214
Views
64
CrossRef citations to date
0
Altmetric
Original

Human disc degeneration is associated with increased MMP 7 expression

, &
Pages 125-131 | Received 29 Jun 2006, Published online: 12 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

S-c Ji, N Han, Y Liu, G Li, Z Sun & Z Li. (2015) Identification of genes associated with disc degeneration using bioinformatics. Biotechnic & Histochemistry 90:5, pages 353-360.
Read now
R Ali, Cl Le Maitre, Sm Richardson, Ja Hoyland & Aj Freemont. (2008) Connective tissue growth factor expression in human intervertebral disc: implications for angiogenesis in intervertebral disc degeneration. Biotechnic & Histochemistry 83:5, pages 239-245.
Read now

Articles from other publishers (61)

Yuheng Liu, Zhen Zhao, Chuan Guo, Zhangheng Huang, Weifei Zhang, Fei Ma, Zhe Wang, Qingquan Kong & Yu Wang. (2023) Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review. Frontiers in Cell and Developmental Biology 11.
Crossref
Chunyu Zhang, Xuchang Zhou, Dongxue Wang, Li Hao, Zhipeng Zeng & Lei Su. (2023) Hydrogel-Loaded Exosomes: A Promising Therapeutic Strategy for Musculoskeletal Disorders. Journal of Clinical Pharmacy and Therapeutics 2023, pages 1-36.
Crossref
Xiaosong Zou, Xingmin Zhang, Song Han, Lin Wei, Zhi Zheng, Yongjie Wang, Jingguo Xin & Shaokun Zhang. (2023) Pathogenesis and therapeutic implications of matrix metalloproteinases in intervertebral disc degeneration: A comprehensive review. Biochimie 214, pages 27-48.
Crossref
Yan Zhang, Chao Fang, Wei Zhang & Kun Zhang. (2022) Emerging pyroptosis-engineered nanobiotechnologies regulate cancers and inflammatory diseases: A double-edged sword. Matter 5:11, pages 3740-3774.
Crossref
Yu-Yang Yi, Hao Chen, Shu-Bao Zhang, Hao-Wei Xu, Xin-Yue Fang & Shan-Jin Wang. (2022) Exogenous Klotho ameliorates extracellular matrix degradation and angiogenesis in intervertebral disc degeneration via inhibition of the Rac1/PAK1/MMP-2 signaling axis. Mechanisms of Ageing and Development 207, pages 111715.
Crossref
Md Entaz Bahar, Jin Seok Hwang, Mahmoud Ahmed, Trang Huyen Lai, Trang Minh Pham, Omar Elashkar, Kazi-Marjahan Akter, Dong-Hee Kim, Jinsung Yang & Deok Ryong Kim. (2022) Targeting Autophagy for Developing New Therapeutic Strategy in Intervertebral Disc Degeneration. Antioxidants 11:8, pages 1571.
Crossref
Sanjay S. Aripaka, Rachid Bech-Azeddine, Louise M. Jørgensen & Jens D. Mikkelsen. (2022) The expression of metalloproteinases in the lumbar disc correlates strongly with Pfirrmann MRI grades in lumbar spinal fusion patients. Brain and Spine 2, pages 100872.
Crossref
Hongyuan Xing, Zengjie Zhang, Qijiang Mao, Chenggui Wang, Youlong Zhou, Xiaopeng Zhou, Liwei Ying, Haibin Xu, Shaojun Hu & Ning Zhang. (2021) Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration. Journal of Nanobiotechnology 19:1.
Crossref
Emanuel J. Novais, Victoria A. Tran, Shira N. Johnston, Kayla R. Darris, Alex J. Roupas, Garrett A. Sessions, Irving M. Shapiro, Brian O. Diekman & Makarand V. Risbud. (2021) Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nature Communications 12:1.
Crossref
Abbie L. A. Binch, Joan C. Fitzgerald, Emily A. Growney & Frank Barry. (2021) Cell-based strategies for IVD repair: clinical progress and translational obstacles. Nature Reviews Rheumatology 17:3, pages 158-175.
