Meaningful within-patient change for clinical outcome assessments: model-based approach versus cumulative distribution functions

Jinma Rena Statistical Research & Data Science Center, Pfizer Inc, Collegeville, Pennsylvania, USACorrespondence[email protected]
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Andrew G. Bushmakinb Statistical Research & Data Science Center, Pfizer Inc, Groton, Connecticut, USAView further author information

Paul R. Cisloc Statistical Research & Data Science Center, Pfizer Inc, New York, New York, USAView further author information

Lucy Abrahamd Global Access & Value, Pfizer Ltd, Tadworth, Kent, UKView further author information

Joseph C. Cappellerib Statistical Research & Data Science Center, Pfizer Inc, Groton, Connecticut, USAView further author information

Robert H. Dworkine Department of Anesthesiology and Perioperative Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USAView further author information

John T. Farrarf Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USAView further author information

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Meaningful within-patient change for clinical outcome assessments: model-based approach versus cumulative distribution functions

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Meaningful within-patient change for clinical outcome assessments: model-based approach versus cumulative distribution functions

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