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Journal of Environmental Science and Health, Part C
Environmental Carcinogenesis and Ecotoxicology Reviews
Volume 26, 2008 - Issue 1
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Original Articles

Toxicity of Kava Kava

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Pages 89-112 | Published online: 05 Mar 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (12)

Mohammed Abdulabbas Hasan, Syam Mohan, Heshu Sulaiman Rahman, Hemn Hasan Othman, Shirwan Hamasalih Omer & Abdullah Farasani. (2023) The sub-acute toxicity of kavalactone in rats: a study of the effect of oral doses and the mechanism of toxicity in combination with ethanol. Drug and Chemical Toxicology 46:3, pages 588-596.
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Salma Pont-Fernandez, Marina Kheyfets, Jeffrey M. Rogers, Kirsten E. Smith & David H. Epstein. (2023) Kava (Piper methysticum) in the United States: the quiet rise of a substance with often subtle effects. The American Journal of Drug and Alcohol Abuse 49:1, pages 85-96.
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Charles R Caffrey & Patrick M Lank. (2018) When good times go bad: managing ‘legal high’ complications in the emergency department. Open Access Emergency Medicine 10, pages 9-23.
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Sofía López-Gil, Natalia Nuño-Lámbarri, Norberto Chávez-Tapia, Misael Uribe & Varenka J. Barbero-Becerra. (2017) Liver toxicity mechanisms of herbs commonly used in Latin America. Drug Metabolism Reviews 49:3, pages 338-356.
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Nan Mei, Xiaoqing Guo, Zhen Ren, Daisuke Kobayashi, Keiji Wada & Lei Guo. (2017) Review of Ginkgo biloba-induced toxicity, from experimental studies to human case reports. Journal of Environmental Science and Health, Part C 35:1, pages 1-28.
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Theertham P. Rao, Motoko Ozeki & Lekh R. Juneja. (2015) In Search of a Safe Natural Sleep Aid. Journal of the American College of Nutrition 34:5, pages 436-447.
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Si Chen, William B. Melchior$suffix/text()$suffix/text() & Lei Guo. (2014) Endoplasmic Reticulum Stress in Drug- and Environmental Toxicant-Induced Liver Toxicity. Journal of Environmental Science and Health, Part C 32:1, pages 83-104.
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PETERP. FU, QINGSU XIA, YUEWEI ZHAO, SHUGUANG WANG, HONGTAO YU & HSIU-MEI CHIANG. (2013) Phototoxicity of Herbal Plants and Herbal Products. Journal of Environmental Science and Health, Part C 31:3, pages 213-255.
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Michael Murray. (2012) Toxicological Actions of Plant-Derived and Anthropogenic Methylenedioxyphenyl-Substituted Chemicals in Mammals and Insects. Journal of Toxicology and Environmental Health, Part B 15:6, pages 365-395.
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Lei Guo, Nan Mei, Qingsu Xia, Tao Chen, Po-Chuen Chan & PeterP. Fu. (2010) Gene Expression Profiling as an Initial Approach for Mechanistic Studies of Toxicity and Tumorigenicity of Herbal Plants and Herbal Dietary Supplements. Journal of Environmental Science and Health, Part C 28:1, pages 60-87.
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Amy J Morgan & Anthony F Jorm. (2009) Outcomes of self-help efforts in anxiety disorders. Expert Review of Pharmacoeconomics & Outcomes Research 9:5, pages 445-459.
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PETERP. FU, HSIU-MEI CHIANG, QINGSU XIA, TAO CHEN, BAI HSIUN CHEN, JUE-JIE YIN, KUO-CHING WEN, GE LIN & HONGTAO YU. (2009) Quality Assurance and Safety of Herbal Dietary Supplements. Journal of Environmental Science and Health, Part C 27:2, pages 91-119.
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Articles from other publishers (51)

