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Original Articles

Development of an HPLC Method for Simultaneous Analysis of Five Antineoplastic Agents

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Pages 109-119 | Published online: 30 Nov 2010

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Claudio Müller-Ramírez, Katherine Squibb & Melissa McDiarmid. (2017) Measuring extent of surface contamination produced by the handling of antineoplastic drugs in low- to middle-income country oncology health care settings. Archives of Environmental & Occupational Health 72:5, pages 289-298.
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A. F. Mistiran, A. A. Dzarr & S. H. Gan. (2010) HPLC method development and validation for simultaneous detection of Arabinoside-C and doxorubicin. Toxicology Mechanisms and Methods 20:8, pages 472-481.
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Ronald Bartzatt. (2006) Identification of Doxorubicin and an Imine Derivative from Liquid and Solid Samples Utilizing Liquid Chromatography. Journal of Liquid Chromatography & Related Technologies 29:15, pages 2303-2312.
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Articles from other publishers (31)

Luciana Stein e Silva, Cibele da Silva Barbosa Machado, Rafael Linden, Marina Venzon Antunes, Laura Cé da Silva, Carlos Alberto Yasin Wayhs, Edison Capp & Sandro Luís Ribeiro Ness. (2023) Residual contamination in antineoplastic drug packaging. Journal of Oncology Pharmacy Practice 29:8, pages 1862-1867.
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Ahmed Abdulhafez Hamad. (2023) The first facile optical density-dependent approach for the analysis of doxorubicin, an oncogenic agent accompanied with the co-prescribed drug; paclitaxel. BMC Chemistry 17:1.
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Wongeon Jung, Mijin Park, Soo Jin Park, Eun Ji Lee, Hee Seung Kim, Sun Ho Chung & Chungsik Yoon. (2023) Occupational Exposure during Intraperitoneal Pressurized Aerosol Chemotherapy Using Doxorubicin in a Pig Model. Safety and Health at Work 14:2, pages 237-242.
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Joyson Paul, Karanvir Singh, Sumit Pannu, Rohit Pal, Shah Alam Khan, Bhupinder Kumar & Md Jawaid Akhtar. (2023) An Update on Recently Developed Analytical and Bio-analytical Methods for Some Anticancer Drugs. Current Pharmaceutical Analysis 19:2, pages 117-135.
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Alessandra Travanut, Patrícia F. Monteiro, Sean Smith, Steven M. Howdle, Anna M. Grabowska, Barrie Kellam, Michael A. R. Meier & Cameron Alexander. (2022) Passerini chemistries for synthesis of polymer pro-drug and polymersome drug delivery nanoparticles. Journal of Materials Chemistry B 10:20, pages 3895-3905.
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Kripa Shanker Kasudhan, Ajay Patial, Nancy Mehra, Savita Verma Attri, Pankaj Malhotra, Smita Pattanaik, Deepesh Lad & Amol N. Patil. (2022) Cyclophosphamide, hydroxycyclophosphamide and carboxyethyl phosphoramide mustard quantification with liquid chromatography mass spectrometry in a single run human plasma samples: A rapid and sensitive method development. Journal of Chromatography B 1198, pages 123228.
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Ravi Saklani, Amrendra K. Tiwari, Pavan K. Yadav, Pooja Yadav & Manish K. Chourasia. (2022) Validated HPLC-UV Method for Simultaneous Estimation of Paclitaxel and Doxorubicin Employing Ion Pair Chromatography: Application in Formulation Development and Pharmacokinetic Studies. BioMed Research International 2022, pages 1-11.
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Ranju Bansal, Ranjit Singh & Khushpal Kaur. (2021) Quantitative analysis of doxorubicin hydrochloride and arterolane maleate by mid IR spectroscopy using transmission and reflectance modes. BMC Chemistry 15:1.
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Yaser Pashaei, Mona Mehrabi & Maryam Shekarchi. (2020) A review on various analytical methods for determination of anthracyclines and their metabolites as anti–cancer chemotherapy drugs in different matrices over the last four decades. TrAC Trends in Analytical Chemistry 130, pages 115991.