Crossref
Hirokazu ISHINO & Iwao SAKONJU. (2021) Expression of metalloproteinases and their inhibitors in degenerated and extruded intervertebral disks in chondrodystrophic dogs. Journal of Veterinary Medical Science 83:4, pages 637-642.
Crossref
Takashi Ohnishi, Emanuel J. Novais & Makarand V. Risbud. (2020) Alterations in ECM signature underscore multiple sub-phenotypes of intervertebral disc degeneration. Matrix Biology Plus 6-7, pages 100036.
Crossref
Andrew K. Chan, Xinyan Tang, Nikhil V. Mummaneni, Dezba Coughlin, Ellen Liebenberg, Annie Ouyang, Stefan Dudli, Michael Lauricella, Nianli Zhang, Erik I. Waldorff, James T. Ryaby & Jeffrey C. Lotz. (2019) Pulsed electromagnetic fields reduce acute inflammation in the injured rat‐tail intervertebral disc. JOR SPINE 2:4.
Crossref
Eszter Szentléleky, Vince Szegeczki, Edina Karanyicz, Tibor Hajdú, Andrea Tamás, Gábor Tóth, Róza Zákány, Dóra Reglődi & Tamás Juhász. (2019) Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Reduces Oxidative and Mechanical Stress-Evoked Matrix Degradation in Chondrifying Cell Cultures. International Journal of Molecular Sciences 20:1, pages 168.
Crossref
Eleni Mavrogonatou, Harris Pratsinis, Adamantia Papadopoulou, Nikos K. Karamanos & Dimitris Kletsas. (2019) Extracellular matrix alterations in senescent cells and their significance in tissue homeostasis. Matrix Biology 75-76, pages 27-42.
Crossref
J. Caldeira, A. Sousa, D.M. Sousa & D. Barros. 2018. Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair. Peptides and Proteins as Biomaterials for Tissue Regeneration and Repair 29 72 .
Xinghuo Wu, Kun Wang, Wenbin Hua, Shuai Li, Xianzhe Liu, Wei Liu, Yu Song, Yukun Zhang, Zengwu Shao & Cao Yang. (2017) Down-regulation of islet amyloid polypeptide expression induces death of human annulus fibrosus cells via mitochondrial and death receptor pathways. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1863:6, pages 1479-1491.
Crossref
James K.C. Liu. 2017. Benzel's Spine Surgery, 2-Volume Set. Benzel's Spine Surgery, 2-Volume Set 119 123.e1 .
Kathryn T. Weber, D. Olivier Alipui, Cristina P. Sison, Ona Bloom, Shaheda Quraishi, M. Chris Overby, Mitchell Levine & Nadeen O. Chahine. (2016) Serum levels of the proinflammatory cytokine interleukin-6 vary based on diagnoses in individuals with lumbar intervertebral disc diseases. Arthritis Research & Therapy 18:1.
Crossref
F.-J. Lv, Y. Peng, F.L. Lim, Y. Sun, M. Lv, L. Zhou, H. Wang, Z. Zheng, K.M.C. Cheung & V.Y.L. Leung. (2016) Matrix metalloproteinase 12 is an indicator of intervertebral disc degeneration co-expressed with fibrotic markers. Osteoarthritis and Cartilage 24:10, pages 1826-1836.
Crossref
Wei Liu, Yukun Zhang, Ping Xia, Shuai Li, Xintong Feng, Yong Gao, Kun Wang, Yu Song, Zhenfeng Duan, Shuhua Yang, Zengwu Shao & Cao Yang. (2016) MicroRNA-7 regulates IL-1β-induced extracellular matrix degeneration by targeting GDF5 in human nucleus pulposus cells. Biomedicine & Pharmacotherapy 83, pages 1414-1421.
Crossref
Chia-Hsian Chen, Chang-Jung Chiang, Lien-Chen Wu, Chih-Hong Yang, Yi-Jie Kuo, Yang-Hwei Tsuang & Tung-Hu Tsai. (2016) Time course investigation of intervertebral disc degeneration in a rat-tail puncture model. Life Sciences 156, pages 15-20.
