow and lymph node lymphoblasts may cause resistance to blinatumomab in relapsed B-cell acute lymphoblastic leukemia/lymphoma

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