Colin G. Rousseaux. 2023. Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3. Haschek and Rousseaux's Handbook of Toxicologic Pathology, Volume 3 183 303 .
Deana Goldin & Deborah Salani. (2022) Calm Down With Kava: What Clinicians Need to Know. Journal of Psychosocial Nursing and Mental Health Services 60:12, pages 17-24.
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Cong Cheng, Shanshan Zhao, Yong‐Li Gu, Jie Pang & Yanyun Zhao. (2022) Characterization and identification of the metabolites of dihydromethysticin by ultra‐high‐performance liquid chromatography orbitrap high‐resolution mass spectrometry. Journal of Separation Science 45:15, pages 2914-2923.
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Rita B. Soares, Ricardo Jorge Dinis-Oliveira & Nuno G. Oliveira. (2022) An Updated Review on the Psychoactive, Toxic and Anticancer Properties of Kava. Journal of Clinical Medicine 11:14, pages 4039.
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Bernie Garrett, Timothy Caulfield, Blake Murdoch, Matt Brignall, Atul Kumar Kapur, Susan Murphy, Erin Nelson, Jillian Reardon, Mark Harrison, Jonathan Hislop, Barbara J. Wilson‐Keates, Joseph Anthony, Peter S. Loewen, Richard M. Musoke & Joan Braun. (2021) A taxonomy of risk‐associated alternative health practices: A Delphi study. Health & Social Care in the Community 30:3, pages 1163-1181.
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Bárbara Nunes Krum, Catiuscia Molz de Freitas, Alcindo Busanello, Larissa Finger Schaffer & Roselei Fachinetto. (2022) Ex vivo and in vitro inhibitory potential of Kava extract on monoamine oxidase B activity in mice. Journal of Traditional and Complementary Medicine 12:2, pages 115-122.
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David Ricardo da Conceição Marçal Alves Nunes, Cristina Sofia de Jesus Monteiro & Jorge Luiz dos Santos. (2022) Herb-Induced Liver Injury—A Challenging Diagnosis. Healthcare 10:2, pages 278.
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Marilisa Pia Dimmito, Azzurra Stefanucci, Alice Della Valle, Giuseppe Scioli, Angelo Cichelli & Adriano Mollica. (2021) An overview on plants cannabinoids endorsed with cardiovascular effects. Biomedicine & Pharmacotherapy 142, pages 111963.
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Mohammed A. Hasan. (2021) The Correlation of Histopathological Findings with Ultrastructural Changes in Hepatocytes after Yangonin “Ya”-Intoxicated Rats Alone and In Combination with EtOH: Sub-Acute & Sub-Chronic Study. Journal of Physics: Conference Series 1879:2, pages 022005.
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Amanda K. Leonberg-Yoo, David Johnson, Nicole Persun, Jehan Bahrainwala, Peter P. Reese, Ali Naji & Jennifer Trofe-Clark. (2020) Use of Dietary Supplements in Living Kidney Donors: A Critical Review. American Journal of Kidney Diseases 76:6, pages 851-860.
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Gulcin Tugcu, Hasan Kırmızıbekmez & Ahmet Aydın. (2020) The integrated use of in silico methods for the hepatotoxicity potential of Piper methysticum. Food and Chemical Toxicology 145, pages 111663.
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Pietro Brunetti, Alfredo Fabrizio Lo Faro, Anastasio Tini, Francesco Paolo Busardò & Jeremy Carlier. (2020) Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects. Pharmaceuticals 13:10, pages 309.
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Peter Fu & Qingsu Xia. 2016. Food Toxicology. Food Toxicology 57 82 .
Marta Rychert & Chris Wilkins. (2016) What products are considered psychoactive under New Zealand's legal market for new psychoactive substances (NPS, ‘legal highs’)? Implications for law enforcement and penalties. Drug Testing and Analysis 8:8, pages 768-778.
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Nan Mei, Jiekun Xuan, Tao Chen, Baitang Ning & Lei Guo. 2016. Nutraceuticals. Nutraceuticals 249 262 .
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Angelique F. Showman, Jonathan D. Baker, Christina Linares, Chrystie K. Naeole, Robert Borris, Edward Johnston, Jerry Konanui & Helen Turner. (2015) Contemporary Pacific and Western perspectives on `awa (Piper methysticum) toxicology. Fitoterapia 100, pages 56-67.
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Si Chen, William B. MelchiorJr.Jr., Yuanfeng Wu & Lei Guo. (2014) Autophagy in drug-induced liver toxicity. Journal of Food and Drug Analysis 22:2, pages 161-168.
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Si Chen, Liqing Wan, Letha Couch, Haixia Lin, Yan Li, Vasily N. Dobrovolsky, Nan Mei & Lei Guo. (2013) Mechanism study of goldenseal-associated DNA damage. Toxicology Letters 221:1, pages 64-72.
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Beatrice J. Edwards & Jin Li. (2012) Endocrinology of menopause. Periodontology 2000 61:1, pages 177-194.
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Lori M. N. Shimoda, Christy Park, Alexander J. Stokes, Henry Halenani Gomes & Helen Turner. (2012) Pacific Island ' Awa (Kava) Extracts, but not Isolated Kavalactones, Promote Proinflammatory Responses in Model Mast Cells . Phytotherapy Research 26:12, pages 1934-1941.
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Anthony Rowe & Iqbal Ramzan. (2012) Are Mould Hepatotoxins Responsible for Kava Hepatotoxicity?. Phytotherapy Research 26:11, pages 1768-1770.
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Kazuhiko Otoguro, Masato Iwatsuki, Aki Ishiyama, Miyuki Namatame, Aki Nishihara-Tsukashima, Hiroaki Kiyohara, Toshihiro Hashimoto, Yoshinori Asakawa, Satoshi Ōmura & Haruki Yamada. (2011) In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum). Journal of Natural Medicines 66:3, pages 558-561.
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Qingsu Xia, Hsiu-Mei ChiangYu-Ting Zhou, Jun-Jie Yin, Fang Liu, Cheng Wang, Lei Guo & Peter P. Fu. (2012) Phototoxicity of Kava — Formation of Reactive Oxygen Species Leading to Lipid Peroxidation and DNA Damage. The American Journal of Chinese Medicine 40:06, pages 1271-1288.
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