Crossref
Stephen M. Richardson, Gauthaman Kalamegam, Peter N. Pushparaj, Csaba Matta, Adnan Memic, Ali Khademhosseini, Reza Mobasheri, Fabian L. Poletti, Judith A. Hoyland & Ali Mobasheri. (2016) Mesenchymal stem cells in regenerative medicine: Focus on articular cartilage and intervertebral disc regeneration. Methods 99, pages 69-80.
Crossref
P. Priyadarshani, Y. Li & L. Yao. (2016) Advances in biological therapy for nucleus pulposus regeneration. Osteoarthritis and Cartilage 24:2, pages 206-212.
Crossref
ZHIRONG WANG, GENLIN WANG, XUESONG ZHU, DECHUN GENG & HUILIN YANG. (2015) Interleukin-2 is upregulated in patients with a prolapsed lumbar intervertebral disc and modulates cell proliferation, apoptosis and extracellular matrix metabolism of human nucleus pulposus cells. Experimental and Therapeutic Medicine 10:6, pages 2437-2443.
Crossref
S. Rajasekaran, Rishi Mugesh Kanna, Natesan Senthil, Muthuraja Raveendran, Veera Ranjani, Kenneth M. C. Cheung, Danny Chan, Patrick Y. P. Kao, Anita Yee & Ajoy Prasad Shetty. (2014) Genetic susceptibility of lumbar degenerative disc disease in young Indian adults. European Spine Journal 24:9, pages 1969-1975.
Crossref
Wen-Jun Wang, Xiao-Hua Yu, Cheng Wang, Wei Yang, Wen-Si He, Shu-Jun Zhang, Yi-Guo Yan & Jian Zhang. (2015) MMPs and ADAMTSs in intervertebral disc degeneration. Clinica Chimica Acta 448, pages 238-246.
Crossref
S.B.G. Blanquer, D.W. Grijpma & A.A. Poot. (2015) Delivery systems for the treatment of degenerated intervertebral discs. Advanced Drug Delivery Reviews 84, pages 172-187.
Crossref
Maria Molinos, Catarina R. Almeida, Joana Caldeira, Carla Cunha, Raquel M. Gonçalves & Mário A. Barbosa. (2015) Inflammation in intervertebral disc degeneration and regeneration. Journal of The Royal Society Interface 12:104, pages 20141191.
Crossref
M.C. Cornejo, S.K. Cho, C. Giannarelli, J.C. Iatridis & D. Purmessur. (2015) Soluble factors from the notochordal-rich intervertebral disc inhibit endothelial cell invasion and vessel formation in the presence and absence of pro-inflammatory cytokines. Osteoarthritis and Cartilage 23:3, pages 487-496.
Crossref
Young-Yul KimDojoon ParkKee-Won Rhyu. (2015) Variations in Matrix Metalloproteinase Expression by Disc Location in Patients with Sequestrated Lumbar Disc Herniation. Journal of Korean Society of Spine Surgery 22:4, pages 160.
Crossref
Munetaka Iwata, Takeshi Aikawa, Takaharu Hakozaki, Kiyotaka Arai, Hiroki Ochi, Hirotaka Haro, Masahiro Tagawa, Yoshinori Asou & Yasushi Hara. (2015) Enhancement of Runx2 Expression Is Potentially Linked to β-Catenin Accumulation in Canine Intervertebral Disc Degeneration. Journal of Cellular Physiology 230:1, pages 180-190.
Crossref
Eleni Mavrogonatou, Maria T. Angelopoulou & Dimitris Kletsas. (2014) The catabolic effect of TNF? on bovine nucleus pulposus intervertebral disc cells and the restraining role of glucosamine sulfate in the TNF?-mediated up-regulation of MMP-3. Journal of Orthopaedic Research 32:12, pages 1701-1707.
Crossref
Catarina Leite Pereira, Raquel M. Gonçalves, Marianna Peroglio, Girish Pattappa, Matteo D'Este, David Eglin, Mário A. Barbosa, Mauro Alini & Sibylle Grad. (2014) The effect of hyaluronan-based delivery of stromal cell-derived factor-1 on the recruitment of MSCs in degenerating intervertebral discs. Biomaterials 35:28, pages 8144-8153.