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Ankush Yadav, Shailesh Pandey, Mrinal Kanti Mandal & Kashyap Kumar Dubey. (2020) Development of cost‐effective RP‐HPLC methods for detection of cyclophosphamide, etoposide and paclitaxel. SEPARATION SCIENCE PLUS 3:3, pages 40-43.
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Vivian Garzón, Daniel Pinacho, Rosa-Helena Bustos, Gustavo Garzón & Sandra Bustamante. (2019) Optical Biosensors for Therapeutic Drug Monitoring. Biosensors 9:4, pages 132.
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Marzena Bonczarowska & Sławomir Brzeźnicki. (2017) Cyclophosphamide. Determination method in workplace air. Podstawy i Metody Oceny Środowiska Pracy 33:3(93), pages 141-150.
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Nicolas Guichard, Davy Guillarme, Pascal Bonnabry & Sandrine Fleury-Souverain. (2017) Antineoplastic drugs and their analysis: a state of the art review. The Analyst 142:13, pages 2273-2321.
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Claudio Müller-Ramírez, Katherine Squibb & Melissa McDiarmid. (2016) Accessible analytical methodology for assessing workplace contamination of antineoplastic drugs in limited-resource oncology health-care settings. Journal of Analytical Science and Technology 7:1.
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Carla Brigagão Pacheco da Silva, Isabelle Prado Julio, Giuliano Engler Donadel & Isarita Martins. (2016) UPLC-MS/MS method for simultaneous determination of cyclophosphamide, docetaxel, doxorubicin and 5-fluorouracil in surface samples. Journal of Pharmacological and Toxicological Methods 82, pages 68-73.
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Luz-María Torres, Liliana Rivera-Espinosa, Juan L. Chávez-Pacheco, Carlos F. Navas, Joel A. Demetrio, Radamés Alemón-Medina, Francisca Trujillo, Martín Pérez, Martha M. Zapata, Rocío Cárdenas, Citlaltepetl Salinas, Arnoldo Aquino, Rafael Velázquez-Cruz & Manuel-de-Jesús Castillejos. (2015) A New Method to Quantify Ifosfamide Blood Levels Using Dried Blood Spots and UPLC-MS/MS in Paediatric Patients with Embryonic Solid Tumours. PLOS ONE 10:11, pages e0143421.
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Masayuki Umemura, Akio Itoh, Yuichi Ando, Kiyofumi Yamada, Yoshifumi Wakiya & Toshitaka Nabeshima. (2014) Effects of outside air temperature on the preparation of antineoplastic drug solutions in biological safety cabinets. Journal of Oncology Pharmacy Practice 21:4, pages 243-248.
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Vijay P. Pattar & Sharanappa T. Nandibewoor. (2015) Electroanalytical method for the determination of 5-fluorouracil using a reduced graphene oxide/chitosan modified sensor. RSC Advances 5:43, pages 34292-34301.
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Edward K. Agyare, Kristen M. Jaruszewski, Geoffry L. Curran, Jens T. Rosenberg, Samuel C. Grant, Val J. Lowe, Subramanian Ramakrishnan, Anant K. Paravastu, Joseph F. Poduslo & Karunya K. Kandimalla. (2014) Engineering theranostic nanovehicles capable of targeting cerebrovascular amyloid deposits. Journal of Controlled Release 185, pages 121-129.
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C. Bobin-Dubigeon, M. Amiand, C. Percheron, C. Audeval, S. Rochard, P. Leynia & J.-M. Bard. (2013) A New, Validated Wipe-Sampling Procedure Coupled to LC-MS Analysis for the Simultaneous Determination of 5-Fluorouracil, Doxorubicin and Cyclophosphamide in Surface Contamination. Journal of Analytical Toxicology 37:7, pages 433-439.
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Shinichiro Maeda & Yoshihiro Miwa. (2013) Multicomponent high-performance liquid chromatography/tandem mass spectrometry analysis of ten chemotherapeutic drugs in wipe samples. Journal of Chromatography B 921-922, pages 43-48.
