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Clinical Research and Regulatory Affairs Volume 25, 2008 - Issue 4
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Research Article

Pharmacokinetic Estimation of Losartan, Losartan Carboxylic Acid and Hydrochlorothiazide in Human Plasma by LC/MS/MS Validated Method

Dipanjan Goswami Department of Clinical Pharmacology and Pharmacokinetics, Ranbaxy Research Laboratories Ltd., Haryana, India
,
Ajay Kumar Department of Clinical Pharmacology and Pharmacokinetics, Ranbaxy Research Laboratories Ltd., Haryana, India
,
Arshad H. Khuroo Department of Clinical Pharmacology and Pharmacokinetics, Ranbaxy Research Laboratories Ltd., Haryana, India
,
Tausif Monif Department of Clinical Pharmacology and Pharmacokinetics, Ranbaxy Research Laboratories Ltd., Haryana, IndiaCorrespondence[email protected]
,
Nageshwar R. Thudi Ranbaxy Pharmaceuticals Canada Inc., Mississauga, Ontario, Canada
,
Vikesh K. Shrivastav Department of Clinical Pharmacology and Pharmacokinetics, Ranbaxy Research Laboratories Ltd., Haryana, India
,
Sunil K. Dubey Department of Clinical Pharmacology and Pharmacokinetics, Ranbaxy Research Laboratories Ltd., Haryana, India
,
Ajay K. Shingla Department of Product Development and Research, Ranbaxy Research Laboratories Ltd., Haryana, India
,
Mukul Prakash Clinical Pharmacology Unit, Ranbaxy Research Laboratories, Majeedia Hospital, Jamia Hamdard (Hamdard University), New Delhi, India
&
Sachin Mehra Clinical Pharmacology Unit, Ranbaxy Research Laboratories, Majeedia Hospital, Jamia Hamdard, New Delhi, India
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Pages 235-258 | Published online: 16 Dec 2008

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Ajay Kumar, Priya Ranjan Prasad Verma, Tausif Monif, Arshad H. Khuroo & Sunil S. Iyer. (2014) Development and validation of a LC-ESI-MS/MS method for simultaneous quantification of olmesartan and hydrochlothiazide in human K3 EDTA plasma and its application to pharmacokinetic biostudy. Clinical Research and Regulatory Affairs 31:1, pages 6-23.
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Dipanjan Goswami, Sanjay Gurule, Arshad H. Khuroo & Tausif Monif. (2009) Bioequivalence model for evaluation of Losartan in human plasma with special reference to drug–metabolite ratio. Clinical Research and Regulatory Affairs 26:4, pages 101-112.
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Articles from other publishers (9)

Rajesh Pradhan, Diksha Mishra, Sunil Kumar Dubey, Rajesh Khadgawat, Garima Kachhawa, Tarang Gupta & Rajeev Taliyan. (2023) Simultaneous estimation of methyl paraben, propyl paraben, and Bisphenol A in the plasma of Indian pregnant women using liquid chromatography–tandem mass spectrometry. SEPARATION SCIENCE PLUS 6:6.
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Geetika Wadhwa, Kowthavarapu Venkata Krishna, Rajeev Taliyan, Neeraj Tandon, Satyapal Singh Yadav, Dipankar Banerjee, Avinash Narwaria, Chandrakant Katiyar & Sunil Kumar Dubey. (2021) A novel UPLC–MS/MS method for simultaneous quantification of trigonelline, 4‐hydroxyisoleucine, and diosgenin from Trigonella foenum‐graecum extract: Application to pharmacokinetic study in healthy and type 2 diabetic rats . Biomedical Chromatography 36:2.
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Miloud El Karbane, Yassine Hameda Benchekroun, Fatima Zahra Abousalih, Ismail Bennani, Mohamed Azougagh, Taoufiq Saffaj & Mustapha Bouatia. (2021) Development and Validation of a UPLC-DAD Method for the Simultaneous Quantification of Eight Antihypertensive Drugs in the Pharmaceutical Matrix. Journal of AOAC INTERNATIONAL 104:3, pages 562-570.
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Geetika Wadhwa, Kowthavarapu Venkata Krishna, Rajeev Taliyan, Neeraj Tandon, Satyapal Singh Yadav, Dipankar Banerjee, Avinash Narwaria, Chandra Kant Katiyar & Sunil Kumar Dubey. (2021) Preclinical pharmacokinetics of trigonelline using ultra‐performance liquid chromatography–tandem mass spectrometry and pharmacological studies targeting type 2 diabetes. SEPARATION SCIENCE PLUS 4:4, pages 185-194.
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Rajesh Pradhan, Siddhanth Hejmady, Rajeev Taliyan, Gautam Singhvi, Rajesh Khadgawat, Garima Kachhawa & Sunil Kumar Dubey. (2021) Bioanalytical methodologies for clinical investigation of endocrine-disrupting chemicals: a comprehensive update. Bioanalysis 13:1, pages 29-44.
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Shraddha Jadhao, Asha Thomas, Amol Raje, Shatrughna Nagrik, Lata Kothapalli & Aaftab Shaikh. (2019) Herb-Drug Interaction of Quercetin on the Pharmacokinetics of Losartan in Rats: A High-Performance Thin-Layer Chromatography Study. JPC - Journal of Planar Chromatography - Modern TLC 32:5, pages 401-409.
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Arvind Kumar, Surya Prakash Dwivedi & Tulika Prasad. (2019) Method Validation for Simultaneous Quantification of Olmesartan and Hydrochlorothiazide in Human Plasma Using LC-MS/MS and Its Application Through Bioequivalence Study in Healthy Volunteers. Frontiers in Pharmacology 10.
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Hisham Hashem, Adel Ehab Ibrahim & Magda Elhenawee. (2016) Simultaneous determination of the antihypertensives hydrochlorothiazide, losartan potassium, irbesartan and valsartan in bulk powders and pharmaceutical preparations by high performance liquid chromatography. Main Group Chemistry 15:4, pages 335-346.
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D Vijaya BharathiKishore Kumar Hotha, Pankaj K Chatki, V Satyanarayana & V Venkateswarlu. (2012) LC–MS/MS method for simultaneous estimation of candesartan and hydrochlorothiazide in human plasma and its use in clinical pharmacokinetics. Bioanalysis 4:10, pages 1195-1204.
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