Crossref
Haiqing Mao, Dechun Geng, Xuesong Zhu, Shundong Ji, Mo Zhu, Maofeng Gao, Jun Zou & Huilin Yang. (2014) Intervertebral disc degeneration induced by intradiscal poly(methyl methacrylate) leakage after spine augmentation in an in vivo rabbit model. Acta Biomaterialia 10:7, pages 3059-3067.
Crossref
H.J. Moon, T. Yurube, T.P. Lozito, P. Pohl, R.A. Hartman, G.A. Sowa, J.D. Kang & N.V. Vo. (2014) Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration. Osteoarthritis and Cartilage 22:2, pages 344-354.
Crossref
Stephen M. Richardson, Anthony J. Freemont & Judith A. Hoyland. 2014. The Intervertebral Disc. The Intervertebral Disc 177 200 .
Kate Louise Eve Phillips, Nikki Jordan-Mahy, Martin J H Nicklin & Christine Lyn Le Maitre. (2013) Interleukin-1 receptor antagonist deficient mice provide insights into pathogenesis of human intervertebral disc degeneration. Annals of the Rheumatic Diseases 72:11, pages 1860-1867.
Crossref
Bashar Akhatib, Patrik Önnerfjord, Rahul Gawri, Jean Ouellet, Peter Jarzem, Dick Heinegård, John Mort, Peter Roughley & Lisbet Haglund. (2013) Chondroadherin Fragmentation Mediated by the Protease HTRA1 Distinguishes Human Intervertebral Disc Degeneration from Normal Aging. Journal of Biological Chemistry 288:26, pages 19280-19287.
Crossref
Jillian E. Mayer, James C. Iatridis, Danny Chan, Sheeraz A. Qureshi, Omri Gottesman & Andrew C. Hecht. (2013) Genetic polymorphisms associated with intervertebral disc degeneration. The Spine Journal 13:3, pages 299-317.
Crossref
Nam V. Vo, Robert A. Hartman, Takashi Yurube, Lloydine J. Jacobs, Gwendolyn A. Sowa & James D. Kang. (2013) Expression and regulation of metalloproteinases and their inhibitors in?intervertebral disc aging and degeneration. The Spine Journal 13:3, pages 331-341.
Crossref
Y. Chen, K. Chen, M. Li, C. Li, H. Ma, Y.S. Bai, X.D. Zhu & Q. Fu. (2013) Genes associated with disc degeneration identified using microarray gene expression profiling and bioinformatics analysis. Genetics and Molecular Research 12:2, pages 1431-1439.
Crossref
Girish Pattappa, Zhen Li, Marianna Peroglio, Nadine Wismer, Mauro Alini & Sibylle Grad. (2012) Diversity of intervertebral disc cells: phenotype and function. Journal of Anatomy 221:6, pages 480-496.
Crossref
Svenja Illien-Jünger, Girish Pattappa, Marianna Peroglio, Lorin M. Benneker, Martin J. Stoddart, Daisuke Sakai, Joji Mochida, Sibylle Grad & Mauro Alini. (2012) Homing of Mesenchymal Stem Cells in Induced Degenerative Intervertebral Discs in a Whole Organ Culture System. Spine 37:22, pages 1865-1873.
Crossref
André N. Tiaden, Marina Klawitter, Vanda Lux, Ali Mirsaidi, Gregor Bahrenberg, Stephan Glanz, Lilian Quero, Thomas Liebscher, Karin Wuertz, Michael Ehrmann & Peter J. Richards. (2012) Detrimental Role for Human High Temperature Requirement Serine Protease A1 (HTRA1) in the Pathogenesis of Intervertebral Disc (IVD) Degeneration. Journal of Biological Chemistry 287:25, pages 21335-21345.
Crossref
Helen E. Gruber, Gretchen L. Hoelscher, Jane A. Ingram & Edward N. HanleyJr.Jr.. (2012) Matrix metalloproteinase-26, a novel MMP, is constitutively expressed in the human intervertebral disc in vivo and in vitro. Experimental and Molecular Pathology 92:1, pages 59-63.