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P Balasubramanian, S Desire, J C Panetta, K M Lakshmi, V Mathews, B George, A Viswabandya, M Chandy, R Krishnamoorthy & A Srivastava. (2012) Population pharmacokinetics of cyclophosphamide in patients with thalassemia major undergoing HSCT. Bone Marrow Transplantation 47:9, pages 1178-1185.
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Jack R Pretty, Thomas H Connor, Ivan Spasojevic, Kristine S Kurtz, Jeffrey L McLaurin, Clayton B’Hymer & D Gayle Debord. (2010) Sampling and mass spectrometric analytical methods for five antineoplastic drugs in the healthcare environment. Journal of Oncology Pharmacy Practice 18:1, pages 23-36.
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Weiluan Chen, Yuanyuan Shen, Haojun Rong, Lei Lei & Shengrong Guo. (2012) Development and application of a validated gradient elution HPLC method for simultaneous determination of 5-fluorouracil and paclitaxel in dissolution samples of 5-fluorouracil/paclitaxel-co-eluting stents. Journal of Pharmaceutical and Biomedical Analysis 59, pages 179-183.
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Susanne Nussbaumer, Pascal Bonnabry, Jean-Luc Veuthey & Sandrine Fleury-Souverain. (2011) Analysis of anticancer drugs: A review. Talanta 85:5, pages 2265-2289.
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Ananda Lima Sanson, Suéllen Cristina Rennó Silva, Matheus Coutinho Gonçalves Martins, Alexandre Giusti-Paiva, Patrícia Penido Maia & Isarita Martins. (2011) Liquid-liquid extraction combined with high performance liquid chromatography-diode array-ultra-violet for simultaneous determination of antineoplastic drugs in plasma. Brazilian Journal of Pharmaceutical Sciences 47:2, pages 363-371.
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Adélia Maria Pimenta de Pádua Alcântara, Ricardo Vilela Vitor, Elisabeth Pizzamiglio Vieira & Isarita Martins. (2010) Simultaneous detection of three antineoplastic drugs on gloves by liquid chromatography with diode array detector. Brazilian Journal of Pharmaceutical Sciences 46:4, pages 731-740.
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Jennifer A MacDiarmid, Nancy B Amaro-Mugridge, Jocelyn Madrid-Weiss, Ilya Sedliarou, Stefanie Wetzel, Kartini Kochar, Vatsala N Brahmbhatt, Leo Phillips, Scott T Pattison, Carlotta Petti, Bruce Stillman, Robert M Graham & Himanshu Brahmbhatt. (2009) Sequential treatment of drug-resistant tumors with targeted minicells containing siRNA or a cytotoxic drug. Nature Biotechnology 27:7, pages 643-651.
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Jennifer A. MacDiarmid, Nancy B. Mugridge, Jocelyn C. Weiss, Leo Phillips, Adam L. Burn, Richard P. Paulin, Joel E. Haasdyk, Kristie-Ann Dickson, Vatsala N. Brahmbhatt, Scott T. Pattison, Alexander C. James, Ghalib Al Bakri, Rodney C. Straw, Bruce Stillman, Robert M. Graham & Himanshu Brahmbhatt. (2007) Bacterially Derived 400 nm Particles for Encapsulation and Cancer Cell Targeting of Chemotherapeutics. Cancer Cell 11:5, pages 431-445.
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Cristina Sottani, Giovanna Tranfo, Paolo Faranda & Claudio Minoia. (2005) Highly sensitive high‐performance liquid chromatography/selective reaction monitoring mass spectrometry method for the determination of cyclophosphamide and ifosfamide in urine of health care workers exposed to antineoplastic agents. Rapid Communications in Mass Spectrometry 19:19, pages 2794-2800.
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S. KREGE, M. KINZIG-SCHIPPERS, F. SÖRGEL, R. BASCHEK, M.C. MICHEL & H. RÜBBEN. (2004) ABSORPTION OF INTRAVESICALLY APPLIED DRUGS: COMPARISON OF NORMAL AND ILEAL AUGMENTED RABBIT BLADDER. Journal of Urology 172:5, pages 2045-2050.
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