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Leukemia & Lymphoma Volume 62, 2021 - Issue 2
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Original Articles

Efficacy and safety of weekly carfilzomib (70 mg/m2), dexamethasone, and daratumumab (KdD70) is comparable to twice-weekly KdD56 while being a more convenient dosing option: a cross-study comparison of the CANDOR and EQUULEUS studies

Xavier Leleua Service d'Hématologie et Thérapie cellulaire, CHU and Inserm, Poitiers, FranceCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-9822-4170
ORCID Icon,
Meral Beksacb Department of Hematology, Ankara University, Ankara, Turkey
,
Takaaki Chouc Department of Internal Medicine, Niigata Cancer Center Hospital, Niigata, Japan
,
Meletios Dimopoulosd Hematology and Medical Oncology, Department of Clinical Therapeutics, National and Kapodistrian University of Athens School of Medicine, Athens, GreeceORCID Iconhttps://orcid.org/0000-0001-8990-3254
ORCID Icon,
Sung-Soo Yoone Department of Internal Medicine, Seoul National University, Seoul, South Korea
,
H. Miles Princef Epworth Healthcare and Sir Peter MacCallum Department of Oncology, University of Melbourne, Melbourne, Australia
,
Ludek Pourg Department of Internal Medicine, Hematology and Oncology, University Hospital Brno, Brno, Czech Republic
,
Tatiana Shelekhovah Clinic of Professional Pathology, Saratov, Russian Federation
,
Ajai Charii Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USAORCID Iconhttps://orcid.org/0000-0002-0405-7480
ORCID Icon,
Monica Khuranaj Clinical Development, Oncology, Amgen Inc., Thousand Oaks, CA, USA
,
Jianqi Zhangk Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA, USA
,
Mihaela Obrejak Global Biostatistical Science, Amgen Inc., Thousand Oaks, CA, USA
,
Ming Qil Hematology and Oncology, Janssen Research and Development, LLC, Spring House, PA, USA
,
Albert Oriolm Institut Català d'Oncologia and Josep Carreras Research Leukaemia Institute, Hospital Germans Trias i Pujol, Barcelona, Spain
&
David Siegeln John Theurer Cancer Center, Hackensack University Medical Center, Hackensack, NJ, USA
 show all
Pages 358-367 | Received 07 Aug 2020, Accepted 26 Sep 2020, Published online: 28 Oct 2020

Citations (12)

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Read on this site (3)

Hanley N Abramson. (2021) Immunotherapy of Multiple Myeloma: Promise and Challenges. ImmunoTargets and Therapy 10, pages 343-371.
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Xavier Leleu, Ajai Chari, Shambavi Richard, Monica Khurana, Akeem Yusuf & Saad Z. Usmani. (2021) A combination of carfilzomib, dexamethasone, and daratumumab for treatment of adult patients with relapsed/refractory multiple myeloma in two dosing regimens: once-weekly and twice-weekly. Expert Review of Hematology 14:12, pages 1049-1058.
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David Siegel, Katja Weisel, Anita Zahlten-Kumeli, Rohan Medhekar, Bifeng Ding & Xavier Leleu. (2021) Health-related quality of life outcomes from the CANDOR study in patients with relapsed or refractory multiple myeloma. Leukemia & Lymphoma 62:12, pages 3002-3010.
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Articles from other publishers (9)

Charlotte Pawlyn, Abdullah M. Khan & Ciara L. Freeman. (2022) Fitness and frailty in myeloma. Hematology 2022:1, pages 337-348.
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Zdeněk Adam, Luděk Pour, Marta Krejčí, David Zeman, Zdeněk Řehák, Renata Koukalová, Viera Sandecká, Martin Štork & Zdeněk Král. (2022) Review of daratumumab efficacy in all monoclonal gammopathies and other diseases and our experience with daratumumab, lenalidomide and dexamethasone therapy in 74 patients. Onkologie 16:Suppl. B, pages 61-82.
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Wojciech Szlasa, Jakub Czarny, Natalia Sauer, Katarzyna Rakoczy, Natalia Szymańska, Jakub Stecko, Maksymilian Kołodziej, Maciej Kaźmierczak & Ewa Barg. (2022) Targeting CD38 in Neoplasms and Non-Cancer Diseases. Cancers 14:17, pages 4169.
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Chihiro Yamamoto, Daisuke Minakata, Shunsuke Koyama, Kaoru Sekiguchi, Yuta Fukui, Rui Murahashi, Hirotomo Nakashima, Sae Matsuoka, Takashi Ikeda, Shin-ichiro Kawaguchi, Yumiko Toda, Shoko Ito, Takashi Nagayama, Kento Umino, Hirofumi Nakano, Kaoru Morita, Ryoko Yamasaki, Masahiro Ashizawa, Masuzu Ueda, Kaoru Hatano, Kazuya Sato, Ken Ohmine, Shin-ichiro Fujiwara & Yoshinobu Kanda. (2022) Daratumumab in first-line therapy is cost-effective in transplant-eligible patients with newly diagnosed myeloma. Blood 140:6, pages 594-607.
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Efstathios Kastritis, Evangelos Terpos & Meletios A. Dimopoulos. (2022) How I treat relapsed multiple myeloma. Blood 139:19, pages 2904-2917.
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Saad Z Usmani, Hang Quach, Maria-Victoria Mateos, Ola Landgren, Xavier Leleu, David Siegel, Katja Weisel, Maria Gavriatopoulou, Albert Oriol, Neil Rabin, Ajay Nooka, Ming Qi, Meral Beksac, Andrzej Jakubowiak, Bifeng Ding, Anita Zahlten-Kumeli, Akeem Yusuf & Meletios Dimopoulos. (2022) Carfilzomib, dexamethasone, and daratumumab versus carfilzomib and dexamethasone for patients with relapsed or refractory multiple myeloma (CANDOR): updated outcomes from a randomised, multicentre, open-label, phase 3 study. The Lancet Oncology 23:1, pages 65-76.
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Klaus Podar & Xavier Leleu. (2021) Relapsed/Refractory Multiple Myeloma in 2020/2021 and Beyond. Cancers 13:20, pages 5154.
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Evangelos Terpos, Kimon Stamatelopoulos, Nikolaos Makris, Georgios Georgiopoulos, Ioannis Ntanasis-Stathopoulos, Maria Gavriatopoulou, Ageliki Laina, Evangelos Eleutherakis-Papaiakovou, Despina Fotiou, Nikolaos Kanellias, Panagiotis Malandrakis, Dimitris Delialis, Ioanna Andreadou, Efstathios Kastritis & Meletios A. Dimopoulos. (2021) Daratumumab May Attenuate Cardiac Dysfunction Related to Carfilzomib in Patients with Relapsed/Refractory Multiple Myeloma: A Prospective Study. Cancers 13:20, pages 5057.
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Cyrille Touzeau, Chloé Antier & Philippe Moreau. (2021) Carfilzomib in combination with daratumumab in the management of relapsed multiple myeloma. Future Oncology 17:9, pages 993-998.
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