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Leukemia & Lymphoma Volume 61, 2020 - Issue 9
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Original Articles

Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience*

Jan Philipp BewersdorfDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ORCID Iconhttp://orcid.org/0000-0003-3352-0902View further author information
ORCID Icon,
Rory M. ShallisDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ORCID Iconhttp://orcid.org/0000-0002-8542-2944View further author information
ORCID Icon,
Lohith GowdaDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Wei WeiDepartment of Biostatistics, Yale School of Public Health, New Haven, CT, USA; View further author information
,
Karl HagerDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Iris IsufiDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Tae Kon KimDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ;Division of Hematology/Oncology, Vanderbilt University Medical Center, Nashville, TN, USA; View further author information
,
Manoj M. PillaiDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Stuart SeropianDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; View further author information
,
Nikolai A. PodoltsevDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ;Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, CT, USA; View further author information
,
Steven D. GoreDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ;Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, CT, USA; View further author information
,
Alexa J. SiddonDepartment of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA; ;Department of Pathology, Section of Hematopathology, Yale School of Medicine, New Haven, CT, USAView further author information
&
Amer M. ZeidanDepartment of Internal Medicine, Section of Hematology, Yale School of Medicine, New Haven, CT, USA; ;Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, New Haven, CT, USA; Correspondence[email protected]
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Pages 2180-2190 | Received 18 Jan 2020, Accepted 16 Apr 2020, Published online: 02 May 2020

Citations (17)

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Yi Chen, Jing Cao, Yaozhen Ye, Luting Luo, Xiaoyun Zheng, Xiaozhu Yang, Zhihong Zheng, Jing Zheng, Ting Yang & Jianda Hu. (2023) Hypomethylating agents combined with low-dose chemotherapy for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: a real-world clinical experience. Journal of Chemotherapy 35:4, pages 322-329.
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Articles from other publishers (15)

Shyam A. Patel, Jan Cerny, William K. Gerber, Muthalagu Ramanathan, Asiri Ediriwickrema, Benjamin Tanenbaum, Lloyd Hutchinson, Xiuling Meng, Julie Flahive, Bruce Barton, Andrew J. Gillis‐Smith, Sakiko Suzuki, Salwa Khedr, William Selove, Anne W. Higgins, Patricia M. Miron, Karl Simin, Bruce Woda & Jonathan M. Gerber. (2023) Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with TP53 disruptions . eJHaem 4:4, pages 1059-1070.
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Zhifeng Wei, Long Su & Sujun Gao. (2023) The roles of ubiquitination in AML. Annals of Hematology.
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Christian J. Puzo, Christopher A. Tormey, Henry M. Rinder & Alexa J. Siddon. (2023) Optimizing Donor Chimerism Threshold for Next-Generation Sequencing Monitoring of Measurable Residual Disease Post-Allogeneic Stem Cell Transplantation for Myeloid Neoplasms. Transplantation and Cellular Therapy 29:7, pages 459.e1-459.e4.
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Kai Shen, De‐Yuan Hu, Zhi‐Bo Zhang, Yu‐Sha Guo, Feng‐Hong Zhang & Su‐Ning Chen. (2023) Molecular characterization and prognosis of mutant TP53 acute myeloid leukemia and myelodysplastic syndrome with excess blasts . International Journal of Laboratory Hematology 45:3, pages 344-352.
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Jennifer Marvin-Peek, Emily F. Mason, Ashwin Kishtagari, Reena V. Jayani, Bhagirathbhai Dholaria, Tae Kon Kim, Brian G. Engelhardt, Heidi Chen, Stephen Strickland, Bipin Savani, Brent Ferrell, Adetola Kassim, Michael Savona, Sanjay Mohan & Michael Byrne. (2023) TP53 Mutations Are Associated with Increased Infections and Reduced Hematopoietic Cell Transplantation Rates in Myelodysplastic Syndrome and Acute Myeloid Leukemia. Transplantation and Cellular Therapy 29:6, pages 390.e1-390.e10.
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Jan Philipp Bewersdorf, Zhuoer Xie & Amer M. Zeidan. (2023) Novel Approaches and Future Directions in Myelodysplastic Syndrome Treatment. The Cancer Journal 29:3, pages 195-202.
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Hasan Issa, Laura E. Swart, Milad Rasouli, Minoo Ashtiani, Sirintra Nakjang, Nidhi Jyotsana, Konstantin Schuschel, Michael Heuser, Helen Blair & Olaf Heidenreich. (2023) Nanoparticle-mediated targeting of the fusion gene RUNX1/ETO in t(8;21)-positive acute myeloid leukaemia. Leukemia 37:4, pages 820-834.
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Rory M. Shallis, Naval G. Daver, Jessica K. Altman, Robert P. Hasserjian, Hagop M. Kantarjian, Uwe Platzbecker, Valeria Santini, Andrew H. Wei, David A. Sallman & Amer M. Zeidan. (2022) TP53 ‐altered acute myeloid leukemia and myelodysplastic syndrome with excess blasts should be approached as a single entity . Cancer 129:2, pages 175-180.
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Naval G. Daver, Abhishek Maiti, Tapan M. Kadia, Paresh Vyas, Ravindra Majeti, Andrew H. Wei, Guillermo Garcia-Manero, Charles Craddock, David A. Sallman & Hagop M. Kantarjian. (2022) TP53 -Mutated Myelodysplastic Syndrome and Acute Myeloid Leukemia: Biology, Current Therapy, and Future Directions . Cancer Discovery 12:11, pages 2516-2529.
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Rory M. Shallis, Jan P. Bewersdorf, Maximilian F. Stahl, Stephanie Halene & Amer M. Zeidan. (2022) Are We Moving the Needle for Patients with TP53-Mutated Acute Myeloid Leukemia?. Cancers 14:10, pages 2434.
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Shyam A. Patel & Jan Cerny. (2022) TP53 -mutant myelodysplastic syndrome and acute myeloid leukemia: the black hole of hematology . Blood Advances 6:6, pages 1917-1918.
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Rory M. Shallis, Maximilian Stahl, Jan Philipp Bewersdorf & Amer M. Zeidan. (2021) The Current Understanding of and Treatment Paradigm for Newly-Diagnosed TP53-Mutated Acute Myeloid Leukemia. Hemato 2:4, pages 748-763.
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Yanfen Li, Hua Wan & Yu Jing. (2021) Molecular Characterization and Clinical Treatment of Acute Myeloid Leukemia (AML) and Myelodysplastic Syndromes (MDS) Patients With TP53 Mutation. Clinical Lymphoma Myeloma and Leukemia 21:12, pages 841-851.
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Rory M. Shallis & Nikolai A. Podoltsev. (2021) Maintenance therapy for acute myeloid leukemia: sustaining the pursuit for sustained remission. Current Opinion in Hematology 28:2, pages 110-121.
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Jane L. Snowdon, Dilhan Weeraratne, Hu Huang, David Brotman, Shang Xue, Van C. Willis, Young Kyung Lee, Kibum Jeon, Dae Young Zang, Hyo Jung Kim, Ho Young Kim, Boram Han & Miyoung Kim. (2021) Clinical insights into hematologic malignancies and comparative analysis of molecular signatures of acute myeloid leukemia in different ethnicities using an artificial intelligence offering. Medicine 100:51, pages e27969.
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