Crossref
Hongsik ChoSang-Hyug ParkSangmin LeeMiji KangKaren A. HastySong-Ja Kim. (2011) Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanisms. Experimental and Molecular Medicine 43:6, pages 334.
Crossref
Akihiko Hiyama, Daisuke Sakai, Makarand V. Risbud, Masahiro Tanaka, Fumiyuki Arai, Koichiro Abe & Joji Mochida. (2010) Enhancement of intervertebral disc cell senescence by WNT/β‐catenin signaling–induced matrix metalloproteinase expression. Arthritis & Rheumatism 62:10, pages 3036-3047.
Crossref
Svenja Illien-Jünger, Benjamin Gantenbein-Ritter, Sibylle Grad, Patrick Lezuo, Stephen J. Ferguson, Mauro Alini & Keita Ito. (2010) The Combined Effects of Limited Nutrition and High-Frequency Loading on Intervertebral Discs With Endplates. Spine 35:19, pages 1744-1752.
Crossref
Ying Cui, Jing Yu, Jill P. G. Urban & David A. Young. (2010) Differential Gene Expression Profiling of Metalloproteinases and Their Inhibitors. Spine 35:11, pages 1101-1108.
Crossref
J. Rutges, L.B. Creemers, W. Dhert, S. Milz, D. Sakai, J. Mochida, M. Alini & S. Grad. (2010) Variations in gene and protein expression in human nucleus pulposus in comparison with annulus fibrosus and cartilage cells: potential associations with aging and degeneration. Osteoarthritis and Cartilage 18:3, pages 416-423.
Crossref
Sibylle Grad, Mauro Alini, David Eglin, Daisuke Sakai, Joji Mochida, Sunil Mahor, Estelle Collin, Biraja Dash & Abhay Pandit. (2010) Cells and Biomaterials for Intervertebral Disc Regeneration. Synthesis Lectures on Tissue Engineering 2:1, pages 1-104.
Crossref
Cornelia Neidlinger-Wilke & Hans-Joachim Wilke. 2010. Surgery for Low Back Pain. Surgery for Low Back Pain 3 10 .
Sibylle Grad, Mauro Alini, David Eglin, Daisuke Sakai, Joji Mochida, Sunil Mahor, Estelle Collin, Biraja Dash & Abhay PanditSibylle Grad, Mauro Alini, Daisuke Sakai & Joji Mochida. 2010. Cells and Biomaterials for Intervertebral Disc Regeneration. Cells and Biomaterials for Intervertebral Disc Regeneration 1 42 .
Christopher A. Sharp, Sally Roberts, Helena Evans & Sharon J. Brown. (2009) Disc cell clusters in pathological human intervertebral discs are associated with increased stress protein immunostaining. European Spine Journal 18:11, pages 1587-1594.
Crossref
Lachlan J. Smith & Nicola L. Fazzalari. (2009) The elastic fibre network of the human lumbar anulus fibrosus: architecture, mechanical function and potential role in the progression of intervertebral disc degeneration. European Spine Journal 18:4, pages 439-448.
Crossref
D. Ireland. (2009) Molecular mechanisms involved in intervertebral disc degeneration and potential new treatment strategies. Bioscience Horizons 2:1, pages 83-89.
Crossref
Peter J. Roughley. 2008. Carbohydrate Chemistry, Biology and Medical Applications. Carbohydrate Chemistry, Biology and Medical Applications 133 154 .
Chang-Qing Zhao, Li-Min Wang, Lei-Sheng Jiang & Li-Yang Dai. (2007) The cell biology of intervertebral disc aging and degeneration. Ageing Research Reviews 6:3, pages 247-261.
Crossref
C.L. Le MaitreA. PockertD.J. ButtleA.J. FreemontJ.A. Hoyland. (2007) Matrix synthesis and degradation in human intervertebral disc degeneration. Biochemical Society Transactions 35:4, pages 652-655.
Crossref
Seong-Hwan Moon. (2007) Biochemical Factors of Intervertebral Disc Degeneration: Implications for Disc Regeneration. Journal of Korean Society of Spine Surgery 14:2, pages 120.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.