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Journal of Biopharmaceutical Statistics Volume 22, 2012 - Issue 3
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Original Articles

A Portfolio-Based Approach to Optimize Proof-of-Concept Clinical Trials

Craig Mallinckrodt Eli Lilly and Company, Indianapolis, Indiana, USACorrespondence[email protected]
,
Geert Molenberghs I-BioStat, Diepenbeek, Belgium
,
Charles Persinger Eli Lilly and Company, Indianapolis, Indiana, USA
,
Stephen Ruberg Eli Lilly and Company, Indianapolis, Indiana, USA
,
Andreas Sashegyi Eli Lilly and Company, Indianapolis, Indiana, USA
&
Stacy Lindborg Eli Lilly and Company, Indianapolis, Indiana, USA
Pages 596-607 | Received 15 Aug 2010, Accepted 15 Feb 2011, Published online: 14 Mar 2012

Citations (4)

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Read on this site (1)

Jiandong Lu & Bin Dong. (2017) The Evaluation of Proof-of-Concept Trial Design for Compound Selection. Statistics in Biopharmaceutical Research 9:4, pages 315-320.
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Articles from other publishers (3)

Rosalind J. Walley & Andrew P. Grieve. (2021) Optimising the trade‐off between type I and II error rates in the Bayesian context . Pharmaceutical Statistics 20:4, pages 710-720.
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Laurence Colin & Brian Smith. 2019. Statistical Methods in Biomarker and Early Clinical Development. Statistical Methods in Biomarker and Early Clinical Development 221 245 .
Roland Fisch, Ieuan Jones, Julie Jones, Jouni Kerman, Gerd Karl Rosenkranz & Heinz Schmidli. (2015) Bayesian Design of Proof-of-Concept Trials. Therapeutic Innovation & Regulatory Science 49:1, pages 155-162.
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