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Journal of Biopharmaceutical Statistics Volume 19, 2009 - Issue 3
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Original Articles

Design Issues in Dose-Finding Phase I Trials for Combinations of Two Agents

Shenghua Kelly Fan Department of Statistics and Biostatistics, California State University, East Bay, Hayward, California, USA
,
Alan P. Venook Department of Medicine, Division of Medical Oncology, UCSF Helen Diller and Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, USA
&
Ying Lu Department of Radiology and Biomedical Imaging, Department of Epidemiology and Biostatistics, Biostatistics Core of UCSF Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USACorrespondence[email protected]
Pages 509-523 | Published online: 21 Apr 2009

Citations (17)

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Bee Leng Lee & Shenghua Kelly Fan. (2012) A Two-Dimensional Search Algorithm for Dose-Finding Trials of Two Agents. Journal of Biopharmaceutical Statistics 22:4, pages 802-818.
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Articles from other publishers (16)

Masahiro Kojima. (2023) Data-dependent early completion of dose-finding trials for drug-combination. Statistical Methods in Medical Research 32:4, pages 820-828.
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Zhaohang Li, Ze Xu, Aijun Zhang, Guanpeng Qi & Zuojing Li. (2023) A clinical phase I dose-finding design with adaptive shrinking boundaries for drug combination trials. BMC Medical Research Methodology 23:1.
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Joleen M. Hubbard, Jun Yin, Erin L. Schenk, Rui Qin, Joel M. Reid, Carrie Strand, Jack Fiskum, Michael Menefee, Grace Lin, L. Austin Doyle, Percy Ivy, Charles Erlichman, Alex Adjei, Paul Haluska & Brian A. Costello. (2021) Phase I study of cediranib, an oral VEGFR inhibitor, in combination with selumetinib, an oral MEK inhibitor, in patients with advanced solid malignancies. Investigational New Drugs 40:1, pages 115-123.
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Teng Zhang, Zhao Yang & Guosheng Yin. (2020) Dynamic ordering design for dose finding in drug‐combination trials . Pharmaceutical Statistics 20:2, pages 348-361.
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Dean C. Bottino, Mayankbhai Patel, Ekta Kadakia, Jilai Zhou, Chirag Patel, Rachel Neuwirth, Natasha Iartchouk, Rachael Brake, Karthik Venkatakrishnan & Arijit Chakravarty. (2019) Dose Optimization for Anticancer Drug Combinations: Maximizing Therapeutic Index via Clinical Exposure-Toxicity/Preclinical Exposure-Efficacy Modeling. Clinical Cancer Research 25:22, pages 6633-6643.
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Takashi Daimon, Akihiro Hirakawa & Shigeyuki MatsuiTakashi Daimon, Akihiro Hirakawa & Shigeyuki Matsui. 2019. Dose-Finding Designs for Early-Phase Cancer Clinical Trials. Dose-Finding Designs for Early-Phase Cancer Clinical Trials 33 79 .
Ruitao Lin & Guosheng Yin. (2015) Bayesian optimal interval design for dose finding in drug-combination trials. Statistical Methods in Medical Research 26:5, pages 2155-2167.
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Ruitao Lin & Guosheng Yin. 2017. Frontiers of Biostatistical Methods and Applications in Clinical Oncology. Frontiers of Biostatistical Methods and Applications in Clinical Oncology 21 35 .
Ruitao Lin & Guosheng Yin. (2016) Bootstrap aggregating continual reassessment method for dose finding in drug-combination trials. The Annals of Applied Statistics 10:4.
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Ruitao Lin & Guosheng Yin. 2016. Advanced Statistical Methods in Data Science. Advanced Statistical Methods in Data Science 55 74 .
Zhichao Sun & Thomas M Braun. (2015) A two-dimensional biased coin design for dual-agent dose-finding trials. Clinical Trials 12:6, pages 596-607.
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Akihiro Hirakawa, Nolan A. WagesHiroyuki Sato & Shigeyuki Matsui. (2015) A comparative study of adaptive dose-finding designs for phase I oncology trials of combination therapies. Statistics in Medicine 34:24, pages 3194-3213.
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M.-K. Riviere, F. Dubois & S. Zohar. (2015) Competing designs for drug combination in phase I dose-finding clinical trials. Statistics in Medicine 34:1, pages 1-12.
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Oleksandr Sverdlov, Weng Kee Wong & Yevgen Ryeznik. (2014) Adaptive clinical trial designs for phase I cancer studies. Statistics Surveys 8:none.
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Takashi Daimon. (2012) The Continual Reassessment Method (CRM) and Related Topics^|^mdash;A Review. Part II: Modified/Extended CRMs and Related Designs.. Japanese Journal of Biometrics 33:1, pages 31-76.
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Thomas M Braun & Todd A Alonzo. (2011) Beyond the 3+3 method: expanded algorithms for dose- escalation in Phase I oncology trials of two agents. Clinical Trials 8:3, pages 247-259.
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